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| 1 | 改良椎板成形术在颈椎管内肿瘤切除术中的应用显示文摘目的评价经改良颈椎管扩大成形术切除椎管内肿瘤的手术疗效及手术后颈椎的生物力学变化。方法自2001年6月至2006年1月,16例颈椎管内肿瘤经后路切除。手术中,整体取下所累节段之椎板及相应后方结构,待肿瘤切除后再将此结构回置,以钛钉-钛板固定,将椎管扩大成形。分析此术式对肿瘤的显露与切除效果,评价手术后患者的神经功能,随访患者远期颈椎生理曲度、颈椎运动度及稳定性。结果16例患者中髓内室管膜瘤5例,髓外-硬膜下神经鞘瘤9例、脊膜瘤2例。椎板成形2~5节段(平均3.5节段),肿瘤全切率100%。术后随访时间6个月至5年(平均19.5个月),JOA评分从术前的(9.21±3.28)分提高到(15.38±1.29)分。颈椎管矢状径较术前增加3.8mm(P=0.004)。颈椎曲度恶化发生率为12.5%;颈椎不稳定发生率为0;颈椎总运动度减少2°,与手术前对比差异无统计学意义(P=0.71)。结论经改良颈椎管扩大成形术入路,手术对椎管内病变显露及切除效果满意,同时扩大了椎管前后径。由于部分保持了颈椎后方张力带,对脊柱的生物力学影响较小。 | 谢京城 Hurlbert R.John | 2007 | 中华神经外科杂志2007，23，11： | 14 |
| 2 | The ruminal microbiome associated with methane emissions from ruminant livestock显示文摘Methane emissions from ruminant livestock contribute significantly to the large environmental footprint of agriculture.The rumen is the principal source of methane, and certain features of the microbiome are associated with low/high methane phenotypes. Despite their primary role in methanogenesis, the abundance of archaea has only a weak correlation with methane emissions from individual animals. The composition of the archaeal community appears to have a stronger effect, with animals harbouring the Methanobrevibacter gottschalki clade tending to be associated with greater methane emissions. Ciliate protozoa produce abundant H_2, the main substrate for methanogenesis in the rumen,and their removal(defaunation) results in an average 11% lower methane emissions in vivo, but the results are not consistent. Different protozoal genera seem to result in greater methane emissions, though community types(A, AB, B and O) did not differ. Within the bacteria, three different ‘ruminotypes' have been identified, two of which predispose animals to have lower methane emissions. The two low-methane ruminotypes are generally characterized by less abundant H_2-producing bacteria. A lower abundance of Proteobacteria and differences in certain Bacteroidetes and anaerobic fungi seem to be associated with high methane emissions. Rumen anaerobic fungi produce abundant H_2 and formate, and their abundance generally corresponds to the level of methane emissions. Thus, microbiome analysis is consistent with known pathways for H_2 production and methanogenesis, but not yet in a predictive manner. The production and utilisation of formate by the ruminal microbiota is poorly understood and may be a source of variability between animals. | Ilma Tapio Timothy J.Snelling Francesco Strozzi R.John Wallace | 2017 | Journal of Animal Science and Biotechnology2017，8，2： | 13 |
| 3 | 生物技术在反刍动物营养中的应用显示文摘 | R.John Wallace 龙玲 | 2002 | 中国畜牧兽医2002，29，6： | 6 |
| 4 | The keystone-design perforator-based flap for leg defects: a synthesis of philosophies显示文摘Aim:The classical keystone-design flap,although elegantly employed for various trunk defects,has limited movement on the leg.This study aims to modify the keystone–design flaps for leg defects.Methods:A keystone-design flap,in which perforators are identified and dissected,is described specifically for elliptical defects overlying the tibia.Results:It retains the unique advantages of both the perforator island flap concept as well as the keystone-design philosophy.Conclusion:The technique as well as the possibilities of raising such flaps over various areas of the leg is outlined. | Jerry R.John Jyoshid R.Balan Satyaswarup Tripathy Ramesh Kumar Sharma Chandan Jadhav | 2014 | Plastic and Aesthetic Research2014，1，1： | 1 |
| 5 | DNA Polymorphism and Selection at the Melanocortin‐1 Receptor Gene in Normally Pigmented Southern African Individuals显示文摘 | PREMILA R.JOHN KATERYNAMAKOVA WEN‐HSIUNGLI TREFORJENKINS MICHELERAMSAY | 2006 | Annals of the New York Academy of Sciences2006，，1： | 1 |
| 6 | Angioleiomyoma:a rare diagnosis of a painful subcutaneous nodule in the hand显示文摘Angioleiomyoma of the hand is a rare differential diagnosis of painful soft tissue nodule in the extremity.It arises from smooth muscle of the blood vessels and the most common symptom is pain.Imaging with magnetic resonance imaging shows characteristic features like a hypodense peripheral capsule with linear or branching internal hyperdensities on T2-weighted images,and post-contrast diffuse homogenous enhancement with a vessel leading up to the lesion.Histopathological examination shows well circumscribed fascicles of mature smooth muscle cells surrounding vascular lumina,lined by normal appearing endothelium without elastic lamina present.These cells stain positive for smooth muscle actin,desmin,vimentin,type IV collagen and S100,but stain negative for HMB-45 and ER.Angioleiomyoma is amenable for surgical resection.We report a case of painful subcutaneous nodule of hand,with radiological and histopathological findings suggestive of angioleiomyoma.We outline the clinical,radiological and histopathological features of this rare diagnosis for painful nodule of extremity. | Sandeep Bhogesha Satyaswarup Tripathy Jerry R.John Debajyoti Chatterjee | 2016 | Plastic and Aesthetic Research2016，3，1： | 0 |
| 7 | 从噬菌体显示程序中筛选抗响尾蛇毒素的组合抗体的特异性和结合亲和性显示文摘我们用 Pharmacia公司的重组噬菌体抗体系统的组合方法制出一种对响尾蛇毒素特异的、具有高亲和力的单克隆单链抗体可变区 (sc Fv)。筛选出一个高亲和力的克隆 ,编号为 A1 0 G,对其 DNA进行了测序。A1 0 G蛋白显示出高的反应特异性 ,只与响尾蛇神经毒素、concolor毒素和 Mojave毒素有密切的关系。用第二组磷脂酶 A2 s (PLA2 s)筛选 ,与 1 1种显示出交叉反应。第一组磷脂酶 A2 s (PLA2 s)在 ELISA中有交叉反应。编码A1 0 G的基因被亚克隆到一个表达载体 ,结果表达非融合蛋白 ,标记为 A1 0 GPE,复性、纯化至表面均一性。A1 0 G与完整响尾蛇毒素和响尾蛇毒素基本亚单位的解离常数分别为 7× 1 0 - 1 0 M和 6.8× 1 0 - 9M。当 A1 0 GPE与响尾蛇毒素基本亚单位或响尾蛇全毒素以摩尔比 5 :1预先孵育 ,则没有抑制磷脂酶活性现象。然而 ,表达蛋白可以在小鼠中部分中和响尾蛇毒素同系物 | JIANXIN MENG TED R.JOHN IVANI.KA ISER 尹惠琼(译) 范泉水(校) | 2002 | 蛇志2002，14，4： | 0 |
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