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| 1 | Mesenchymal stem cell transplantation in tight-skin mice identifies miR-151-5p as a therapeutic target for systemic sclerosis显示文摘全身的硬化(SSc ) ,自体免疫的疾病,可以由于 IL4R/mTOR 小径的激活引起重要 osteopenia。间充质的干细胞移植(MSCT ) 能改善在经由导致有免疫力的忍耐的 SSc 的有免疫力的混乱。然而, MSCT 是否在 SSc 救 osteopenia 显型,是未知的。这里,我们证明 MSCT 能有效地改善在由 rescuing 的 SSc 老鼠的 osteopenia 损害了接受者骨头髓 MSC 的系区别。机械学地,我们证明施主 MSC 在 SSc 老鼠把 miR-151-5p 转移到接受者骨头髓 MSC 禁止 IL4R 表示,这样提高 osteogenic 区别和还原剂 adipogenic 区别的 downregulating mTOR 小径激活。而且, miR-151-5p 的全身的交货能够在 SSc 老鼠的 rescuing osteopenia,损害骨头髓 MSC,紧密的皮,和有免疫力的混乱,建议那 miR-151-5p 可以是为 SSc 治疗的一个特定的目标。我们发现在把 miRNAs 转移到接受者干细胞改善识别 MSCT 的一个以前未被认出的角色经由 rescuing 的 osteopenia 一条非编码的 RNA 小径。 | Chider Chen Dandan Wang Alireza Moshaverinia Dawei Liu Xiaoxing Kou Wenjing Yu Ruili Yang Lingyun Sun Songtao Shi | 2017 | Cell Research2017，27，4： | 26 |
| 2 | Dietary supplementation with Clostridium butyricum improves growth performance of broilers by regulating intestinal microbiota and mucosal epithelial cells显示文摘Clostridium butyricum has been widely considered an antibiotic substitute in recent years.It can promote growth performance,improve the immune response and enhance the intestinal barrier function of the host.In the present study,1-d-old Arbor Acres(AA)broilers were fed C.butyricum(1×109 cfu/kg)for 28 d.The transcriptomic characteristics of epithelial cells of the cecal mucosa were determined by RNA-sequence,and the cecal microbiota composition was explored by 16 S ribosomal RNA gene sequencing.The changes in the intestinal mucosa of broilers were then analyzed by tissue staining.Gene Ontology(GO)annotations identified substance transport and processes and pathways that might participate in intestinal development and cell viability.Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis revealed that the differentially expressed genes are involved in numerous pathways related to amino acid and vitamin metabolism and antioxidant and defensive functions,among others.The relative expression of some genes associated with intestinal barrier function(claudins 2,15,19,and 23,tight junction proteins 1,2,and 3 and mucin 1)was significantly increased in the treatment group(P<0.05 or P<0.01).Moreover,the proportion of Firmicutes was higher in the C.butyricum-treated group,whereas the proportion of Proteobacteria was higher in the control group.At the genus level,the relative abundances of Butyricicoccus and Lactobacillus,among other bacteria,were increased after C.butyricum supplementation.The tissue staining analysis showed that the cecal mucosa of broilers was significantly ameliorated after the addition of C.butyricum(P<0.05 or P<0.01).These results showed that dietary supplementation with C.butyricum can enhance the antioxidant capacity,mucosal barrier function,and stabilize the cecal microbiota,resulting in improving the growth performance. | Laipeng Xu Xiangli Sun Xianhua Wan Keke Li Fuchun Jian Wenting Li Ruirui Jiang Ruili Han Hong Li Xiangtao Kang Yanbin Wang | 2021 | Animal Nutrition2021，，4： | 12 |
| 3 | Nanostructured ultrathin catalyst layer with ordered platinum nanotube arrays for polymer electrolyte membrane fuel cells显示文摘Fabrication of novel electrode architectures with nanostructured ultrathin catalyst layers is an effective strategy to improve catalyst utilization and enhance mass transport for polymer electrolyte membrane fuel cells (PEMFCs).Herein,we report the design and construction of a nanostructured ultrathin catalyst layer with ordered Pt nanotube arrays,which were obtained by a hard-template strategy based on ZnO,via hydrothermal synthesis and magnetron sputtering for PEMFC application.Because of the crystallographically preferential growth of Pt (111) facets,which was attributed to the structural effects of ZnO nanoarrays on the Pt nanotubes,the catalyst layers exhibit obviously higher electrochemical activity with remarkable enhancement of specific activity and mass transport compared with the state-of-the-art randomly distributed Pt/C catalyst layer.The PEMFC fabricated with the as-prepared catalyst layer composed of optimized Pt nanotubes with an average diameter of 90(±10) nm shows excellent performance with a peak power density of 6.0W/mgPt at 1 A/cm^2,which is 11.6%greater than that of the conventional Pt/C electrode. | Ruoyi Deng Zhangxun Xia Ruili Sun Suli Wang Gongquan Sun | 2020 | Journal of Energy Chemistry2020，29，4： | 8 |
