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| 1 | E-cadherin expression pattern in primary colorectal carcinomas and their metastases reflects disease outcome显示文摘瞄准:调查在颜色在转移的进程期间发生在 E-cadherin 表示的变化表面的癌症。方法:E-cadherin 表示被免疫组织化学检测,表示的二个索引是计算的它反映了表示和地点(膜和细胞质) 的水平。Univariate 并且多,变量幸存分析被用来作为两个的预言者估计这二个 E-cadherin 索引的价值没有疾病(DFS ) 并且疾病特定(决策支持系统) 幸存。结果:E-cadherin 膜索引(MI ) ,然而并非细胞质的索引(CI ) ,比他们的转移在原发性瘤是显著地更高的(P = 0.0001 ) 。而且,原发性瘤 MI 和 CI 在开发了随后的转移的病人之中是更高的(P = 0.022 并且 P = 0.007,分别地) 。有趣地,两个索引在与另外的解剖地点相比的肝转移是更高的(MI, P = 0.034 并且 CI, P = 0.022 ) 。原发性瘤的 CI 是 DFS 的一个重要预言者(P = 0.042, univariate 分析) ,与在 CI 和 DFS 之间的强壮的反的关联(P = 0.006,多变量分析) 。最后,原发性瘤的 MI 证明了是决策支持系统的一个重要独立预言者,与与更有利的结果被联系的更高的索引(P = 0.016 ) 。结论:在颜色的 E-cadherin 表示和分发的检查表面的肿瘤能在预言是极其珍贵的疾病复发。E-cadherin 的异常细胞质的表示能预言疾病复发为病人和临床医生显然是很重要的,并且显著地有关病人的治疗和管理影响决定的观察。 | Adam Elzagheid Annika lgars Riyad Bendardaf Hanan Lamlum Raija Ristamaki Yrjo Collan Kari Syrjanen Seppo Pyrhonen | 2006 | World Journal of Gastroenterology2006，12，27： | 17 |
| 2 | 不同产地沙棘果的成分分析显示文摘通过沙棘甘油三酯和甘油磷脂中的糖、果酸(气相色谱-质谱法,TMS衍生物)、矿物质(FAAS,ETAAS)、挥发性物质(顶部空间气相色谱-质谱法)、Vc(高压液相色谱)和脂肪酸(气相色谱-质谱法,甲基酯)的分析方法,优化不同产地的沙棘果。对1997年10-11月采集的中国沙棘果(CH)和8月底采集的芬兰沙棘果(FI)和俄罗斯沙棘果(RU)的成分进行比较,得到了为今后开展更广泛的沙棘项目所需要的足够的资料。中国沙棘果汁中的Vc含量极高,平均8g/l(4.2-13.2g/l),是芬兰沙棘果汁中含量的5倍。主要矿物元素的含量比其它可食用的浆果中丰富得多,钾是沙棘果(6-14g/kg,干重)和沙棘籽(5-9g/kg,干重)中的主要矿物质之一,在一些样品中铅和镉含量的增加表明存在轻微的污染。压榨的沙棘果汁中糖的含量从1-20g/100ml有很大的变化,含量最高的是晚秋收获的中国沙棘果,最低的是8月收获的芬兰沙棘果。糖主要是葡萄糖(占总糖分的50%以上)、果糖及葡萄糖衍生物。苹果酸和奎宁酸是主要的果酸(77%-97%),含量为每100ml果汁中4.2-9.1g。果汁上部油脂的特点是形成了C2-C5n-、iso-、和ante-iso乙醇,C4-C5n-,iso,及ante-ISO酸,也呈现出挥发性油脂的籽油乙醇前体。不同的产地和采收时间对挥发物有着明显的影响,整个果中的含油量为2%-11%(鲜重)。 | Heikki Kallio Yang Baoru Raija Tahvonen Mari Hakala 许涛 卢顺光 | 2003 | 国际沙棘研究与开发2003，，1： | 7 |
| 3 | Fecal Transplantation, Through Colonoscopy, Is Effective Therapy for Recurrent Clostridium difficile Infection显示文摘 | Eero Mattila Raija Uusitalo–Sepp?l? Maarit Wuorela Laura Lehtola Heimo Nurmi Matti Ristikankare Veikko Moilanen Kimmo Salminen Maaria Sepp?l? Petri S. Mattila Veli–Jukka Anttila Perttu Arkkila | 2012 | Gastroenterology2012，，3： | 3 |
| 4 | Bcl-2 expression significantly correlates with thymidylate synthase expression in colorectal cancer patients显示文摘AIM: To examine the expression of thymidylate synthase (TS) and oncoprotein Bcl-2 in advanced colorectal cancer (CRC) patients,and to determine their mutual relationship,association to therapeutic response and impact on disease outcome.METHODS: Tumor samples from 67 patients with CRC,who were treated at advanced stage with either irinotecan alone or in combination with 5-fluorouracil/ leucovorin,were analyzed for expression of TS and Bcl-2 using immunohistochemistry.RESULTS: A significant linear correlation between lower expression levels of Bcl-2 and lower levels of TS expression was found (P = 0.033).Patients with high levels of both TS and Bcl-2 expression had a significantly longer disease-free survival (DFS) (42.6 mo vs 5.4 mo,n = 25) than those with low TS/Bcl-2 index (P = 