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1篇 您的检索式:作者名="Rupert Ollinger"
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1Indirect targeting of MYC sensitizes pancreatic cancer cells to mechanistic target of rapamycin (mTOR) inhibition显示文摘Dear Editor,Pancreatic ductal adenocarcinoma(PDAC)remains a significant health problem with an increase in the incidence and a five-year survival rate of only 10%[1].The Phosphoinositide 3-kinase-protein kinase-B-mechanistic target of rapamycin(PI3K-AKT-mTOR)pathway is a driver pathway in PDAC and an important therapeutic target[2].We[3]and others[4–6]have demonstrated that the mTOR kinase is a therapeutic target in PDAC,and rationally designed mTOR inhibitor(mTORi)-based combination therapies are emerging[2].Christian Schneeweis Zonera HassanKatja Ascherl Matthias Wirth Stella Koutsouli Felix Orben Lukas Krauß Carolin Schneider Rupert Ollinger Oliver HKrämer Roland Rad Maximilian Reichert Maria SRobles Dieter Saur Günter Schneider 2022Cancer Communications2022,42,4:0
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