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| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | Gastric cancer: Epidemiology, risk factors and prevention strategies显示文摘Gastric cancer(GC) is a global health problem, with more than 1 million people newly diagnosed with GC worldwide each year. GC is more prevalent in less developed countries than in more developed countries. About half of all GC cases worldwide occur in East Asia, notably China. Globally, overall incidence rates of GC are declining, which is potentially attributed to a decrease in Helicobacter pylori(H. pylori) infection and the use of refrigeration to preserve foods rather than salt. GC is a multifactorial disease, and its occurrence and development were impacted by environmental and genetic factors. H. pylori infection is the primary risk factor for GC, especially for non-cardia. The prognosis of GC is poor due to stages at the first diagnosis. The 5-year survival rate is less than 10% when patients are diagnosed at an advanced stage, but the rate is as high as 85% if patients are detected at an earlier stage. Endoscopic screening can potentially prevent GC by early diagnosis and early treatment and has been widely adopted in screening programs in East Asian countries, such as Japan and Korea. This review summarizes updated epidemiological aspects, risk factors, and prevention strategies of GC in recent years to help researchers determine the most effective intervention strategies for reducing risk of GC. | Lei Yang Xiangji Ying Shuo Liu Guoqing Lyu Zekuan Xu Xi Zhang Huichao Li Qingyu Li Ning Wang Jiafu Ji | 2020 | Chinese Journal of Cancer Research2020，32，6： | 52 |
| 3 | Synthesis of Porous NiO Nanocrystals with Controllable Surface Area and Their Application as Supercapacitor Electrodes显示文摘We report a facile way to grow various porous NiO nanostructures including nanoslices,nanoplates,and nanocolumns,which show a structure-dependence in their specific charge capacitances.The formation of controllable porosity is due to the dehydration and re-crystallization of β-Ni(OH)_(2) nanoplates synthesized by a hydrothermal process.Thermogravimetric analysis shows that the decomposition temperature of the β-Ni(OH)_(2) nanostructures is related to their morphology.In electrochemical tests,the porous NiO nanostructures show stable cycling performance with retention of specific capacitance over 1000 cycles.Interestingly,the formation of nanocolumns by the stacking of β-Ni(OH)_(2) nanoslices/plates favors the creation of small pores in the NiO nanocrystals obtained after annealing,and the surface area is over five times larger than that of NiO nanoslices and nanoplates.Consequently,the specific capacitance of the porous NiO nanocolumns(390 F/g)is significantly higher than that of the nanoslices(176 F/g)or nanoplates(285 F/g)at a discharge current of 5 A/g.This approach provides a clear illustration of the process-structure-property relationship in nanocrystal synthesis and potentially offers strategies to enhance the performance of supercapacitor electrodes. | Xiaojun Zhang Wenhui Shi Jixin Zhu Weiyun Zhao Jan Ma Subodh Mhaisalkar Tuti Lim Maria Yanhui Yang Hua Zhang Huey Hoon Hng Qingyu Yan | 2010 | Nano Research2010，3，9： | 24 |
