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| 1 | Radioembolization for the treatment of unresectable hepatocellular carcinoma:A clinical review显示文摘Hepatocellular carcinoma(HCC)is the sixth most common cancer in the world.The majority of patients with HCC present with unresectable disease.These patients have historically had limited treatment options secondary to HCC demonstrating chemoresistance to the currently available systemic therapies.Additionally, normal liver parenchyma has shown intolerance to tumoricidal radiation doses,limiting the use of external beam radiation.Because of these limitations,novel percutaneous liver-directed therapies have emerged. The targeted infusion of radioactive microspheres (radioembolization)represents one such therapy. Radioembolization is a minimally invasive transcatheter therapy through which radioactive microspheres are infused into the hepatic arteries that supply tumor. Once infused,these microspheres traverse the hepatic vascular plexus and selectively implant within the tumor arterioles.Embedded within the arterioles, the 90Y impregnated microspheres emit high energy and low penetrating radiation doses selectively to the tumor.Radioembolization has recently shown promise for the treatment of patients with unresectable HCC. The objective of this review article is to highlight twocurrently available radioembolic devices(90Y,188Rh)and provide the reader with a recent review of the literature. | Saad M Ibrahim Robert J Lewandowski Kent T Sato Vanessa L Gates Laura Kulik Mary F Mulcahy Robert K Ryu Reed A Omary Riad Salem | 2008 | World Journal of Gastroenterology2008，14，11： | 14 |
| 2 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 3 | Electromagnetic fields about a loop source of current显示文摘 | Ryu J Morrison F H Ward S H | 1970 | Geophysics1970，35，： | 1 |
| 4 | Plant growth-promoting rhizobacteria systemically protect Ara- bidopsis thaliana against cucumber mosaic virus by a salicylic acid and NPRl-independent and jasmonic acid- dependent signaling pathway 显示文摘 | RYU C M MUROHY J F MYSORE K S | 2004 | The Plant Journal2004，39，3： | 1 |
| 5 | Measurement and analysis of thermal stresses in 3D integrated structures containing through-silicon-vias显示文摘 | JIANG T F RYU S K ZHAO Q | 2013 | Microelectronics Reliability2013，53，1： | 1 |
| 6 | Evaluation of the flavor-- noid oroxylin A as an inhibitor of P--glycoprotein--mediated cellular efflux-- 显示文摘 | Go W J Ryu J H Qiang F | 2009 | JNatProd2009，72，9： | 1 |
| 7 | Ce-doped YAG phosphor powders prepared by co-precipitation and heterogeneous precipitation显示文摘 | Yuan F Ryu H | | 0，，： | 1 |
| 8 | In vivo and scanning electron microscopy imaging of upconverting nanophosphors in caenorhabditis elegans显示文摘 | LIM S F RIEHN R RYU W S | 2006 | Nano Lett2006，6，： | 1 |
| 9 | Analysing Interaction Prob- lems with Cyclic Interaction Theory: Low-level In- teraction Walkthrough 显示文摘 | RYU H MONK A F | 2004 | PsychNology Journal2004，2，3： | 1 |
| 10 | Dopamine transporter expression distinguishes dopaminergic neurons from other cate cholaminergic neurons in the developing zebrafish embryo显示文摘 | HOLZSCHUH J RYU S ABERGER F | 2001 | Mech Dev2001，101，12： | 1 |
| 11 | Supporting the dynamic evolution of web service protocols in service-oriented architec- tures显示文摘 | Ryu S H Casati F Skogsrud H | 2008 | ACM Transactions on the Web2008，2，2： | 1 |
| 12 | Electromagnetic fields about a loop source of current 显示文摘 | Ryu J Morrison H F and Ward S H | 1970 | Geophysics1970，35，5： | 1 |
| 13 | Rhizobacteria-mediated growth promotion of tomato leads to protection against Cucumber mosaic virus 显示文摘 | Murphy J F Reddy M S Ryu C M | 2003 | Phytopathology2003，93，： | 1 |
| 14 | Electromag-netic fields about a loop source of current显示文摘 | RYU J MORRISON H F WARD S H | 1970 | Geo-physics1970，35，5： | 1 |
| 15 | The diagnostic utili- ties of anti-agalactosyl IgG antibodies,anti-cyclic citrulli- nated peptide antibodies,and rheumatoid factors in rheu- matoid arthritis显示文摘 | Ryu HJ Takeuchi F Kuwata S | 2011 | Rheumatol Int2011，31，3： | 1 |
| 16 | Engineering of primary car-bohydrate metabolism for increased production of actinorhodin in Strepto-myces coelicolor显示文摘 | RYU Y G BUTLER M J CHATER K F | 2006 | Appl Environ Microbiol2006，72，： | 1 |
| 17 | Combustion of refuse-derived fuel in a fluidised bed显示文摘 | Hernandez-Atonal F D Ryu C Sharifi V N | | 0，，01： | 1 |
| 18 | Attachment and biofilm formation on stainless steel by Escherichia coli O157:H7 as affected by curli production显示文摘 | Ryu J H Kim H Frank J F | 2004 | Lett Appl Microhiol2004，39，： | 1 |
| 19 | Supporting the dy-namic evolution of Web service protocols in service-orientedarchitectures显示文摘 | RYU S H CASATI F SKOGSRUD H | 2007 | ACM Transactions on the Web2007，2，2： | 1 |
| 20 | Dissemination of cancer cells into circulation occurs by incisional biopsy of oral squamous cell carcinoma显示文摘 | Kusukawa J Suefuji Y Ryu F | 2000 | J Oral Pathol Med2000，29，7： | 1 |
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