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| 1 | Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known liver-restorative herb Polygonum multiflorum显示文摘草药的药最近在美国作为导致药的肝损害(DILI ) 的第二个很普通的原因被认出了。然而,识别一些植物的 DILI 诱发性的可靠方法例如 Heshouwu (蓼 multiflorum 的弄干的根) ,留下缺乏。在这研究,有肝机能障碍和 Heshouwu DILI 的 147 个报导文学的案例的 12 307 个住院病人的一个总数被屏蔽。一个一般算法仅仅显示了那 22.5%(9/40 ) 并且(45/147 ) 分别地, 30.6% 所有住院和文学案例报告表明 Heshouwu 的 DILI 诱发性的高概率。由对比,(19/20 )95% 生药学,植物化学,和 metabolomic 有希望地调查的所有情况测试展出高度可能的诱发性,包括不正确地以前被归因的一个病人和从由 pharmacognostic 证据的 Heshouwu 诱发性被排除的一个案例。污染也是的毒素(重金属,杀虫剂,和 mycotoxins ) 从 Heshouwu DILI 诱发性排除了。为 Heshouwu DILI 诊断地址安全的这些屏蔽方法的客观性担心考虑包含芪的草药的药和饮食的补充。 | Jiabo Wang Zhijie Ma Ming Niu Yun Zhu Qingsheng Liang Yanling Zhao Jingyuan Song Zhaofang Bai Yaming Zhang Ping Zhang Na Li Yakun Meng Qi Li Lushan Qin Guangju Teng Junling Cao Baosen Li Shilin Chen Yonggang Li Zhengsheng Zou Honghao Zhou Xiaohe Xiao | 2015 | Frontiers of Medicine2015，9，4： | 47 |
| 2 | Comprehensive power-supply planning for active distribution system considering cooling,heating and power load balance显示文摘An active distribution system power-supply planning model considering cooling,heating and power load balance is proposed in this paper.A regional energy service company is assumed to be in charge of the investment and operation for the system in the model.The expansion of substations,building up distributed combined cooling,heating and power(CCHP),gas heating boiler(GHB)and air conditioner(AC)are included as investment planning options.In terms of operation,the load scenarios are divided into heating,cooling and transition periods.Also,the extreme load scene is included to assure the power supply reliability of the system.Numerical results demonstrate the effectiveness of the proposed model and illustrate the economic benefits of applying distributed CCHP in regional power supply on investment and operation. | Xinwei SHEN Yingduo HAN Shouzhen ZHU Jinghong ZHENG Qingsheng LI Jing NONG | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，4： | 24 |
| 3 | Alkaline modification of ZSM-5 catalysts for methanol aromatization: The effect of the alkaline concentration显示文摘ZSM-5 催化剂的物理性质上并且在他们为到 aromatics 变换的甲醇的活动的碱的处理的效果被调查了。一个温和碱的处理(0.2 和 0.3 mol/L NaOH ) 在酸味上没有明显的效果在父母沸石创造了 mesopores。mesopores 的存在为 aromatics 给催化剂更长的一生和更高的选择。有 0.4 mol/L NaOH 的处理减少了 Br 的数字 ? nsted 酸地点由于 dealumination 和 desilication,它导致了更低的释放率。另外,更多的 mesopores 比与温和碱的处理被生产。作为结果,与 0.4 mol/L NaOH 对待的样品的一生是乘父母 ZSM-5 的的几乎五。有更高碱的集中(0.5 mol/L ) 的处理极大地减少了 Br 的数字 ? nsted 酸地点和导致不完全的甲醇变换的 micropores 的数字。当碱对待的催化剂与酸被洗时,一些孔被恢复,为 aromatics 的选择的细微增加被获得。 | Zhenhao Wei Tengfei Xia Minghui Liu Qingsheng Cao Yarong Xu Kake Zhu Xuedong Zhu | 2015 | Frontiers of Chemical Science and Engineering2015，9，4： | 18 |
| 4 | Effects of particle size on crushing and deformation behaviors of rockfill materials显示文摘Strength and deformation behaviors of rockfill materials,key factors for determining the stability of dams,pertain strongly to the grain crushing characteristics.In this study,single-particle crushing tests were carried out on rockfill materials with nominal particle diameters of 2.5 mm,5 mm and 10 mm to investigate the particle size effect on the single-particle strength and the relationship between the characteristic stress and probability of non-failure.Test data were found to be described by the Weibull distribution with the Weibull modulus of 3.24.Assemblies with uniform nominal grains were then subjected to one-dimensional compression tests at eight levels of vertical stress with a maximum of 100 MPa.The yield stress in one-dimensional compression tests increased with decreasing the particle size,which could be estimated from the single-particle crushing tests.The void ratio-vertical stress curve could be predicted by an exponential function.The particle size distribution curve increased obviously with applied stresses less than 16 MPa and gradually reached the ultimate fractal grading.The relative breakage index became constant with stress up to 64 MPa and was obtained from the ultimate grading at the fractal dimension(a?2:7).A hyperbolical function was also found useful for describing the relationship between the relative breakage index and input work during one-dimensional compression tests. | Yang Xiao Minqiang Meng Ali Daouadji Qingsheng Chen ZhijunWu Xiang Jiang | 2020 | Geoscience Frontiers2020，11，2： | 17 |
| 5 | Lymph node metastasis in early gastric cancer显示文摘 | Chen Rong He Qingsheng Cui Jianxin Bian Shibo Chen Lin | 2014 | Chinese Medical Journal2014，，3： | 15 |
