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| 1 | The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis显示文摘Artemisia annua,通常已知的同样香甜的苦恼或 Qinghao,是到中国的一个灌木土著人并且长被用于药用的目的。A。annua 现在作为有势力抗疟药混合物的唯一的生来的来源全球性被栽培, artemisinin。这里,我们报导 A 的 1.74-gigabase 染色体的一个高质量的草稿集会。annua,高度异质接合,富于重复定序,并且包含 63 ? 226 编码蛋白质的基因,在定序的植物种类之中的最大的数字之一。我们发现了那,作为在 Asteraceae 的一些定序的染色体之一, A。annua 染色体包含对这大被子植物 clade 特定的很多基因。尤其是,扩大和编码涉及萜烯生合成的酶的基因的功能的多样化与 artemisinin biosynthetic 小径的进化一致。我们进一步由介绍那 A 的 transcriptome 揭示了。annua 发展了复杂 transcriptional 规章的网络位于 \O 下面 artemisinin 生合成。把转基因的 A 基于我们产生了的全面 genomic 和 transcriptomic 分析。artemisinin 高级的生产的 annua 线,它现在为大规模生产准备好了并且将从而帮助遇见增加 artemisinin 的全球需求的挑战。 | Qian Shen Lida Zhang Zhihua Liao Shengyue Wang Tingxiang Yan Pu Shi Meng Liu Xueqing Fu Qifang Pan Yuliang Wang Zongyou Lv Xu Lu Fangyuan Zhang Weimin Jiang Yanan Ma Minghui Chen Xiaolong Hao Ling Li Yueli Tang Gang Lv Yan Zhou Xiaofen Sun Peter E. Brodelius Jocelyn K.C. Rose Kexuan Tang | 2018 | Molecular Plant2018，11，6： | 47 |
| 2 | Dietary Bacillus spp.enhanced growth and disease resistance of weaned pigs by modulating intestinal microbiota and systemic immunity显示文摘Background:Previous research has shown that dietary supplementation of Bacillus spp.probiotics exerts beneficial effects on animals’growth.However,limited studies have evaluated the efficacy of Bacillus spp.on weaned pigs and their effects on host gut health and microbiome,and systemic immunity using a disease challenge model.The objective of this experiment was to investigate the effects of two Bacillus spp.strains(Bacillus subtilis DSM 32540 and Bacillus pumilus DSM 32539)on growth performance,diarrhea,intestinal health,microbiome,and systemic immunity of weaned pigs experimentally infected with an enterotoxigenic Escherichia coli(ETEC).Results:Pigs in PRO1(Bacillus subtilis DSM 32540)had greater(P<0.05)body weight on d 7 and 14 PI,greater(P<0.05)ADG from d 0 to 7 and d 7 to 14 PI,compared with pigs in CON(Control).Pigs in PRO1 had milder(P<0.05)diarrhea on d 2 and 3 PI compared with pigs in CON.However,no differences were observed in growth performance and diarrhea score between PRO2(Bacillus pumilus DSM 32539)and CON groups.Supplementation of PRO1 decreased(P<0.05)lymphocyte counts on d 7 and 14 PI,compared with CON.Supplementation of PRO1 and PRO2 both reduced(P<0.05)total coliforms in mesenteric lymph nodes on d 21 PI.Pigs in PRO2 had greater(P<0.05)goblet cell number and sulfomucin percentage in duodenal villi and greater(P<0.05)sialomucin percentage in jejunal villi than pigs in CON.Supplementation of PRO1 up-regulated(P<0.05)MUC2 gene expression in jejunal mucosa and reduced(P<0.05)PTGS-2 and IL1B gene expression in ileal mucosa on d 21 PI,compared with CON.Pigs in PRO1 had reduced(P<0.05)relative abundance of families Lachnospiraceae,Peptostreptococcaceae and Pasteurellaceae in the ileum.Conclusions:Supplementation of Bacillus subtilis DSM 32540 improved growth performance,alleviated diarrhea severity,enhanced gut health,and reduced systemic inflammation of weaned pigs infected with ETEC F18.Although Bacillus pumilus DSM 32539 was able to alleviate systemic inflammation,it had limited impacts on growth performance and severity of diarrhea of ETEC F18 challenged weaned pigs. | Yijie He Cynthia Jinno Kwangwook Kim Zhaohai Wu Bie Tan Xunde Li Rose Whelan Yanhong Liu | 2021 | Journal of Animal Science and Biotechnology2021，12，2： | 2 |
| 3 | Signaling pathways in rheumatoid arthritis:implications for targeted therapy显示文摘Rheumatoid arthritis(RA)is an incurable systemic autoimmune disease.Disease progression leads to joint deformity and associated loss of function,which significantly impacts the quality of life for sufferers and adds to losses in the labor force.In the past few decades,RA has attracted increased attention from researchers,the abnormal signaling pathways in RA are a very important research field in the diagnosis and treatment of RA,which provides important evidence for understanding this complex disease and developing novel RA-linked