|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 遗传性肥胖与心房颤动的关系显示文摘观察性研究已经确定了体质量指数(body mass index,BMI)与心房颤动之间的关联。然而,从观察性研究中推断因果关系会受到混杂因素、逆因果关系和偏倚的影响。该研究的主要目的是应用BMI的遗传学预测因子评估BMI与心房颤动之间的因果关系。方法:纳入1987-2002年期间在美国、冰岛和荷兰实施的7个前瞻性人群队列研究中基线无心房颤动的欧洲血统个体51 646人, | 刘莉 叶鹏 Chatterjee NA Giulianini F Geelhoed B Lunetta KL Misialek JR Niemeijer MN Rienstra M Rose LM Smith AV Arking DE Ellinor PT Heeringa J Lin H Lubitz SA Soliman EZ Verweij N Alonso A Benjamin EJ Gudnason V Stricker BH van der Harst P Chasman DI Albert CM | 2017 | 中华高血压杂志2017，25，2： | 2 |
| 2 | Desflurane or sevoflurane for gynaecological day-case an aesthesia with spontaneous respiration7显示文摘 | Mahmoud NA Rose DJA Laiarence AS | 2001 | Anaesthesia2001，56，2： | 1 |
| 3 | The pathogenesis of postinfectious myocarditis 显示文摘 | Rose NA Hill SL | 1996 | Clin Immunol Immunopathol1996，80，32： | 1 |
| 4 | The stress kinase gene MtSK1 in Medicago truncatula with particular reference to somatic embryogenesis显示文摘 | KE Nolan NA Saeed and RJ Rose | 2006 | Plant Cell Rep2006，25，7： | 1 |
| 5 | Substance P microinjected into the periaqueductal gray matter induces antinociception and is released following morphine administration显示文摘 | Rose'na A Zhang YX Lund I | 2004 | Brain Res2004，1001，： | 1 |
| 6 | Structur- al basis for diverse N-glycan recognition by HIV-l-neutralizing V1-V2 directed antibody PG16显示文摘 | Pancera M Shahzad-U1-Hussan S Doria Rose NA | 2013 | Nat Struct Mol Bioi2013，20，7： | 1 |
| 7 | Focused evolution of HIV-1 neu- tralizing antibodies revealed by structures and deep sequen- cing显示文摘 | Wu X Zhou T Zhu J Zhang B Georgiev I Wang C Chen X Longo NS Louder M MeKee K O'Dell S Perfet- to S Schmidt SD Shi W Wu L Yang Y Yang ZY Yang Z Zhang Z Bonsignori M Crump JA Kapiga SH Sam NE Haynes BF Simek M Burton DR Koff WC Doria- Rose NA Connors M NISC Comparative Sequencing Pro- gram Mullikin JC Nabel GJ Roederer M Shapiro L Kwong PD Mascola JR | 2011 | Science2011，333，6049： | 1 |
| 8 | Frequency and phenotype of human immunodeficiency virus envelope-specific B cells from patients with broadly cross-neutralizing antibodies显示文摘 | Doria Rose NA Klein RM Manion MM | 2009 | J Virol2009，83，1： | 1 |
| 9 | Albumin dialysis reduces brain water and intracranial pressure in acute liver failure: A radomized controlled study in a pig model显示文摘 | Sen S Rose C Ytrebo LM Davies NA | 2003 | Hepatology2003，38，1： | 1 |
| 10 | Method development and validation for the quantification of dasatinib,erlotinib,gefitinib,imatinib,lapatinib,nilotinib,sorafenib and sunitinib in human plasma by liquid chromatography coupled with tandem mass spectrometry显示文摘 | LANKHEET NA HILLEBRAND MJ ROSING H | 2013 | Biomed Chromatogr2013，27，4： | 1 |
| 11 | Antibacterial activity and inhibition against Staphylococcus aureus NorA efflux pump by ferulic acid and its esterified derivatives显示文摘Objective:To evaluate the inhibitory activity of ferulic acid and four of its esterified derivatives(methyl,ethyl,propyl,and butyl)against resistance mechanisms in Staphylococcus aureus strains.Methods:Ferulic acid derivatives were obtained by esterification with methanol,ethanol,propanol,and butanol,and then characterized by hydrogen and carbon-13 nuclear magnetic resonance analysis.The minimum inhibitory concentrations(MIC)of ferulic acid and its esterified derivatives,ethidium bromide,and norfloxacin were obtained using the microdilution test,while the efflux pump inhibition test was conducted by examining reduction in the MICs of norfloxacin and ethidium bromide.Molecular docking was also carried out using the Schrodinger Suite 2015 molecular modeling software.A three-dimensional model of NorA efflux pump was generated using I-TASSER.The best scoring model was used