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| 1 | Decreased serum platelet derived growth factor BB levels in acute and increased in chronic pancreatitis显示文摘AIM: To examine circulating growth factor concentrations in patients with acute pancreatitis(AP) and chronic pancreatitis(CP), and walled-off pancreatic necrosis(WOPN). METHODS: Forty patients with mild AP, 40 patients with alcoholic CP, 33 patients with WOPN and 40 healthy subjects were examined. Serum concentrations of platelet derived growth factor BB(PDGF-BB), transforming growth factor β-1(TGFβ-1), chemerin and high-mobility group box chromosomal protein 1(HMBG1) were assayed by enzyme linked immunosorbent assay.RESULTS: Patients with mild AP and those with WOPN had significantly lower serum levels of PDGF-BB compared to healthy subjects(4.0 ± 0.61 ng/mL vs 6.2 ± 0.76 ng/mL, P = 0.027, and 1.60 ± 0.31 ng/mL vs 6.2 ± 0.76 ng/mL, P < 0.001, respectively), while CP was associated with higher serum levels of PDGF-BB(12 ± 1.3 ng/mL vs 6.2 ± 0.76 ng/mL, P < 0.001). Circulating TGFβ-1 and chemerin levels were elevated in CP patients(57 ± 3.6 ng/mL vs 39 ± 3.6 ng/mL, P < 0.001 and 73 ± 7.2 ng/mL vs 48 ± 2.3 ng/mL, P < 0.001, respectively), but not in patients with AP and WOPN. No significant changes in serum HMBG1 levels were found either in patients with AP, WOPN or CP. CONCLUSION: The serum levels of some growth factors and cytokines differ significantly in AP, WOPN and CP. These data suggest that selected growth factors and cytokines may be considered as potential diagnostic biomarkers in patients with pancreatic diseases. | Magdalena Stojek Krystian Adrych Lukasz Rojek Marian Smoczynski Tomasz Sledzinski Sylwia Szrok Julian Swierczynski | 2014 | World Journal of Gastroenterology2014，20，36： | 2 |
| 2 | Reliability assement for sheet metal forming operations显示文摘 | KLEIBER M ROJEK J STOCKI R | 2002 | Computer Method in Applied Mechanics and Engineering2002，191，3940： | 1 |
| 3 | A current view of the mammalian aquaglyceroporins 显示文摘 | Rojek A Praetorius J Fr kiaer J | 2008 | Annu Rev Physiol2008，70，： | 1 |
| 4 | Combination of discrete element and finite element methods for dynamic analysis of geo- mechanics problems显示文摘 | ONATE E ROJEK J | 2004 | Computer methods in applied mechanics and engineering2004，193，27： | 1 |
| 5 | Neonatal death following clozapine self-poisoning in late pregnancy:an unusual case report显示文摘 | Klys M Rojek S Rzepecka-Wozniak E | | 0，，01： | 1 |
| 6 | Decreased expression of AQP 2 and AQP 4 water channels and Na, K-ATPase in kidney collecting duct in AQP 3 null mice显示文摘 | Kim SW Gresz V Rojek A | 2005 | Biol Cell2005，97，10： | 1 |
| 7 | Defective glycerol metabolism in aquaporin 9 (AQP9) knockout mice 显示文摘 | Rojek AM Skowronski MT Fu chtbauer EM | 2007 | Proc Natl Acad Sci U S A2007，104，9： | 1 |
| 8 | Defective glyc-erol metabolism in aquaporin 9(AQP9)knockout mice显示文摘 | Rojek A M Skowronski M T Fuchtbauer E M | 2007 | ProcNatl Acad Sci USA2007，104，9： | 1 |
| 9 | Posttranslational modification of alpha-dystroglycan,- the cellular receptor for arenaviruses, by the glycosyltransferase LARGE is critical for virus binding显示文摘 | Kunz S Rojek JM Kanagawa M | 2005 | J Virol2005，79，14： | 1 |
| 10 | Combination of discrete element and finite element methods for dynamic analysis of geomechanics problems显示文摘 | ONATE E ROJEK J | 2004 | Computer Methods in Applied Mechanics and Engineering2004，193，： | 1 |
| 11 | Effect of if-channel inhibition on hemodynamic status and exercise tolerance in heart failure with preserved ejection fraction: a randomized trial显示文摘 | Kosmala W Holland DJ Rojek A | 2013 | Am Coll Cardiol2013，62，15： | 1 |
| 12 | Development and feasibility of a smartphone,ECG and GPS based system for remotely monitoring exercise in cardiac rehabilitation显示文摘 | Worringham C Rojek A Stewart I | | Plos ONE0，6，14： | 1 |
| 13 | Def-ective glycerol metabolism in aquaporin 9 (AQP9)knockoutmice显示文摘 | Rojek AM Skowronski MT Fuchtbauer EM | 2007 | Proc Natl Acad Sci USA2007，104，8： | 1 |
| 14 | Defective glycerol metabolism in aquaporin 9 ( AQP9 ) knockout mice 显示文摘 | Rojek A M Skowronski M T Fuchtbauer E M | 2007 | Proc Natl Acad Sci USA2007，104，8： | 1 |
| 15 | AQP7 is localized in capillaries of adipose tissue, cardiac and striated muscle: implications in glycerol metabolism 显示文摘 | Skowronski M T LebeckJ Rojek Av | 2007 | American Journal of Physiology-Renal Physiology2007，292，： | 1 |
| 16 | Reliability assessment for sheet metal forming operations 显示文摘 | Kleiber M Rojek J Stocki R | 2002 | Computer Methods in Applied Mechanics and Engineering2002，191，： | 1 |
| 17 | Defective glycerol metabolism in aquaporin 9(AQP9) knockout mice 显示文摘 | ROJEK AM SKOWRONSKI MT FU CHTBAUER EM | 2007 | Proc Nat l Acad Sci USA2007，104，9： | 1 |
| 18 | Combination of discrete element and finite element methods for dynamic analysis of geomechanics problems显示文摘 | ONATE E ROJEK J | 2004 | Computer Methods in Applied Mechanics and Engineering2004，193，27： | 1 |
| 19 | Severe urinary concentrating defect in renal collecting duct-selective AQP2 conditional-knockout mice显示文摘 | Rojek A Füchtbauer EM Kwon TH | | 0，，： | 1 |
| 20 | Pulse wave velocity is associated with early clinical outcome after ischemic stroke显示文摘 | Gasecki D Rojek A Kwarciany M | | 0，，： | 1 |
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