|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | Precision atomic gravimeter based on Bragg diffraction显示文摘 | P A Altin M T Johnsson V Negnevitsky G R Dennis R P Anderson J E Debs S S Szigeti K S Hardman S Bennetts G D McDonald L D Turner J D Close N P Robins | 2013 | New Journal of Physics2013，，2： | 2 |
| 3 | Systemic hyperthermia and ICE chemotherapy for sarcoma patients:rationale and clinical status 显示文摘 | Wiedemann G J Robins H I Katschinski D M | 1997 | Anticancer Res1997，17，4： | 1 |
| 4 | Genetic mapping of biomass production in tetraploid alfalfa显示文摘 | Robins J G Luth D Campbell I A | 2007 | Crop Science2007，47，： | 1 |
| 5 | Wheat genotypes differ in Zn efficiency when grown in chelate-buffered nutrient solution显示文摘 | Rengel Z Robin D G | 1995 | Plant and Soil1995，176，： | 1 |
| 6 | Systemic hyperthermia and ICE chemotherapy for sarcoma patients:rationale and clinical status显示文摘 | Wiedemann G J Robins H I Katschinski D M | 1997 | Anticancer Res1997，17，4： | 1 |
| 7 | Molecularpaleohydrology: Interpreting the hydrogen isotopiccomposition of lipid biomarkers from photosynthesizing organisms 显示文摘 | Sachse D Billault I Bowen G Y Chikaraishi Y Dawson T E Feakins S J Freeman K H Magill C R McInerney F A vander Meer M T J Polissar P Robins R J Sachs J P Schmidt HL Sessions A L White J W C West J B Kahmen A | 2012 | Ann Rev Earth Planet Sci2012，40，： | 1 |
| 8 | Polycystic ovary syndrome: A model of follicular excess 显示文摘 | Robin G Catteau-Jonard S Dewailly D | 2010 | Gynecol Obstet Fertil2010，38，6： | 1 |
| 9 | Genetic mapping of persistence in tetraploid alfalfa显示文摘 | Robins J G Hansen J L Viands D R | 2008 | Crop Science2008，48，： | 1 |
| 10 | Bax crystal structures reveal how BH3domains activate Bax and nucleate its oligomerization to induce apoptosis显示文摘 | Czabotar P E Westphal D Dewson G Ma S Hockings C Fairlie W D Lee E F Yao S Robin A Y Smith B J Huang D C Kluck R M Adams J M Colman P M | 2013 | Cell2013，152，3： | 1 |
| 11 | Bak core and latch domains separate during activation,and freed core domains form symmetric homodimers显示文摘 | Brouwer J M Westphal D Dewson G Robin A Y Uren R T Bartolo R Thompson G V Colman P M Kluck R M Czabotar P E | 2014 | Mol Cell2014，55，6： | 1 |
| 12 | Nb-Ta alloys by aluminothermic reduction of Nb2O5/Ta2O5 mixtures and electron beam melting显示文摘 | Nunes C A Pinatti D G Robin A | 1999 | International Journal of Refractory Metals & Hard Materials1999，17，： | 1 |
| 13 | The radial artery in coronary surgery: a 5-year experience—clinical and angiographic results显示文摘 | James Tatoulis Alistair G Royse Brian F Buxton John A Fuller Peter D Skillington John C Goldblatt Robin P Brown Michael A Rowland | 2002 | The Annals of Thoracic Surgery2002，，： | 1 |
| 14 | The role of strain variation in murine Bleomycin-induced pulmonary fibrosis 显示文摘 | Denis J Schrier D Robin G | 1983 | Am Rev Respir Dis1983，127，： | 1 |
| 15 | Characterization and quantitative analysis of serum IgG class and subclass response to Shigella sonnei and Shigella flexneri 2a lipopolysaccharide following natural Shigella infection 显示文摘 | Robin G Cohen D Orr N | 1997 | J Infect Dis1997，175，5： | 1 |
| 16 | Asthma exacerbations during long term β2 agonist use:influence of β2 - adrenoceptor polymorphism显示文摘 | Robin D Taylor J ejj rey M Drazen Peter G Herbison | 2000 | Thorax2000，55，： | 1 |
| 17 | Migration and sediment logy of long-shore dunes,long point,lake Erie显示文摘 | Robin G D Davidson A Anthony G V H | 2003 | Canada Sediment logy2003，50，： | 1 |
| 18 | New cometabolites of gliotoxin in Gliocladium virens显示文摘 | KIRBY G W RAO G V ROBINS D J | 1988 | J Chem Soc:Perkin Trans 11988，，2： | 1 |
| 19 | Biosynthesis of bisdethiobis (methylthio) gliotoxin,a new metabolite of Gliocladium deliquescens显示文摘 | KIRBY G W ROBINS D J SEFTON M A | 1980 | J Chem Soc:Perkin Trans 11980，，1： | 1 |
| 20 | A modification of the adenosine triphosphatase method to demonstrate epidermal Langerhans cells显示文摘 | Robins P G Brandon D | 1981 | Stain Technology1981，56，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员