| 4 | Cloning, expression and biocharacterization of OfCht5, the chitinase from the insect Ostrinia furnacalis显示文摘Chitinase 在几丁质催化 -1,4-glycosidic 连接并且由于它吸引了研究兴趣为 N 乙酰的准备是一个潜在的杀虫剂目标和一个酶的工具 -- D-glucosamine。一只单个昆虫包含编码 chitinases 的多重基因,它在域体系结构,表达式模式,生理的角色和生物化学的性质变化。此处, OfCht5, glycoside hydrolase 家庭从普遍鳞翅类的害虫 Ostrinia furnacalis 的 18 chitinase,被克隆,在酵母 Pichia pastoris 表示了并且生物化学地在一次尝试描绘了便于害虫控制和 biomaterial 准备。互补 DNA 顺序分析显示 OfCHT5 由 1 665-bp 核苷酸的一个开的读物框架组成了。系统发生的分析建议 OfCht5 属于这个组我昆虫 chitinases。在 Pichia pastoris 的 OfCht5 的表示与甲醇在正式就职的 120 h 以后导致了最高特定的活动。通过纯化的二步,由铵硫酸盐降水和金属 chelating 层析组成, recombinant OfCht5 的大约 7 mg 从 1 L 文化上层清液被净化到同质。OfCht5 有效地把胶体的几丁质变换成 chitobiose,但是向几丁质举办了相对低的活动。什么时候 chitooligosaccharides [(GlcNAc ) n, n= 36 ] 被用作底层, OfCht5 被观察拥有最高催化的效率参数向(GlcNAc ) 4 并且 predominantely hydrolyzed 从非减少的结束的第二张 glycosidic 契约。和 -N-acetyl-D-hexosaminidase OfHex1, OfCht5 在产出 N 乙酰的几丁质降级完成了它的最高的效率 -- D-glucosamine,珍贵药理学试剂和食物补充,在在 9 的范围的 OfCht5 对 OfHex1 的臼齿的集中比率以内:115:1。这个工作为杀虫剂和另外的应用提供一种选择给 chitinase 的存在准备。 | Qingyue Wu Tian Liu Qing Yang | 2013 | Insect Science2013，20，2： | 19 |
| 5 | Carbon nanotube-polypyrrole core-shell sponge and its application as highly compressible supercapacitor electrode显示文摘 | Peixu Li Enzheng Shi Yanbing Yang Yuanyuan Shang Qingyu Peng Shiting Wu Jinquan Wei Kunlin Wang Hongwei Zhu Quan Yuan Anyuan Cao Dehai Wu | 2014 | Nano Research2014，7，2： | 10 |
| 6 | Plasma metabolomic and lipidomic alterations associated with COVID-19显示文摘The pandemic of the coronavirus disease 2019(COVID-19)has become a global public health crisis.The symptoms of COVID-19 range from mild to severe,but the physiological changes associated with COVID-19 are barely understood.In this study,we performed targeted metabolomic and lipidomic analyses of plasma from a cohort of patients with COVID-19 who had experienced different symptoms.We found that metabolite and lipid alterations exhibit apparent correlation with the course of disease in these patients,indicating that the development of COVID-19 affected their whole-body metabolism.In particular,malic acid of the TCA cycle and carbamoyl phosphate of the urea cycle result in altered energy metabolism and hepatic dysfunction,respectively.It should be noted that carbamoyl phosphate is profoundly down-regulated in patients who died compared with patients with mild symptoms.And,more importantly,guanosine monophosphate(GMP),which is mediated not only by GMP synthase but also by CD39 and CD73,is significantly changed between healthy subjects and patients with COVID-19,as well as between the mild and fatal cases.In addition,dyslipidemia was observed in patients with COVID-19.Overall,the disturbed metabolic patterns have been found to align with the progress and severity of COVID-19.This work provides valuable knowledge about plasma biomarkers associated with COVID-19 and potential therapeutic targets,as well as an important resource for further studies of the pathogenesis of COVID-19. | Di Wu Ting Shu Xiaobo Yang Jian-Xin Song Mingliang Zhang Chengye Yao Wen Liu Muhan Huang Yuan Yu Qingyu Yang Tingju Zhu Jiqian Xu Jingfang Mu Yaxin Wang Hong Wang Tang Tang Yujie Ren Yongran Wu Shu-Hai Lin Yang Qiu Ding-Yu Zhang You Shang Xi Zhou | 2020 | National Science Review2020，7，7： | 9 |
| 7 | Graphene and cobalt phosphide nanowire composite as an anode material for high performance lithium-ion batteries显示文摘合成一经由一个灵巧的热水的方法的磷化物 nanowires 和减少的 graphene 氧化物(表示 CoP/RGO ) 与随后的退火步相结合的钴合成被报导。结果合成介绍大特定的表面区域和提高的电导率,它能有效地便于充电运输并且在 lithiation/de-lithiation 过程期间在体积提供变化。作为结果, CoP/RGO nanocomposite 表明 960 | Jun Yang Yu Zhang Chencheng Sun Hongzheng Liu Laiquan Li Weili Si Wei Huang Qingyu Yan Xiaochen Dong | 2016 | Nano Research2016，9，3： | 8 |
