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| 1 | Percutaneous radiofrequency ablation for early hepatocellular carcinoma: Risk factors for survival显示文摘AIM: To evaluate outcomes of radiofrequency ablation(RFA) therapy for early hepatocellular carcinoma(HCC) and identify survival- and recurrence-related factors. METHODS: Consecutive patients diagnosed with early HCC by computed tomography(CT) or magnetic resonance imaging(MRI)(single nodule of ≤ 5 cm, or multi-(up to 3) nodules of ≤ 3 cm each) and who underwent RFA treatment with curative intent between January 2010 and August 2011 at the Instituto do Cancer do Estado de S o Paulo, Brazil were enrolled in the study. RFA of the liver tumors(with 1.0 cm ablative margin) was carried out under CT-fluoro scan and ultrasonic image guidance of the percutaneous ablation probes. Procedure-related complications were recorded. At 1-mo post-RFA and 3-mo intervals thereafter, CT and MRI were performed to assess outcomes of complete response(absence of enhancing tissue at the tumor site) or incomplete response(enhancing tissue remaining at the tumor site). Overall survival and diseasefree survival rates were estimated by the Kaplan-Meier method and compared by the log rank test or simple Cox regression. The effect of risk factors on survival was assessed by the Cox proportional hazard model. RESULTS: A total of 38 RFA sessions were performed during the study period on 34 patients(age in years: mean, 63 and range, 49-84). The mean follow-up time was 22 mo(range, 1-33). The study population showed predominance of male sex(76%), less severe liver disease(Child-Pugh A, n = 26; Child-Pugh B, n = 8), and single tumor(65%). The maximum tumor diameters ranged from 10 to 50 mm(median, 26 mm). The initial(immediately post-procedure) rate of RFAinduced complete tumor necrosis was 90%. The probability of achieving complete response was significantly greater in patients with a single nodule(vs patients with multi-nodules, P = 0.04). Two patients experienced major complications, including acute pulmonary edema(resolved with intervention) and intestinal perforation(led to death). The 1- and 2-year overall survival rates were 82% and 71%, respectively. Sex, tumor size, initial response, and recurrence status influenced survival, but did not reach the threshold of statistical significance. Child-Pugh class and the model for end-stage liver disease score were identified as predictors of survival by simple Cox regression, but only Child-Pugh class showed a statistically significant association to survival in multiple Cox regression analysis(HR = 15; 95%CI: 3-76 mo; P = 0.001). The 1-and 2-year cumulative disease-free survival rates were 65% and 36%, respectively. CONCLUSION: RFA is an effective therapy for local tumor control of early HCC, and patients with preserved liver function are the best candidates. | Luciana Kikuchi Marcos Menezes Aline L Chagas Claudia M Tani Regiane SSM Alencar Marcio A Diniz Venncio AF Alves Luiz Augusto Carneiro D’Albuquerque Flair José Carrilho | 2014 | World Journal of Gastroenterology2014，20，6： | 5 |
| 2 | Can baseline ML Flow test results predict leprosy reactions? An investigation in a cohort of patients enrolled in the uniform multidrug therapy clinical trial for leprosy patients in Brazil显示文摘Background:The predictive value of the serology to detection of IgM against the Mycobacterium leprae-derived phenolic glycolipid-I/PGL-I to identify leprosy patients who are at higher risk of developing reactions remains controversial.Whether baseline results of the ML Flow test can predict leprosy reactions was investigated among a cohort of patients enrolled in The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil(U-MDT/CT-BR).Methods:This was a descriptive study focusing on the main clinical manifestations of leprosy