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| 1 | Gather wisdom to overcome barriers:Well-designed nano-drug delivery systems for treating gliomas显示文摘Due to the special physiological and pathological characteristics of gliomas,most therapeutic drugs are prevented from entering the brain.To improve the poor prognosis of existing therapies,researchers have been continuously developing non-invasive methods to overcome barriers to gliomas therapy.Although these strategies can be used clinically to overcome the blood-brain barrier(BBB),the accurate delivery of drugs to the glioma lesions cannot be ensured.Nano-drug delivery systems(NDDS)have been widely used for precise drug delivery.In recent years,researchers have gathered their wisdom to overcome barriers,so many well-designed NDDS have performed prominently in preclinical studies.These meticulous designs mainly include cascade passing through BBB and targeting to glioma lesions,drug release in response to the glioma microenvironment,biomimetic delivery systems based on endogenous cells/extracellular vesicles/protein,and carriers created according to the active ingredients of traditional Chinese medicines.We reviewed these well-designed NDDS in detail.Furthermore,we discussed the current ongoing and completed clinical trials of NDDS for gliomas therapy,and analyzed the challenges and trends faced by clinical translation of these well-designed NDDS. | Jiwei Cui Yuanxin Xu Haiyan Tu Huacong Zhao Honglan Wang Liuqing Di Ruoning Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 2 |
| 2 | Multidimensional Least-Squares Fitting with a Fuzzy Model显示文摘 | Ruoning Xu Chulin Lin | 2001 | Fuzzy Sets and Systems2001，，119： | 1 |
| 3 | Extensions of the Analytic Hierarchy Process in Fuzzy Environment显示文摘 | Xu Ruoning Zhai Xiaoyan | 1992 | Fuzzy sets and Systems1992，52，： | 1 |
| 4 | Fuzzy Least-squares Priority Method in the Analytic Hierarchy Process显示文摘 | Xu Ruoning | 2000 | Fuzzy Sets and Systems2000，112，3： | 1 |
| 5 | Analysis of Supply Chain Coordination Under Fuzzy Demand in a Two - stage Supply Chain 显示文摘 | Ruoning Xu Xiaoyan Zhai | 2010 | Applied Mathematical Modeling2010，34，1： | 1 |
| 6 | Optimal models for single-period supply chain problems with fuzzy demand显示文摘 | RUONING XU XIAOYAN ZHAI | 2008 | Information Sciences2008，178，17： | 1 |
| 7 | Approximated Unimodal Region Elimination Based Global Optimisation Method for Engineering Design显示文摘 | Younis Adel Xu Ruoning Dong Zuomin | 2009 | International Journal of Product Development2009，9，123： | 1 |
| 8 | Fuzzy logarithmic least squares ranking method in analytic hierarchy process显示文摘 | Xu Ruoning Zhai Xiaoyan | 1996 | Fuzzy Sets and Systems1996，，2： | 1 |
| 9 | Fuzzy Logarithmic Least Squares Ranking Method in Analytic Hierarchy Process显示文摘 | Zhai Xiaoyan | 1996 | Fuzzy Sets and Systems1996，77，： | 1 |
| 10 | Fuzzy logarithmic least squares ranking method in analytic hierarchy process显示文摘 | Xu Ruoning | 1996 | Fuzzy Set and Systems1996，，77： | 1 |
| 11 | Optimal models for single- period supply chain problems with fuzzy demand 显示文摘 | Xu Ruoning Zhai Xiaoyan | 2008 | Information Sciences2008，178，17： | 1 |
| 12 | Analysis of supply chain coordination under fuzzy demand in a two-stage supply chain显示文摘 | Xu Ruoning Zhai Xiaoyan | 2010 | Applied Mathematical Modelling2010，34，1： | 1 |
| 13 | Analysis of supply chain coordination under fuzzy demand in a two-stage supply chain显示文摘 | Ruoning Xu Xiaoyan Zhai | 2009 | Applied Mathematical Modelling2009，，1： | 1 |
| 14 | Fuzzy logarithmic least squares ranking method in analytic hierarchy process 显示文摘 | Xu Ruoning Zhai Xiaoyan | 1996 | Fuzzy Sets and Systems1996，77，： | 1 |
| 15 | Extension of the analytic hierarchy process in fuzzy environment显示文摘 | Xu Ruoning Zhai Xiaoyan | 1992 | Fuzzy sets and Systems1992，52，： | 1 |
| 16 | Fuzzy least - squares priority method in analytic hierarchy process 显示文摘 | Xu Ruoning | 2000 | Fuzzy sets and Systems2000，112，： | 1 |
| 17 | Optimal models for single-period supply chain problems with fuzzy demand显示文摘 | Ruoning Xu Xiaoyan Zhai | 2008 | Information Sciences2008，，17： | 1 |
| 18 | Fuzzy logarithmic Least squares ranking method in analytic hierarchy process 显示文摘 | Xu Ruoning Zhai Xiaoyan | 1996 | Fuzzy sets and Systems1996，77，： | 1 |
| 19 | Structure transformation from Sierpiński triangles to chains assisted by gas molecules显示文摘Reversible transformations between fractals and perio dic structures are of fundamental importance for understanding the formation mechanism of fractals.Currently,it is still a challenge to controllably achieve such a transformation.We investigate the effect of CO and CO_(2)molecules on Sierpiński triangles(STs)assembled from Fe atoms and 4,4″-dicyano-1,1′:3′,1″-terphenyl(C3PC)molecules on Au surfaces.Using scanning tunneling microscopy,we discover that the gas molecules induce a transition from STs into 1D chains.Based on density functional theory modeling,we propose that the atomistic mechanism involves the transformation of a stable 3-fold coordination Fe(C3PC)_(3)motif to Fe(C3PC)_(4)with an axially bonded CO molecule.CO_(2)causes the structural transformation through a molecular catassembly process. | Chao Li Zhen Xu Yajie Zhang Jie Li Na Xue Ruoning Li Mingjun Zhong Tianhao Wu Yifan Wang Na Li Ziyong Shen Shimin Hou Richard Berndt Yongfeng Wang Song Gao | 2023 | National Science Review2023，10，7： | 0 |
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