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| 1 | Origin of Middle Triassic high-K tale-alkaline granitoids and their potassic microgranular enclaves from the western Kunlun orogen, northwest China: A record of the closure of Paleo- Tethys 显示文摘 | Jiang Yaohui Jia Ruya Liu Zheng | 2013 | Lithos2013，，： | 1 |
| 2 | SSIC model: Amulti-layer model for intervention of online rumors spreading 显示文摘 | Tian Ruya Zhang Xuefu Liu Yijun | 2015 | Physica A4272015，，： | 1 |
| 3 | Engineering the high-entropy phase of Pt-Au-Cu nanowire for electrocatalytic hydrogen evolution显示文摘Hydrogen economy,as the most promising alternative energy system,relies on the hydrogen production through sustainable water splitting which in turn relies on the high efficiency electrocatalysts.PtAuCu A1-phase alloy has been predicted to be a promising electrocatalyst for the hydrogen evolution.As such preferred phase of Pt-Au-Cu is not thermodynamically favored,herein,we stabilize PtAuCu alloy by engineering the high-entropy phase in the form of nanowire.Density functional theory(DFT)calculations indicate that,in comparison with the ordered phase and segregated phases with discrete hydrogen binding energy,the high-entropy phase provides a diverse combination of site composition to continuously tune the hydrogen binding energy,and thus generate a series of highly active sites for the hydrogen evolution.Reflecting the theoretical prediction,electrochemical tests show that the A1-phase PtAuCu nanowire significantly outperforms its nanoparticle counterpart with phase segregation,toward the electrocatalysis of hydrogen evolution,offering one of the best hydrogen evolution electrocatalysts. | Yanan Yu Guangdong Liu Shuaihu Jiang Ruya Zhang Huiqiu Deng Eric AStach Shujuan Bao Zhenhua Zeng Yijin Kang | 2023 | Nano Research2023，16，8： | 0 |
| 4 | Circadian clock control of MRTF/SRF pathway suppresses beige adipocyte thermogenic recruitment显示文摘The morphological transformation of adipogenic progenitors into mature adipocytes requires dissolution of actin cytoskeleton with loss of myocardin-related transcription factor(MRTF)/serum response factor(SRF)activity.Circadian clock confers temporal control in adipogenic differentiation,while the actin cytoskeleton–MRTF/SRF signaling transduces extracellular physical niche cues.Here,we define a novel circadian transcriptional control involved in actin cytoskeleton–MRTF/SRF signaling cascade that modulates beige fat thermogenic function.Key components of actin dynamic–MRTF/SRF pathway display circadian regulation in beige fat depot.The core clock regulator,brain and muscle arnt-like 1(Bmal1),exerts direct transcriptional control of genes within the actin dynamic–MRTF/SRF cascade that impacts actin cytoskeleton organization and SRF activity.Employing beige fat-selective gene-targeting models together with pharmacological rescues,we further demonstrate that Bmal1 inhibits beige adipogenesis and thermogenic capacity in vivo via the MRTF/SRF pathway.Selective ablation of Bmal1 induces beigeing with improved glucose homeostasis,whereas its targeted overexpression attenuates thermogenic induction resulting in obesity.Collectively,our findings identify the clock–MRTF/SRF regulatory axis as an inhibitory mechanism of beige fat thermogenic recruitment with significant contribution to systemic metabolic homeostasis. | Xuekai Xiong Weini Li Ruya Liu Pradip Saha Vijay Yechoor Ke Ma | 2022 | Journal of Molecular Cell Biology2022，14，12： | 0 |
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