patients enrolled in the U-MDT/CT-BR from March 2007 to February 2012 at two Brazilian leprosy reference centers.For research purposes,753 leprosy patients were categorized according to a modified Ridley-Jopling(R&J)classification and according to the development of leprosy reactions(reversal reaction/RR and erythema nodosum leprosum/ENL),and whether they had a positive or negative bacillary index/BI.Results:More than half of the patients(55.5%)reported leprosy reaction:18.3%(138/753)had a RR and 5.4%(41/753)had ENL.Leprosy reactions were more frequent in the first year following diagnosis,as seen in 27%(205/753)of patients,while 19%(142/753)developed reactions during subsequent follow-up.Similar frequencies of leprosy reactions and other clinical manifestations were observed in paucibacillary(PB)and multibacillary(MB)leprosy patients treated with U-MDT and regular MDT(R-MDT)(P=0.43 and P=0.61,respectively).Compared with PB patients,leprosy reactions were significantly more frequent in MB patients with a high BI,and more patients developed RR than ENL.However,RR and neuritis were also reported in patients with a negative BI.At baseline,the highest rate of ML Flow positivity was observed in patients with a positive BI,especially those who developed ENL,followed by patients who had neuritis and RR.Among reaction-free patients,81.9%were ML Flow positive,however,the differences were not statistically significant compared to reactional patients(P=0.45).Conclusions:MB and PB patients treated with R-MDT and U-MDT showed similar frequencies of RR and other clinical manifestations.Positive ML Flow tests were associated with MB leprosy and BI positivity.However,ML Flow test results at baseline showed limited sensitivity and specificity for predicting the development of leprosy reactions. | Emerith Mayra Hungria Regiane Morillas Oliveira Gerson Oliveira Penna Lúcio Cartaxo Aderaldo Maria Araci de Andrade Pontes Rossilene Cruz Heitor de SáGonçalves Maria Lúcia Fernandes Penna Ligia Regina Franco Sansigolo Kerr Mariane Martins de Araújo Stefani Samira Bührer-Sékula | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 3 | Triiodothyronine and breast cancer显示文摘The thyroid hormones(THs), triiodothyronine(T3) and thyroxine(T4), are essential for survival; they are involved in the processes of development, growth, and metabolism. In addition to hyperthyroidism or hypothyroidism, THs are involved in other diseases. The role of THs in the development and differentiation of mammary epithelium is well established; however, their specific role in the pathogenesis of breast cancer(BC) is controversial. Steroid hormones affect many human cancers and the abnormal responsiveness of the mammary epithelial cells to estradiol(E2) in particular is known to be an important cause for the development and progression of BC. The proliferative effect of T3 has been demonstrated in various types of cancer. In BC cell lines, T3 may foster the conditions for tumor proliferation and increase the effect of cell proliferation by E2; thus, T3 may play a role in the developmentand progression of BC. Studies show that T3 has effects similar to E2 in BC cell lines. Despite controversy regarding the relationship between thyroid disturbances and the incidence of BC, studies show that thyroid status may influence the development of tumor, proliferation and metastasis. | Maria Teresa De Sibio Miriane de Oliveira Fernanda Cristina Fontes Moretto Regiane Marques Castro Olimpio Sandro José Conde Aline Carbonera Luvizon Célia Regina Nogueira | 2014 | World Journal of Clinical Oncology2014，5，3： | 2 |
| 4 | Benefits of a home-based pulmonary rehabilitation program for patients with severe chronic obstructive pulmonary disease显示文摘 | Regiane Resqueti V Gorostiza A Gáldiz JB | 2007 | Arch Bronconeumol2007，43，11： | 1 |
