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| 1 | Feasibility of gastric endoscopic submucosal dissection with continuous low-dose aspirin for patients receiving dual antiplatelet therapy显示文摘BACKGROUND Endoscopic submucosal dissection(ESD) for gastric neoplasms during continuous low-dose aspirin(LDA) administration is generally acceptable according to recent guidelines. This retrospective study aimed to investigate the effect of continuous LDA on the postoperative bleeding after gastric ESD in patients receiving dual antiplatelet therapy(DAPT).AIM To investigate the feasibility of gastric ESD with continuous LDA in patients with DAPT.METHODS A total of 597 patients with gastric neoplasms treated with ESD between January2010 and June 2017 were enrolled. The patients were categorized according to type of antiplatelet therapy(APT).RESULTS The postoperative bleeding rate was 6.9%(41/597) in all patients. Patients were divided into the following two groups: no APT(n = 443) and APT(n = 154). APT included single-LDA(n = 95) and DAPT(LDA plus clopidogrel, n = 59)subgroups. In the single-LDA and DAPT subgroups, 56 and 39 patients were received continuous LDA, respectively. The bleeding rate with continuous singleLDA(10.7%) was similar to that with discontinuous single-LDA(10.3%)(P >0.99). Although the bleeding rate with continuous LDA in patients receiving DAPT(23.1%) was higher than that with discontinuous LDA in patients receiving DAPT(5.0%), no significant difference was observed(P = 0.141).CONCLUSION The bleeding rate with continuous LDA in patients receiving DAPT was not statistically different from that with discontinuous LDA in patients receiving DAPT. Therefore, continuous LDA administration may be acceptable for ESD in patients receiving DAPT, although patients should be carefully monitored for possible bleeding. | Hideaki Harada Satoshi Suehiro Daisuke Murakami Ryotaro Nakahara Takuya Nagasaka Tetsuro Ujihara Ryota Sagami Yasushi Katsuyama Kenji Hayasaka Yuji Amano | 2019 | World Journal of Gastroenterology2019，25，4： | 6 |
| 2 | Tingley's Problem on Symmetric Absolute Normalized Norms on R^2显示文摘In this paper,we study Tingley's problem on symmetric absolute normalized norms on R2.We construct new methods for Tingley's problem on two-dimensional spaces by using isosceles orthogonality,which does not make use of the notion of natural extension.Furthermore,using our methods,several sufficient conditions for Tingley's problem on symmetric absolute normalized norms on R2 are given.As applications,we present various new examples including the two-dimensional Lorentz sequence space d(2)(ω,q) and its dual d(2)(ω,q)*by simple arguments. | Ryotaro TANAKA | 2014 | Acta Mathematica Sinica,English Series2014，30，8： | 5 |
| 3 | Endoscopic submucosal dissection for small submucosal tumors of the rectum compared with endoscopic submucosal resection with a ligation device显示文摘AIM To evaluate the efficacy and safety of endoscopic submucosal dissection(ESD) for small rectal submucosal tumors(SMTs).METHODS Between August 2008 and March 2016, 39 patients were treated with endoscopic submucosal resection with a ligation device(ESMR-L)(n = 21) or ESD(n = 18) for small rectal SMTs in this study. Twenty-five lesions were confirmed by histological evaluation of endoscopic biopsy prior to the procedure, and 14 lesions were not evaluated by endoscopic biopsy. The results for the ESMR-L group and the ESD group were retrospectively compared, including baseline characteristics and therapeutic outcomes.RESULTS The rate of en bloc resection was 100% in both groups. Although the rate of complete endoscopic resectionwas higher in the ESD group than in the ESMR-L group(100% vs 95.2%), there were no significant differences between the two groups(P = 0.462). In one patient in the ESMR-L group with a previously biopsied tumor, histological complete resection with a vertical margin involvement of carcinoid tumor could not be achieved, whereas there was no incomplete resection in the ESD group. The mean length of the procedure was significantly greater in the ESD group than in the ESMR-L group(14.7 ± 6.4 min vs 5.4 ± 1.7 min, P < 0.05). The mean period of the hospitalization was also significantly longer in the ESD group than in the ESMR-L group(3.7 ± 0.9 d vs 2.8 ± 1.5 d, P < 0.05). Postoperative bleeding was occurred in one patient in the ESMR-L group.CONCLUSION Both ESMR-L and ESD were effective for treatment of small rectal SMTs. ESMR-L was simpler to perform than ESD and took less time. | Hideaki Harada Satoshi Suehiro Daisuke Murakami Ryotaro Nakahara Takanori Shimizu Yasushi Katsuyama Yasunaga Miyama Kenji Hayasaka Shigetaka Tounou | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，2： | 5 |
