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| 1 | Immunoexpression of cyclooxygenase-2 in primary gastric carcinomas and lymph node metastases显示文摘AIM: To evaluate immunoexpression of cyclooxygenase-2 (COX-2) in primary gastric carcinomas and respective lymph node metastases. METHODS: Immunohistochemistry to analyze COX-2 expression was performed on tissue microarray slices obtained from 36 specimens of gastrectomy and satellite lymph nodes from patients with gastric carcinoma. RESULTS: Immunostaining was seen in most cases, and COX-2 expression was higher in lymph node me-tastases than in corresponding primary gastric tumors of intestinal, diffuse and mixed carcinomas, with a statistically signif icant difference in the diffuse histotype (P = 0.0108). CONCLUSION: COX-2 immunoexpression occurs frequently in primary gastric carcinomas, but higher expression of this enzyme is observed in lymph node metastases of the diffuse histotype. | Paulo RC Almeida Francisco VA Ferreira Cássio C Santos Francisco D Rocha-Filho Raul RP Feitosa Esther AA Falco Belise K Cavada Roberto CP Lima-Júnior Ronaldo A Ribeiro | 2012 | World Journal of Gastroenterology2012，18，8： | 14 |
| 2 | Evaluation of VEGF gene polymorphisms and proliferative diabetic retinopathy in Mexican population显示文摘● AIM: To assess if the included vascular endothelial growth factor(VEGF) polymorphisms rs3025035, rs3025021 and rs2010963 are associated to proliferative retinopathy in a Mexican population with type 2 diabetes mellitus(T2DM).● METHODS: A case-control study was conducted in adult individuals with T2 DM associated to proliferative retinopathy or non-proliferative retinopathy from Oct. 2014 to Jun. 2015 from the Retina Department of the Asociation to Prevent Blindness in Mexico. The selected patients were adults with a diagnosis of T2 DM ≥5y. All subjects had a comprehensive ocular examination and the classification of the retinopathy severity was made considering the Early Treatment Diabetic Retinopathy Study(ETDRS) standardization protocols. Genomic DNA was extracted from whole fresh blood. All samples were genotyped by q PCR for selected VEGF polymorphisms. Hardy-Weinberg equilibrium was calculated by comparing Chi-square values between the expected and the observed values for genotype counts.● RESULTS: In total 142 individuals were enrolled, 71 individuals with T2 DM and associated proliferative retinopathy and 71 individuals with non-proliferative retinopathy. One-sided Fisher's exact test was performed for rs3025021[OR(95% CI)=0.44(0.08-2.2); P=0.25] and rs2010963 [OR(95% CI)=0.63(0.25-1.6); P=0.23]. The minor allelic frequencies obtained were 26% for rs3025021, 10% for rs3025035 and 61% for rs2010963. The pairwise linkage disequilibrium between the three SNP was assessed, and was as follows: rs3025021 vs rs3025035: D'=1.0, r^2=0.1043, P≤0.0001; rs3025021 vs rs2010963: D'=0.442, r^2=0.0446, P=0.149; rs3025035 vs rs2010963: D'=0.505, r^2=0.0214, P=0.142.● CONCLUSION: This is the first analysis involving VEGFA polymorphisms and proliferative diabetic retinopathy in a Mexican population. A major finding of the present study is that none of the polymorphisms studied was significantly associated with proliferative retinopathy. Based on these results, we can infer that different populations have different associations for the same polymorphisms. | Roberto Gonzalez-Salinas Maria C Garcia-Gutierrez Gerardo Garcia-Aguirre Virgilio Morales-Canton Raul Velez-Montoya Vidal R Soberon-Ventura Victoria Gonzalez Rodrigo Lechuga Pablo Garcia-Solis David G Garcia-Gutierrez Marco Vinicio Garcia-Solis Manuel Saenz de Viteri Juan C Solis-S | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 12 |
