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| 1 | Antioxidant, antiangiogenic and antiproliferative activities of root methanol extract of Calliandra portoricensis in human prostate cancer cells显示文摘OBJECTIVE: Prostate cancer(PCa) is a major health concern. Calliandra portoricensis(CP) is traditionally known for its analgesic, anti-ulcerogenic and anticonvulsant properties. However, its antiproliferative properties for PCa still need to be investigated. METHODS: Antioxidant activities of CP were determined by 1,1-diphenyl-2-picryhydrazyl(DPPH) and hydroxyl(OH-) radicals-scavenging methods. PC-3 and LNCa P(androgen-refractory and androgendependent PCa-derived cell lines) were cultured and treated with CP(10, 50 and 100 μg/m L). Effects of CP on cells were determined by cytotoxicity assay(lactate dehydrogenase, LDH) and viability assay(sodium 3′-[1-(phenylaminocarbonyl)-3,4-tetrazolium]-bis(4-methoxy-6-nitro) benzene sulfonic acid hydrate, XTT). DNA fragmentation was detected by cell death detection enzyme-linked immunosorbent assay plus kit. CP was tested as an inhibitor of angiogenesis using chicken chorioallantoic membrane(CAM) assay. RESULTS: CP showed significant scavenging of DPPH and OH- radicals. CP significantly(P<0.05) inhibited lipid peroxidation in a dose-dependent manner. Precisely, CP(10, 50 and 100 μg/m L) inhibited PC-3 and LNCa P growth by 7%, 74% and 92%, and 27%, 73%, and 85% respectively at 48 h. CP had low toxicity in vitro at its half inhibitory concentration dose. Detection of cell death induced by CP at 50 μg/m L showed higher enrichment factors in LNCa P(7.38±0.95) than PC-3(3.48±0.55). Also, treatment with CP(50 μg/m L) significantly reduced network of vessels in CAM, suggesting its antiangiogenic potential. CONCLUSION: Calliandra portoricensis elicited antioxidant, antiangiogenic and antiproliferative effects in PCa cells. | Oluwatosin Adaramoye Bettina Erguen Olubukola Oyebode Bianca Nitzsche Michael H?pfner Klaus Jung Anja Rabien | 2015 | Journal of Integrative Medicine2015，13，3： | 2 |
| 2 | Reversion- inducing cysteine rich protein with Kazal motif (RECK) ex- pression: an independent prognostic marker of survival in colo- rectal cancer显示文摘 | Stenzinger A von Winterfeld M Rabien A | 2012 | Hum Pathol2012，43，13： | 1 |
| 3 | RECK overexpression decreases invasive potential in prostate cancer cells 显示文摘 | Rabien A Ergttu B Erbersdobler A | 2012 | Prostate2012，72，9： | 1 |
| 4 | Reversion-inducing cysteine-rich protein with Kazal motif (RECK) expression: an independent prognostic marker of survival in colorectal cancer 显示文摘 | Stenzinger A yon W'mterfeld M Rabien A | 2012 | Hum Pathol2012，43，8： | 1 |
| 5 | Cell-free DNA in the blood as a solid tumor biomarker: a critical appraisal of the literature显示文摘 | JUNG K FLEISCHHACKER M RABIEN A | 2010 | Clin Chim Acta2010，411，2122： | 1 |
| 6 | Human kallikreins as tumor markers: Vali- dation of potential marker of prostate cancer in serum and tissue显示文摘 | Rabien A | 2007 | Urologe A2007，46，9： | 1 |
| 7 | Cell-free DNA in the blood as a solid tumor biomarker-a critical appraisal of the literature显示文摘 | Jung K Fleischhacker M Rabien A | 2010 | Clin Chim Acta2010，411，2122： | 1 |
| 8 | RECK overexpression decreases invasive potential in prostate cancer cells 显示文摘 | Rabien A Ergiin B Erbersdobler A | 2012 | Prostate2012，72，9： | 1 |
| 9 | Feedback networks between microRNAs and epigenetic modifications in urological tumors显示文摘 | Liep J Rabien A Jung K | | 0，，04： | 1 |
| 10 | Decreased RECK epression indicating proteolytic imbalance in prostate can cer is associated with hiiger tumor aggressnessness after radical prostatatectomy显示文摘 | Rabien A Burkhardt MJung M | 2007 | J orthop Res2007，25，30： | 1 |
| 11 | Feedback networks between microRNAs and epigenetic modifications in urological tumors 显示文摘 | Liep J Rabien A Jung K | 2012 | Epigeneties2012，7，4： | 1 |
| 12 | Reversion-inducing cysteine-rich protein with Kazal motif (RECK) expression: an independent prognostic marker of survival in colorectal cancer 显示文摘 | Stenzinger A von Winterfeld M Rabien A | 2012 | Hum Pathol2012，43，8： | 1 |
| 13 | Decreased RECK and Increased EMMPRIN Expression in Urothelial Carcinoma of the Bladder Are Associated with Tumor Aggressiveness显示文摘 | Wittschieber Daniel Stenzinger Albrecht Klauschen Frederick Stephan Carsten Jung Klaus Erbersdobler Andreas Rabien Anja | 2011 | EN2011，，3： | 1 |
| 14 | Renal cell neo- plasias: reversion-inducing cysteine-rich protein with Ka-zal motifs discriminates tumor subtypes, while extracellular matrix metalloproteinase inducer indicates prognosis显示文摘 | RABIEN A STEPHAN C KILIC E | 2013 | J Transl Med2013，11，1： | 1 |
| 15 | Gene expression studies in prostate cancer tissue: which reference gene should be selected for normalization?显示文摘 | Falk Ohl Monika Jung Chuanliang Xu Carsten Stephan Anja Rabien Mick Burkhardt Andreas Nitsche Glen Kristiansen Stefan A. Loening Aleksandar Radoni? Klaus Jung | 2005 | Journal of Molecular Medicine2005，，12： | 1 |
| 16 | Cell-free DNA in the blood as a solid tumor biomarker-a critical appraisal of the literature显示文摘 | Jung K Fleischhacker M Rabien A | | 0，，21： | 1 |
| 17 | Cell -free DNA in the blood as a solid tumor biomarker a critical appraisal of the literature显示文摘 | JUNG K FLEISCHHACKER M RABIEN A | 2010 | Clin Chim Acta2010，411，2122： | 1 |
| 18 | Cell-free DNA in the blood as a solid tumor biomarker-a critical appraisal of the literature显示文摘 | Jung K Fleischhacker M Rabien A | 2010 | Clin Chim Acta2010，411，2122： | 1 |
| 19 | Cell-free DNA in the blood as a solid tumor biomarker-a critical appraisal of the literature显示文摘 | Jung K Fleischhacker M Rabien A | 2010 | Clin Chim Acta2010，411，286： | 1 |
| 20 | RECK overex- pression decreases invasive potential in prostate cancer cells 显示文摘 | Rabien A Ergtin B Erbersdobler A | 2012 | Prostate2012，72，9： | 1 |
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