|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Feasibility of pancreatectomy following high-dose proton therapy for unresectable pancreatic cancer显示文摘AIM To review surgical outcomes for patients undergoing pancreatectomy after proton therapy with concomitant capecitabine for initially unresectable pancreatic adenocarcinoma.METHODS From April 2010 to September 2013,15 patients with initially unresectable pancreatic cancer were treated withproton therapy with concomitant capecitabine at 1000 mg orally twice daily. All patients received 59.40 Gy(RBE) to the gross disease and 1 patient received 50.40 Gy(RBE) to high-risk nodal targets. There were no treatment interruptions and no chemotherapy dose reductions. Six patients achieved a radiographic response sufficient to justify surgical exploration,of whom 1 was identified as having intraperitoneal dissemination at the time of surgery and the planned pancreatectomy was aborted. Five patients underwent resection. Procedures included:Laparoscopic standard pancreaticoduodenectomy(n = 3),open pyloris-sparing pancreaticoduodenectomy(n = 1),and open distal pancreatectomy with irreversible electroporation(IRE) of a pancreatic head mass(n = 1). RESULTS The median patient age was 60 years(range,51-67). The median duration of surgery was 419 min(range,290-484),with a median estimated blood loss of 850 cm^3(range,300-2000),median ICU stay of 1 d(range,0-2),and median hospital stay of 10 d(range,5-14). Three patients were re-admitted to a hospital within 30 d after discharge for wound infection(n = 1),delayed gastric emptying(n = 1),and ischemic gastritis(n = 1). Two patients underwent R0 resections and demonstrated minimal residual disease in the final pathology specimen. One patient,after negative pancreatic head biopsies,underwent IRE followed by distal pancreatectomy with no tumor seen in the specimen. Two patients underwent R2 resections. Only 1 patient demonstrated ultimate local progression at the primary site. Median survival for the 5 resected patients was 24 mo(range,10-30).CONCLUSION Pancreatic resection for patients with initially unresectable cancers is feasible after high-dose [59.4 Gy(RBE)] proton radiotherapy with a high rate of local control,acceptable surgical morbidity,and a median survival of 24 mo. | Kathryn E Hitchcock R Charles Nichols Christopher G Morris Debashish Bose Steven J Hughes John A Stauffer Scott A Celinski Elizabeth A Johnson Robert A Zaiden Nancy P Mendenhall Michael S Rutenberg | 2017 | World Journal of Gastrointestinal Surgery2017，9，4： | 1 |
| 2 | Microbial response to surface microtopography:The role of metabolism in localized mineral dissolution显示文摘 | Edwards K J Rutenberg A D | 2001 | Chemical Geology2001，180，4： | 1 |
| 3 | Alveolar bone turnover in male Rats:site-and age-specific chages显示文摘 | King GJ Latta L Rutenberg J | 1995 | Anat Rec1995，242，： | 1 |
| 4 | Histochemical and ultrastructural demonstration of r-glutamyltranspeptidase activity 显示文摘 | Rutenberg AM Kim H Fischbein J | 1968 | J Histochem Cytochem1968，17，： | 1 |
| 5 | Histochemical and ultrastructural demonstration of r-glutamyltranspeptidase activity显示文摘 | Rutenberg AM Kim H Fischbein J | 1968 | J Histochem Cytochem1968，17，： | 1 |
| 6 | In vitro detoxification of bacterial endotoxin by macrophages显示文摘 | RUTENBERG S H SCHWEINBURG F B FINE J | 1960 | The Journal of Experimental Medicine1960，112，： | 1 |
| 7 | Extemal beam radiotherapy for pediatric and young adult desmoid tumors 显示文摘 | Rutenberg MS Indelicato D J Knapik JA | | Pediatr Blood Cancer0，57，3： | 1 |
| 8 | Determination of the epoxide equivalent weight of glycidyl ethers by proton magnetic resonance spectrometry显示文摘 | Dorsey J D Dorsey G F Rutenberg A C | 1977 | Anal Chem1977，49，8： | 1 |
| 9 | Dynamics of dislocations and surface instabilities in misfitting heteroepi- taxial films显示文摘 | Haataja M Mtiller J Rutenberg A D | 2001 | Phys Rev B2001，65，03： | 1 |
| 10 | Cross-flow filtration of dissolved and colloidal nitrogen and phosphorus in seawater:results from an intercomparison study显示文摘 | BAUER J E RUTENBERG K C WOLGAST D M | 1996 | Mar Chem1996，55，： | 1 |
| 11 | Alveolar bone turnover and tooth movement in male rats after removal of orthodontic appliances显示文摘 | King G J Latta L Rutenberg J | 1997 | Am J Orthod Dentofacial Orthop1997，111，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员