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| 1 | Chemical composition and antioxidant activity of certain Morus species显示文摘In the present work,the fruits of four Morus species,namely Morus alba (white mulberry),Morus nigra (black mulberry),Morus laevigata (large white fruit),and Morus laevigata (large black fruit),were analyzed for proximate composition,essential minerals,and antioxidant potentials.For this purpose,the ripe fruits were collected from the northern regions of Pakistan.The major nutritional components moisture,ash,lipids,proteins,fibres,carbohydrates,and total sugar) were found to be in the suitable range along with good computed energy.Total dry weight,pH,and titratable acidity (percent citric acid) were (17.60±1.94)–(21.97±2.34) mg/100 g,(3.20±0.07)–(4.78±0.15),and (0.84±0.40)%–(2.00±0.08)%,respectively.Low riboflavin (vitamin B2) and niacin (vitamin B3) contents were recorded in all the fruits,while ascorbic acid (vitamin C) was in the range from (15.20±1.25) to (17.03±1.71) mg/100 g fresh weight (FW).The mulberry fruits were rich with regard to the total phenol and alkaloid contents,having values of (880±7.20)–(1650±12.25) mg/100 g FW and (390±3.22)–(660±5.25) mg/100 g FW,respectively.Sufficient quantities of essential macro-(K,Ca,Mg,and Na) and micro-(Fe,Zn,and Ni) elements were found in all the fruits.K was the predominant element with concentration ranging from (1270±9.36) to (1731±11.50) mg/100 g,while Ca,Na,and Mg contents were (440±3.21)–(576±7.37),(260±3.86)–(280±3.50),and (240±3.51)–(360±4.20) mg/100 g,respectivly.The decreasing order of micro-minerals was Fe>Zn>Ni.The radical scavenging activity of methanolic extract of fruits was concentration-dependent and showed a correlation with total phenolic constituents of the respective fruits.Based on the results obtained,mulberry fruits were found to serve as a potential source of food diet and natural antioxidants. | Mohammad IMRAN Hamayun KHAN Mohibullah SHAH Rasool KHAN Faridullah KHAN | 2010 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2010，11，12： | 14 |
| 2 | Physicochemical characteristics of various milk samples available in Pakistan显示文摘We report physicochemical characteristics of various kinds of liquid milk commercially available in Pakistan in comparison with those of fresh natural milk from animals. Milk samples were collected from local markets at Peshawar, Pakistan, and analyzed for their physical features, including moisture, total solids, specific gravity, conductivity, viscosity and titratable acidity (lactic acid equivalent), and chemical components and macro-minerals, including total protein, casein, lactose, ash and minerals (Na, K and Mg). These items were compared with the physicochemical characteristics of the fresh natural milk samples from buffalo, cow and goat. The results were also compared with reported nutritional quality of milk from various countries and World Health Organization (WHO) standards. We found that all the physical features and chemical components of commercially available milk in Pakistan markets meet WHO's requirements, except for Na, K, Ca and Mg, which are below the standards. | Mohammad IMRAN Hamayun KHAN Syed Shah HASSAN Rasool KHAN | 2008 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2008，9，7： | 4 |
| 3 | Evaluation of biomarkers, genetic mutations, and epigenetic modifications in early diagnosis of pancreatic cancer显示文摘BACKGROUND Pancreatic cancer(PC)is one of the deadliest malignancies with an alarming mortality rate.Despite significant advancement in diagnostics and therapeutics,early diagnosis remains elusive causing poor prognosis,marred by mutations and epigenetic modifications in key genes which contribute to disease progression.AIM To evaluate the various biological tumor markers collectively for early diagnosis which could act as prognostic biomarkers and helps in future therapeutics of PC in Kashmir valley.METHODS A total of 50 confirmed PC cases were included in the study to evaluate the levels of carbohydrate antigen 19-9(CA 19-9),tissue polypeptide specific antigen(TPS),carcinoembryonic antigen(CEA),vascular endothelial growth factor-A(VEGF-A),and epidermal growth factor receptor(EGFR).Mutational analysis was performed to evaluate the mutations in Kirsten rat sarcoma(KRAS),Breast cancer type 2(BRCA-2),and deleted in pancreatic cancer-4(DPC-4)genes.However,epigenetic modifications(methylation of CpG islands)were performed in the promoter regions of cyclin-dependent kinase inhibitor 2A(p16;CDKN2A),MutL homolog 1(hMLH1),and Ras association domain-containing protein 1(RASSF1A)genes.RESULTS We found significantly elevated levels of biological markers CA 19-9(P≤0.05),TPS(P≤0.05),CEA(P≤0.001),and VEGF(P≤0.001).Molecular genetic analysis revealed that KRAS gene mutation is predominant in codon 12(16 subjects,P≤0.05),and 13(12 subjects,P≤0.05).However,we did not