| 4 | Novel Ag nanocrystals based dental resin composites with enhanced mechanical and antibacterial properties显示文摘The aim of this work was to investigate the effect of trace addition of oleic acid coated Ag nanocrystals(Ag NCs) on mechanical and antibacterial properties of dental resin composites.Composites(70 wt%of silica loading) with 25 ppm,50 ppm,75 ppm and 100 ppm(wt) Ag NCs were prepared and the composite without Ag NCs served as a control.The experimental results showed that the addition of Ag NCs significantly improved the strength and modulus of the resin composite without compromising the shade.For the composite with 50 ppm Ag NCs,fiexural strength(140.3 MPa),modulus(13.2 GPa)and compressive strength(347.2 MPa) were increased by 4.1%,22.2%,13.3%,respectively,compared with the control.The antibacterial test demonstrated that trace Ag NCs provided the resin composites with an antibacterial effect.Such strong and antibacterial dental resin composites might be advantageous to prevent secondary caries and be potential for future clinical applications. | Fengwei Liu Ruili Wang Yuyuan Shi Xiaoze Jiang Bin Sun Meifang Zhu | 2013 | Progress in Natural Science:Materials International2013，23，6： | 5 |
| 5 | Biodistribution of fullerene derivative C_(60)(OH)_x(O)_y显示文摘The biological behavior of fullerene derivatives shows their considerable potential application in medicine field. To understand the biodistribution of C60 derivatives as drugs or drug carriers, a simple water-soluble derivative C60(OH)x(O)y was labeled with 99mTc. A r-counter and a single photo emission computed tomography (SPECT) were used to assess the biodistribution and metabolism of the labeled compound in mice and rabbits, respectively. The results showed that the compound could be absorbed rapidly by tissues, especially by coronal bone, breastbone, backbone, extremity honeycomb, liver and spleen. The clearance was slow from all tissues except for brain. The compound might be excreted through urine and enteron. The biodistribution shows some difference from that of Yamago et al. In this note, we discuss the possible reason leading to the difference. Further study is needed to find out to what extent the C60 itself determines the biodistribution of derivatives. | LI Qingnuan, XIU Yan, ZHANG Xiaodong, LIU Ruili, DU Qianqian, SUN Xiaoguang, CHEN Shaoliang & LI Wenxin1. Shanghai Institute of Nuclear Research, Chinese Academy of Sciences, Shanghai 201800, China 2. Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China | 2001 | Chinese Science Bulletin2001，46，19： | 5 |
| 6 | Identification of novel QTL associated with soybean isoflavone content显示文摘Soybean isoflavones are essential secondary metabolites synthesized in the phenylpropanoid pathway and benefit human health. In the present study, highresolution QTL mapping for isoflavone components was performed using specific-locus amplified fragment sequencing(SLAF-seq) with a recombinant inbred line(RIL) population(F5:7) derived from a cross between two cultivated soybean varieties, Luheidou 2(LHD2) and Nanhuizao(NHZ). Using a high-density genetic map comprising 3541 SLAF markers and the isoflavone contents of soybean seeds in the 200 lines in four environments, 24 stable QTL were identified for isoflavone components, explaining 4.2%–21.2% of phenotypic variation.Of these QTL, four novel stable QTL(qG8, qMD19, qMG18, and qTIF19) were identified for genistin, malonyldaidzin, malonylgenistin, and total isoflavones, respectively. Gene annotation revealed three genes involved in isoflavone biosynthesis(Gm4CL, GmIFR, and GmCHR) and 13 MYB-like genes within genomic regions corresponding to stable QTL intervals, suggesting candidate genes underlying these loci. Nine epistatic QTL were identified for isoflavone components, explaining 4.7%–15.6% of phenotypic variation. These results will facilitate understanding the genetic basis of isoflavone accumulation in soybean seeds. The stable QTL and tightly linked SLAF markers may be used for markerassisted selection in soybean breeding programs. | Ruili Pei Jingying Zhang Ling Tian Shengrui Zhang Fenxia Han Shurong Yan Lianzheng Wang Bin Li Junming Sun | 2018 | The Crop Journal2018，6，3： | 3 |