| 5 | Numerical simulation of cavitating flows with homogeneous models显示文摘 | Eric Goncalves Regiane Fortes Patella | 2009 | Computers and Fluids2009，，9： | 1 |
| 6 | Effects of 8-Week, Interval-Based Inspiratory Muscle Training and Breathing Retraining in Patients With Generalized Myasthenia Gravis显示文摘 | Guilherme Augusto de Freitas Fregonezi Vanessa Regiane Resqueti Rosa Güell Jesus Pradas Pere Casan | 2005 | Chest2005，，3： | 1 |
| 7 | Cavitation erosion; Fluid/material coupling; Elastoplastic constitutive equation ; Profilometry; Damage modeling; Damage testing 显示文摘 | Regiane F P Thierry C Jean-Luc R | 2013 | Wear2013，300，12： | 1 |
| 8 | Cavitation damage measurement by 3D laser profilometry显示文摘 | Regiane Fortes Patella Jean-Luc Reboud | 2000 | Wear2000，，246： | 1 |
| 9 | A preliminary empirical evaluation of virtual reality as an instructionmedium for visual-spatial tasks 显示文摘 | Regian J W Shebilske W Monk J | 1992 | Journal of Communication1992，42，4： | 1 |
| 10 | Posttreatment assessment of response using FDG-PET/CT for patients treated with definitive radiation therapy for head and neck cancers显示文摘 | Regiane S. Andrade Dwight E. Heron Berna Degirmenci Pedro A.A. Filho Barton F. Branstetter Raja R. Seethala Robert L. Ferris Norbert Avril | 2006 | International Journal of Radiation Oncology, Biology, Physics2006，，5： | 1 |
| 11 | Lepstospira in- terrogans shotgun phage display identified LigB as a heparin-bind- ing protein显示文摘 | Ana Tung C C Regiane D F Swiany S L | 2012 | Bioehem Biophys Res Commun2012，427，4： | 1 |
| 12 | Numerical simulation of cavitating flows with homogeneous models显示文摘 | GONCALVES ERIC FORTES PATELLA REGIANE | 2009 | Computers & Fluids2009，38，9： | 1 |
| 13 | Frey syndrome prevalence after partial parotidectomy 显示文摘 | Regiane Cristina Santos Jose Francisco de Salles Chagas Thiago Freire Pinto Bezerra | 2006 | Rev Bras Otorrinolaringol2006，72，1： | 1 |
| 14 | Incorpora- ting priorities for waiting customers in the hypercube queuing model with application to an emergency medical service system in Brazil显示文摘 | REGIANE M REINALDO M FERNANDO Y | 2015 | European Journal of Operational Research2015，242，： | 1 |
| 15 | Numerical analysis of cavitation instabilities in inducer blade cascade显示文摘 | BENOIT P REGIANE F P | 2008 | Journal of Fluids Engineering2008，130，4： | 1 |
| 16 | A New Approach to Evalutate the Cavitation Erosion Power 显示文摘 | Regiane Fortes Patella and Jean-Luc Reboud | 1998 | Journal of Fluids Engineering1998，1998，120： | 1 |
| 17 | Crystal-oriented wrinkles with origami-type junctions in few-layer hexagonal boron nitride显示文摘理解层相互影响是利用为设备应用叠不同二维的材料形成的分层的 heterostructures 的关键。硼氮化物被表明了是与改进活动性造 graphene 设备的理想的底层。这里我们形态学和六角形的硼氮化物薄片在硅底层上扔了的退火的很少层的光反应上的现在的研究沿着明确的结晶的方向揭示线性皱纹的形成。皱纹在整个样品形成了首先三方面、偶尔四折的 origami 类型连接的一个网络,并且所有三方面的连接和皱纹沿着扶手椅形成了结晶的方向。而且,通过自发的对称碎,产出的分子的动力学模拟起皱与试验性的结果和建议合拢 origami 一致的连接形态学当模特儿。我们的调查结果显示这形态学可以是在合适的压力紧张条件下面的几二维的材料的一个一般特征,在设备紧张工程导致直接后果。 | Camilla K. Oliveira Egleidson F. A. Gomes Mariana C. Prado Thonimar V. Alencar Regiane Nascimento Leandro M. Malard Ronaldo J. C. Batista Alan B. de Oliveira Helio Chacham Ana M. de Paula Bernardo R, A. Neves | 2015 | Nano Research2015，8，5： | 1 |
| 18 | An application of chemometric techniques to analyze the effects of the wave function modifications on the intermolecular stretching frequencies of the hy- drogen-bonded complexes显示文摘 | Kelson C L Flavia S P Regiane CMUA | 2004 | Chemometrics and Intelligent Labo- ratory Systems2004，70，： | 1 |
| 19 | Optimizing urban traffic flow using genetic algorithm with Petri net analysis as fitness function显示文摘 | Henrique D Regiane D S B Norian M | 2014 | Neurocomputing2014，124，： | 1 |
| 20 | Transgenerational toxicity of Zearalenone in pigs 显示文摘 | Eric J S Regiane R S Ben C | 2012 | Reproductive Toxicology2012，34，1： | 1 |
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