find a mutation in DPC-4(1203G>T)and BRCA-2(617delT)genes.Furthermore,epigenetic modification revealed that CpG methylation in 21(P≤0.05)and 4 subjects in the promoter regions of the p16 and hMLH1 gene,respectively.CONCLUSION In conclusion,CA 19-9,TPS,CEA,and VEGF levels were significantly elevated and collectively have potential as diagnostic and prognostic markers in PC.Global data of mutation in the KRAS gene commonly in codon 12 and rare in codon 13 could augment the predisposition towards PC.Additionally,methylation of the p16 gene could also modulate transcription of genes thereby increasing the predisposition and susceptibility towards PC. | Bilal Rah Manzoor Ahmad Banday Gh Rasool Bhat Omar J Shah Humira Jeelani Fizalah Kawoosa Tahira Yousuf Dil Afroze | 2021 | World Journal of Gastroenterology2021，27，36： | 2 |
| 4 | Morpho-Physiological,Biochemical and Molecular Adaptation of Millets to Abiotic Stresses:A Review显示文摘Abiotic stresses such as drought,heat,cold,nutrient deficiency,excess salt and hazardous metals can hamper plantgrowth and development.Intensive agriculture of only a few major staple food crops that are sensitive and intolerant to environmental stresses has led to an agrarian crisis.On the other hand,nutritionally rich,gluten free and stress tolerant plants like millets are neglected and underutilized.Millets sustain about one-third of the world’s population and show exceptional tolerance to various abiotic and biotic stresses.Millets are C4 plants that are adapted to marginal and dry lands of arid and semi-arid regions,and survive low rainfall and poor soils.Abiotic stresses significantly affect plant growth which ultimately results in reduced crop yields.However,various adaptation mechanisms have evolved in millets to withstand different stresses.This review aims at exploring various of these morphophysiological,biochemical and molecular aspects of mechanisms in millets.Morphological adaptations include short life span,smallplant height and leaf area,dense root system,adjusted flowering time,increased root and decreased shoot lengths,high tillering,and leaf folding.A high accumulation of various osmoprotectants(proline,soluble sugars,proteins)improves hyperosmolarity and enhances the activity of antioxidant enzymes(e.g.,Ascorbate peroxidase,Superoxide dismutase,Catalase,Peroxidase)providing defense against oxidative damage.Physiologically,plants show low photosynthetic and stomatal conductance rates,and root respiration which help them to escape from water stress.Molecular adaptations include the upregulation of stress-related transcriptional factors,signalling genes,ion transporters,secondary metabolite pathways,receptor kinases,phytohormone biosynthesis and antioxidative enzymes.Lack of genetic resources hampers improvement of millets.However,several identified and characterized genes for stress tolerance can be exploited for further development of millet resilience.This will provide them with an extra characteristic plant resistance to withstand environmental pressures,besides their excellent nutritional value over the conventional staple crops like rice,wheat and maize. | Seerat Saleem Naveed Ul Mushtaq Wasifa Hafiz Shah Aadil Rasool Khalid Rehman Hakeem Reiaz Ul Rehman | 2021 | Phyton-International Journal of Experimental Botany2021，90，5： | 2 |
| 5 | Cost-Effectiveness of Community-Based Strategies for Blood Pressure Control in a Low-Income Developing Country: Findings From a Cluster-Randomized, Factorial-Controlled Trial显示文摘 | Tazeen H. Jafar Muhammad Islam Rasool Bux Neil Poulter Juanita Hatcher Nish Chaturvedi Shah Ebrahim Peter Cosgrove | 2011 | Circulation2011，，15： | 1 |
| 6 | Chemical Composition and Vasorelaxant and Antispasmodic Effects of Essential Oil from Rosa indica L. Petals显示文摘 | Hafiz Majid Rasheed Taous Khan Fazli Wahid Rasool Khan Abdul Jabbar Shah Micha? Tomczyk | 2015 | Evidence-Based Complementary and Alternative Medi2015，，： | 1 |
| 7 | Chemical composition and antioxidant activity of certain Morus species显示文摘 | Mohammad Imran Hamayun Khan Mohibullah Shah Rasool Khan Faridullah Khan | 2010 | Journal of Zhejiang University SCIENCE B2010，，12： | 1 |
| 8 | Study of TLR4 and IL-8 Gene Polymorphisms in H.pylori -Induced Inflammation in Gastric Cancer in an Ethnic Kashmiri Population显示文摘 | Qurteeba Qadri Roohi Rasool Dil Afroze Sameer Naqash G. M. Gulzar Adfar Yousuf M. A. Siddiqi Zafar A. Shah | 2014 | Immunological Investigations2014，，4： | 1 |
| 9 | The blues of P(16)INK(4a) :aberrant promoter methylation and association with colorectal cancer in the Kashmir valley 显示文摘 | Sameer A S Abdullah S Nissar S Rasool R Shah Z A Afroze D | 2012 | Mol Med Report2012，5，： | 1 |
| 10 | Effect of butachlor (G) on soil enzyme activity显示文摘 | Nazima Rasool Zafar A. Reshi Manzoor A. Shah | 2014 | European Journal of Soil Biology2014，，： | 1 |