| 6 | Brown adipose tissue transplantation improves whole-body energy metabolism显示文摘 | Qingsheng Chi Dehua Wang Zhaoyun Zhang Chenzhong Li Yiming Li Yaoming Xue John R Speakma Wanzhu Jin Xiaomeng Liu Zongji Zhen Xiaoming Zhu Minghui Meng Lan Li Yanyan Shen | 2013 | Cell Research2013，23，6： | 11 |
| 7 | Overburden fracture evolution laws and water-controlling technologies in mining very thick coal seam under water-rich roof显示文摘Considering the danger of water inrush in mining very thick coal seam under water-rich roof in Majialiang Coal Mine,the universal discrete element(UDEC)software was used to simulate the overburden fracture evolution laws when mining 4#coal seam.Besides,this study researched on the influence of face advancing length,speed and mining height on the height of the water flowing fractured zones(HWFFZ),and analyzed the correlation of face advancing length and change rules of aquifer water levels and goaf water inflow.Based on those mentioned above,this research proposed the following water-controlling technologies:draining the roof water before mining,draining goaf water,reasonable advancing speed and mining thickness.These water-controlling technologies were successfully used in the feld,thus ensured safely mining the very thick coal seam under water-rich roof. | Zhang Youxi Tu Shihao Bai Qingsheng Li Jianjun | 2013 | International Journal of Mining Science and Technology2013，23，5： | 8 |
| 8 | Genetic algorithms for determining the parameters of cellular automata in urban simulation显示文摘This paper demonstrates that cellular automata(CA) can be a useful tool for analyzing the process of many geographical phenomena.There are many studies on using CA to simulate the evolution of cites.Urban dynamics is determined by many spatial variables.The contribution of each spatial variable to the simulation is quantified by its parameter or weight.Calibration procedures are usually required for obtaining a suitable set of parameters so that the realistic urban forms can be simulated.Each pa-rameter has a unique role in controlling urban morphology in the simulation.In this paper,these pa-rameters for urban simulation are determined by using empirical data.Genetic algorithms are used to search for the optimal combination of these parameters.There are spatial variations for urban dynam-ics in a large region.Distinct sets of parameters can be used to represent the unique features of urban dynamics for various subregions.A further experiment is to evaluate each set of parameters based on the theories of compact cities.It is considered that the better set of parameters can be identified ac-cording to the utility function in terms of compact development.This set of parameters can be cloned to other regions to improve overall urban morphology.The original parameters can be also modified to produce more compact urban forms for planning purposes.This approach can provide a useful ex-ploratory tool for testing various planning scenarios for urban development. | LI Xia YANG QingSheng LIU XiaoPing | 2007 | Science China Earth Sciences2007，50，12： | 8 |
| 9 | Hydraulic support crushed mechanism for the shallow seam mining face under the roadway pillars of room mining goaf显示文摘While the fully-mechanized longwall mining technology was employed in a shallow seam under a room mining goaf and overlained by thin bedrock and thick loose sands, the roadway pillars in the abandoned room mining goaf were in a stress-concentrated state, which may cause abnormal roof weighting, violent ground pressure behaviours, even roof fall and hydraulic support crushed(HSC) accidents. In this case,longwall mining safety and efficiency were seriously challenged. Based on the HSC accidents occurred during the longwall mining of 3-1-2 seam, which locates under the intersection zone of roadway pillars in the room mining goaf of 3-1-1 seam, this paper employed ground rock mechanics to analyse the overlying strata structure movement rules and presented the main influence factors and determination methods for the hydraulic support working resistance. The FLAC3 D software was used to simulate the overlying strata stress and plastic zone distribution characteristics. Field observation was implemented to contrastively analyse the hydraulic support working resistance distribution rules under the roadway pillars in strike direction, normal room mining goaf, roadway pillars in dip direction and intersection zone of roadway pillars. The results indicate that the key strata break along with rotations and reactions of the coal pillars deliver a larger concentrated load to the hydraulic support under intersection zone of roadway pillars than other conditions. The ‘‘overburden strata-key strata-roadway pillars-immediate roof' integrated load has exceeded the yield load that leads to HSC accidents. Findings in HSC mechanism provide a reasonable basis for shallow seam mining, and have important significance for the implementation of safe and efficient mining. | Wang Fangtian Duan Chaohua Tu Shihao Liang Ningning Bai Qingsheng | 2017 | International Journal of Mining Science and Technology2017，27，5： | 8 |