0.001).Tumors with low levels of both TS and Bcl-2 were associated with a longer survival with metastasis (WMS) interval in the whole patients group (n = 67,P = 0.035).TS/Bcl-2 index was not significantly related to disease-specific survival.CONCLUSION: The present data suggest that CRC patients with low TS/Bcl-2 demonstrate a significantly shorter DFS and longer WMS. | Riyad Bendardaf Raija Ristmaki Kari Syrjnen Seppo Pyrhnen | 2008 | World Journal of Gastroenterology2008，14，40： | 2 |
| 5 | Relationships between native tree species and soil properties in the indigenous forest fragments of the Eastern Arc Mountains of the Taita Hills, Kenya显示文摘The relationship between soil properties and spatial distribution of native woody species was studied in three Taita Hills forest fragments which, although degraded, are ranked among 34 biodiversity hotspots of the world due to their high biodiversity of both plant and animal species. This relationship was assessed by using Spearman correlation and principal component analyses (PCA). The results of these analyses should be useful in instituting forest restoration programs that are crucial for the forests. Both the soil and vegetation studied were sampled from 17 subplots in the natural forest fragments of Ngangao (120 ha), Chawia (86 ha) and Mbololo (185 ha). The soil variables measured were: pH, texture, soil nutrients of C, N, Ca, P, K, Mg and Na. In total 36 native tree species from 13 families were identified from the three forest fragments. Ordination results show that axis 1 accounted for 35% and axis 2 for 25% of the total variation in species composition, indicating that the structure of vegetation is related to two major environmental gradients. The correlation analyses of species and soil properties showed that Na and clay particles were the most important determinants of species distribution; pH and soil variables such as C, N, Ca and P also played minor roles. Unexpectedly, some species (e.g. Psychotria petitii) showed positive relationships with Na attributed to possible substitution for K. Relationships with P were both positive (e.g. Craibia zimmermannii) and negative (e.g. Albizia gummifera) with some species, attributable to pH levels. An ANOVA for soil variables showed that there were differences in the Ca content in Mbololo (due to the parent material) and P in Ngangao where a special relationship was observed between some of the species. The presence of gaps accounted for the distribution of seedlings but not for the saplings, whose distribution responded more to factors similar to those to which mature trees respond. Soil-species relationships that were established may be utilized along with soil analyses when choosing native species for restoration. | Loice Mildred Akinyi OMORO Raija LAIHO Michael STARR Petri K.E.PELLIKKA | 2011 | Forestry Studies in China2011，13，3： | 2 |
| 6 | Burning characteristics of selected substances:production of heat,smoke and chemical species显示文摘 | Jukka Hietaniemi Raija Kallonen Esko Mikkda | 1999 | Fire and Materials1999，23，4： | 1 |