| 4 | Mesenchymal stem cells for treatment of aortic aneurysms显示文摘An aortic aneurysm(AA) is a silent but life-threatening disease that involves rupture. It occurs mainly in aging and severe atherosclerotic damage of the aortic wall. Even though surgical intervention is effective to prevent rupture, surgery for the thoracic and thoraco-abdom-inal aorta is an invasive procedure with high mortality and morbidity. Therefore, an alternative strategy for treatment of AA is required. Recently, the molecular pathology of AA has been clarified. AA is caused by an imbalance between the synthesis and degradation of extracellular matrices in the aortic wall. Chronic inflam-mation enhances the degradation of matrices directly and indirectly, making control of the chronic inflamma-tion crucial for aneurysmal development. Meanwhile, mesenchymal stem cells(MSCs) are known to be ob-tained from an adult population and to differentiate into various types of cells. In addition, MSCs have not only the potential anti-inflammatory and immunosuppres-sive properties but also can be recruited into damagedtissue. MSCs have been widely used as a source for celltherapy to treat various diseases involving graft-versus-host disease, stroke, myocardial infarction, and chronicinflammatory disease such as Crohn's disease clinically.Therefore, administration of MSCs might be availableto treat AA using anti-inflammatory and immnosup-pressive properties. This review provides a summary ofseveral studies on 'Cell Therapy for Aortic Aneurysm'including our recent data, and we also discuss the pos-sibility of this kind of treatment. | Aika Yamawaki-Ogata Ryotaro Hashizume Xian-Ming Fu Akihiko Usui Yuji Narita | 2014 | World Journal of Stem Cells2014，6，3： | 2 |
| 5 | Do liver metastases from gastric cancer contraindicate aggressive surgical resection?A 14-year single-center experience显示文摘BACKGROUND Advanced gastric cancer(GC)with liver metastasis is often characterized by multiple and bilobular metastases and may also be associated with extrahepatic metastatic lesions.Hence,many physicians consider that radical surgeries are contraindicated for liver metastases from GC(LMGC).According to the 2017 Japanese treatment guideline for GC,a smaller number of liver metastases without unresectable factors may be an indication for liver resection(LR)with curability.The actual 5-year overall survival(OS)rate ranges from 0 to 0.37.AIM To present the institutional indications for LR for LMGC and identify important factors for prognostic outcomes.METHODS In total,30 patients underwent LR for LMGC during a 14-year period,and we evaluated the clinical,surgical,and oncological findings.In all patients,radical surgery with intentional lymphadenectomy was performed for the primary GC.The median follow-up duration after the initial LR was 33.7 mo,and three patients with no recurrence died of causes unrelated to the LMGC.The OS and recurrence-free survival rates after the initial LR were assessed.RESULTS Seventeen patients had metachronous LMGC.The initial LR achieved curability in 29 patients.Perioperative chemotherapy was introduced in 23 patients.The median greatest LMGC dimension was 30 mm,and the median number of LMGC was two.Twenty-two patients had unilobular LMGC.The 5-year OS and recurrence-free survival rates were 0.48 and 0.28,respectively.The median survival duration and recurrence-free duration after the initial LR were 16.8 and 8.6 mo,respectively.Twenty-one patients developed recurrence after the initial LR.Additional surgeries for recurrence were performed in nine patients,and these surgeries clearly prolonged the patients’survival.Pathological serosal invasion was an independent predictor of a poor prognostic outcome after the initial LR.Aggressive LR may be indicated for carefully selected patients with LMGC.CONCLUSION Our results of LR for LMGC seem acceptable.Additional surgeries for recurrence after the initial LR might prolong OS.Pathological serosal invasion is important for poor prognostic outcomes. | Takefumi Yazawa Tomohide Hori Hidekazu Yamamoto Hideki Harada Michihiro Yamamoto MasahiroYamada Masaki Tani Asahi Sato Yasuyuki Kamada Ryotaro Tani Ryuhei Aoyama Yudai Sasaki MasazumiZaima | 2020 | World Journal of Gastrointestinal Pharmacology and Therapeutics2020，11，5： | 2 |
| 6 | Duplex real- time SYBR Green PCR assays for detection of 17 species of food-or waterborne pathogens in stools显示文摘 | Hiroshi Fukushima Yoshie Tsunomori Ryotaro Seki | 2003 | J Clin Microbiol2003，41，11： | 1 |
| 7 | Duplex Real-Time SYBR Green PCR Assays for Detection of 17 Species of Food or Waterborne Pathogens in Stools显示文摘 | Hiroshi Fukushima Yoshie Tsunomori Ryotaro Seki | 2003 | Journal of Clinical Microbiology2003，11，： | 1 |
| 8 | Duplex RealTime SYBR Green PCR Assays for Detection of 17 Species of Food or Waterborne Pathogens in Stools显示文摘 | Fukushima Iroshi shieYo Tsunomori Seki Ryotaro | 2003 | Journal of Clinical Microbiology2003，41，11： | 1 |