| 8 | Inverse opal manganese dioxide constructed by few-layered ultrathin nanosheets as high-performance cathodes for aqueous zinc-ion batteries显示文摘Considering the high safety,low-cost and high capacity,aqueous zinc ion batteries have been a potential candidate for energy storage ensuring smooth electricity supply.Herein,we have synthesized inverse opal manganese dioxide constructed by few-layered ultrathin nanosheets by a solution template method at mild temperature.The ultrathin nanosheets with the thickness as small as 1 nm are well separated without obvious aggregation.Used as cathode material for aqueous zinc ion batteries,the few-layered ultrathin nanosheets combined with the inverse opal structure guarantee excellent performance.A high specific discharge capacity of 262.9 mAh·g^-1 is retained for the 100th cycle at a current density of 300 mA·g^-1 with a high capacity retention of 95.6%.A high specific discharge capacity of 121 mAh·g^-1 at a high current density of 2,000 mA·g^-1 is achieved even after 5,000 long-term cycles.The ex-situ X-ray diffraction (XRD) patterns,selected-area electron diffraction (SAED) patterns and high-resolution transmission electron microscopy (HRTEM) results demonstrate that the discharge/charge processes involve the reversible formation of zinc sulfate hydroxide hydrate on the cathode while in-plane crystal structure of the layered bimessite MnO2 could be maintained.This unique structured MnO2 is a promising candidate as cathode material for high capacity,high rate capability and long-term aqueous zinc-ion batteries. | Hao Ren Jin Zhao Lan Yang Qinghua Liang Srinivasan Madhavi Qingyu Yan | 2019 | Nano Research2019，12，6： | 8 |
| 9 | Highly Efficient and Stable Hydrogen Production in All pH Range by Two-Dimensional Structured Metal-Doped Tungsten Semicarbides显示文摘Transition-metal-doped tungsten semicarbide nanosheets(M-doped W_(2)C NSs,M=Fe,Co,and Ni)have been synthesized through carburization of the mixture of tungsten trioxide,polyvinylpyrrolidone,and metal dopant.Te nanosheets grow directly on the W mesh and have the lateral dimension of several hundreds of nm to a few�m with a thickness of few tens nm.It is demonstrated that the M-doped W_(2)C NSs exhibit superior electrocatalytic activity for hydrogen evolution reaction(HER).Impressively,the Nidoped W_(2)C NSs(2 at%Ni)with the optimized HER activity show extremely low onset overpotentials of 4,9,and 19 mV and modest Tafel slopes of 39,51,and 87 mV dec−1 in acidic(pH=0),neutral(pH=7.2),and basic(pH=14)solutions,respectively,which is close to the commercial Pt/C catalyst.Density functional theory(DFT)calculations also demonstrate that the Gibbs free energy for H adsorption of Ni-W_(2)C is much closer to the optimal valueG_(H∗)=-0.073 eV as compared to-0.16 eV of W_(2)C.Furthermore,nearly 100%Faradaic efciency and long-term stability are obtained in those environments.Tis realization of highly tolerant metal semicarbide catalyst performing on par with commercial Pt/C in all range of pH ofers a key step towards industrially electrochemical water splitting. | Edison H.Ang Khang N.Dinh Xiaoli Sun Ying Huang Jun Yang Zhili Dong Xiaochen Dong Wei Huang Zhiguo Wang Hua Zhang Qingyu Yan | 2019 | Research2019，，1： | 7 |
| 10 | Influences of accumulated mileage and technological changes on emissions of regulated pollutants from gasoline passenger vehicles显示文摘In this study, the influences of accumulated mileage(deterioration) and technological changes(emission standards) on emission factors(EFs) of regulated pollutants(CO, HC, and NO_x) from gasoline passenger vehicles were investigated based on Inspection and Maintenance(I/M) data using the chassis dynamometer method. The accumulated mileage of passenger vehicles was significantly linearly correlated with vehicle age. For most cases,the average EFs of CO, HC and NO_x were significantly linearly correlated with accumulated mileage, indicating that emission deterioration had a significant impact on pollutant EFs.Implemented emission standards markedly influenced the EFs of regulated pollutants, and EFs markedly decreased with progressing emission standards. The present study also compared EFs of regulated pollutants between this study and the International vehicle emission(IVE) model, and marked differences in EFs were seen with variations in emission standards, vehicle types and accumulated mileage; NO_x EFs in this study were higher than in the IVE model. The results provide new insight into estimating regulated pollutant emissions using the IVE model. | Qingyu Zhang Juwang Fan Weidong Yang Fang Ying Zhen Bao Yi Sheng Cheng Lin Xuan Chen | 2018 | Journal of Environmental Sciences2018，30，9： | 5 |
