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| 1 | In vivo effects of Chinese herbal recipe, Danshaohuaxian, on apoptosis and proliferation of hepatic stellate cells in hepatic fibrotic rats显示文摘AIM: To investigate the effects of Danshaohuaxian (DSHX),a Chinese herbal recipe, on the apoptosis and cell cycles of hepatic stellate cells (HSCs) in rat hepatic fibrosis and its possible mechanisms. METHODS: Seventy-six male Wistar rats were randomly divided into normal control group, hepatic fibrosis group,non-DSHX-treated group and DSHX-treated group. Except for the normal control group, rat hepatic fibrotic models were induced by subcutaneous injection of carbon tetrachloride (CCl4), drinking alcohol, giving diet of hyperlipid and hypoprotein for 8 wk. When the hepatic fibrotic models were produced, 12 rats of hepatic fibrosis group (15 rats survived, others died during the 8 wk) were sacrificed to collect blood and livers. HSCs were isolated from the other 3 rats to detect the apoptotic index (AI) and cell cycles by flow cytometry. DSHX was then given to the DSHX-treated group (1.0 g/kg, PO daily) for 8 wk. At the same time, normal control group and non-DSHX-treated group were given normal saline for 8 wk. At end of the experiment, some rats in these three groups were sacrificed to collect blood and livers, the other rats were used for HSC isolation to detect the apoptotic index (AI) and cell cycles. Then the liver index, serum hyaluronic acid (HA) and alanine aminotransferase (ALT),degree of hepatic fibrosis, urinary excretion of hydroxyproline (Hyp) and expression of collagen types Ⅰ and Ⅲ (COL Ⅰ and Ⅲ) in these four groups were detected respectively.RESULTS: Compared with the indexes of the hepatic fibrosis group and non-DSHX-treated group, the DSHX-treated group revealed a liver index of (0.0267±0.0017 vs 0.0423±0.0044, 0.0295±0.0019, P<0.05), levels of serum HA (200.78±31.71 vs316.17±78.48, 300.86±72.73, P<0.05)and ALT(93.13±5.79 vs 174.5±6.02, 104.75±6.54, P<0.01),and stage of hepatic fibrosis (1.30 vs 4.25, 2.60, P<0.01)all reduced. The urinary excretion of Hyp increased (541.09±73.39 vs 62.00±6.40, 182.44±30.83, P<0.01),the COL Ⅰ and Ⅲ expression decreased (COL Ⅰ: 1.07±0.96 vs4.18±2.26, 3.22±1.44, P<0.01; COL Ⅲ: 1.09±0.58 vs 3.04±0.62, 2.23±0.58, P<0.01), the HSCs apoptotic index of HSCs (7.81±0.47 vs 1.63±0.25, 1.78±0.4, P<0.05) and the ratio of G0-G1 phase cells increased (94.30±1.33 vs 62.27±17.96, 50.53±2.25, P<0.05). The ratios of S-phase cells (3.11±1.27 vs 9.83±1.81, 11.87±1.9, P<0.05) and G2-M phase cells (2.58±0.73 vs23.26±10.95, 13.60±1.15, P<0.01)declined.CONCLUSION: DSHX capsule shows certain therapeutic effects on hepatic fibrosis in rats and inhibits abnormal deposition of COL Ⅰ and Ⅲ in rat livers by promoting the apoptosis of HSCs and preventing their proliferation. | Xiao-XiaGeng QinYang Ru-JiaXie Xin-HuaLuo BingHan LiMa Cheng-XiuLi Ming-LiangCheng | 2005 | World Journal of Gastroenterology2005，11，4： | 8 |
| 2 | A method for weighing broiler chickens using improved amplitude-limiting filtering algorithm and BP neural networks显示文摘Broiler chickens are traditionally weighed by steelyard or platform scale,which is timeconsuming and labor-intensive.Broiler chickens usually exhibit stress-related behavior during weighing.The 3D camera-based weighing system for broiler chickens can only weigh the broiler chicken in the monitoring area.Usually,it makes poor weight prediction due to poor segmentation especially when the broiler chicken is flapping its wings.To solve these issues,we developed one simple and low-cost weighing system with high stability and accuracy.A validity value extraction method from dynamic weighing was proposed.Then,an improved amplitude-limiting filtering algorithm and a BP neural networks model were developed to avoid accidental interference.The BP neural networks model used daily weight gain,day-age,average velocity,and the