| 7 | Metadiscourse in Persuasive Writing: A Study of Texts Written by American and Finish University Students显示文摘 | Crismore Avon Markkanen Raija Steffensen Margaret S | 1993 | Written Communication1993，，： | 1 |
| 8 | Weekly paclitaxel-an effective treatment for advanced breast cancer显示文摘 | Pirkko KL Tuija T Raija A | 2013 | Antieancer Research2013，33，6： | 1 |
| 9 | The effect of air side fouling on the thermal-hydraulic characteristics of a compact heat exchanger 显示文摘 | Raija Lankinen Juhani Suihkonen Pertti Sarkomaa | 2003 | International Journal of Energy Research2003，27，4： | 1 |
| 10 | Tissue distribution and subcellular localization of hyaluronan synthase isoenzymes显示文摘 | Kari T?rr?nen Kaisa Nikunen Riikka K?rn? Markku Tammi Raija Tammi Kirsi Rilla | 2014 | Histochemistry and Cell Biology2014，，1： | 1 |
| 11 | Critical factors in electronic grocery shopping 显示文摘 | RAIJAS A TUUNAIN EN V K | 2001 | Distribution and Consumer Research2001，11，3： | 1 |
| 12 | Burning characteristics of selected substances production of heat, smoke and chemical species显示文摘 | Jukka Hietaniemi Raija Kallonen Esko Mikkola | 1999 | Fire and Materials1999，23，4： | 1 |
| 13 | Differential expression of collagen typesⅩⅧ/endostatin and ⅩⅤ in normal,keratoconus,and scarred human corneas显示文摘 | Marko M Ritva H Raija S | 2006 | Cornea2006，25，3： | 1 |
| 14 | Antihypertensive Treat- ment and Resistant Hypertension in Patients With Type 1 Diabetes by Stages of Diabetic Nephropathy 显示文摘 | Lithovius Raija Harjutsalo Valma Forsblom Carol Sara- heimo Markku Groop Per-Henrik | 2014 | Diabetes Care2014，373，： | 1 |
| 15 | Axis Ⅰ and Ⅱ psychiatric disorders after traumatic brain injury:a 30-years follow-up study显示文摘 | Salla K Tero T Raija P | 2002 | Am J Psychiatry2002，159，： | 1 |
| 16 | Determination of γ-hydroxybutyrate (GHB) and its precursors in blood and urine sampies: A sahing-out approach显示文摘 | Aino Kankaanpaa Raija Liukkonen Karl Ariniemi | 2007 | Forensic Sci Int2007，170，23： | 1 |
| 17 | Antihypertensive treatment and resistant hypertension in patients with type 1 diabetes by stages of diabetic nephropathy显示文摘 | Lithovius Raija Harjutsalo Valma Forsblom Carol Saraheimo Markku Groop Per-Henrik | 2013 | Diabetes care2013，，： | 1 |
| 18 | Burning characteristics of selected substances production of heat smoke and chemical species 显示文摘 | Jukka Hietaniemi Raija Kallonen | 1999 | Fire and Materials1999，23，4： | 1 |
| 19 | Localization of epidermal hyaluronic acid using the hyaluronate binding region of cartilage proteoglycan as a specific probe显示文摘 | Raija Tammi James A Ripellino Richard U Margolis | 1988 | J Invest Dermatol1988，90，3： | 1 |
| 20 | Rapid and sensitive HBsAg immunoassay based on fluorescent nanoparticle labels and time - resolved detection 显示文摘 | Antti V Saila H Raija V | 2005 | J Viral Methods2005，12，9： | 1 |
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