as a receptor for ligand-receptor docking.Results:The methyl and butyl ester derivatives did not demonstrate significant antimicrobial activity.However,a significant synergic effect was evidenced when norfloxacin was combined with the ethyl and propyl esterified derivatives.The docking study demonstrated favorable energy of interaction between ferulate derivatives and NorA,and amino acid residues TYR57,TYR58,and LEU255 were present commonly in stabilizing all complexes.The PCA analysis corroborated the docking hypothesis that the lipophilic character and hydrogen bond interactions were the most relevant characteristics involved with NorA inhibitors.The pharmacokinetic parameters of ferulic acid derivatives showed good ADMET properties,demonstrating that they can be easily absorbed and have no effect or inhibit the cytochrome P450 enzyme complex,revealing their potential as drug candidates.Conclusions:This study provides strong evidence that the molecular basis for this activity is potentially due to the NorA efflux pump. | Patrícia Gonçalves Pinheiro Gilvandete Maria Pinheiro Santiago Francisco Erivaldo Freitas da Silva Ana Carolina Justino de Araújo Cícera Rejane Tavares de Oliveira Priscilla Ramos Freitas Janaína Esmeraldo Rocha JoséBezerra de Araújo Neto Maria Milene Costa da Silva Saulo Relison Tintino Irwin Rose Alencar de Menezes Henrique Douglas Melo Coutinho JoséGalberto Martins da Costa | 2021 | Asian Pacific Journal of Tropical Biomedicine2021，11，9： | 0 |
| 12 | HPLC-DAD analysis and antifungal effect of Hyptis martiusii Benth(Lamiaceae) against Candida strains显示文摘Objective: To evaluate the anti Candida activity of Hyptis martiusii decoction and its major compound, caffeic acid alone or in the presence of fluconazole, as well as their cytotoxic effect. Methods: The decoction was characterized using high performance liquid chromatography coupled with diode array detector. For the antifungal activity, the minimum inhibitory concentration(MIC) and the potential effect of the decoction with the fluconazole were evaluated by microdilution method using 96-well microtiter trays. The osmotic fragility test was performed using erythrocytes under saline stress. All tests were performed in triplicate. Results: The chemical characterization of the decoction was performed by high performance liquid chromatography and revealed the presence of seven compounds, including caffeic acid as major constituent. The antifungal tests demonstrated that both decoction(DHm) and caffeic acid obtained from Hyptis martiusii presented MIC and MFC ≥4096 μg/mL against Candida albicans and Candida tropicalis strains. However, in the presence of fluconazole, DHm and caffeic acid presented IC_(50) of 2.60 and 2.53 μg/mL respectively, demonstrating significant synergistic effects against Candida strains. The modulator activity of DHm might be due to the presence of caffeic acid. Moreover, DHm and caffeic acid did not cause significant hemolytic effects, indicating that they present low cytotoxicity. Conclusions: These data indicate that DHm potentiates the activity of the fluconazole, without enhancement of the toxicity, encouraging further toxicological, pharmacological and phytochemical studies to provide consistent evidence of the potential of this plant to be used in drug development. | Janaína Esmeraldo Rocha Henrique Douglas Melo Coutinho Cícero Roberto Nascimento Saraiva Antonia Thassya Lucas dos Santos Ant?nio Judson Targino Machado Jo?o Tavares Calixto Júnior Irwin Rose Alencar Menezes José Galberto Martins da Costa Jaime Ribeiro-Filho Aracelio Viana Colares | 2019 | Asian Pacific Journal of Tropical Biomedicine2019，9，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员