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| 1 | IRESfinder:Identifying RNA internal ribosome entry site in eukaryotic cell using framed k-mer features显示文摘In eukaryotic cells,initiation of protein translation is to recruit the ribosome to a specific mRNA,which is generally dependent on the 5'cap structure.However,protein translation can also be initiated in a cap-independent manner by using a cis-regulatory element termed the internal ribosome entry site(IRES).The first experimentally validated IRES was reported in the | Jian Zhao Jing Wu Tianyi Xu Qichang Yang Junhao He Xiaofeng Song | 2018 | Journal of Genetics and Genomics2018，45，7： | 14 |
| 2 | 2001-2005年中国4省份精神疾病的患病率、治疗情况和相关残疾:一项流行病学调查显示文摘背景在中国和其他中等收入国家,神经精神状况是影响男性和女性健康的最重要的原因,但由于缺乏有关各种精神疾病患病率、治疗情况和相关残疾的高质量的和具有国家特异性的资料,这些国家提高精神卫生服务的工作受到了限制。因此,我们在中国4个省份开展了一系列流行病学研究,以此来估算相关数据。方法采用多阶段分层随机抽样的方法在中国的4个省抽取了96个城市和267个农村作为初级抽样点;1.13亿个年龄≥18岁的成年人的抽样框架涵盖了中国12%的成年人。在抽样点使用简单随机抽样法选取63004例受试者,采用一般健康问卷(GHQ)的扩展版对这些个体进行筛查,并由精神科医生使用中文版的诊断与统计手册(DSM).Iv轴I障碍定式临床检查(SCID)问卷对其中的16577例受试者进行调查。结果所有精神疾病近1个月的校正患病率为17.5%(95%CI16.6%~18.5%)。其中,心境障碍患病率为6.1%(95%CI5.7%~6.6%),焦虑障碍为5.6%(95%cI5.0%~6.3%),物质滥用障碍为5.9%(95%CI5-3%~6.5%),精神病性障碍为1.0%(95%C10.8%~1.1%)。女性的心境障碍和焦虑障碍的患病率比男性高,年龄〉140岁个体的患病率高于年龄〈40岁的个体。男性酒精使用障碍的患病率是女性的48倍。农村居民比城市居民更可能患有抑郁障碍和酒精依赖。在被诊断患有某种精神疾病的人群中,24%存在由所患精神疾病引起的中度或重度残疾,8%曾向专业人员寻求过帮助,5%曾就诊于精神科。结论本研究结果与全球疾病负担分析中使用的中国精神疾病的患病率、残疾和治疗率估计值有相当大的差距,这需要引起中、低收入国家注意,在提高精神卫生服务前需针对国家具体情况进行详细的现状分析。 | Jingxuan Zhang Qichang Shi Zhiqiang Song Zhijie Ding Shutao Pang Xianyun Li Yali Zhang Zhiqing Wang 张亚利(译) 安静(审校) 费立鹏(审校) | 2009 | 世界临床医学2009，，11： | 5 |
| 3 | Improved root zone temperature buffer capacity enhancing sweet pepper yield via soil-ridged substrate-embedded cultivation in solar greenhouse显示文摘A novel soilless cultivation method,called as soil-ridged substrate-embedded cultivation(SSC)was invented,and an experiment was designed to investigate root zone temperature and production efficiency of sweet pepper cultivated by two SSC patterns,i.e.,SSC-P(polyethylene groove inserted)and SSC-W(wire-mesh groove inserted),and also other two cultivation methods,i.e.,soil ridge(SR)and naked polyethylene groove(PG).Results showed that PG,SSC-P and SSC-W increased the average minimal root zone temperature by 1.01℃,0.75℃,and 1.16℃ compared to SR(16.33℃)during March 16-20,2015.During June 1-5,SSC-P and SSC-W decreased the average maximal root zone temperature by 1.28℃ and 1.29℃ compared to SR(34.99℃),while PG increased it by 1.44℃.PG,SSC-P,and SSC-W decreased the differences of average daytime and night time temperatures by 1.34℃,2.13℃,and 2.88℃ compared to SR(4.56℃)during early stage.However,SSC-P and SSC-W decreased temperature differences of average daytime and night time by 0.9℃ and 1.07℃ compared to SR(0.95℃)during later stage,but PG improved by 2.85℃.Temperature difference of daytime and night time of SSC-W was minimal,and the temperature difference between the diurnal highest and the lowest temperature of SSC-W was also minimal.The buffer capacity of SSC-W was slightly better than that of SSC-P.SSC-W significantly improved the growth of sweet pepper compared to SR.Similarly,fruit yield per square meter of sweet pepper cultivated on SSC-P and SSC-W improved by 21.24%and 50.33%,respectively compared to SR(3.06 kg/m^(2)),while PG lowered the yield by 13.72%.SSC-W was a better SSC pattern compared with SSC-P in terms of production efficiency. | Guohai Fu Zonggeng Li Wenke Liu Qichang Yang | 2018 | International Journal of Agricultural and Biological Engineering2018，11，2： | 4 |
| 4 | Beneficial effects of C-peptide on renal morphology in diabetic rats显示文摘学习被承担在 glomerular 上检验 C 肽的效果在有差或中等的 glycemic 的糖尿病的老鼠控制的 streptozotocin (STZ ) 的体积(VGLOM ) , mesangial 矩阵合成,和降级。(差的 glycemic 控制) 系列 1 包括了一些健康老鼠, hyperglycemic 老鼠,糖尿病的对待胰岛素的老鼠和糖尿病的 C-peptide-treated 老鼠。(中等 glycemic 控制) 系列 2 包括了一些健康老鼠,糖尿病的对待胰岛素的老鼠,糖尿病的 insulin-peptide-treated 和 C-peptide-treated 老鼠。在 8 个星期以后,左肾经由轻显微镜学为 VGLOM 和 mesangial 矩阵区域的评估被切除。Mesangial 房间是有教养的因为 48 h 和类型 IV 骨胶原表示和矩阵 metalloproteinase (MMP )-2 表示被 ELISA 和 RTPCR 测量。结果显示在系列 1, C 肽管理在 VGLOM 和 mesangial 矩阵区域压制了导致糖尿病的增加。在系列 2, C 肽管理在 mesangial 矩阵区域在 VGLOM 和更大的减少导致了类似的减少什么时候与胰岛素治疗相比独自一个。而且, C 肽(300 nM ) 完全在在 30 公里葡萄糖媒介有教养的 mesangial 房间禁止了骨胶原 IV mRNA 表示和蛋白质集中的导致葡萄糖的增加。MMP-2 mRNA 表示没被 C 肽影响。在结论,到为 8 个星期的 STZ 糖尿病的老鼠的 C 肽管理导致 mesangial 矩阵的导致糖尿病的扩大的抑制。这效果独立于 glycemic 控制的水平,从 mesangial 的导致糖尿病的过多的形成的抑制的结果打 IV 骨胶原。 | Wei Sun Xin Gao Xiaolong Zhao Dafu Cui Qichang Xia | 2010 | Acta Biochimica et Biophysica Sinica2010，42，12： | 3 |