| 9 | Duplex Real-Time SYBR Green PCR Assays for Dectection of 17 Species of Food-or Waterborne Pathogens in Stools 显示文摘 | Hiroshi Fukushima Yoshie Tsunomori Ryotaro Seki | 2003 | Journal of Clinical Microbiology2003，41，11： | 1 |
| 10 | Surgical treatment of gallbladder cancer:An eight-year experience in a single center显示文摘BACKGROUND Gallbladder cancer(GBC)is the most common biliary malignancy and has the worst prognosis,but aggressive surgeries[e.g.,resection of the extrahepatic bile duct(EHBD),major hepatectomy and lymph node(LN)dissection]may improve long-term survival.GBC may be suspected preoperatively,identified intraoperatively,or discovered incidentally on histopathology.AIM To present our data together with a discussion of the therapeutic strategies for GBC.METHODS We retrospectively investigated nineteen GBC patients who underwent surgical treatment.RESULTS Nearly all symptomatic patients had poor outcomes,while suspicious or incidental GBCs at early stages showed excellent outcomes without the need for two-stage surgery.Lymph nodes around the cystic duct were reliable sentinel nodes in suspicious/incidental GBCs.Intentional LN dissection and EHBD resection prevented metastases or recurrence in early-stage GBCs but not in advanced GBCs with metastatic LNs or invasion of the nerve plexus.All patients with positive surgical margins(e.g.,the biliary cut surface)showed poor outcomes.Hepatectomies were performed in sixteen patients,nearly all of which were minor hepatectomies.Metastases were observed in the left-sided liver but not in the caudate lobe.We may need to reconsider the indications for major hepatectomy,minimizing its use except when it is required to accomplish negative bile duct margins.Only a few patients received neoadjuvant or adjuvant chemoradiation.There were significant differences in overall and disease-free survival between patients with stages≤IIB and≥IIIA disease.The median overall survival and disease-free survival were 1.66 and 0.79 years,respectively.CONCLUSION Outcomes for GBC patients remain unacceptable,and improved therapeutic strategies,including neoadjuvant chemotherapy,optimal surgery and adjuvant chemotherapy,should be considered for patients with advanced GBCs. | Yasuyuki Kamada Tomohide Hori Hidekazu Yamamoto Hideki Harada Michihiro Yamamoto MasahiroYamada Takefumi Yazawa Masaki Tani Asahi Sato Ryotaro Tani Ryuhei Aoyama Yudai Sasaki MasazumiZaima | 2020 | World Journal of Hepatology2020，12，9： | 1 |
| 11 | A highly active catalyst composed of ansa-fluorenylamidodimethyltitanium derivative for propene polymerization显示文摘 | Takeshi Shiono Ryotaro Harada Zhengguo Cai | 2009 | Top Catal2009，52，： | 1 |
| 12 | Circulating omentin is associated with coronary artery disease in men显示文摘 | Rei Shibata Noriyuki Ouchi Ryosuke Kikuchi Ryotaro Takahashi Kyosuke Takeshita Yoshiyuki Kataoka Koji Ohashi Nobuo Ikeda Shinji Kihara Toyoaki Murohara | 2011 | Atherosclerosis2011，，2： | 1 |
| 13 | Duplex real-time SYBR Green PCR assays for detection of 17 species of food-or waterborne pathogens in stools显示文摘 | Hiroshi Fukushima Yoshie Tsunomori Ryotaro Seki | 2003 | J Clin Microbiol2003，41，11： | 1 |
| 14 | Clinical CaseReport of Injectable Tissu-Engineered Bone for Alveolar Augmentation with Simultaneous Implant Placement 显示文摘 | Minoru Ueda Yoichi Yamada Ryotaro Ozawa | 2005 | Int Periodont Restor Dent2005，25，1： | 1 |
| 15 | Electrically tunable lasing based on defect mode in one-dimensionalphotonic crystal with conducting polymer and liquid crystal defect layer显示文摘 | Ryotaro Ozaki Yuko Matsuhisa Masanori Ozaki and Katsumi Yoshino | 2004 | Applied Physics Letters2004，84，11： | 1 |
| 16 | Duplex Real-time SYBR Green PCR assays for detection of 17 species of food or waterborne pathogens in stools显示文摘 | Hiroshi F Yoshie T Ryotaro S | 2003 | J Clinical Microbiol2003，41，11： | 1 |
| 17 | Density-matrix renormalization-group study of the spin gap in a one-dimensional Hubbard model: Effect of the distant transfer and exchange coupling显示文摘 | Ryotaro Arita Kazuhiko Kuroki Hideo Aoki | 1998 | Phys Rev B1998，57，10： | 1 |
| 18 | Characterization of the protease-activated receptor-1-mediated contraction and relaxation in the rat duodenal smooth muscle显示文摘 | Atsufumi Kawabata Ryotaro Kuroda Naoko Kuroki Hiroyuki Nishikawa Kenzo Kawai Hiromasa Araki | 2000 | Life Sciences2000，，20： | 1 |
| 19 | Characterization of polymer-enzyme complex as a novel biocatalyst for nonaqueous enzymology显示文摘 | Yoshihiko M Ryotaro H Akira H | 2003 | Journal of Molecular Catalysis B:Enzymatic2003，22，1： | 1 |
| 20 | Borate buffer dramatically enhances the activity of poly(ethylene glycol)-chymotrypsin complex catalytically active in anhydrous isooctane than conventional phosphate buffer even at low concentration显示文摘 | Yoshihiko M Ryotaro H Akira H | 2001 | Biotechnology Letters2001，23，1： | 1 |
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