weight data after filtering algorithm as the input layer.The weighing system was tested in a commercial Beijing Fatty Chickens house with Beijing Fatty Chickens.We tested thirteen groups of Beijing Fatty Chickens of different weights,from 500 g to 1800 g in intervals of 100 g,using the three different methods:no filtering algorithm or BP neural networks,only the improved amplitude-limiting filtering algorithm and a hybrid of the improved amplitude-limiting filtering algorithm and BP neural networks.The results showed that the hybrid algorithm had a better performance in minimizing the error,lowering from the original 6%down to 3%.The accurate weight data was transmitted to the remote service platform for further decision-making,such as activity analysis,feeding management,and health alerts. | Weihong Ma Qifeng Li Jiawei Li Luyu Ding Qinyang Yu | 2021 | Information Processing in Agriculture2021，8，2： | 5 |
| 3 | Dynamic distribution of Ser-10 phosphorylated histone H3 in cytoplasm of MCF-7 and CHO cells during mitosis显示文摘The dynamic distribution of phosphorylated Histone H3 on Ser10 (phospho-H3) in cells was investigated to determineits function during mitosis. Human breast adenocarcinoma cells MCF-7, and Chinese hamster cells CHO were analyzedby indirect immunofluorescence staining with an antibody against phospho-H3. We found that the phosphorylationbegins at early prophase, and spreads throughout the chromosomes at late prophase. At metaphase, most of the phospho-H3 aggregates at the end of the condensed entity of chromosomes at equatorial plate. During anaphase and telophase,the fluorescent signal of phospho-H3 is detached from chromosomes into cytoplasm. At early anaphase, phospho-H3shows ladder bands between two sets of separated chromosome, and forms “sandwich-like structure” when the chro-mosomes condensed. With the cleavage progressing, the “ladders” of the histone contract into a bigger bright dot. Thenthe histone aggregates and some of compacted microtubules in the midbody region are composed into a “bar-like”complex to separate daughter cells. The daughter cells seal their plasma membrane along with the ends of the “bar”,inside which locates microtubules and modified histones, to finish the cytokinesis and keep the “bar complex” out of thecells. The specific distribution and kinetics of phospho-H3 in cytoplasm suggest that the modified histones may takepart in the formation of midbody and play a crucial role in cytokinesis. | DengWenLI QinYANG JiaTongCHEN HaoZHOU RuMingLIU XiTaiHUANG | 2005 | Cell Research2005，15，2： | 4 |
| 4 | 土堤仓双环流熏蒸杀虫暨机械通风防结露显示文摘在土堤仓仓底和仓顶同时设置风道.采用环流熏蒸,使毒气在短时间即可到达全仓各个部位,且分布均匀,保证了熏蒸杀虫效果;进行机械通风降温降水,有效地解决了仓顶结露的问题. | (Qinyang Grain Bureau, Henan) | 1994 | 粮食储藏1994，23，5： | 2 |
| 5 | Deformation mechanisms in aβ-quenched Ti-5321 alloy:In-situ investigation related to slip activity,orientation evolution and stress induced martensite显示文摘The deformation behavior ofβ-quenched nearβTi-5321(Ti-5Al-3Mo-3V-2Cr-2Zr-1Nb-1Fe)alloy was systematically studied using in-situ tensile test monitored by the scanning electron microscopy(SEM).Besides,the electron backscatter diffraction(EBSD)was performed to thoroughly discuss the deformation mechanisms.The results indicated that slip activities,crystal rotation and stress induced martensite transformation were the major deformation mechanisms in theβ-quenched Ti-5321 alloy during in-situ tensile testing.The slip activities were investigated by using the EBSD-trace analysis,which demonstrated that{110}<111>,{112}<111>and{123}<111>slip systems were activated and the{110}<111>slip system dominated.Besides,βgrains rotated about 7.8°to accommodate the increased macrostrain.Notably,the stress induced martensiteα″which was related to the double yielding behavior during tensile process exhibited multiple characteristics.The differentα″variants divided theβmatrix into smallerβblocks with a typical zigzag morphology,in which oneα″variant passed through another one by deflecting its initial growth direction.Moreover,the deformation twinning in martensiteα″and slip bands cutting through martensiteα″effectively accommodated the local strain.These systematically analysis can provide insightful information about the deformation mechanisms in nearβtitanium alloys. | Cong Wu Qinyang Zhao Shixing Huang Yongqing Zhao Lei Lei Junqiang Ren Qiaoyan Sun Lian Zhou | 2022 | Journal of Materials Science & Technology2022，，17： | 2 |