| 10 | MicroRNAs are key regulators controlling iNKT and regulatory T-cell development and function显示文摘MicroRNAs(miRNAs)are an abundant class of evolutionarily conserved,small,non-coding RNAs that post-transcriptionally regulate expression of their target genes.Emerging evidence indicates that miRNAs are important regulators that control the development,differentiation and function of different immune cells.Both CD4^(+)CD25^(+)Foxp3^(+) regulatory T(Treg)cells and invariant natural killer T(iNKT)cells are critical for immune homeostasis and play a pivotal role in the maintenance of self-tolerance and immunity.Here,we review the important roles of miRNAs in the development and function of iNKT and Treg cells. | Li Zhou Jang-June Park Quanhui Zheng Zheng Dong Qingsheng Mi | 2011 | Cellular & Molecular Immunology2011，8，5： | 7 |
| 11 | Interaction between diet composition and gut microbiota and its impact on gastrointestinal tract health显示文摘A substantial amount of emerging research is indicating that the gut microbiota has a significant impact on human health.Alterations of gut microbiota have clear consequences on intestinal homeostasis,physiology,gut microbiome,immune system and host metabolic pathways.Diet composition plays an important role in the control of gut microbial populations and,thus,in the prevention,management and treatment of certain diseases such as cancer,diabetes.A comprehensive analysis of previously reported results revealed that the gut microbiota can be modulated by diet and the composition of gut microbiota can be influenced by various diet components.The symbiotic relationship between different gut microbial communities regulates the immune system and,therefore,any dysbiosis can dysregulate the immune system.Further research is needed to fully understand the mechanisms involved in the interactions between diet composition,gut microbiota and associated diseases. | Muhammad Shahid Riaz Rajoka Junling Shi Hafiza Mahreen Mehwish Jing Zhu Qi Li Dongyan Shao Qingsheng Huang Hui Yang | 2017 | Food Science and Human Wellness2017，6，3： | 7 |
| 12 | Characterization and mapping of a novel mutant sms1 (senescence and male sterility 1) in rice显示文摘Plant senescence plays diverse important roles in development and environmental responses.However,the molecular basis of plant senescence is remained largely unknown.A rice spontaneous mutant with the character of early senescence and male sterility (sms) was found in the breeding line NT10-748.In order to identify the gene SMS1 and the underlying mechanism,we preliminarily analyzed physiological and biochemical phenotypes of the mutant.The mutant contained lower chlorophyll content compared with the wild type control and was severe male sterile with lower pollen viability.Genetic analysis showed that the mutant was controlled by a single recessive gene.By the map-based cloning approach,we fine-mapped SMS1 to a 67 kb region between the markers Z3-4 and Z1-1 on chromosome 8 using 1,074 F2 recessive plants derived from the cross between the mutant sms1 (japonica) × Zhenshan 97 (indica),where no known gene involved in senescence or male sterility has been identified.Therefore the SMS1 gene will be a novel gene that regulates the two developmental processes.The further cloning and functional analysis of the SMS1 gene is under way. | Wenyi Yan Shenghai Ye Qingsheng Jin Longjun Zeng Yu Peng Dawei Yan Weibing Yang Donglei Yang Zuhua He Yanjun Dong Xiaoming Zhang | 2010 | Journal of Genetics and Genomics2010，37，1： | 6 |
| 13 | ANALYTICAL SOLUTIONS FOR A ONE-DIMENSIONAL CHEMO-MECHANICAL COUPLING PROBLEM显示文摘Chemo-mechanical coupling exists in a lot of intelligent materials including hydrogels, biological tissues and other soft materials. These materials are able to respond to external stimulus, such as temperature, chemical concentration, and pH value. In this paper, a one-dimensional theoretical model for chemo-mechanical coupling is proposed for analyzing the uniaxial stress/strain state of coupling materials. Based on the chemo-mechanical coupled governing equation, the displacement function and concentration function are derived and the stress and chemical potential are obtained. It is shown that the present chemo-mechanical theory can characterize the chemo-mechanical coupling behavior of intelligent materials. | Qingsheng Yang Hui Tian Qinghua Qin | 2014 | Acta Mechanica Solida Sinica2014，27，2： | 6 |
