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46篇 您的检索式:作者名="Rhun"
    题名 作者 年代 出处 被引量
1经气管灌注血管紧张素Ⅱ导致凋亡性急性肺损伤(英文)显示文摘为研究外源性血管紧张素Ⅱ(angiotensinⅡ,ANG)在急性肺损伤和肺泡上皮细胞凋亡中的作用,经气管分别给雄性Wistar大鼠(175~200g)灌注ANG、ANG加caspase抑制剂ZVAD-fmk、ANG加ANG受体1阻断剂losartan和仅灌注磷酸盐缓冲溶液(PBS)。6或20h后在体灌洗动物肺脏,测定灌洗液中血红蛋白(hemoglobin,Hb)和荧光物质(BODIPY)标定的白蛋白含量(在灌洗前15min静脉注入BODIPY-白蛋白)。TUNEL测定显示,灌注ANG6h后,支气管和肺泡上皮细胞内标定的DNA片断显著增加(P<0.05);ANG所致的DNA片断增加可被同时灌注ZVAD-fmk或losartan阻断。灌注ANG后免疫标定caspase3阳性细胞数量显著增多(P<0.01),ZVAD-fmk或losartan同样显著减少caspase3阳性细胞的数量。灌注ANG显著增加肺泡灌洗液中荧光标定的白蛋白(P<0.01)和Hb的含量(P<0.05);ZVAD-fmk或losartan亦显著抑制荧光白蛋白和Hb含量的变化。结果表明,肺泡上皮细胞在体暴露于外源性ANG足以引起ANG受体1介导的上皮细胞凋亡和肺泡屏障损伤。庄甲举 李小鹏 Bruce David Uhal Koh Rhun Yian 2008生理学报2008,60,6:7
2Rabeprazole test for the diagnosis of gastro-oesophageal reflux disease: Results of a study in a primary care setting显示文摘瞄准:为了决定病人的 rabeprazole 测试的诊断价值,由全科医生看。方法:有 GERD 暗示的症状的 83 个病人被全科医生在这个多中心注册,使随机化并且双窗帘学习。所有病人收到了 rabeprazole (20 mg 出价) 或安慰剂一个星期。GERD 的诊断在内视镜检查法或反常食道的 24-h pH 测试在粘膜裂缝的存在上被建立。如果病人们报导至少,“ 7 点 Likert 上的症状的清楚的改进”可伸缩,测试被认为阳性。结果:为 rabeprazole 和安慰剂的测试的敏感分别地是 83% 和 40% 。相应特性,积极、否定的预兆的价值是 45% 和 67% , 71% 和 71% ,和 62% 和 35% 分别地。操作特征(巨鸟) 分析的接收装置证实最好差别对待截止对应于对“清楚的改进”的描述。结论:禁止者(PPI ) 测试的质子泵的差的特性不支持如此的一条途径在一个主要照顾背景建立 GERD 的诊断。Stanislas Bruley des Varannes Sylvie Sacher-Huvelin Fabienne Vavasseur Claude Masliah Marc Le Rhun Philippe Aygalenq Sylvie Bonnot-Marlier Yves Lequeux Jean Paul Galmiche 2006World Journal of Gastroenterology2006,12,16:4
3Self-care support in paediatric patients with type 1 diabetes:Bridging the gap between patient education and health promotion?显示文摘Pelicand J Fournier C Le Rhun A 2013Health Expect2013,14,8:1
4Regulated expression of platelet factor 4 in human monocytes-role of PARs as a quantitatively important monocyte activation pathway 显示文摘SCHAFFNER A RHUN P SCHOEDON G 2005J Leukoc Biol2005,78,1:1
5Detection andquantification of CSF malignant cells by the cell search technologyin patients with melanoma leptomeningeal metastasis显示文摘Le Rhun E Tu Q De Carvalho Bittencourt M 2013Med Oncol2013,30,2:1
6Carcinomatous meningitis: Leptomeningeal metastases in soild tumors 显示文摘Le Rhun E Taillibert S Chamberlain MC 2013Surg Neurol Int2013,4,4:1
7Use of mitochondrial RNA genes for the differentiation of four Trichinella species by multiplex PCR amplification显示文摘BLAGA R FU B Q LE RHUN D 2009J Helminthol2009,83,2:1
8Strategies of exploitation of mammalian reservoirs by Bartonella species 显示文摘Deng H Le Rhun D Buffet JP 2012Vet Res2012,43,1:1
9High resolution colonoscopy with chromoscopy versus standard colonoscopy for the detection of colonic neoplasia:a randomized study显示文摘Le Rhun M Coron E Parlier D 0,,03:1
10Compli-cations related to the placement of an intraventricular chemotherapydevice显示文摘Zairi F Le Rhun E Tetard MC Kotecki N Assaker R 2011J Neurooncol2011,104,1:1
11Short-Circuit Pho- tocurrent in Epitaxial Lead Zirconate-Titanate Thin Films 显示文摘Pintilie L Vrejoiu I Rhun G L 2007Journal of Appllied Physics2007,101,6:1
12Development of a new method for identification and quantification in cerebrospi- nal fluid of malignant cells from breast carcinoma lepto- meningeal metastasis显示文摘Le Rhun E Massin F Tu Q 2012BMC Clin Pathol2012,12,1:1
13Relevance of gamma knife radiosurgery alone for the treatment of non-small cell lung cancer brain metastases显示文摘Zairi F Ouammou Y Le Rhun E 2014Clin Neurol Neurosurg2014,125,:1
14Follow-up and Surgical Management of Peutz-Jeghers Syndrome in Children显示文摘Isabelle Vidal Guillaume Podevin Hugues Piloquet Marc Le Rhun Benjamin Frémond Didier Aubert Marc-David Leclair Yves Héloury 2009Journal of Pediatric Gastroenterology and Nutrition2009,,4:1
15Cellular responses to DNA damage in the absence of poly (ADP-ribose) polymerase 显示文摘Le Rhun Y Kirkland JB Shah GM 1998Biochem Biophys Res Commun1998,245,1:1
16Carcinomatous meningitis:Leptomeningeal metastases in solid tumors显示文摘Le Rhun E Taillibert S Chamberlain MC 2013Surg Neurol Int2013,44,:1
17Strategies of exploitation of mammalian reservoirs by Bartonella species显示文摘Deng H Le Rhun D Buffet JP 2012Vet Res2012,43,15:1
18Self-care support in paediatric patients with type 1 diabetes:bridging the gap between patient education and health promotion? A review显示文摘Pelicand J Fournier C Le Rhun A 2013Health Expect2013,14,:1
19Natural history of primary progressive aphasia显示文摘Le Rhun E Richard F Pasquier F 2005Neurology2005,65,6:1
20Topical corticosteroid phobia in atopic dermatitis:a study of its nature,origins and frequency显示文摘Aubert-Wastiaux H Moret L Le Rhun A 2011Br J Dermatol2011,165,4:1
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