| 6 | Effect of processing parameters on hot deformation behavior and microstructural evolution during hot compression of as-cast Ti60 titanium alloy显示文摘 | Wenwen Peng Weidong Zeng Qingjiang Wang Qinyang Zhao Hanqing Yu | 2014 | Materials Science & Engineering A2014，，： | 1 |
| 7 | New insights in the development ofαphase during continuously heating in aβ-quenched Ti-5321 alloy显示文摘Near β titanium alloys are attractive materials for aeronautical applications due to their high specific strength,excellent damage tolerance performance and good hardenability.Their mechanical properties are strongly governed by the microstructural characteristics,especially the morphology,volume fraction,orientation and distribution of theαphase. | Cong Wu Qinyang Zhao Shixing Huang Yongqing Zhao Lei Lei Qiaoyan Sun Lian Zhou | 2022 | Journal of Materials Science & Technology2022，，8： | 1 |
| 8 | The relationship between slip behavior and dislocation arrangement for large-size Mo-3Nb single crystal at room temperature显示文摘The slip behavior and mechanism of large-size Mo-3Nb single crystal have been investigated and disclosed comprehensively at room temperature by quasi-static compression with various strains.With the increase of deformation,the slip traces change from shallow non-uniform slip lines to dense and uniform slip bands.Different slip traces in the same deformation condition were observed,suggesting that the slip traces in the single crystal are controlled by different types and arrangement mechanisms of mobile dislocation.To clarify the relationship between slip behavior and dislocation arrangement,TEM and AFM analyses were performed.Significant discrepancy between the mobility of screw segments and edge segments caused by double cross-slip multiplication mechanism is the reason why different slip features were witnessed.During the whole slip deformation process,screw dislocations play a dominant role and they are inclined to form wall-substructures by interaction and entanglement.With the development of dislocation accumulation,the entangled dislocation walls evolve into dislocation cells with higher stability. | Benqi Jiao Qinyang Zhao Yongqing Zhao Laiping Li Zhongwu Hu Xuanqiao Gao Wen Zhang Jianfeng Li | 2021 | Journal of Materials Science & Technology2021，，33： | 1 |
| 9 | Galanin in adjuvant arthritis in the rat显示文摘 | Qinyang W Hultenby K Adlan E | 2004 | J Rheumatol2004，31，2： | 1 |
| 10 | An intelligent and privacy-enhanced data sharing strategy for blockchain-empowered Internet of Things显示文摘With the development of the Internet of Things(IoT),the massive data sharing between IoT devices improves the Quality of Service(QoS)and user experience in various IoT applications.However,data sharing may cause serious privacy leakages to data providers.To address this problem,in this study,data sharing is realized through model sharing,based on which a secure data sharing mechanism,called BP2P-FL,is proposed using peer-to-peer federated learning with the privacy protection of data providers.In addition,by introducing the blockchain to the data sharing,every training process is recorded to ensure that data providers offer high-quality data.For further privacy protection,the differential privacy technology is used to disturb the global data sharing model.The experimental results show that BP2P-FL has high accuracy and feasibility in the data sharing of various IoT applications. | Qinyang Miao Hui Lin Jia Hu Xiaoding Wang | 2022 | Digital Communications and Networks2022，8，5： | 1 |