| 7 | Solid phase microwave-assisted fabrication of Fe-doped ZIF-8 for single-atom Fe-N-C electrocatalysts on oxygen reduction显示文摘Fe-N-C endowed with inexpensiveness,high activity,and excellent anti-poisoning power have emerged as promising candidate catalysts for oxygen reduction reaction(ORR).Single-atom Fe-N-C electrocatalysts derived from Fe-doped ZIF-8 represent the top-level ORR performance.However,the current fabrication of Fe-doped ZIF-8 relies on heavy consumption of time,energy,cost and organic solvents.Herein,we develop a rapid and solvent-free method to produce Fe-doped ZIF-8 under microwave irradiation,which can be easily amplified in combination with ball-milling.After rational pyrolysis,Fe-N-C catalysts with atomic FeN4 sites well dispersed on the hierarchically porous carbon matrix are obtained,which exhibit exceptional ORR performance with a half-wave potential of 0.782 V(vs.reversible hydrogen electrode(RHE))and brilliant methanol tolerance.The assembled direct methanol fuel cells(DMFCs)endow a peak power density of 61 mW cm^(-2) and extraordinary stability,highlighting the application perspective of this strategy. | Xinlong Xu Xiaoming Zhang Zhangxun Xia Ruili Sun Huanqiao Li Junhu Wang Shansheng Yu Suli Wang Gongquan Sun | 2021 | Journal of Energy Chemistry2021，30，3： | 2 |
| 8 | Impact of hydroelectric projects on river environment: Analysis of water quality changes in Ningxia Reach of Yellow River显示文摘In this paper, the relationship between hydroelectric projects and the river environment is analyzed. Recently, the large-scale regulation of runoff by large hydroelectric projects in the Ningxia Reach of the Yellow River has altered natural runoff processes, causing an increase in the probability of low discharge and an overall adjustment of riverbed evolution and river characteristics. During low-flow years, the combined effects of these two changes can weaken the self-purification capacity and reduce the water environmental capacity of the river. This is one of the main reasons for the recent decrease of water quality in the Ningxia Reach. This research shows that it is necessary to implement river training projects to maintain stable flow paths, not only for adjusting river regimes and for flood control, but also for increasing the self-purification capacity and the water environmental capacity of the river. Methods and proposals for coordinating the operation of hydroelectric projects with the protection of the river environment are presented in the interest of promoting sustainable development. | Sun Dongpo Lu Ruili Song Yongjun Yan Jun | 2008 | Water Science and Engineering2008，1，2： | 2 |
| 9 | Interannual variability of thermal front west of Luzon Island in boreal winter显示文摘Interannual variability of thermal front west of Luzon Island during the winter of 1993–2013 is examined with the method of singular value decomposition(SVD) and a suite of satellite measurements in this paper. It is found that both the area and intensity of the thermal front west of Luzon Island show apparent interannual variability.Further study based on SVD shows that the interannual variability of the thermal front is highly associated with El Ni?o and Southern Oscillation(ENSO), and the correlation coefficient between Ni?o3.4 index and the first Principal Component(PC1) of thermal front can reach –0.65. The mechanism can be described as follows. In El Ni?o(La Ni?a) years, the East Asian winter monsoon(EAWM) is weakened(enhanced), inducing weaker(stronger) local wind stress curl(WSC) west of Luzon Island, and resulting in weakened(enhanced) Luzon cold eddy, which finally leads to the weakening(enhancement) of the thermal front. | SUN Ruili LING Zheng CHEN Changlin YAN Yunwei | 2015 | Acta Oceanologica Sinica2015，34，11： | 2 |
