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| 1 | Endoscopic stenting for inoperable malignant biliary obstruction: A systematic review and meta-analysis显示文摘AIM: To analyze through meta-analyses the benefits of two types of stents in the inoperable malignant biliary obstruction.METHODS: A systematic review of randomized clinical trials(RCT) was conducted, with the last update on March 2015, using EMBASE, CINAHL(EBSCO), MEDLINE, LILACS/CENTRAL(BVS), SCOPUS, CAPES(Brazil), and gray literature. Information of the selected studies was extracted in sight of six outcomes: primarily regarding dysfunction, complication and reintervention rates; and secondarily costs, survival, and patency time. The data about characteristics of trial participants, inclusion and exclusion criteria and types of stents were also extracted. The bias was mainly assessed through the JADAD scale. This meta-analysis was registered in the PROSPERO database by the number CRD42014015078. The analysis of the absolute risk of the outcomes was performed using the software Rev Man, by computing risk differences(RD) of dichotomous variables and mean differences(MD) of continuous variables. Data on RD and MD for each primary outcome were calculated using the MantelHaenszel test and inconsistency was qualified and reported in χ2 and the Higgins method(I2). Sensitivity analysis was performed when heterogeneity was higher than 50%, a subsequent assay was done and other findings were compiled. Student's t-test was used for the comparison of weighted arithmetic means regarding secondary outcomes.RESULTS: Initial searching identified 3660 studies; 3539 were excluded through title, repetition, and/or abstract, while 121 studies were fully assessed and were excluded mainly because they did not compare self-expanding metal stents(SEMS) and plastic stents(PS), leading to thirteen RCT selected, with 13 articles and 1133 subjects meta-analyzed. The mean age was 69.5 years old, that were affected mostly by bile duct(proximal) and pancreatic tumors(distal). The preferred SEMS diameter used was the 10 mm(30 Fr) and the preferred PS diameter used was 10 Fr. In the metaanalysis, SEMS had lower overall stent dysfunction compared to PS(21.6% vs 46.8%, P < 0.00001) and fewer re-interventions(21.6% vs 56.6%, P < 0.00001), with no difference in complications(13.7% vs 15.9%, P = 0.16). In the secondary analysis, the mean survival rate was higher in the SEMS group(182 d vs 150 d, P < 0.0001), with a higher patency period(250 d vs 124 d, P < 0.0001) and a lower cost per patient(4193.98 vs 4728.65 Euros, P < 0.0985).CONCLUSION: SEMS are associated with lower stent dysfunction, lower re-intervention rates, better survival, and higher patency time. Complications and costs showed no difference. | Leonardo Zorrón Pu Eduardo Guimaraes Hourneaux de Moura Wanderley Marques Bernardo Felipe Iankelevich Baracat Ernesto Quaresma Mendonca AndréKondo Gustavo Oliveira Luz Carlos Kiyoshi Furuya Júnior Everson Luiz de Almeida Artifon | 2015 | World Journal of Gastroenterology2015，21，47： | 10 |
| 2 | Cholesterol levels and sensory characteristics of meat from broilers con- suming moderate to high levels of alfalfa显示文摘 | PONTE P I P MENDES I QUARESMA M | 2004 | Poultry Science2004，83，5： | 1 |
| 3 | Fulvestrant,foremerly ICI182,780, is as effective as anastrozole in postmenopausal women with advanced breast cancer progressing after prior endocrine treatment 显示文摘 | Howell A Robertson JF Quaresma Albano J | 2002 | J Clin Oneol2002，20，16： | 1 |
