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| 1 | Current status and future perspectives of immunotherapy in bladder cancer treatment显示文摘The treatment strategy of bladder cancer has evolved not only through the traditional modalities of surgery and chemotherapy but also by immunotherapy over the past several decades.Immunotherapies such as intravesical Bacillus Calmette-Guérin(BCG)vaccines and immune checkpoint blockades(ICBs)are sometimes used for treating patients with bladder cancer,especially those who develop resistance to conventional first-line treatments such as surgery and chemotherapy.Unfortunately,it is a limited number of individuals that see clinical benefits from this approach,and complicating matters more is that many of these patients suffer severe immune-related adverse events(ir AEs).If current momentum continues to result in improved response rates and managed ir AEs,immunotherapy could be poised to revolutionize the landscape of urothelial carcinoma therapeutics. | Zhangsong wu Jinjian Liu Ruixiang Dai Song Wu | 2021 | Science China(Life Sciences)2021，64，4： | 6 |
| 2 | Using finite difference method to simulate casting thermal stress显示文摘Thermal stress simulation can provide a scientific reference to eliminate defects such as crack,residual stress centralization and deformation etc.,caused by thermal stress during casting solidification.To study the thermal stress distribution during casting process,a unilateral thermal-stress coupling model was employed to simulate 3D casting stress using Finite Difference Method(FDM),namely all the traditional thermal-elastic-plastic equations are numerically and differentially discrete.A FDM/FDM numerical simulation system was developed to analyze temperature and stress fields during casting solidification process.Two practical verifications were carried out,and the results from simulation basically coincided with practical cases.The results indicated that the FDM/FDM stress simulation system can be used to simulate the formation of residual stress,and to predict the occurrence of hot tearing.Because heat transfer and stress analysis are all based on FDM,they can use the same FD model,which can avoid the matching process between different models,and hence reduce temperature-load transferring errors.This approach makes the simulation of fluid flow,heat transfer and stress analysis unify into one single model. | Liao Dunming Zhang Bin Zhou Jianxin Liu Ruixiang Chen Liliang | 2011 | China Foundry2011，8，2： | 6 |
| 3 | Recent developments of InteCAST software and its applications on special castings显示文摘with the development of computer technology, foundry CAE technology has made rapid progress. Commercialsoftware packages of casting process simulation, therefore, have become more and more practical. This paper introducesboth the recent developments and some applications of InteCAST software, a commercial numerical simulation softwarepackage for foundry industry, with more than 120 customers all over the world. The function modules of lnteCAST8.0 andsome new techniques, such as uneven mesh technology for mold filling simulation and numerical mouse technology fordata visualization, were introduced. Several applications on special castings such as investment casting, low pressure diecasting, and high pressure die casting, were given. These applications showed that the software can help engineers tooptimize casting process by forecasting casting defect. | Jianxin ZHOU Ruixiang LIU Liliang CHEN Dunming LIAO | 2005 | China Foundry2005，2，3： | 6 |
| 4 | Numerical Simulation of Solidification Microstructure and Effects of Phase-field Parameters on Grain Growth Morphologies显示文摘By a simple phase field model, a series of numerical simulations of solidification microstructure was performed to show a rich variety of dendritic patterns. At the same time, the relation between the morphology of grain growth and some parameters including the strength of anisotropy, dimensionless latent heat and the size of initial solid zone was studied. It is for the first time that patterns of grain growth were associated with the size of initial solid zone, which is an interesting issue. The possible reason for this may be that variation in the size of initial solid zone may bring about fluctuation of the interface energy, making the interface unstable. | Jingfeng LIU+, Ruixiang LIU and Liliang CHEN Research Studio of Solidification Simulation, College of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China | 2005 | Journal of Materials Science & Technology2005，21，6： | 4 |