| 10 | Floralozone protects endothelial function in atherosclerosis by ameliorating NHE1显示文摘Endothelial dysfunction is the pathological basis of atherosclerosis.Incomplete understanding of endothelial dysfunction etiology has impeded drug development for this devastating disease despite the currently available therapies.Floralozone,an aroma flavor,specifically exists in rabbit ear grass.Recently,floralozone has been demonstrated to inhibit atherosclerosis,but the underlying mechanisms are undefined.The present study was undertaken to explore whether floralozone pharmacologically targets endothelial dysfunction and therefore exerts therapeutic effects on atherosclerosis.The Na+/H+exchanger 1(NHE1),a channel protein,plays a vital role in atherosclerosis.Whether NHE1 is involved in the therapeutic effects of floralozone on endothelial dysfunction has yet to be further answered.By performing oil red staining and hematoxylin–eosin staining,vascular functional study,and oxidative stress monitoring,we found that floralozone not only reduced the size of carotid atherosclerotic plaque but also prevented endothelial dysfunction in atherosclerotic rats.NHE1 expression was upregulated in the inner membrane of carotid arteries and H2O2-induced primary rat aortic endothelial cells.Inspiringly,floralozone prevented the upregulation of NHE1 in vivo and in vitro.Notably,the administration of NHE1 activator LiCl significantly weakened the protective effect of floralozone on endothelial dysfunction in vivo and in vitro.Our study demonstrated that floralozone exerted its protective effect on endothelial dysfunction in atherosclerosis by ameliorating NHE1.NHE1 maybe a drug target for the treatment of atherosclerosis,and floralozone may be an effective drug to meet the urgent needs of atherosclerosis patients by dampening NHE1. | Ning Huang Yue Qiu Yanhua Liu Tianheng Liu Xianjun Xue Ping Song Jian Xu Yutian Fu Ruili Sun Yaling Yin Peng Li | 2021 | Acta Biochimica et Biophysica Sinica2021，53，10： | 2 |
| 11 | Cold Water in the Lee of the Batanes Islands in the Luzon Strait显示文摘Using satellite remote sensing data and hydrological observation data,this study investigated the cold water in the lee of the Batanes Islands in the Luzon Strait.The formation of cold water in climate is mainly due to the geostrophic heat advection on the east and west sides of the Batanes Islands:the Kuroshio separates into two branches on the east and west sides of the Batanes Islands.These two branches cause two warm tongues by transferring heat from low latitudes to mid-latitudes,and then the two warm tongues lead to the formation of the relatively cold water in the lee of the Batanes Islands.Further study shows that the cold water range has obvious seasonal and inter-annual variations.Except for August,the seasonal variation of the cold water range is caused by the interaction of geostrophic heat advection and net surface heat flux,whereas the low temperature in August in the lee of the Batanes Islands is caused by the island wake effect.The inter-annual of the cold water range is related to the difference in the meridional velocity between the east and west sides of the Batanes Islands,and the correlation coefficient can reach−0.68 at the 95%confidence level. | SUN Ruili ZHAI Fangguo ZHANG Guosheng GU Yanzhen CHI Nianping | 2020 | Journal of Ocean University of China2020，19，6： | 1 |
| 12 | Distinct tissue expression profiles of chicken Lpin1 - α / β isoforms and the effect of the variation on muscle fiber traits显示文摘 | Suya Li Wen Chen Xiangtao Kang Ruili Han Guirong Sun Yanqun Huang | 2012 | Gene2012，，： | 1 |
| 13 | Photo-induced effect in the layered perovskite manganite La_(1.2)Sr_(1.8)Mn_(1.8)Co_(0.2)O_(7)显示文摘It is helpful to study the photo-induced effect in the perovskite manganites not only for elucidating the mechanism of colossal magnetoresistance (CMR) effect but also for potential applications in technology. The laser-induced effect in the Co doping layered perovskite manganites La1.2Sr1.8Mn1.8Co0.2O7 is studied in this paper and the obtained results are also compared with that gained in the Nd-doping manganites with cubic perovskite structure. | ZHANG Ruili1, DAI Jianming1, SONG Wenhai1, MA Yongqing1, YANG Jie1 & SUN Yuping1,2 1. Key Laboratory of Internal Friction and Defects in Solids, Institute of Solid State Physics, Chinese Academy of Sciences, Hefei 230031, China 2. National Laboratory of Solid State Microstructures, Nanjing University, Nanjing 210008, China Correspondence should be addressed to Zhang Ruili (email: rlzhang@issp.ac.cn) Received September 1, 2003 | 2004 | Science China(Physics,Mechanics & Astronomy)2004，47，1： | 1 |