| 14 | Ability of lower teardrop edge to restore anatomical hip center height in total hip arthroplasty显示文摘 | Lu Yufeng Cheng Liming Guo Wanshou Yu Qingsheng Gao Fuqiang Zhang Qidong Liu Zhaohui Sun Wei Shi Zhencai | 2014 | Chinese Medical Journal2014，，22： | 5 |
| 15 | Theoretical analysis on the deformation characteristics of coal wall in a longwall top coal caving face显示文摘Against the background of analyzing coal wall stability in 14101 fully mechanized longwall top coal caving face in Majialiang coal mine,based on the torque equilibrium of the coal wall,shield support and the roof strata,an elastic mechanics model was established to calculate the stress applied on the coal wall.The displacement method was used to obtain the stress and deformation distributions of the coal wall.This study also researched the influence of support resistance,protective pressure to the coal wall,fracture position of the main roof and mining height on the coal wall deformation.The following conclusions are drawn:(1) The shorter the distance from the longwall face,the greater the vertical compressive stress and horizontal tensile stress borne by the coal wall.The coal wall is prone to failure in the form of compressive-shear and tension;(2) With increasing support resistance,the revolution angle of the main roof decreases linearly.As the support resistance and protective force supplied by the face guard increases,the maximum deformation of the coal wall decreases linearly;(3) As the face approaches the fracture position of the main roof,coal wall horizontal deformation increases significantly,and the coal wall is prone to instability;and(4) The best mining height of 14101 longwall face is 3.0 m. | Bai Qingsheng Tu Shihao Li Zhaoxin Tu Hongsheng | 2015 | International Journal of Mining Science and Technology2015，25，2： | 5 |
| 16 | Magnetic Structure of Archean Kongling Group from Yangtze Craton,South China显示文摘ThepaperissupportedbyNationalNaturalScienceFoundation,NationalEducationCommiteeandMinistryofGeologyandMineralResourcesofChina... | Liu Qingsheng Department of Applied Geophysics, China University of Geosciences, Wuhan 430074 Gao Shan Faculty of Earth Sciences, China University of Geosciences, Wuhan 430074 Xu Qidong Faculty of Earth Resources, China University of Geosciences, W | 1998 | Journal of Earth Science1998，17，2： | 5 |
| 17 | High-efficiency simultaneous extraction of rare earth elements and iron from NdFeB waste by oxalic acid leaching显示文摘Iron can not be recovered at high value because only rare earth elements are effectively recovered from NdFeB waste via oxidation roasting-hydrochloric acid leaching process.In this study,a new method for leaching NdFeB waste with oxalic acid was developed.The high-efficiency,simultaneous and high-value recovery of rare earth elements and iron was realized to simplify the process and improve the economic benefit.Results of the oxalic acid leaching experiments show that under the optimum leaching conditions at 90℃ for 6 h in the aqueous solution of oxalic acid(2 mol/L) with a liquid-solid ratio of60 mL/g,the iron leaching efficiency and precipitation rate of rare earth oxalate reach 93.89% and 93.17%,respectively.Rare earth oxalate and Fe(C_(2)O_(4))3^(3-) were left in the residue and the leaching solution,respectively.The leaching mechanism was further analyzed by characterising the leach residues obtained through X-ray powder diffraction(XRD) and scanning electron microscopy-energy dispersive X-ray spectroscopy(SEM-EDS).Results of the leaching kinetics study indicate that the process of oxalic acid leaching follows the shrinking nucleus model,and the leaching kinetics model is controlled by the mixed factors of diffusion and chemical reaction.The leaching residue was calcined at 850℃ for 3 h and then decomposed into rare earth oxide,which can be directly used to prepare rare earth alloy via molten salt electrolysis.For the leaching solution,ferric oxalate solution was reduced using Fe powder to prepare the ferrous oxalate(FeC_(2)O_(4)-2H_(2)O). | Qingsheng Liu Tao Tu Hao Guo Huajin Cheng Xuezhong Wang | 2021 | Journal of Rare Earths2021，39，3： | 4 |