| 5 | Modified Carbothermal Synthesis of TiC Whiskers显示文摘A new approach to the massive production of TiC whiskers with high purity and low cost was presented. It is a modified carbothermal reduction method (MCTR) characterized by argon stream flowing vertically and passing through the interior of the mixture of raw materials. It is found for the first time that there is an optimum flow of the upward flowing argon stream, at which large quantity of high quality TiC can be obtained. This paper described the new method, analyzed the mechanism and conditions for the formation of high purity TiC whiskers on a large scale, and compared MCTR with the traditional carbothermal reduction method (TCTR). Based on the analysis and comparison, it is concluded that in order to produce high quality transition metal carbides, nitrides and carbonitrides with low cost TCTR must be replaced by MCTR. | Ruixiang Cao Cuirong Liu Zhisheng Wu Jinsheng Pan | 2011 | Journal of Materials Science & Technology2011，27，11： | 3 |
| 6 | Construction of the Chinese Veteran Clinical Research (CVCR) Platform for the assessment of non-communicable diseases显示文摘 | Tan Jiping Li Nan Gao Jing Guo Yuhe Hu Wei Yang Jinsheng Yu Baocheng Yu Jianmin Du Wei Zhang Wenjun Cui Lianqi Wang Qingsong Xia Xiangnan Li Jianjun Zhou Peiyi Zhang Baohe Liu Zhiying Zhang Shaogang Sun Lanying Liu Nan Deng Ruixiang Dai Wenguang Yi Fang Chen Wenjun Zhang Yongqing Xue Shenwu Cui Bo Zhao Yiming Wang Luning | 2014 | Chinese Medical Journal2014，，3： | 3 |
| 7 | The Distribution of Green Algal Micro-Propagules and Macroalgae at the Early Stage of Green Tide in the Coastal Area of South Jiangsu Province in 2014显示文摘An integrated investigation was carried out during late April to late May of 2014 in the coastal area of South Jiangsu Province to understand the early development of green tide in the Yellow Sea and discover the temporal and spatial distribution of green algal micro-propagules and macroalgae at the early stage of green tide. The results showed that green algal micro-propagules distributed in all stations from late April to late May, and micro-propagules of high density(> 300 ind. L^(-1)) concentrated in the adjacent Porphyra aquaculture area. Floating macroalgae were initially observed in the northern survey areas, and increased gradually. The dominant species was U. prolifera in the floating macroalgae, ranging between 90% and 100%. The seawater surface temperature and salinity in the above mentioned time period were suitable for the growth of macroalgae. This work can help government to strengthen management to reduce the blooms of macroalgae in the coastal area of South Jiangsu Province and also facilitate the decision-making for managers at the early stage of green tide. | LIU Xiangqing WANG Zongling FAN Shiliang ZHANG Xuelei LI Ruixiang LI Yan | 2017 | Journal of Ocean University of China2017，16，1： | 3 |
| 8 | Structure and seasonal variability of fronts in the Southeast Indian Ocean along sections from Fremantle, Australia to Antarctic Zhongshan Station显示文摘Four sections of expendable conductivity-temperature-depth(XCTD) profiles from Fremantle, Australia to Antarctic Zhongshan Station and Moderate Resolution Imaging Spectroradiometer-Aquarius(MODIS-A) sea surface temperature(SST) products were used to study the structure and seasonal variability of Southeast Indian Ocean fronts. Water mass analysis showed that surface water masses in the Southeast Indian Ocean were less salty in March than in November. Compared with November, the subtropical front(STF) moved southward about one degree of latitude in March, whereas seasonal variability of the subantarctic front(SAF) and polar front(PF) locations was not obvious. In March, the saline front moved northward about two degrees of latitude relative to the thermal front in the upper 100 m at the SAF, which was the northern boundary of subAntarctic surface water(SASW). Analysis of climatological SST gradients from the satellite data showed that regions of enhanced sea surface temperature(SST) gradients were collocated with frontal locations identified with the XCTD data using water mass criteria. The surface expression of the PF identified by the SST gradient was further south by about one degree of latitude relative to the subsurface expression of the PF identified by the northern boundary of cold water. | YANG Wei GAO Libao LI Ruixiang LIU Changjian YAN Jinhui | 2016 | Advances in Polar Science2016，27，1： | 2 |
| 9 | Strength analysis of a large centrifugal dredge pump case显示文摘 | Peng Guangjie Wang Zhengwei Yan Zongguo Liu Ruixiang | 2008 | Engineering Failure Analysis2008，，1： | 2 |