| 11 | Urinary metabonomic study of lung cancer by a fully automatic hyphenated hydrophilic interaction/RPLC‐MS system显示文摘 | QinYang XianzheShi YuanWang WenzhaoWang HongbinHe XinLu GuowangXu | 2010 | J Sep Science2010，，10： | 1 |
| 12 | Processing of metastable beta titanium alloy:Comprehensive study on deformation behaviour and exceptional microstructure variation mechanisms显示文摘Thermomechanical processing(TMP)is especially crucial for metastableβtitanium alloys,which has received significant attention in the community for a long time.In this contribution,the processing-responding behaviour including microstructure evolution process,texture variation mechanism,and un-derlying deformation process of powder metallurgy Ti-5553 alloy in a wide processing parameter range was comprehensively investigated.Thermal physical simulation was performed on the alloy at temper-atures ranging from 800℃ to 1100℃,and strain rates between 0.001 s^(−1) and 10 s^(−1),to varied defor-mation degrees of 20%-80%height reduction.It was found that the processing parameters(i.e.temper-ature,strain rate,and deformation degree)are influential on the deformation process and resultant mi-crostructure.Varied microstructural evolution processes forβphase including flow localization,dynamic recovery,dynamic recrystallization,and grain coarsening are activated in different processing domains,while different evolution mechanisms forαphase including dynamic precipitation,phase separation,dy-namic coarsening,and mechanical shearing also play their roles under different processing conditions.In particular,four exceptional evolution mechanisms ofαprecipitation which have not been previously reported in titanium alloys were discovered and clearly demonstrated,more specifically,they are multi-interior twinning,internal compositing,layered coarsening and selective diffusion-actuated separation.After the establishment of comprehensive microstructural evolution mechanism maps,the guidance for precise processing and the knowledge reserve extension for deformation process of metastableβtita-nium alloys can be effectively achieved. | Qinyang Zhao Leandro Bolzoni Yongnan Chen Yiku Xu Rob Torrens Fei Yang | 2022 | Journal of Materials Science & Technology2022，，31： | 1 |
| 13 | Identification of Lepidium meyenii (Walp.) based on spectra and chromatographic characteristics of its principal functional ingredients显示文摘 | WenwenJin YongzhongZhang SongMei YueXiong QinYang LongjiangYu | 2007 | J Sci Food Agric2007，，12： | 1 |
| 14 | Distribution ofleucine-enkephalin in bone and joint tissues 显示文摘 | Qinyang W Lindgren J U Elhassan A M | 2002 | Neuropeptides2002，36，28： | 1 |
| 15 | Molecular Engineering of g-C_(3)N_(4)with Dibenzothiophene Groups as Electron Donor for Enhanced Photocatalytic H_(2)-Production显示文摘The construction of donor-acceptor(D-A)molecular structure is an attractive strategy to enhance the photocatalytic performance of polymeric semiconductors.Herein,dibenzothiophene(DBT)-4-carbaldehyde as the precursor is introduced into g-C_(3)N_(4)(TCN)prepared by two-step thermal polymerization to construct an intramolecular D-A type copolymer(TCN-DBT_(x)).DFT calculation and experimental results reveal that DBT plays the role of electron donor unit to modify g-C_(3)N_(4).The incorporation of DBT not only adjusts the band gap to improve reduction ability,but also induces an internal electric field with extendingπ-conjugated system for effective charge transfer.As a result,TCN-DBT_(x)exhibits much better photocatalytic performance with an optimal hydrogen production rate of 3334μmol h^(-1)g^(-1),which is 2.5 times that of TCN.This work provides a protocol for preparing high-performance g-C_(3)N_(4)-based photocatalysts toward various applications. | Shanren Tao Sijie Wan Qinyang Huang Chengming Li Jiaguo Yu Shaowen Cao | 2022 | Chinese Journal of Structural Chemistry2022，41，6： | 1 |