intervention targets.The current review intends to provide a comprehensive overview of RA,including a general introduction to the disease,historical events,epidemiology,risk factors,and pathological process,highlight the primary research progress of the disease and various signaling pathways and molecular mechanisms,including genetic factors,epigenetic factors,summarize the most recent developments in identifying novel signaling pathways in RA and new inhibitors for treating RA.therapeutic interventions including approved drugs,clinical drugs,pre-clinical drugs,and cutting-edge therapeutic technologies.These developments will hopefully drive progress in new strategically targeted therapies and hope to provide novel ideas for RA treatment options in the future. | Qian Ding Wei Hu Ran Wang Qinyan Yang Menglin Zhu Meng Li Jianghong Cai Peter Rose Jianchun Mao Yi Zhun Zhu | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 2 |
| 4 | The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators in macrophages显示文摘 | Whiteman M Li L Rose P | | 0，，10： | 1 |
| 5 | Using automatic vehicle identification data to gain insight into travel time variability and its causes显示文摘 | Li R M Rose G Sarvi M | | 0，，1945： | 1 |
| 6 | Excitation and propagation of non - axi- symmetric guided waves in a hollow cylinder 显示文摘 | LI Jian Rose J L | 2001 | Acoustical Society of American2001，109，2： | 1 |
| 7 | The effect of hydrogen sulfide donors on lipopolysaceharide-induced formation of inflammatory mediators inmacrophages显示文摘 | Whiteman M Li L Rose P | 2010 | Antioxid Redox Signal2010，12，10： | 1 |
| 8 | Expression of scinderin in megakaryo-blastic leukemia cells induces differentiation, maturation, and apoptosiswith release of plateletlike particles and inhibits proliferation and tu-morigenesis显示文摘 | Zunino R Li Q Rose S D | 2001 | Blood2001，98，7： | 1 |
| 9 | Intracell coope- ration and resource allocation in a heterogeneous network with relays 显示文摘 | Qian Li Rose Qingyang Hu Yi Qian | 2013 | IEEE Transactions on Vehicular Technology2013，62，4： | 1 |
| 10 | Implementing guided wave mode controlby use of a phased transducer array显示文摘 | LI J ROSE J L | 2001 | IEEE Transactionon Ultrasonics Ferroelectrics and Frequency Control2001，48，3： | 1 |
| 11 | The Tail Risk of Emerging Stock Markets显示文摘 | Li X M Rose L C | 2009 | Emerging Markets Review2009，10，4： | 1 |
| 12 | Bromocriptine update显示文摘 | Rose LI | 1984 | Am Fam Physician1984，30，2： | 1 |
| 13 | A microsphere-based assay for multiplexed single nucleotide polymorphism analysis using single base chain extension 显示文摘 | Chen J Iannone MA Li MS Taylor JD Rivers P Nelsen A J Slentz-Kesler KA Roses A Weiner MP | 2000 | Genome Res2000，10，4： | 1 |
| 14 | Effect of oscillating fluid flow stimula- tion on osteocyte mRNA expression 显示文摘 | Li J Rose E Frances D | 2012 | J Biomech2012，45，2： | 1 |
| 15 | Using surface imaging and visual coaching to improve the reproducibility and stability of deep- inspiration breath hold for left-breast-cancer radiotherapy显示文摘 | Cervino LI Gupta S Rose MA | 2009 | Phys Med Biol2009，54，22： | 1 |
| 16 | Implementing guided wave mode control by use of a phased transducer array显示文摘 | LI Jian ROSE J L | 2001 | IEEE Transaction on Ultrasonics Ferroelectfivs and Frequency Control2001，48，3： | 1 |
| 17 | Angular-profile tuning of guided waves in hollow cylinders using a circumferential phased array显示文摘 | LI Jian ROSE J L | 2002 | IEEE Transaction on Ultrasonics Ferroelectrivs and Frequency Control2002，49，12： | 1 |
| 18 | Implementing guided wave mode control by use of a phased transducer array显示文摘 | Li J Rose J L | 2001 | IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control2001，48，3： | 1 |
| 19 | Ultrasonic guided wave flexural mode tuning for limited access pipe in- spection 显示文摘 | ROSE J L LI Jian ZHAO Xiaoliang | 2002 | Quantitative Nondestructive Evaluation2002，20，： | 1 |
| 20 | Hydrogen sulfide and cellsignaling显示文摘 | Li L Rose P Moore PK | 2011 | Annu Rev Pharmacol Toxicol2011，51，： | 1 |
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