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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Innovation networks:From technological development to business model reconfiguration显示文摘 | Rogerio C Fabio M G Gilnei L M | 2007 | Technovation2007，27，8： | 1 |
| 3 | Quality characteristics of high pressure-induced hake (Merluccius capensis)protein gels with and without MTGase显示文摘 | CARLOS L C ROGERIO 0 M JORGE A S | 2010 | Journal of Aquatic Food Product Technology2010，19，34： | 1 |
| 4 | Depositional and diagenetic controls on the reservoir quality of lower Cretaceous Pendencia sandstones, Poliguar rift basin, Brazil 显示文摘 | Anjos Sylvia M C dos Deros L F Rogerio desouza Schiffer | 2000 | AAPG Bulletin2000，84，11： | 1 |
| 5 | Domain size effects in molecular dynamics simulation of phonon transport in silicon 显示文摘 | ROGERIO F S MARCIO A R C A JANDIR M H | 2003 | Appl Phys Lett2003，89，17： | 1 |
| 6 | Depositional and diagenetic controls on the reservoir quality of Lower Cretaceous Pendencia sandstones Potiguar rift basin, Brazil显示文摘 | Sylvia M C dos Anjos Luiz F De Ros Rogerio Schiffer de Souza | 2000 | AAPG Bullentin2000，84，11： | 1 |
| 7 | Innovation networks:from tech- nological development to business model reconfiguration显示文摘 | Rogerio C Fabio G Gilnei M | 2007 | Technovation2007，27，8： | 1 |
| 8 | Depositional anddiagenetic controls on the reservoir quality of lower Creta-ceous Pendencia sandstones,Potiguar rift basin,Brazil显示文摘 | Sylvia M C Luiz F Rogerio Schiffer | 2002 | AAPG Bulletin2002，86，11： | 1 |
| 9 | Combined laser and intravitreal triamcinolone for proliferative diabetic retinopathy and macular edema:One-year results of a randomized clinical trial显示文摘 | Otacilio O M J Beatriz S T Rogerio A C | 2009 | American Journal of Ophthalmology2009，147，2： | 1 |
| 10 | Innovation Networks: From Technological Development to Business ModelReconfiguration 显示文摘 | Rogerio C Calia Fabio M Guerrini Gilnei L Moura | 2007 | Technovafion2007，27，8： | 1 |
| 11 | Biofermentation of modified flavonoids: an example of in vivo diversification of secondary metabolites 显示文摘 | Michael G Willits Maite Giovanni Rogerio T N Prata Catherine M Kramer Vincenzo De Luca John C Steffens Gerson Graser | 2004 | Phytochemistry2004，65，： | 1 |
| 12 | Depositional and diagenetic controls on the reservoir quality of Lower Cretaceous Pendencia sandstones, Potiguar rift basin, Brazil 显示文摘 | Sylvia M C dos Anjos Luiz F De Ros Rogerio Schiller de Souza | 2000 | AAPG Bulletin2000，84，11： | 1 |
| 13 | Waxy crude oil emulsion gel: impact on flow assurance显示文摘 | MARCIA C K de OLIVEIRA ROGERIO M C ALEXANDRE B C | 2010 | Energy Fuels2010，24，： | 1 |
| 14 | Depositional and diagenetic controls on the reservoir quanlity of Lower Creta- ceous Pendencia sandstones, Potiguar rift basin, Brazil显示文摘 | Sylvia M C dos Anjos Luiz F De Ros Rogerio Schiffer de Souza | 2000 | AAPG2000，84，11： | 1 |
| 15 | Depositional and di- agenetic controls on the reservoir quality of Lower Cretaceous Pendencial Sandstones,Potiguar Rift Basin,Brazil显示文摘 | Sylvia M C Luiz F D Rogerio S D | 2000 | AAPG Bulletin2000，84，11： | 1 |
| 16 | Depositional and diagenetic con trols on the reservoir quality of lower Cretaceous Pen dencia sandstones, Poliguar rift basin, Brazil 显示文摘 | ANJOS Sylvia M C dos DEROS L F ROGERIO des ouza Schiffer | 2000 | AAPG Bulletin2000，84，11： | 1 |
| 17 | Corticosterone inhibits uncoupling protein gene expression in brown adipose tissue显示文摘 | Anselmo M Rogerio R Antonio C B | 1993 | The American Physiological Society1993，265，： | 1 |
| 18 | Depositional and diagenetic controls on the reservoir quality of lower cretaceous Pendencia sand- stones, Potiguar rift basin, Brazil显示文摘 | Sylvia M C Luiz F Rogerio | 2002 | AAPG Bulletin2002，86，11： | 1 |
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