| 16 | Synthesis and optical properties of novel double perovskite Ca_(2)MgTeO_(6):Dy^(3+),Na^(+) phosphors for white LEDs显示文摘Novel yellow-emitting phosphors of Dy^(3+)-doped double perovskite Ca_(2)MgTeO_(6) were synthesized by using a conventional high-temperature solid-state reaction.The phase purity,particle morphology,size distribution,elemental composition,luminescence properties,and luminescence decay curves of the resulting products were then analyzed in detail.The Ca_(2)MgTeO_(6):Dy^(3+),Na^(+) phosphors show three emission peaks after near-ultraviolet excitation at 350 nm,which correspond to ^(4)F_(9/2)→^(6)H_(11/2),^(4)F_(9/2)→^(6)H_(13/2),and ^(4)F_(9/2)→^(6)H_(13/2) transitions,respectively.Among them,the strongest peak is observed at 573 nm.The best doping content of Dy^(3+)in Ca_(2)MgTeO_(6):xDy^(3+),xNa^(+) phosphors is x=5 mol%.The calculated critical distance of energy transfer between Dy^(3+) ions is 1.6 nm.Luminescence quenching is confirmed to be due to dipole-dipole interactions among Dy^(3+) ions.The phosphors show excellent thermal stability with high activation energy(0.27 eV).The Commission Internationale de l’Eclairage(CIE) chromaticity coordinates of the Ca_(2)MgTeO_(6) Dy^(3+),Na^(+) phosphors are located in the yellow region.White light-emitting diodes(w-LEDs) were fabricated with a high color rendering index(R_(a)) of 88 and a good correlated color temperature(CCT) of 5440 K.All observed properties indicate that Ca_(2)MgTeO_(6):Dy^(3+),Na^(+) phosphors have potential applications in display and photonic devices. | Junzhi Che Bin Deng Qinyang Song Jianxu Wang Tao Wang Shoucheng Zhao Ruijin Yu | 2021 | Journal of Rare Earths2021，39，6： | 1 |
| 17 | Time Series Forecasting Fusion Network Model Based on Prophet and Improved LSTM显示文摘Time series forecasting and analysis are widely used in many fields and application scenarios.Time series historical data reflects the change pattern and trend,which can serve the application and decision in each application scenario to a certain extent.In this paper,we select the time series prediction problem in the atmospheric environment scenario to start the application research.In terms of data support,we obtain the data of nearly 3500 vehicles in some cities in China fromRunwoda Research Institute,focusing on the major pollutant emission data of non-road mobile machinery and high emission vehicles in Beijing and Bozhou,Anhui Province to build the dataset and conduct the time series prediction analysis experiments on them.This paper proposes a P-gLSTNet model,and uses Autoregressive Integrated Moving Average model(ARIMA),long and short-term memory(LSTM),and Prophet to predict and compare the emissions in the future period.The experiments are validated on four public data sets and one self-collected data set,and the mean absolute error(MAE),root mean square error(RMSE),and mean absolute percentage error(MAPE)are selected as the evaluationmetrics.The experimental results show that the proposed P-gLSTNet fusion model predicts less error,outperforms the backbone method,and is more suitable for the prediction of time-series data in this scenario. | Weifeng Liu Xin Yu Qinyang Zhao Guang Cheng Xiaobing Hou Shengqi He | 2023 | Computers, Materials & Continua2023，，2： | 0 |
| 18 | A traditional formula of aconitum complex alleviates post-ischemic stroke by improving neural function显示文摘Stroke is the second leading cause of death worldwide.There are more than 2 million new stroke patients in China every year,and ischemic strokes account for 60%-70%of these patients[1].Even with proper hospital treatment,30%of stroke patients still die within a year after diagnosis.Furthermore,more than 80%of stroke survivors suffer from motor disorders(e.g.,hemiplegia and aphasia),and approximately 15%-30%are permanently disabled.Stroke affects not only individuals but also their families,causing severe social consequences[2]. | Ji Ma Ruiqi Pu Qinyang Zhou Maoru Li Jing Shang | 2024 | Acta Biochimica et Biophysica Sinica2024，56，2： | 0 |