| 3 | Cost-sensitive learning based on Bregman divergences 显示文摘 | RAUL S R ROCIO A R ALICIA G C | 2009 | Machine Learning Journal2009，76，： | 1 |
| 4 | Quantitative analysis of malic and citric acids in fruit juices using proton nuclear magnetic resonance spectroscopy 显示文摘 | Gloria del C Inaki B Raul C | 2006 | Analytica Chimica Acta2006，556，2： | 1 |
| 5 | Ethylene polymerization using dealuminated ZSM-2 zeolite nanocrystals as an active metallocene catalyst support显示文摘 | Cristian C Raul Q Rene R | 2008 | Applied catalysis A: General2008，347，2： | 1 |
| 6 | Spatially-resolved EELS analysis of antibody distribution on biofunctionalized magnetic nanoparticles显示文摘 | Raul A Laura D M Laura C Alvaro M Marcel T Valeria G Jesus M D L F Clara M Ricardo 1 | 2013 | ACS Nano2013，7，5： | 1 |
| 7 | Plasma kintics and biodistribution of a lipid emulsion resembling low density lipoprotein in patients with acute leukemia显示文摘 | Bermardo Garicichea | 1994 | Cancer Res1994，54，： | 1 |
| 8 | Staphylococ-cus aureus invasion of bovine mammary epithelial cells显示文摘 | RAUL A A KARL R M EDUARDO C | | 0，，6： | 1 |
| 9 | An ice test for the diagnosis of myasthenia gravis显示文摘 | Karl C Golnik Raul Pena Andrew G Lee Eric R Eggenberger | 1999 | Ophthalmology1999，，7： | 1 |
| 10 | Mode of action of laetocin 705, a two-component bacteriocin from LactobaciUus casei CRL705显示文摘 | Patrieia C Raul R Graeiela V | 2003 | Int J Foods Microbiol2003，85，2： | 1 |
| 11 | Adsorption of fluoride from water solution on bone char显示文摘 | NAHUM A M C ROBERTO L R RAUL O P | 2007 | Industrial Engineering Chemistry Research2007，46，26： | 1 |
| 12 | Scientific and technological fundamentals for the development of the controlled short-circuiting MIG/MAG welding process: a review of the literature显示文摘 | SILVA R H G DUTRA J C RAUL G J | 2009 | 23 (2): 141-1492009，23，2： | 1 |
| 13 | Finite-element models of the human head and their applications in forensic practice显示文摘 | Raul J S Deck C Willinger R | | 0，，05： | 1 |
| 14 | The importance of water regimes operating at small spatial scales for the diversity and structure of wetland vegetation 显示文摘 | Raulings E J Morris K Roache M C | 2010 | Freshwater Biology2010，55，3： | 1 |
| 15 | Hydrogen bonding and conformational equilibrium in p-tert-butyldihomooxacalixarene显示文摘 | RAUL J Bernardino BENEDITO J Costa Cabral Pereira J L C | 1998 | J Mole Stru1998，455，： | 1 |
| 16 | Paclitaxel as sociated with cholesterol-rieh nanoemulsions promotes atheroselerosis regression in the rabbit显示文摘 | Raul C Maranhao Elaine R Tavares | 2008 | Atheroscle rosis2008，197，： | 1 |
| 17 | Impact of deltamethrin on arthropods in maize under conventional and no-tillage cultivation显示文摘 | RAUL NARCISO C GUEDSE ANTONIO A SILVA | 2004 | Crop Protection2004，，23： | 1 |
| 18 | A novel Gauss2Mmkov random fieht approach for regularization of diffusion tensor maps显示文摘 | Marcos M F Raul S J E west in C F | 2003 | Lecture Notes in Computer Science2003，28，9： | 1 |
| 19 | Mesostructured SiO2-doped TiO2 with enhanced thermal stability prepared by a soft-templating sol-gel route 显示文摘 | Guillermo C David P S Raul S | 2008 | Micropor Mesopor Mater2008，111，13： | 1 |
| 20 | A finite element model investigation of gunshot injury显示文摘 | Raul J Deck C Meyer F | | 0，，02： | 1 |
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