| 11 | Occurrence, spatial distribution and ecological risks of antibiotics in soil in urban agglomeration显示文摘Antibiotics in soil environment are regarded as emerging pollutants and have introduced increasing risks to soil ecosystem and human health in rapid urbanization areas. Identifying the occurrence and spatial variability of antibiotics in soils is an urgent issue in sustaining soil security. In this study, antibiotics in soils were investigated and analyzed in BeijingTianjin-Hebei urban agglomeration. The occurrence, spatial distribution, and related affecting factors of antibiotics in soils were identified and ecological risks of antibiotics in soil environment were assessed. Results showed that(1) The mean concentration of soil antibiotics in Beijing-Tianjin-Hebei urban agglomeration was 21.79 μg/kg. Land use substantially affected the occurrence and concentration of antibiotics in soils. Concentrations of antibiotics in cropland and orchard soils were 2-3 times higher than the other land use types.(2)The concentrations of antibiotics in soils in Beijing-Tianjin-Hebei urban agglomeration presented a spatial pattern of high values in southeast, and low values in northwest. Spatial variability of antibiotics in soils was closely related to the application of organic fertilizer and wastewater irrigation as well as topographical features. Furthermore, soil properties and land management policy had substantial influences on soil antibiotics, and soil heavy metals may aggravate the accumulation of antibiotics in soils.(3) Ecological risks assessment of antibiotics in soils demonstrated that erythromycin(ERY), sulfamethoxazole(SMX), and doxycycline(DOX) may introduce high risks to soil ecosystem health, and more attention should be paid to the areas with intensive human activities that had potential high risk to soil ecosystem health. This study suggests that scientific land and soil management should be considered to prevent soil antibiotic pollution and sustain soil security in urban agglomeration. | Min Li Lei Yang Haw Yen Fangkai Zhao Xinmiao Wang Tianhui Zhou Qingyu Feng Liding Chen | 2023 | Journal of Environmental Sciences2023，，3： | 5 |
| 12 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection显示文摘Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined.Here,we exploited antibody cooperativity to develop a therapeutic antibody cocktail against SARS-CoV-2.On the basis of our previously identified humanized cross-neutralizing antibody H014,we systematically an a lyzed a fully human n aive antibody library and rationally identified a potent neutralizing antibody partner,P17,which confers effective protection in animal model.Cryo-EM studies dissected the nature of the P17 epitope,which is SARS-CoV-2 specific and distinctly different from that of HOI4.High-resolution structure of the SARS-CoV-2 spike in complex with HOM and P17,together with functional investigations revealed that in a two-antibody cocktail,synergistic neutralization was achieved by S1 shielding and conformational locking,thereby blocking receptor attachment and viral membrane fusion,conferring high potency as well as robustness against viral mutation escape.Furthermore,cluster analysis identified a hypothetical 