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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Prediction of impact damage in composite plates显示文摘 | Hou J P Petrinic N Ruiz C Hallett S R | 2006 | Composites Science and Technology2006，60，： | 1 |
| 3 | Impact loading of plates: An experimental investigation显示文摘 | Corran R S J Shadbolt P J Ruiz C | 1983 | InternationalJournal of Impact Engineering1983，1，1： | 1 |
| 4 | Germanium recovery from gasification fly ash: Evaluation of end-products obtained by precipitation methods 显示文摘 | ARROYO F FONT O FERNANDEZ-PEREIRA C QUEROL X JUAN R RUIZ C COCA P | 2009 | Journal of Hazardous Materials2009，167，123： | 1 |
| 5 | Uncertainty management in the uint commitment problem显示文摘 | Ruiz P A Philbrick C R Zak E | 2009 | IEEE Transactions on Power Systems2009，24，2： | 1 |
| 6 | Modulation of renal disease in MRL/Ipr mice by suberoylanilide hydroxamic acid 显示文摘 | Reilly C M Mishra N Miller J M Joshi D Ruiz P Riehon V M | 2004 | J ImmunoI2004，173，： | 1 |
| 7 | Restoration SPOT images using PSF-drived deconvolution filters 显示文摘 | Ruiz C P Ariza Lopez F J | 2002 | International Journal of Remote Sensing2002，23，12： | 1 |
| 8 | Serum values of metalloproteinase-2 and metalloproteinase-9 as related to unstable plaque and inflammatory cells in patients with greater than 70% carotid artery stenosis显示文摘 | Alvarez B Ruiz C Chacón P | 2004 | J Vasc Surg2004，40，3： | 1 |
| 9 | Impact Loading of Plates-An Experimental Investigation 显示文摘 | Corran R S J Shadbolt P J Ruiz C | 1983 | Int J Impact Eng1983，1，1： | 1 |
| 10 | Prediction of impact damage in composite plates显示文摘 | HOU J P PETRINIC N RUIZ C | 2000 | Composites Science and Technology2000，60，： | 1 |
| 11 | Resistance to cold and heat stress: accumulation of phenolic compounds in tomato and watermel- on plants显示文摘 | Rivem R M Ruiz J M Garcia P C | 2001 | Plant Science2001，160，： | 1 |
| 12 | Expectant management of severe preeclampsia and preeclampsia superimposed on chronic hypertension between 24 and 34 weeks' gestation显示文摘 | Vigil-De Gracia P Montufar-Rueda C Ruiz J | | 0，，01： | 1 |
| 13 | Prediction of impact damage in composite plates显示文摘 | Hou J P Petrinic N Ruiz C | 2000 | Composite Science and Technology2000，60，2： | 1 |
| 14 | High-sensitivity C-reactive protein in high-grade carotid stenosis: risk marker for unstable carotid plaque 显示文摘 | Garcia BA Ruiz C Chacon P | 2003 | J Vasc Surg2003，38，5： | 1 |
| 15 | Prediction of impact damage in composite plates显示文摘 | HOU J P PETRINIC N RUIZ C | 2000 | Composites Science & Technology2000，60，2： | 1 |
| 16 | Tissue micro array analysis of ganglioside N-glycolyl GM3 expression and signal transducer and activator of transcription(STAT)-3 activation in relation to dendritic cell infiltration and microvessel density in non-small cell lung cancer显示文摘 | VAN C H RUIZ M G VAN D V P | 2009 | BMC Cancer2009，9，： | 1 |
| 17 | Prediction of impactdamage in composite plates 显示文摘 | Hou J P Petrinic N Ruiz C | 2000 | Composite Science andTechnology2000，60，2： | 1 |
| 18 | Evaluation ofsteam explosion pre-treatment for enzymatic hydrolysis ofsunflower stalks显示文摘 | Ruiz E Cara C Manzanares P | 2008 | Enzyme and Microbial Technology2008，42，2： | 1 |
| 19 | A delamination criterion for laminated composites under low-velocity impact显示文摘 | HOU J P PETRINIC N RUIZ C | 2001 | Composites Science & Technology2001，61，14： | 1 |
| 20 | High-sensitivity C-reactive protein in high-grade carotid stenosis : risk marker for unstable carotid plaque 显示文摘 | Alvarez Garcia B Ruiz C Chacon P | 2003 | JVasc Surg2003，38，5： | 1 |
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