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| 1 | 冠状动脉内影像学临床应用专家共识(第一部分):对冠状动脉介入治疗的指导与优化显示文摘欧洲心血管介入协会(EAPCI)专家组系统总结了血管内超声(IVUS)和光学相干断层成像(OCT)这两种血管内影像学检查临床应用指征的现有证据,提供了关于IVUS和OCT指导经皮冠状动脉介入治疗(PCI)的应用价值,并明确了最可能从腔内影像学指导的介入治疗中获得临床收益的患者或病变类型,同时详细论述了PCI前如何使用IVUS或OCT优化支架尺寸(支架长度和直径)和手术策略的选择。此外,专家推荐对支架失败(支架内再狭窄或支架内血栓形成)的患者应常规进行冠状动脉内影像学检查,并首选OCT。最后,重点论述了IVUS和OCT在指导PCI和评估支架失败两个方面的优势和局限性,并对未来需要深入研究的领域进行了展望。 | Lorenz Raber Gary S Mintz Konstantinos C Koskinas Thomas W Johnson Niels R Holm Yoshinubo Onuma Maria D Radu Michael Joner Bo Yu Haibo Jia Nicolas Meneveau Jose M.de la Torre Hemandez Javier Escaned Jonathan Hill Francesco Prati Antonio Colombo Carlo di Mario Evelyn Regar Davide Capodanno William Wijns Robert A Byme Giulio Guagliumi | 2019 | 中华心血管病杂志2019，47，1： | 17 |
| 2 | Investor protection and corporate governance显示文摘 | Rafael La Porta Florencio Lopez-de-Silanes Andrei Shleifer Robert Vishny | 2000 | Journal of Financial Economics2000，，1： | 16 |
| 3 | Investor protection and corporate governance显示文摘 | Rafael La Porta Florencio Lopez-de-Silanes Andrei Shleifer Robert Vishny | 2000 | Journal of Financial Economics2000，，1： | 3 |
| 4 | Telaprevir/boceprevir era: From bench to bed and back显示文摘Hepatitis C virus (HCV) infects approximately 200 million people worldwide. Interferon-based therapies have dominated over the past two decades. However, the overall response rates remain suboptimal. Thanks to the tremendous effort from both academia and industry, two serine protease inhibitors telaprevir and boceprevir for treating chronic hepatitis C have finally reached the clinic. Although these compounds are only approved for combination use with interferon and ribavirin in genotype 1 HCV infected chronic patients, the management of HCV patients however is now evolving incredibly. Here, we overviewed a series of landmark studies, regarding the clinical development of telaprevir and boceprevir. We discussed the mechanism-of-action of telaprevir/boceprevir and their potential application in HCV-positive liver transplantation patients. We further emphasized some emerging concerns with perspective of further development in this field. | Maikel P Peppelenbosch Harry LA Janssen Robert J de Knegt | 2012 | World Journal of Gastroenterology2012，18，43： | 3 |
| 5 | Regulated upon activation,normal T cell expressed and secreted(RANTES)levels in the peripheral blood of patients with Alzheimer’s disease显示文摘Alzheimer’s disease(AD)is the most common type of dementia,but it is very difficult to diagnose with certainty,so many AD studies have attempted to find early and relevant diagnostic markers.Regulated upon activation,normal T cell expressed and secreted(RANTES,also known as C-C chemokine ligand)is a chemokine involved in the migration of T cells and other lymphoid cells.Changes in RANTES levels and its expression in blood or in cerebrospinal fluid have been reported in some neurodegenerative diseases,such as Parkinson’s disease and multiple sclerosis,but also in metabolic diseases in which inflammation plays a role.The aim of this observational study was to assess RANTES levels in peripheral blood as clinical indicators of AD.Plasma levels of RANTES were investigated in 85 AD patients in a relatively early phase of AD(median 8.5 months after diagnosis;39 men and 46 women;average age 75.7 years),and in 78 control subjects(24 men and 54 women;average age 66 years).We found much higher plasma levels of RANTES in AD patients compared to controls.A negative correlation of RANTES levels with age,disease duration,Fazekas scale score,and the medial temporal lobe atrophy(MTA)score(Scheltens’s scale)was found in AD patients,i.e.,the higher levels corresponded to earlier stages of the disease.Plasma RANTES levels were not correlated with cognitive scores.In AD patients,RANTES levels were positively correlated with the levels of pro-inflammatory cytokines interleukin-6 and tumor necrosis factor-α,which is consistent with the wellknown fact that AD