| 14 | Apoptotic vesicles ameliorate lupus and arthritis via phosphatidylserine-mediated modulation of T cell receptor signaling显示文摘Mesenchymal stem cells(MSCs)influence T cells in health,disease and therapy through messengers of intercellular communication including extracellular vesicles(EVs).Apoptosis is a mode of cell death that tends to promote immune tolerance,and a large number of apoptotic vesicles(apoVs)are generated from MSCs during apoptosis.In an effort to characterize these apoVs and explore their immunomodulatory potential,here we show that after replenishing them systemically,the apoV deficiency in Fas mutant mice and pathological lymphoproliferation were rescued,leading to the amelioration of inflammation and lupus activity.ApoVs directly interacted with CD4^(+)T cells and inhibited CD25 expression and IL-2 production in a dose-dependent manner.A broad range of Th1/2/17 subsets and cytokines including IFNγ,IL17A and IL-10 were suppressed while Foxp3^(+)cells were maintained.Mechanistically,exposed phosphatidylserine(PtdSer/PS)on apoVs mediated the interaction with T cells to disrupt proximal T cell receptor signaling transduction.Remarkably,administration of apoVs prevented Th17 differentiation and memory formation,and ameliorated inflammation and joint erosion in murine arthritis.Collectively,our findings unveil a previously unrecognized crosstalk between MSC apoVs and CD4^(+)T cells and suggest a promising therapeutic use of apoVs for autoimmune diseases. | Runci Wang Meng Hao Xiaoxing Kou Bingdong Sui Maria Laura Sanmillan Xiao Zhang Dawei Liu Jun Tian Wenjing Yu Chider Chen Ruili Yang Lingyun Sun Yi Liu Claudio Giraudo Deepak A.Rao Nan Shen Songtao Shi | 2023 | Bioactive Materials2023，，7： | 1 |
| 15 | A new adapted constructed flora using in tomato paste wastewater treatment 显示文摘 | Sun Shiyang Sheng Zhigang Yang Ruili | 2013 | Korean J Chem Eng2013，18，2： | 1 |
| 16 | Functional Analysis of Phosphate Transporter OsPHT4 Family Members in Rice显示文摘The transport of phosphate between cytoplasm and subcellular compartments is critical for plant metabolic regulation.We conducted bioinformatic analysis,heterologous expression in yeast,gene expression pattern and subcellular localization analysis to characterize the possible functions of OsPHT4 gene family in rice.Together with the PHT4 genes from higher plants,OsPHT4s can be classified into six distinct groups.OsPHT4;1-OsPHT4;4 are targeted to chloroplasts,and OsPHT4;6-1 and OsPHT4;6-2 are located to Golgi apparatus.OsPHT4 proteins can mediate inorganic phosphate(Pi)transport in yeast.In addition,dynamic transcriptional changes determined by qRT-PCR revealed different expression profiles of OsPHT4 genes in response to phosphate starvation,salicylic acid,abscisic acid and salt stress treatments.These results suggested that OsPHT4 proteins are involved in Pi distribution between the cytoplasm and chloroplast or Golgi apparatus and also involved in stress responses. | Li Ruili Wang Jiaoling Xu Lei Sun Meihao Yi Keke Zhao Hongyu | 2020 | Rice science2020，27，6： | 1 |
| 17 | A simple approach towards sulfonated multi-walled carbon nanotubes supported by Pd catalysts for methanol electro-oxidation 显示文摘 | Sun Zhipeng Zhang Xiaogang Liu Ruili | 2008 | J Power Sources2008，185，2： | 1 |
| 18 | Experimental measurement of proton conductivity and electronic conductivity of membrane electrode assembly for proton exchange membrane fuel cells显示文摘Charge transport processes involving the proton migration and electron transfer for different parts of membrane electrode assemble(MEA)play an essential role for developing the novel electrode and enhancing the electrochemical performance towards proton exchange membrane fuel cells(PEMFCs).However,the coupled charge transport processes make it difficult for evaluating proton conductivity and electronic conductivity of different parts in MEAs under operation conditions of fuel cells.Here in this work,we propose an experiment approach for