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| 1 | Sclerostin activity plays a key role in the negative effect of glucocorticoid signaling on osteoblast function in mice显示文摘Stress during prenatal development is correlated with detrimental cognitive and behavioral outcomes in offspring. However, the long-term impact of prenatal stress(PS) and disrupted glucocorticoid signaling on bone mass and strength is not understood. In contrast, the detrimental effect of lead(Pb) on skeletal health is well documented. As stress and Pb act on common biological targets via glucocorticoid signaling pathways and co-occur in the environment, this study first sought to assess the combined effect of stress and Pb on bone quality in association with alterations in glucocorticoid signaling. Bone parameters were evaluated using microCT, histomorphometry, and strength determination in 8-month-old male mouse offspring subjected to PS on gestational days 16 and 17, lifetime Pb exposure(100 p.p.m. Pb in drinking water), or to both. Pb reduced trabecular bone mass and, when combined with PS, Pb unmasked an exaggerated decrement in bone mass and tensile strength. Next, to characterize a mechanism of glucocorticoid effect on bone, prednisolone was implanted subcutaneously(controlled-release pellet, 5 mg·kg^(-1) per day) in 5-month-old mice that decreased osteoblastic activity and increased sclerostin and leptin levels. Furthermore, the synthetic glucocorticoid dexamethasone alters the anabolic Wnt signaling pathway. The Wnt pathway inhibitor sclerostin has several glucocorticoid response elements, and dexamethasone administration to osteoblastic cells induces sclerostin expression. Dexamethasone treatment of isolated bone marrow cells decreased bone nodule formation, whereas removal of sclerostin protected against this decrement in mineralization.Collectively, these findings suggest that bone loss associated with steroid-induced osteoporosis is a consequence of sclerostin-mediated restriction of Wnt signaling, which may mechanistically facilitate glucocorticoid toxicity in bone. | Eric E Beier Tzong-Jen Sheu Emily A Resseguie Masahiko Takahata Hani A Awad Deborah A Cory-Slechta J Edward Puzas | 2017 | Bone Research2017，5，2： | 3 |
| 2 | Is there IgA form gut mucosal origin in theserum of children with Henoch-SchonleinPurpura显示文摘 | Moja P Quesnet A Resseguier V | | 0，，03： | 1 |
| 3 | Patterns of pain--{ree response in 497 cases o- classic trigeminal neuralgia treated with Gamma Kni{e surgery and {ol-lowed up for least 1 year显示文摘 | Tuleasca C Carton R Resseguier N | 2012 | J Neurosurg2012，117，： | 1 |
| 4 | Spallation in laser shock-loaded tin below and just above melting on release 显示文摘 | de Resseguier T Signor L Dragon A | 2007 | J Appl Phys2007，102，07： | 1 |
| 5 | Patterns of pain-- free response in 497 cases of classic trigeminal neuralgia trea- ted with Gamma Knife surgery and followed up for least 1 year显示文摘 | Tuleasca C Carron R Resseguier N | 2012 | J Neurosurg2012，7，： | 1 |
| 6 | Primary and secondary prevention programs for dating violence: A review of the literature 显示文摘 | Cornelius TL Resseguie N | 2007 | Aggression Violent Behav2007，12，3： | 1 |
| 7 | Characterization of laser-driven shocks of high intensity using piezoelectric polymers 显示文摘 | de Resseguier T Couturier S Boustie M | 1996 | J Appl Phys1996，80，7： | 1 |
| 8 | Experimental Investigation of Liquid Spall in Laser Shock-Loaded Tin显示文摘 | Resseguier T Signor L Boustie M | 2007 | J Appl Phys2007，101，01： | 1 |
| 9 | Is there IgA from gutmucosal origin in the serum of children with Henoch - Schonlein purpura 显示文摘 | Moja P Quesnel A Resseguier V | 1998 | Clin Immunol Immunopathol1998，，86： | 1 |
| 10 | Is there IgA from gut mucosal origin in the serum of children with Henoch-Schonlein purpura显示文摘 | Moja P Quesnel A Resseguier V | 1998 | Clin Immunol Immunopathol1998，86，： | 1 |
| 11 | 157 :Surgery of chro- nic functional mitral regurgitation: Interest of mitral valve re- placement in severe heart failure patients显示文摘 | Theron A Morera P Resseguier N | 2013 | Archives of Car- diovascular Diseases Supplements2013，5，1： | 1 |
| 12 | Patterns of pain-free response in 497 cases of classic trigeminal neuralgia treated with Gamma Knife surgery and followed up for least 1 year:Clinical article显示文摘 | Tuleasca C Carron R Resseguier N | 2012 | J Neurosurg2012，，： | 1 |
| 13 | Multiple sclerosis relat- ed trigeminal neuralgia:a prospective series of 43 patients treated with gamma knife surgery with more than one year of follow-up 显示文摘 | Tuleasca C Carron R Resseguier N | 2014 | Stereotact Funct Neurosurg2014，92，4： | 1 |
| 14 | Is there IgA form gut mucosal origin in the serum of children with Henoch-Schonlein Purpura?显示文摘 | Moja P Quesnel A Resseguier V | 1998 | Clin Immunol Immunopathol1998，86，3： | 1 |
| 15 | Intertidal clay-drape couplets (Gironde estuary,France)显示文摘 | Hugues Fenies Amaury De Resseguier Jean-Pierre Tastet | 1999 | Sedimentology1999，46，： | 1 |
| 16 | Experimental Investigation of Liquid Spall in Laser Shock-Loaded Tin 显示文摘 | Resseguier T Signor L Boustie M | 2007 | J Appl Phys2007，101，01： | 1 |
| 17 | Shock proflie induced by short laser pulses 显示文摘 | COUTURIER S de RESSEGUIER T HALLOUIN M | 1996 | J A P1996，79，12： | 1 |
| 18 | Evaluation of Different Strategies for Prevention of Venous Thromboembolism in Elective Orthopedic Surgery显示文摘 | Danielle M Carter Andrea Resseguie John Fanikos Julie Atay | 2014 | Journal of Pharmacy and Pharmacology2014，2，6： | 1 |
| 19 | Multiple sclerosis-related trigeminal neuralgia:a prospective series of 43 patients treated with gamma knife surgery with more than one year of follow-up显示文摘 | Tuleasca C Carron R Resseguier N | 2014 | Stereotact Funct Neurosurg2014，92，： | 1 |
| 20 | Spallation of metal targets subjected to interse laser shocks显示文摘 | de Resseguier T Couturier S | 1997 | J Appl Phys1997，82，5： | 1 |
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