| 11 | The Investigation of the Fractional-View Dynamics of Helmholtz Equations Within Caputo Operator显示文摘It is eminent that partial differential equations are extensively meaningful in physics,mathematics and engineering.Natural phenomena are formulated with partial differential equations and are solved analytically or numerically to interrogate the system’s dynamical behavior.In the present research,mathematical modeling is extended and the modeling solutions Helmholtz equations are discussed in the fractional view of derivatives.First,the Helmholtz equations are presented in Caputo’s fractional derivative.Then Natural transformation,along with the decomposition method,is used to attain the series form solutions of the suggested problems.For justification of the proposed technique,it is applied to several numerical examples.The graphical representation of the solutions shows that the suggested technique is an accurate and effective technique with a high convergence rate than other methods.The less calculation and higher rate of convergence have confirmed the present technique’s reliability and applicability to solve partial differential equations and their systems in a fractional framework. | Rashid Jan Hassan Khan Poom Kumam Fairouz Tchier Rasool Shah Haifa Bin Jebreen | 2021 | Computers, Materials & Continua2021，，9： | 0 |
| 12 | Newly identified genetic variant rs2294693 in UNC5CL gene is associated with decreased risk of esophageal carcinoma in the J&K Population–India显示文摘Esophageal cancer is the second most common type of cancer after lung carcinoma in the state of Jammu and Kashmir(J&K).The understanding of genetics in Esophageal cancer development is poor in the state.Genome wide association studies(GWAS)has proved to be unsurpassed tool in identification of new loci associated with different cancers.GWAS in Chinese population has identified SNP rs2294693 present in UNC5CL(UNC-5 Family C-Terminal like)to be associated with non-cardia gastric cancer.We performed a case control association study and genotyped the SNP rs2294693 using Taqman allele discrimination assay in 566 individuals(166 esophageal cancer patients and 400 controls)belonging to the J&K population.A statistically significant protective association with allelic odds ratio of 0.73(0.56–0.94 at 95%CI)and p value=0.016 was observed.This is the first study in relation to esophageal cancer in the Jammu and Kashmir population,so far it has been studied in association with gastric carcinoma in the Chinese population only.The results indicate that the polymorphism rs2294693 is associated with esophageal cancer susceptibility and the mutant(T)allele might be a protective factor for esophageal cancer among Jammu and Kashmir population.Further the functional characterization of the variation is also warranted. | RUCHI SHAH SONALI VERMA AMRITA BHAT GH RASOOL BHAT VARUN SHARMA INDU SHARMA HEMENDER SINGH SANDEEP KAUL EKTA RAI SWARKAR SHARMA | 2021 | BIOCELL2021，45，3： | 0 |
| 13 | Salt Stress Threshold in Millets:Perspective on Cultivation on Marginal Lands for Biomass显示文摘Millets hold an immense assurance for food safety and nourishment amid ever-rising agricultural expenses and climate alterations.They are healthful,have supplementary wellbeing profit and need remarkably fewer effort overheads for crop growing.These characters draw attention to millets as a plant of preference for the humankind in the course of emergent alarm about environmental changes.Millets have the prospect to provide biomass and thus bioenergy,reduced carbon emission,carbon footprint and sustainable modern agriculture.As the rate of expansion in budding countries is increasing day by day,the scarcity of energy is a big panic and there is a mounting turn in the direction and rehearsal of waste and biomass as an energy source.Globally,at least 20%of total irrigated land has been injured by salt and 1.5 million hectares is taken away of cultivation every year.Thus,in future,we will have a requirement of efficient crops and utilisation of marginal lands for agriculture.Millet is an answer to the efficient crop.Plants are subjected to various environmental pressures(high/low temperature,heavy metal,salinity,pesticides,etc.)as well as biotic stresses(virus,bacteria,fungi,etc.)and millets are not an exception to it.Millets are categorised as glycophytes and can tolerate average salt threshold of about 6(ECe)(dS/m)with some variation from specie to specie.Increase in the salt concentrations can lead to retarded growth and development,thus need for mitigants arise to reduce such stresses.Some mitigants to overcome the stress levels include proline,polyamine and betaines,Na2SeO3,H2S,KNO3,Mg(NO3)2,etc. | Naveed Ul Mushtaq Seerat Saleem Aadil Rasool Wasifa Hafiz Shah Khalid Rehman Hakeem Reiaz Ul Rehman | 2021 | Phyton-International Journal of Experimental Botany2021，90，1： | 0 |
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