| 10 | Psychometric properties of the Caregiver Strain Questionnaire among Chinese parents of children with ADHD or ASD显示文摘Background There is an urgent need in clinical practice to measure the stress of parenting.The Caregiver Strain Questionnaire(CGSQ)was found to be useful to measure parenting stress,but it has not been validated among the Chinese population.Aims To assess the reliability and construct validity of the Chinese version of CGSQ among Chinese parents.Methods From 2016 to 2017,266 parents(patient group)with a child having DSM-5-defined attention deficit hyperactivity disorder(ADHD)(n=107)or autism spectrum disorder(ASD)(n=159)and 268 parents of healthy children(control group)were recruited to the present study in Kunming,Yunnan province.All the parents were asked to fill out the Chinese version of CGSQ.We conducted exploratory factor analysis and confirmatory factor analysis(CFA)to verify construct validity of CGSQ in both patient and control groups.Cronbach’s α coefficient as an index of internal consistency was assessed for each subscale.Fourteen days later,23 subjects filled out the scale again.Intra-class correlation coefficient was calculated to evaluate the test-retest reliability.Results(1)Cronbach’s alpha of the global scale was 0.901 for the control group and 0.952 for the patient group.The test-retest reliability for the whole scale was 0.890;(2)CFA indicated that the three-factor model had better fitting indices compared with the two-factor model in both groups.Besides,the fitting indices in the patient group were more favourable than those of the control group,withχ2/df=1.564,Goodness-of Fit Index=0.841,Comparative Fit Index=0.954,and root mean square error of approximation=0.065 for the patient group at three-factor model;(3)The caregiver strain of ASD parents was statistically higher than that of ADHD parents,and caregiver strain of ADHD parents was higher than that of control group.Conclusion These findings provide initial evidence to support the construct validity and reliability of CGSQ as a parenting stress measurement tool for Chinese parents,especially for parents of children with ADHD or ASD. | Runxu Yang Huizhi Zhou Jin Liu Yufeng Wang Yan Zhang Yanjiao Wang Ruixiang Liu Xia Cao Dong Han Shuran Yang Jianzhong Yang Chuanyuan Kang | 2021 | General Psychiatry2021，34，2： | 2 |
| 11 | Surface-Modified Graphene Oxide/Lead Sulfide Hybrid Film-Forming Ink for High-Efficiency Bulk Nano-Heterojunction Colloidal Quantum Dot Solar Cells显示文摘Solution-processed colloidal quantum dot solar cells(CQDSCs) is a promising candidate for new generation solar cells.To obtain stable and high performance lead sulfide(PbS)-based CQDSCs,high carrier mobility and low non-radiative recombination center density in the PbS CQDs active layer are required.In order to effectively improve the carrier mobility in PbS CQDs layer of CQDSCs,butylamine(BTA)-modified graphene oxide(BTA@GO) is first utilized in PbS-PbX2(X=I-,Br-) CQDs ink to deposit the active layer of CQDSCs through one-step spin-coating method.Such surface treatment of GO dramatically upholds the intrinsic superior hole transfer peculiarity of GO and attenuates the hydrophilicity of GO in order to allow for its good dispersibility in ink solvent.The introduction of B TA@GO in CQDs layer can build up a bulk nano-heterojunction architecture,which provides a smooth charge carrier transport channel in turn improves the carrier mobility and conductivity,extends the carriers lifetime and reduces the trap density of PbS-PbX2 CQDs film.Finally,the BTA@GO/PbS-PbX2 hybrid CQDs film-based relatively large-area(0.35 cm2) CQDSCs shows a champion power conversion efficiency of 11.7% which is increased by 23.1% compared with the control device. | Yaohong Zhang Guohua Wu Chao Ding Feng Liu Dong Liu Taizo Masuda Kenji Yoshino Shuzi Hayase Ruixiang Wang Qing Shen | 2020 | Nano-Micro Letters2020，12，9： | 2 |
| 12 | Numerical experiments of HAB inducement in Qingdao adjacent coastal area显示文摘A three-dimension ecological dynamic model was established to numerically study the relationship of HAB and environmental conditions.The numerical experiments showed that the growth of diatom,the dominant HAB specie,was mainly restricted by phosphate and silicate.If the concentrations of phosphate and silicate reach 17-25 μg/L and 300-375 μg/L respectively,the water is in a state of eutrophication.When phosphate and silicate up to 26-32 μg/L and 350-500 μg/L respectively,HAB could be induced.The major regions of HAB occurrence are Jiaozhou Bay mouth,coastal bays,and coastal area from Maidao to Shilaoren.To avoid HAB occurrence,concentration of phosphate and silicate should not exceed 17-20 μg/L and 300 μg/L as a whole.Reasonable control of pollutant discharge is a key point to prevent water eutrophication and HAB occurrence. | LIU Xuehai LI Ruixiang YUAN Yeli | 2010 | Acta Oceanologica Sinica2010，29，5： | 2 |