3rd antibody partner for further reinforcing the cocktail as pan-SARS-CoVs therapeutics. | Hangping Yao Yao Sun Yong-Qiang Deng Nan Wang Yongcong Tan Na-Na Zhang Xiao-Feng Li Chao Kong Yan-Peng Xuc Qi Chen Tian-Shu Cao Hui Zhao Xintian Yan Lei Cao Zhe Lv Dandan Zhu Rui Feng Nanping Wu Wenhai Zhang Yuhao Hu Keda Chen Rong-Rong Zhang Qingyu Lv Shihui Sun Yunhua Zhou Run Yan Guan Yang Xinglu Chanjuan Liu Xiangyun Lu Linfang Cheng Hongying Qiu Xing-Yao Huang Tianhao Weng Danrong Shi Weidong Jiang Junbin Shao Lei Wang Jie Zhang Tao Jiang Guojun Lang Cheng-Feng Qinc Lanjuan Li Xiangxi Wang | 2021 | Cell Research2021，31，1： | 5 |
| 13 | The latest process and challenges of microwave dielectric ceramics based on pseudo phase diagrams显示文摘The explosive process of 5G communication evokes the urgent demand of miniaturized and integrated dielectric ceramics filter It is a pressing need to advance the development of dielectric ceramics utilization of emerging technology to design new materials and understand the polarization mechanism.This review provides the summary of the study of microwave dielectric ceramics(MWDCs)sintered higher than 1000℃ from 2010 up to now,with the purpose of taking a broad and historical view of these ceramics and illustrating research directions.To date,researchers endeavor to explain the structure-property relationship of ceramics with multitude of approaches and design a new formula or strategy to obtain excellent microwave dielectric properties.There are variety of factors that impact the permittivity,dielectric loss,and temperature stability of dielectric materials,covering intrinsic and extrinsic factors.Many of these factors are often intertwined,which can complicate new dielectric material discovery and the mechanism investigation.Because of the various ceramics systems,pseudo phase diagram was used to classify the dielectric materials based on the composition.In this review,the ceramics were firstly divided into ternary systems,and then brief description of the experimental probes and complementary theoretical methods that have been used to discern the intrinsic polarization mechanisms and the origin of intrinsic loss was mentioned.Finally,some perspectives on the future outlook for high-temperature MWDCs were offered based on the synthesis method,characterization techniques,and significant theory developments. | Hongcheng YANG Shuren ZHANG Hongyu YANG Qingyu WEN Qiu YANG Ling GUI Qian ZHAO Enzhu LI | 2021 | Journal of Advanced Ceramics2021，10，5： | 5 |
| 14 | Circular cladding waveguides in Pr:YAG fabricated by femtosecond laser inscription:Raman,luminescence properties and guiding performance显示文摘We report on the fabrication of circular cladding waveguides with cross-section diameters of 60−120μm in Pr:YAG crystal by applying femtosecond laser inscription.The fabricated waveguides present 2D guidance on the cross-section and fairly low propagation losses.Multiple high-order guiding modes are observed in waveguides with different diameters.Corresponding simulation results reveal the origin of a specific kind of guiding modes.Confocal micro-Raman(μ-Raman)experiments demonstrate the modification effects in femtosecond laser affected areas and ascertain the refractive index induced guiding mechanism.In addition,luminescence emission properties of Pr3+ions at waveguide volume are well preserved during the femtosecond laser inscription process,which may result in a potential high-power visible waveguide laser. | Quanxin Yang Hongliang Liu Shan He Qingyu Tian Bin Xu Pengfei Wu | 2021 | Opto-Electronic Advances2021，4，2： | 4 |