is associated with inflammatory processes.RANTES levels were also positively correlated with insulin levels in AD patients,with insulin resistance(HOMA-R)and pancreatic beta cell function(HOMA-F).This study evaluated several clinical and metabolic factors that may affect plasma levels of RANTES,but these factors could not explain the increases in RANTES levels observed in AD patients.Plasma levels of RANTES appear to be an interesting peripheral marker for early stages of AD.The study was approved by the Ethics Committee of Institute of Endocrinology,Prague,Czech Republic on July 22,2011. | Gabriela Vacínová Daniela Vejražkova Robert Rusina Iva Holmerová Hana Vaňková Eva Jarolímová Josef Včelák Běla Bendlová Markéta Vaňková | 2021 | Neural Regeneration Research2021，16，4： | 3 |
| 6 | Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial显示文摘 | Harry LA Janssen Monika van Zonneveld Hakan Senturk Stefan Zeuzem Ulus S Akarca Yilmaz Cakaloglu Christopher Simon Thomas MK So Guido Gerken Robert A de Man Hubert GM Niesters Pieter Zondervan Bettina Hansen Solko W Schalm | 2005 | The Lancet . 2005 (9454)2005，，： | 2 |
| 7 | Electrochemical characterization of LiCoO 2 as rechargeable electrode in aqueous LiNO 3 electrolyte显示文摘 | Riccardo Ruffo Fabio La Mantia Colin Wessells Robert A. Huggins Yi Cui | 2010 | Solid State Ionics2010，，1： | 2 |
| 8 | SAFETY AND EFFICACY OF PARTIAL NEPHRECTOMY FOR ALL T1 TUMORS BASED ON AN INTERNATIONAL MULTICENTER EXPERIENCE显示文摘 | JEAN-JACQUES PATARD OLEG SHVARTS JOHN S. LAM ALLAN J. PANTUCK HYUNG L. KIM VINCENZO FICARRA LUCA CINDOLO KEN-RYU HAN ALEXANDRE DE LA TAILLE JACQUES TOSTAIN WALTER ARTIBANI CLAUDE C. ABBOU BERNARD LOBEL DOMINIQUE K. CHOPIN ROBERT A. FIGLIN PETER F.A. MULDE | 2004 | The Journal of Urology2004，，6： | 2 |
| 9 | Law and Finance显示文摘 | Rafael La Port Florencio Lopez-de-Silanes Andrei Shleifer and Robert Vishny | 1998 | Journal of Political Economy1998，106，6： | 1 |
| 10 | Primary sclerosing cholangitis and ulcerative colitis: Evidence for increased neoplastic potential显示文摘 | Ulrika Broomé Robert L?fberg Béla Veress Ljusk Siw Eriksson | 1995 | Hepatology1995，，5： | 1 |
| 11 | Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial显示文摘 | Harry LA Janssen Monika van Zonneveld Hakan Senturk Stefan Zeuzem Ulus S Akarca Yilmaz Cakaloglu Christopher Simon Thomas MK So Guido Gerken Robert A de Man Hubert GM Niesters Pieter Zondervan Bettina Hansen Solko W Schalm | 2005 | 2005 (9454)2005，，9454： | 1 |
| 12 | Corporate Ownership Around the World显示文摘 | Rafael La Port Florencio Lopez-de-Silanes Andrei Shleifer and Robert Vishny | 1999 | Journal of Finance1999，，54： | 1 |
| 13 | Law and Finance显示文摘 | Rafael La Porta Florencio Lopez- de- Silanes Andrei Shleifer Robert W Vishny | 1998 | Journal of Political Economy1998，，106： | 1 |
| 14 | The epidemiologic and clinical importance of noro virus infection显示文摘 | Robert LA Mary KE | 2006 | Gastroenterol Clin N Am2006，35，2： | 1 |
| 15 | Investor Protection and Corporate Governance显示文摘 | Rafael La Port Florencio Lopez-de-Silanes An drei Shleifer and Robert Vishny | 2000 | Journal of Financial Economics2000，，58： | 1 |
| 16 | Panel discussion:cosmetic surgery of the buttocks region显示文摘 | Roberts TL De La Pena JA Toledo LS | 2003 | Aesthetic Surg J2003，23，5： | 1 |
| 17 | Are rice chromosomes components of a holocentric chromosome ancestor? 显示文摘 | Moore G Alcaide LA Robert M | 1997 | Plant Molecular Biology1997，35，： | 1 |
| 18 | Law and finance显示文摘 | La Porta Rafael Florencio Lopez-de-Silanes Andrei Shleifer and Robert Vishny | 1998 | Journal of Political Economy1998，106，： | 1 |
| 19 | Law and Finance 显示文摘 | La Porta Rafael Lopez-de-Silanes Florencio Shleifer Andrei Vishny Robert W | 1998 | Journal of Political Economy1998，106，6： | 1 |
| 20 | Agency problems and dividend policy around the world显示文摘 | Rafael Florencio Lopez-De Silanes Andrei Shleifer and Robert Vishny | 2002 | Journal of Finance2002，，55： | 1 |
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