| 5 | In-plane dynamics of a fluid-conveying corrugated pipe supported at both ends显示文摘The dynamics and stability of fluid-conveying corrugated pipes are investigated. The flow velocity is assumed to harmonically vary along the pipe rather than with time. The dimensionless equation is discretized with the differential quadrature method (DQM). Subsequently, the effects of the mean flow velocity and two key parameters of the corrugated pipe, i.e., the amplitude of the corrugations and the total number of the corrugations, are studied. The results show that the corrugated pipe will lose stability by flutter even if it has been supported at both ends. When the total number of the corrugations is sufficient, this flutter instability occurs at a micro flow velocity. These phenomena are verified via the Runge-Kutta method. The critical flow velocity of divergence is analyzed in detail. Compared with uniform pipes, the critical velocity will be reduced due to the corrugations, thus accelerating the divergence instability. Specifically, the critical flow velocity decreases if the amplitude of the corrugations increases. However, the critical flow velocity cannot be monotonously reduced with the increase in the total number of the corrugations. An extreme point appears, which can be used to realize the parameter optimization of corrugated pipes in practical applications. | Yingjie WANG Qichang ZHANG Wei WANG Tianzhi YANG | 2019 | Applied Mathematics and Mechanics(English Edition)2019，40，8： | 3 |
| 6 | Three-dimensional virtual-real mapping of aircraft autom atic spray operation and online simulation monitoring显示文摘Background This study aims at addressing the lack of closed-loop feedback optimization enabling tool in aircraft automatic spraying systems;we systematically analyze a three-dimensional(3D)virtual-real mapping technique,namely the digital twin technique,used by the automatic spraying system.Methods With the sensors installed in the spraying system,the spraying working parameters are collected online and are used for driving the 3D virtual spraying system to realize the total-factor monitoring of the spraying operation.Furthermore,the operation-evaluation model is applied for analyzing and managing the key indexes of the spraying quality;once the data value of the key indexes exceeds a threshold,the operation shall be optimized automatically.Results This approach can effectively support the high-efficiency analysis,evaluation,and optimization of the spraying process. | Shiguang QIU Shuntao LIU Deshuai KONG Qichang HE | 2019 | Virtual Reality & Intelligent Hardware2019，1，6： | 3 |
| 7 | Global bifurcations of strongly nonlinear oscillator induced by parametric and external excitation显示文摘The global bifurcation of strongly nonlinear oscillator induced by parametric and external excitation is researched. It is known that the parametric and external excitation may induce additional saddle states, and result in chaos in the phase space, which cannot be detected by applying the Melnikov method directly. A feasible solution for this problem is the combination of the averaged equations and Melnikov method. Therefore, we consider the averaged equations of the system subject to Duffing-Van der Pol strong nonlinearity by introducing the undetermined fundamental frequency. Then the bifurcation values of homoclinic structure formation are detected through the combined application of the new averaged equations with Melnikov integration. Finally, the explicit application shows the analytical conditions coincide with the results of numerical simulation even disturbing parameter is of arbitrary magnitude. | WANG Wei ZHANG QiChang FENG JingJing | 2011 | Science China(Technological Sciences)2011，54，8： | 3 |