| 18 | Skull repair materials applied in cranioplasty: History and progress显示文摘The skull provides protection and mechanical support, and acts as a container for the brain and its accessory organs. Some defects in the skull can fatally threaten human life.Many efforts have been taken to repair defects in the skull, among which cranioplasty is the most prominent technique. To repair the injury, numerous natural and artificial materials have been adopted by neurosurgeons. Many cranioprostheses have been tried in the past decades, from autoplast to bioceramics. Neurosurgeons have been evaluating their advantages and shortages through clinical practice. Among those prostheses, surgeons gradually prefer bionic ones due to their marvelous osteoconductivity,osteoinductivity, biocompatibility, and biodegradability. Autogeneic bone has been widely recognized as the 'gold standard' for renovating large-sized bone defects. However, the access to this technique is restricted by limited availability and complications associated with its use. Many metal and polymeric materials with mechanical characteristics analogous to natural bones were consequently applied to cranioplasty. But most of them were unsatisfactory concerning osteoconductiion and biodegradability owe to their intrinsic properties. With the microstructures almost identical to natural bones, mineralized collagen has biological performance nearly identical to autogeneic bone, such as osteoconduction. Implants made of mineralized collagen can integrate themselves into the newly formed bones through a process called 'creeping substitution'. In this review, the authors retrospect the evolution of skull repair material applied in cranioplasty. The ultimate skull repair material should have microstructure and bioactive qualities that enable osteogenesis induction and intramembranous ossification. | Qingsheng Yu Lin Chen Zhiye Qiu Yuqi Zhang Tianxi Song Fuzhai Cui | 2017 | Translational Neuroscience and Clinics2017，3，1： | 4 |
| 19 | Molecular Weight Controllable Degradation of Laminaria japonica Polysaccharides and Its Antioxidant Properties显示文摘In this study, molecular weight controllable degradation of algal Laminaria japonica polysaccharides(LPS) was investigated by ultrasound combined with hydrogen peroxide. Three main factors, i.e., ultrasonic power(A), ultrasonic time(B), and H_2O_2 concentration(C) were chosen for optimizing parameters by employing three-factors, three-levels BBD. The influence of degradation on structure change and antioxidant activities was also investigated. A second-order polynomial equation including molecular weight(Y) of Laminaria japonica polysaccharides and each variable parameter, i.e., ultrasonic power(A), ultrasonic time(B), and H_2O_2 concentration(C), was established: Y=20718.67-4273.13A-4000.38B-1438.75C+2333.25AB+1511.00AC+873.00BC+2838.29A^2 + 2490.79B^2+873.04C^2. The equation regression coefficient value(R^2 = 0.969) indicated that this equation was valid. The value of the adjusted determination coefficient(adjusted R^2 = 0.914) also confirmed that the model was highly significant. The results of selected experimental degradation conditions matched with the predicted value. FT-IR spectra revealed that the structures of LPS before and after degradation were not significantly changed. Antioxidant activities of LPS revealed that low Mws possessed stronger inhibitory than the original polysaccharides. The scavenging effects on superoxide radicals was the highest when IC50 of crude LPS was 4.92 mg mL^(-1) and IC50 of Mw 18.576 KDa was 1.02 mg mL^(-1), which was fourfold higher than initial polysaccharide. | ZHA Shenghua ZHAO Qingsheng ZHAO Bing OUYANG Jie MO Jianling CHEN Jinjin CAO Lili ZHANG Hong | 2016 | Journal of Ocean University of China2016，15，4： | 4 |
| 20 | Application of Electroless Fe-42Ni(P) Film for Under-bump Metallization on Solder Joint显示文摘Because Fe has a more negative standard reduction potential than Ni, the simultaneous electroless deposition of Fe and Ni is difficult. In this study, Fe-42Ni(P) electroless deposit was prepared by using disodium ethylene diamine tetraacetate (ETDA-2Na) as complexing agent to reduce the difference in the electrode potential between Ni2+ and Fe2+ . The solderability and the interfacial reaction between Fe-42Ni(P) alloy and Sn were investigated. It was found that the electroless Fe-42Ni(P) alloy has excellent wettability with Sn. Moreover, the interfacial reaction rate between Fe-42Ni(P) and Sn is very slow. These results suggest that Fe-42Ni(P) alloy may become an attractive under-bump metallization (UBM). | Haifei Zhou Jingdong Guo Qingsheng Zhu Jianku Shang | 2013 | Journal of Materials Science & Technology2013，29，1： | 3 |
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