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| 1 | Murine model to study brain,behavior and immunity during hepatic encephalopathy显示文摘AIM:To propose an alternative model of hepatic encephalopathy(HE) in mice,resembling the human features of the disease.METHODS:Mice received two consecutive intraperitoneal injections of thioacetamide(TAA) at low dosage(300 mg/kg).Liver injury was assessed by serum transaminase levels(ALT) and liver histology(hematoxylin and eosin).Neutrophil infiltration was estimated by confocal liver intravital microscopy.Coagulopathy was evaluated using prolonged prothrombin and partial thromboplastin time.Hemodynamic parameters were measured through tail cuff.Ammonia levels were quantified in serum and brain samples.Electroencephalography(EEG) and psychomotor activity score were performed to show brain function.Brain edema was evaluated using magnetic resonance imaging.RESULTS:Mice submitted to the TAA regime developed massive liver injury,as shown by elevation of serum ALT levels and a high degree of liver necrosis.An intense hepatic neutrophil accumulation occurred in response to TAA-induced liver injury.This led to mice mortality and weight loss,which was associated with severe coagulopathy.Furthermore,TAA-treated mice presented with increased serum and cerebral levels of ammonia,in parallel with alterations in EEG spectrum and discrete brain edema,as shown by magnetic resonance imaging.In agreement with this,neuropsychomotor abnormalities ensued 36 h after TAA,fulfilling several HE features observed in humans.In this context of liver injury and neurological dysfunction,we observed lung inflammation and alterations in blood pressure and heart rate that were indicative of multiple organ dysfunction syndrome.CONCLUSION:In summary,we describe a new murine model of hepatic encephalopathy comprising multiple features of the disease in humans,which may provide new insights for treatment. | Lindisley Ferreira Gomides Pedro Elias Marques Bruno Engler Faleiros Rafaela Vaz Pereira Sylvia Stella Amaral Thais Reis Lage Gustavo Henrique Souza Resende Patricia Alves Maia Guidine Giselle Foureaux Fabíola Mara Ribeiro Fabiana Paiva Martins Marco Antonio Peliky Fontes Anderson José Ferreira Remo Castro Russo Mauro Martins Teixeira Márcio Flávio Moraes Antonio Lúcio Teixeira Gustavo Batista Menezes | 2014 | World Journal of Hepatology2014，6，4： | 2 |
| 2 | Engineered RNA-mediated resistance to tomato spotted wilt virus is sequence specific显示文摘 | DE OLIEEIRA RESENDE R ANKER C | 1996 | Mol Plant-Microbe Interact1996，9，： | 1 |
| 3 | Estimation of mass transfer parameters in a Taylor-Couette-Poiseuille heterogeneous reactor显示文摘 | Resende M M Vieira P G Sousa Jr R | 2004 | Brazilian Journal of Chemical Engineering2004，21，2： | 1 |
| 4 | Atmospheric reaction between the HS radical and chlorine显示文摘 | Resende S M Ornellas F R | 2000 | C P Lett2000，318，： | 1 |
| 5 | Information Asymmetry and Traceability Incentives for Food Safety 显示文摘 | Resende - Filho M A Hurley T M | 2012 | International Journal of Production Economics2012，139，2： | 1 |
| 6 | GRASP and path relinking for the max-min diversity problem显示文摘 | Resende M G C Marti R Gallego M | 2010 | Computers & Operations Research2010，37，3： | 1 |
| 7 | A polymomial-time primal-dual affine scaling algorithm for linear and convex quadrtic programming and its power series extension显示文摘 | Alder I Resende M G C | 1990 | Mathematics of Operations Research1990，15，： | 1 |
| 8 | A genetic algorithm for the resource constrained multi-project scheduling problem显示文摘 | Goncalves J F Mendes J J M Resende M G C | 2008 | European Journal of Operational Research2008，189，3： | 1 |
| 9 | Multi-start methods for combinatorial optimization显示文摘 | Marti R Resende M G C Ribeiro C C | 2013 | European Journal of Operational Research2013，226，1： | 1 |
| 10 | Doppler study of the uterine arteries and ovarian stroma in patients with polycystic ovary syndrome显示文摘 | Resende AV Mendes MC Dias M | | 0，，： | 1 |
| 11 | A hy- brid genetic algorithm for the job shop scheduling problem显示文摘 | Goncalves J F de Magalhaes Mendes J J Resende M G C | 2005 | European Journal of Operational Research2005，167，1： | 1 |
| 12 | Membrane structure and interactions of human catestatin by muhidimen--sional solution and solid-state NMR spectroscopy显示文摘 | Sugawara M Resende JM Moraes CM | 2001 | Faseb J2001，24，： | 1 |
| 13 | Doppler study of the uterine arteries and ovarian strom a in patients with polycystic ovary syndrome显示文摘 | Resende AV Mendes MC Dias de Moura M | 2001 | Gynecol Obstet Invest2001，52，3： | 1 |
| 14 | A fast swap- based local search procedure for location problems 显示文摘 | RESENDE M G C WERNECK R C | 2007 | Annals of Operations Research2007，150，： | 1 |
| 15 | Amtimutagenicity of ursolic acid and oleanolic acid against doxorubicin-induced clastogenesis in mice显示文摘 | RESENDE F A CLAVDETE A M MARCIA C | 2006 | Life Sci2006，79，5： | 1 |
| 16 | A genetic algorithm for the resource constrained multi-project scheduling problem显示文摘 | GONCALVES J F MENDES J J M RESENDE M G C | 2008 | European Journal of Operational Research2008，189，3： | 1 |
| 17 | Parallel GRASP with path-relinking for job shop scheduling 显示文摘 | Aiex R M Binato S Resende M G C | 2003 | Parallel Computing2003，29，： | 1 |
| 18 | A genetic algorithm for the resource constrained multi-project scheduling problem显示文摘 | Goncalves J Mendes J Resende M | 2008 | European Journal of Operational Research2008，189，3： | 1 |
| 19 | A genetic algorithm for the weight setting problem in OSPF routing 显示文摘 | ERICSSON M RESENDE M G C PARDALOS P M | 2002 | Journal of Combinatorial Optimizaiton2002，6，3： | 1 |
| 20 | A Probabilistic Heuristic for a Computationally Difficult Set Covering Problem显示文摘 | Feo T A Resende M G C | 1989 | Operations Research Letters1989，8，4： | 1 |
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