| 15 | Targeting PFKL with penfluridol inhibits glycolysis and suppresses esophageal cancer tumorigenesis in an AMPK/FOXO3a/BIM-dependent manner显示文摘As one of the hallmarks of cancer,metabolic reprogramming leads to cancer progression,and targeting glycolytic enzymes could be useful strategies for cancer therapy.By screening a small molecule library consisting of 1320 FDA-approved drugs,we found that penfluridol,an antipsychotic drug used to treat schizophrenia,could inhibit glycolysis and induce apoptosis in esophageal squamous cell carcinoma(ESCC).Gene profiling and Ingenuity Pathway Analysis suggested the important role of AMPK in action mechanism of penfluridol.By using drug affinity responsive target stability(DARTS)technology and proteomics,we identified phosphofructokinase,liver type(PFKL),a key enzyme in glycolysis,as a direct target of penfluridol.Penfluridol could not exhibit its anticancer property in PFKL-deficient cancer cells,illustrating that PFKL is essential for the bioactivity of penfluridol.High PFKL expression is correlated with advanced stages and poor survival of ESCC patients,and silencing of PFKL significantly suppressed tumor growth.Mechanistically,direct binding of penfluridol and PFKL inhibits glucose consumption,lactate and ATP production,leads to nuclear translocation of FOXO3a and subsequent transcriptional activation of BIM in an AMPK-dependent manner.Taken together,PFKL is a potential prognostic biomarker and therapeutic target in ESCC,and penfluridol may be a new therapeutic option for management of this lethal disease. | Cancan Zheng Xiaomei Yu Yiyao Liang Yidong Zhu Yan He Long Liao Dingkang Wang Yanming Yang Xingfeng Yin Ang Li Qingyu He Bin Li | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 4 |
| 16 | Ameliorating effects of Inonotus obliquus on high fat diet-induced obese rats显示文摘根据从的数据,将在在一年 2030 的世界上有 21.6 亿过重和 11.2 亿个肥胖的个人[1 ] ,它提起多重疾病的风险例如高血压,癌症的糖尿病,心血管的疾病,和几种类型[2,3 ] 。肥胖被看作新陈代谢的混乱,它被高精力吸入主要导致。在哺乳动物,过量精力首先在脂肪质的织物作为 triglyceride (TG ) 被存储。在过去的十年,调整 adipogenesis 的过程的众多的分子很好被记录了。Peroxisome 激活 proliferator 的受体(PPAR-) 为脂肪质的织物的累积被要求并且贡献肥胖[4 ] 。甾醇规章的元素绑定蛋白质(SREBP ) 作为激活胆固醇和丰满的酸合成的全部节目的抄写因素的一个家庭被识别了[5 ] 。Glyceraldehydes 3 磷酸盐 acyltransferase (GPAT ) 和 diacylglycerol acyltransferase (DGAT ) 广泛地在哺乳动物的纸巾被表示并且催化第一并且在 TG 合成的最后的步,分别地[6 ] 。因此,这些分子可以是为肥胖和类脂化合物新陈代谢的评估的大目标。最近,阳光等。[7 ] 证明了在糖尿病的老鼠的类脂化合物的浆液层次显著地与 Inonotus obliquus 的文化肉汤的干燥的事在 3 星期的治疗以后被减少。李和 Hyun [8 ] 证明水摘录从我。obliquus 减少了高脂肪的饮食的胖重量喂的肥胖的老鼠。因此,我们对什么进一步感兴趣,是怎么能我。obliquus 摘录影响类脂化合物新陈代谢并且什么是位于这反肥胖效果下面的可能的机制。在现在的学习,我们造了一个高脂肪的导致食谱的老鼠模型。 | Tao Wu Qingyu Shu Kai Yang Xiaoxian Xie Xia Wang Yangling Wang Anqi Guo Nate Y-uan Binggong Zhao Binbin Chi QiaobeiWu Zhengwei Fu | 2015 | Acta Biochimica et Biophysica Sinica2015，47，9： | 4 |
| 17 | Forecasting Scenario Generation for Multiple Wind Farms Considering Time-series Characteristics and Spatial-temporal Correlation显示文摘Scenario forecasting methods have been widely studied in recent years to cope with the wind power uncertainty problem. The main difficulty of this problem is to accurately and comprehensively reflect the time-series characteristics and spatial-temporal correlation of wind power generation. In this paper, the marginal distribution model and the dependence structure are combined to describe these complex characteristics. On this basis, a scenario generation method for multiple wind farms is proposed. For the marginal distribution model, the autoregressive integrated moving average-generalized autoregressive conditional heteroskedasticity-t (ARIMA-GARCH-t) model is proposed to capture the time-series characteristics of wind power generation. For the dependence structure, a time-varying regular vine mixed Copula (TRVMC) model is established to capture the spatial-temporal correlation of multiple wind farms. Based on the data from 8 wind farms in Northwest China, sufficient scenarios are generated. The effectiveness of the scenarios is evaluated in 3 aspects. The results show that the generated scenarios have similar fluctuation characteristics, autocorrelation, and crosscorrelation with the actual wind power sequences. | Qingyu Tu Shihong Miao Fuxing Yao Yaowang Li Haoran Yin Ji Han Di Zhang Weichen Yang | 2021 | Journal of Modern Power Systems and Clean Energy2021，9，4： | 3 |