| 4 | Rapid prototyping as a tool for diagnosis and treatment planning for maxillary canine impaction显示文摘 | Faber J Berto PM Quaresma M | 2006 | Am J Orthod Dentofacial Orthop2006，129，4： | 1 |
| 5 | Identification and characterization of proteins that selectively interact with isoforms of the mRNA binding protein AUF1 ( hnRNP D) 显示文摘 | Moraes KC Quaresma A J Maehnss K | 2003 | Biological Chemistry2003，384，1： | 1 |
| 6 | Focussed microwave-assisted sample preparation: Total phenol determination in petroleum refinery effluents by flow injection spectrophotometry 显示文摘 | Quaresma M C B Cassella R J Carvalho M F B Santelli R E | 2004 | Microchemical Journal2004，78，1： | 1 |
| 7 | Dermatoscopic findings as a complementary tool in the differential diagnosis of the etiological agent of tinea capitis显示文摘 | Schechtman RC Silva ND Quaresma MV | 2015 | An Bras Dermatol2015，90，3： | 1 |
| 8 | IKK is key to induction of insulin resistance in the hypothalamus,and its inhibition reverses obesity显示文摘 | Weissmann L Quaresma P G Santos A C | 2014 | Diabetes2014，63，10： | 1 |
| 9 | Hydroxyapatite nano-powders produced hydrothermally from nacreous material显示文摘 | Lemos A F Rocha J H G Quaresma S S F | 2006 | Journal of the European Ceramic Society2006，26，16： | 1 |
| 10 | Cancer survival in five continents: a worldwide population- based study (Concord)显示文摘 | Coleman MP Quaresma M Berrino F | 2008 | Lancet Oncol2008，9，： | 1 |
| 11 | Cholesterol levels and sensory characteristics of meat from broilers consu- ming moderate to high levels of Medicago sativa 显示文摘 | Ponte P I P Mendes I Quaresma M | 2004 | Poultry Science2004，83，5： | 1 |
| 12 | Determination of transientinterfacial heat transfer coefficients in chill mold castings 显示文摘 | Santos C A Quaresma J M V Garcia A | 2001 | Journalof Alloys and Compounds2001，319，： | 1 |
| 13 | Cancer survival in five continents:a worldwide population-based study(CONCORD)显示文摘 | Coleman MP Quaresma M Berrino F | 2008 | Lancet Oncol2008，9，8： | 1 |
| 14 | Subnuclear domain proteins in cancer cells support the functions of RUNX2 in the DNA damage response 显示文摘 | Yang S Quaresma A J Nickerson J A | 2015 | J Cell Sci2015，128，4： | 1 |
| 15 | Some aspects of the behavior of the hypothalamus–pituitary–adrenal axis in patients with uncomplicated Plasmodium falciparum malaria: Cortisol and dehydroepiandrosterone levels显示文摘 | Rosana Maria Feio Libonati Berenice Bilharinho de Mendon?a José Ant?nio Maués Juarez Antonio Sim?es Quaresma José Maria de Souza | 2006 | Acta Tropica2006，，3： | 1 |
| 16 | IKK epsi- Ion is key to induction of insulin resistance in the hypothalamus and its inhibition reverses obesity显示文摘 | WEISSMANN L QUARESMA PG SANTOS AC | 2014 | Diabetes2014，63，20： | 1 |
| 17 | Fulvestrant is as effective as anastrozole in postmenopausal women with advanced breast cancer progressing after prior endocrine treatment显示文摘 | Howell A Robertson JF Quaresma A | 2002 | J Clin Oncol2002，20，16： | 1 |
| 18 | Relia bility of pain scales in the assessment of literate and illi terate patients with rheumatoid arthritis显示文摘 | Ferraz M B Quaresma M R Aquino L R | 1990 | J Rheuma tol1990，17，8： | 1 |
| 19 | Cancer survival in five con- tinents: a worldwide population - baaed study (CONCORD)显示文摘 | Coleman MP Quaresma M Berrino F | 2008 | Lan- cet Oneo12008，9，8： | 1 |
| 20 | Relationship between ultrasound measurements of body fat reserves and body condition score in female donkeys显示文摘 | Quaresma M Payan-Carreira R Silva S R | | 0，，02： | 1 |
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