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| 1 | Molecular alterations in gastric cancer with special reference to the early-onset subtype显示文摘Currently, gastric cancer(GC) is one of the most frequently diagnosed neoplasms, with a global burden of 723000 deaths in 2012. It is the third leading cause of cancer-related death worldwide. There are numerous possible factors that stimulate the procarcinogenic activity of important genes. These factors include genetic susceptibility expressed in a singlenucleotide polymorphism, various acquired mutations(chromosomal instability, microsatellite instability, somatic gene mutations, epigenetic alterations) and environmental circumstances(e.g., helicobcter pylori infection, EBV infection, diet, and smoking). Most of the aforementioned pathways overlap, and authors agree that a clear-cut pathway for GC may not exist. Thus, the categorization of carcinogenic events is complicated. Lately, it has been claimed that research on early-onset gastric carcinoma(EOGC) and hereditary GC may contribute towards unravelling some part of the mystery of the GC molecular pattern because young patients are less exposed to environmental carcinogens and because carcinogenesis in this setting may be more dependent on genetic factors. The comparison of various aspects that differ and coexist in EOGCs and conventional GCs might enable scientists to: distinguish which features in the pathway of gastric carcinogenesisare modifiable, discover specific GC markers and identify a specific target. This review provides a summary of the data published thus far concerning the molecular characteristics of GC and highlights the outstanding features of EOGC. | Malgorzata Skierucha Anya NA Milne G Johan A Offerhaus Wojciech P Polkowski Ryszard Maciejewski Robert Sitarz | 2016 | World Journal of Gastroenterology2016，22，8： | 6 |
| 2 | An aspect-based approach to modeling access control concerns 显示文摘 | lndrakshi R Robert B F Li Na | 2004 | Information & Software Technology2004，46，9： | 1 |
| 3 | Neonatal transfusion practice显示文摘 | Murray NA Roberts IA | 2004 | Arch Dis Child Fetal Neonatal Ed2004，89，2： | 1 |
| 4 | Deficiencies in pro- genitor ceils of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c- Mpl显示文摘 | Alexander WS Roberts AW Nicola NA | 1996 | Blood1996，87，6： | 1 |
| 5 | The human colonisation of Australia:optical dates of 53,000 and 60,000 years bracket human arrival at Deaf Adder Gorge,Northern Territory显示文摘 | Roberts RG Jones R Spooner NA | 1994 | Quaternary Science Reviews1994，13，5： | 1 |
| 6 | Reduced dosage of the modifiers of epigenetic reprogramming Dnmt1,Dnmt3L,SmcHD1 and Foxo3a has no detectable effect on mouse telomere length in vivo显示文摘 | Roberts AR Blewitt ME Youngson NA | | 0，，： | 1 |
| 7 | Surgical anatomy pertaining to liver resection,Surg Gynecol Obst显示文摘 | Goldsmith NA Robert B Daseler JE | 1957 | 105:3101957，105，： | 1 |
| 8 | Adding quetiapine to SRI in treatment-resistant obsessive-compulsive disorder: a randomized controlled treatment study 显示文摘 | Fineberg NA Sivakumaran T Roberts A | 2005 | Int Clin Psychopharmacol2005，20，： | 1 |
| 9 | Therapeutic Apheresis in Neurology Critical Care显示文摘 | Neela Na Robert We | 2005 | Intensive Care Med2005，20，4： | 1 |
| 10 | Haemolytic disease of the newborn显示文摘 | Murray NA Roberts IA | 2007 | Arch Dis Child Fetal Neonatal2007，92，2： | 1 |
| 11 | In-vitro and in-vivo efficacy of influenza neuraminidase inhibitors 显示文摘 | Roberts NA | 1998 | Curr Opin in Infect Disease1998，11，6： | 1 |
| 12 | Treatment of influenza with neuraminidase in hibitors virological implieations显示文摘 | Roberts NA | 2001 | Philos Trans R Soc Lond B Biol Sci2001，353，： | 1 |
| 13 | Thrombocytopenia in the newbom显示文摘 | Roberts IA Murray NA | 2003 | Current Opinion in Pediatrics2003，，： | 1 |
| 14 | A prospective observational study of the clinical toxicology of glyphosate-containing herbicides in adults with acute self-poisoning显示文摘 | Roberts DM Buckley NA Mohamed F | 2010 | Clin Toxicol(Phila)2010，48，2： | 1 |
| 15 | RNA and DNA hy- drolysis are catalyzed by the influenza virus endonuclease显示文摘 | KLUMPP DOAN L ROBERTS NA | 2000 | J Biol Chem2000，275，9： | 1 |
| 16 | Safety and feasibility of a CT protocol for acute stroke:combined CT,CT angiography,and CT perfusion imaging in 53 consecutive patients显示文摘 | Smith WS Roberts HC Chuang NA | 2003 | Am J Neuroradiol2003，24，3： | 1 |
| 17 | Extracorporeal blood purification for acute organophosphorus pesticide poisoning显示文摘 | Roberts DM Peng A Zhu K Buckley NA | | 0，，02： | 1 |
| 18 | Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl 显示文摘 | Alexander WS Roberts AW Nicola NA | 1996 | Blood1996，87，6： | 1 |
| 19 | Thrombocytopenia in the neonate 显示文摘 | Roberts I Stanworth S Murray NA | 2008 | Blood Rev2008，22，4： | 1 |
| 20 | Neonatal thrombocytopenia: causes and management 显示文摘 | Roberts I Murray NA | 2003 | Arch Dis Child Fetal Neonatal Ed2003，88，5： | 1 |
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