separating the electronic conductivity and proton conductivity of different components of MEA at the operating conditions of PEMFCs.This approach involves two different measuring devices,which both consist of electron or proton conducting layers,sealing layers and sample layer,followed by tailoring the thickness of sample layers and via electrochemical impedance spectroscopy(EIS)to quantity the electronic conductivity and proton conductivity of different layers.These experiment results show the great potential in the development of different components of MEA. | Ruili Sun Zhangxun Xia Congrong Yang Fenning Jing Suli Wang Gongquan Sun | 2020 | Progress in Natural Science:Materials International2020，30，6： | 1 |
| 19 | Is It Easy to Recognize Baby's Age and Gender?显示文摘Face analysis tasks,e.g.,estimating gender or age from a face image,have been attracting increasing interest in recent years.However,most existing studies focus mainly on analyzing an adult's face and ignore an interesting question:is it easy to estimate gender and age from a baby's face?In this paper,we explore this interesting problem.We first collect a new face image dataset for our research,named BabyFace,which contains 15528 images from 5872 babies younger than two years old.Besides gender,each face image is annotated with age in months from 0 to 24.In addition,we propose new age estimation and gender recognition methods.In particular,based on SSR-Net backbone,we introduce the attention mechanism module to solve the age estimation problem on the BabyFace dataset,named SSR-SE.In the part of gender recognition,inspired by the age estimation method,we also use a two-stream structure,named Two-Steam SE-block with Augment(TSSEAug).We extensively evaluate the performance of the proposed methods against the state-of-the-art methods on BabyFace.Our age estimation model achieves very appealing performance with an estimation error of less than two months.The proposed gender recognition method obtains the best accuracy among all compared methods.To the best of our knowledge,we are the first to study age estimation and gender recognition from a baby's face image,which is complementary to existing adult gender and age estimation methods and can shed some light on exploring baby face analysis. | Yang Liu Ruili He Xiaoqian Lv Wei Wang Xin Sun Shengping Zhang | 2021 | Journal of Computer Science & Technology2021，36，3： | 0 |
| 20 | High-throughput screening of novel TFEB agonists in protecting against acetaminopheninduced liver injury in mice显示文摘Macroautophagy(referred to as autophagy hereafter)is a major intracellular lysosomal degradation pathway that is responsible for the degradation of misfolded/damaged proteins and organelles.Previous studies showed that autophagy protects against acetaminophen(APAP)-induced injury(AILI)via selective removal of damaged mitochondria and APAP protein adducts.The lysosome is a critical organelle sitting at the end stage of autophagy for autophagic degradation via fusion with autophagosomes.In the present study,we showed that transcription factor EB(TFEB),a master transcription factor for lysosomal biogenesis,was impaired by APAP resulting in decreased lysosomal biogenesis in mouse livers.Genetic loss-of and gain-of function of hepatic TFEB exacerbated or protected against AILI,respectively.Mechanistically,overexpression of TFEB increased clearance of APAP protein adducts and mitochondria biogenesis as well as SQSTM1/p62-dependent non-canonical nuclear factor erythroid 2-related factor 2(NRF2)activation to protect against AILI.We also performed an unbiased cell-based imaging high-throughput chemical screening on TFEB and identified a group of TFEB agonists.Among these agonists,salinomycin,an anticoccidial and antibacterial agent,activated TFEB and protected against AILI in mice.In conclusion,genetic and pharmacological activating TFEB may be a promising approach for protecting against AILI. | Xiaojuan Chao Mengwei Niu Shaogui Wang Xiaowen Ma Xiao Yang Hua Sun Xujia Hu Hua Wang Li Zhang Ruili Huang Menghang Xia Andrea Ballabio Hartmut Jaeschke Hong-Min Ni Wen-Xing Ding | 2024 | Acta Pharmaceutica Sinica B2024，14，1： | 0 |
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