| 13 | Determination of sulfurcontaining compounds in diesel oils by comprehensive two-dimensional gas chromatography with a sulfur chemiluminescence detector 显示文摘 | Hua Ruixiang Li Yanyan Liu Wei | 2003 | Journal of Chromatography:A2003，，1019： | 1 |
| 14 | Current Kevelopment sand Applieation soft CAST Software显示文摘 | Zhou jianxin Liu Ruixiang Chen Liliang | 2002 | Cast-MetalsRes2002，15，4： | 1 |
| 15 | The implementation and application of programming port communication between industry PC and Mitsubishi FX series PLC显示文摘 | Sun Jian Lu Peng Fu Yaqiong Liu Ruixiang Chen Le | 2008 | Intelligent System and Knowledge Engineering2008，3，1： | 1 |
| 16 | Modulatory effects of Lactiplantibacillus plantarum on chronic metabolic diseases显示文摘The increased global incidence of chronic metabolic diseases,a vital threat to human health and a burden on our healthcare systems,includes a series of clinical metabolic syndromes such as obesity,diabetes,hypertension,and dyslipidemia.One of the well-known probiotic microorganisms,Lactiplantibacillus plantarum plays an important role in promoting human health,including inhibiting the occurrence and development of a variety of chronic metabolic diseases.The present study provides an overview of the preventive and therapeutic effects of L.plantarum on diabetes,obesity,non-alcoholic fatty liver disease,kidney stone disease,and cardiovascular diseases in animal models and human clinical trials.Ingesting L.plantarum demonstrated its ability to reduce inflammatory and oxidative stress levels by regulating the production of cytokines and short-chain fatty acids(SCFAs),the activity of antioxidant enzymes,and the balance of intestinal microbial communities to alleviate the symptoms of chronic metabolic diseases.Furthermore,updated applications and technologies of L.plantarum in food and biopharmaceutical industries are also discussed.Understanding the characteristics and functions of L.plantarum will guide the development of related probiotic products and explore the modulatory benefit of L.plantarum supplementations on the prevention and treatment of multiple chronic metabolic diseases. | Lei Tian Ruixiang Zhao Xinyi Xu Zhiwei Zhou Xiaofang Xu Dongmei Luo Zhiqiang Zhou Yu Liu Ariel Kushmaro Robert S.Marks András Dinnyés Qun Sun | 2023 | Food Science and Human Wellness2023，12，4： | 1 |
| 17 | Current Kevelopment sand Applieation soft CAST Software 显示文摘 | Zhou jianxin Liu Ruixiang Chen Liliang | 2002 | Cast Metals Res2002，15，4： | 1 |
| 18 | A new non-uniform elements method for temperature field simulation 显示文摘 | Yang Chong Zhou Jianxing Liu Ruixiang | 2001 | Cast Metals2001，13，5： | 1 |
| 19 | Current Kevelopments and Application soft CAST Software显示文摘 | Zhou Jianxin Liu Ruixiang Chen Liliang etal | 2002 | Cast-Metals Res2002，15，4： | 1 |
| 20 | Origin and formation of the Ryukyu Current revealed by HYCOM reanalysis显示文摘The origin of the Ryukyu Current(RC)and the formation of its subsurface velocity core were investigated using a 23-year(1993–2015)global Hybrid Coordinate Ocean Model(HYCOM)dataset.The volume transport of the RC comes from the Kuroshio eastward branch(KEB)east of Taiwan and part of the North Pacific Subtropical Gyre(p-NPSG).From the surface to 2000m depth,the KEB(p-NPSG)transport contributes 41.5%(58.5%)to the mean total RC transport.The KEB originally forms the subsurface velocity core of the RC east of Taiwan due to blockage of the subsurface Kuroshio by the Ilan Ridge(sill depth:700 m).Above 700m,the Kuroshio can enter the East China Sea(ECS)over the Ilan Ridge,meanwhile,the blocked Kuroshio below 700m turns to the right and flows along the Ryukyu Islands.With the RC flowing northeastward,the p-NPSG contribution strengthens the subsurface maximum structure of the RC owing to the blockage of the Ryukyu Ridge.In the surface layer,the p-NPSG cannot form a stable northeastward current due to frequent disturbance by mesoscale eddies and water exchange through the gaps(with net volume transport into ECS)between the Ryukyu Islands. | Min Wang Zhaojun Liu Xiaohua Zhu Xiaomei Yan Zhongzhe Zhang Ruixiang Zhao | 2019 | Acta Oceanologica Sinica2019，38，11： | 1 |
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