| 19 | Evaluation Indicator System for China's Agricultural Industrial Safety显示文摘On the basis of new characteristics and trend of China's agricultural development in the post-WTO period,combining analysis of factors influencing agricultural industrial safety,this paper builds an evaluation indicator system for China's agricultural industrial safety by scientific indicator system design method.This indicator system includes risk factor indicators(showing risk degree)and capacity factor indicators(showing guaranteeing ability),and consists of 7 subsystems:consumption safety,production safety,industrial controlling capacity,industrial development capacity,industrial development environment,government functions and industrial foundation condition.Risk factor is divided into 5 levels:higher risk,high risk,medium risk,low risk and lower risk;guarantee risk is also divided into five levels:strong,healthy,normal,weak and disabled.According to the overall evaluation score obtained from weighting sum,the agricultural industrial safety includes 5 types:very safe,safe,basically safe,not safe and hazardous.This evaluation indicator system is expected to providing theoretical reference for evaluating China's agricultural industrial safety. | Qingpeng GAO Bin CHEN Qinyang LI | 2013 | Asian Agricultural Research2013，5，9： | 0 |
| 20 | Toughening effects of Mo and Nb addition on impact toughness and crack resistance of titanium alloys显示文摘Ti-6Al,Ti-6Al-2Mo and Ti-6Al-3Nb alloys were prepared to investigate the toughening effects ofβstabilizers Mo and Nb on impact toughness and crack resistance of titanium alloys.Instrumented Charpy impact tests showed that the total impact absorbed energy of Ti-6Al-2Mo and Ti-6Al-3Nb(∼64 J)were two times higher than that of Ti-6Al(∼30 J),indicating the higher impact toughness of Ti-6Al-2Mo and Ti-6Al-3Nb alloys.Analysis of load-displacement curves revealed the similar crack initiation energy of Ti-6Al,Ti-6Al-2Mo and Ti-6Al-3Nb(15.4 J,16.1 J and 15.0 J,respectively).However,the higher crack propagation energy of Ti-6Al-2Mo and Ti-6Al-3Nb(46.7 J and 48.3 J,respectively)were about three times higher than that of Ti-6Al(14.4 J),indicating the stronger resistance to crack propagation in Ti-6Al-2Mo and Ti-6Al-3Nb.Post-mortem analysis of impact samples demonstrated that the increased dislocation density and deformation twinning were mainly responsible for the stronger resistance to crack propagation in Ti-6Al-2Mo and Ti-6Al-3Nb.Due to the invisibility of dislocation activation and deformation twinning during the Charpy impact process,a mathematical model has been proposed to evaluate the effects of Al,Mo and Nb elements on dislocation mobility based on the Yu Rui-huang electron theory.Addition of Mo and Nb elements significantly improved the dislocation mobility in Ti-6Al-2Mo and Ti-6Al-3Nb compared to that in Ti-6Al alloy.Therefore,more dislocations were activated in Ti-6Al-2Mo and Ti-6Al-3Nb which supplied the larger plastic deformation under impact loading.A dislocation-based model also has been proposed to interpret the nucleation and propagation of deformation twinning under the impact loading.Dislocation pileup atα/βinterfaces provided potential sites for nucleation of deformation twinning in Ti-6Al-2Mo and Ti-6Al-3Nb.Furthermore,deformation twinning facilitated the dislocation motion inαgrains with hard orientations.The increased dislocation mobility and deformation twinning were responsible for the stronger crack resistance as well as the higher impact toughness of Ti-6Al-2Mo and Ti-6Al-3Nb alloys. | Shixing Huang Qinyang Zhao Yongqing Zhao Cheng Lin Cong Wu Weiju Jia Chengliang Mao Vincent Ji | 2021 | Journal of Materials Science & Technology2021，，20： | 0 |
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