| 18 | Low Sulfur Low Olefin Gasoline Production by RIDOS Technology显示文摘By analysis of the component and structure of a real high olefinic FCC naphtha, a technology of deep desulfurization and olefin saturation with minimal octane loss is developed, which is named RIDOS. The multi functions of RIDOS technology are achieved by using a series of new catalysts, which show the good feed adaptability and operation flexibility. The results of the first commercial RIDOS unit showed that an ultra low sulfur (<10 μg/g), low olefin(<20%) gasoline was produced, while the road octane number lost only 1.3 unit. RIDOS technology provides the possibility for producing the clean fuels meeting most strict specifications. | Li Dadong 1, Shi Yahua 1, Yang Qingyu 2 (1. Research Institute of Petroleum Processing, SINOPEC, Beijing 100083 2. Yanshan Petrochemical Company, SINOPEC, Beijing 102503) | 2003 | 工程科学(英文版)2003，1，2： | 3 |
| 19 | Parameters measurement for the thermal neutron beam in the thermal column hole of Xi'an pulse reactor显示文摘The distribution of the neutron spectra in the thermal column hole of Xi'an pulse reactor was measured with the time-of-flight method.Compared with the thermal Maxwellian theory neutron spectra,the thermal neutron spectra measured is a little softer,and the average neutron energy of the experimental spectra is about 0.042±0.01 eV.The thermal neutron fluence rate at the front end of thermal column hole,measured with gold foil activation techniques,is about 1.18×105 cm-2 s-1.The standard uncertainty of the measured thermal neutron fluence is about 3%.The spectra-averaged cross section of 197Au(n,γ) determined by the experimental thermal neutron spectra is(92.8±0.93) ×10-24 cm2. | ShuHuan Liu XinBiao Jiang YunHong Zhong QingYu Yu WenShou Zhang Kai Wang Jun Yang YingLin Wang | 2010 | Science China(Technological Sciences)2010，53，5： | 2 |
| 20 | From similarity perspective: a robust collaborative filtering approach for service recommendations显示文摘Collaborative filtering (CF) is a technique commonly used for personalized recommendation and Web service quality-of-service (QoS) prediction. However, CF is vulnerable to shilling attackers who inject fake user profiles into the system. In this paper, we first present the shilling attack problem on CF-based QoS recommender systems for Web services. Then, a robust CF recommendation approach is proposed from a user similarity perspective to enhance the resistance of the recommender systems to the shilling attack. In the approach, the generally used similarity measures are analyzed, and the DegSim (the degree of similarities with top k neighbors) with those measures is selected for grouping and weighting the users. Then, the weights are used to calculate the service similarities/differences and predictions. We analyzed and evaluated our algorithms using WS-DREAM and Movielens datasets. The experimental results demonstrate that shilling attacks influence the prediction of QoS values, and our proposed features and algorithms achieve a higher degree of robustness against shilling attacks than the typical CF algorithms. | Min GAO Bin LING Linda YANG Junhao WEN Qingyu XIONG Shun LI | 2019 | Frontiers of Computer Science2019，13，2： | 2 |
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