| 8 | Tim‐3/galectin‐9 signaling pathway mediates T‐cell dysfunction and predicts poor prognosis in patients with hepatitis B virus‐associated hepatocellular carcinoma显示文摘 | Hang Li Ke Wu Kaixiong Tao Libo Chen Qichang Zheng Xiaoming Lu Jun Liu Liang Shi Chuanqiao Liu Guobin Wang Weiping Zou | 2012 | Hepatology2012，，： | 2 |
| 9 | 肝细胞肝癌自发破裂出血:87例回顾性分析(英文)显示文摘Objective: The aim of the study was to review the management of ruptured hepatocellular carcinoma (HCC) in a single teaching hospital over 13-year period; to determine the prognostic factor of in-hospital mortality and evaluate the safety and efficacy of liver resection. Methods: A retrospective collection of medical records of 87 patients with spontaneous ruptured HCC was carried out. The 28 patients underwent emergency intervention including transarterial chemoembolization (TACE) and laparotomy with/without liver resection. Conservative treatment was performed in 59 patients and 16 of which underwent delayed hepatectomy or TACE. Results: The overall in-hospital mortality and median survival time was 54% and 22 days respectively. Albumin level (OR = 0.874, 95% CI: 0.778-0.973, P = 0.024), number of tumors (OR = 5.011, 95% CI: 1.015-24.750, P = 0.048) and laparotomy (OR = 0.069, 95% CI: 0.012-0.406, P = 0.003) were all independent factors affecting overall in-hospital mortality, but for patients undergone laparotomy, only total bilirubin level (OR = 1.138, 95% CI: 1.024-1.264, P = 0.016) was independent factor affecting overall in-hospital mortality. Age, total bilirubin level, maximum tumor size, number of tumors, portal vein tumor thrombosis and extra-hepatic metastasis were all significantly different between groups with laparotomy and without. There were no significant differences between emergency and delayed liver resection groups in in-hospital mortality (0 vs. 0), median survival time (788 vs. 750 days respectively) as well as 1-year and 3-year survival rates (66.7%, 44.4% vs. 70%, 30%, respectively) (P = 0.763, log-rank test). Conclusion: Both underlying chronic liver disease and tumor stage can affect the in-hospital mortality, but for patients undergone laparotomy, only total bilirubin level is independent factor. Surgeons are more prone to choose patients with younger age, better liver function and earlier tumor stage to do surgery. In well selected patients, both emergency and delayed liver resections are safe and could achieve prolonged survival. | Ping Sun Zifang Song Qinggang Hu Jun Xiong Xiao Yang Qichang Zheng | 2013 | The Chinese-German Journal of Clinical Oncology2013，12，4： | 2 |
| 10 | Application status and challenges of machine vision in plant factory—A review显示文摘Plant factories have a great potential for mitigating the contradiction between the world’sgrowing population and food scarcity. During the process of its automatic production,machine vision plays a significant role. This technique almost covers every production linkfrom raising seedlings, transplanting, management, and harvesting to fruit grading. To provide references and a starting point for those who are committed to studying this issue. Inthis paper, the application prospects of machine vision in plant factories were analyzed,and the present researches were summarized from the fields of plant growth monitoring,robot operation assistance, and fruit grading. The results found that although the existingmethods have solved some practical problems at low cost, high efficiency and precision,some challenges still are faced by machine vision. Firstly, the changing lighting, complexbackgrounds, and color similarity within plant different parts cause the commonly usedimage segmentation algorithms to fail. The shortage of standard agricultural datasets alsokeeps deep learning and unsupervised classification algorithms from making progress.Secondly, there are some theoretical knowledge gaps for machine vision application in aparticular environment of plant factories, which seriously contains its application effect.Thirdly, the lack of special image acquisition devices and supporting facilities resulted inpoor image quality. All these factors hinder machine vision application in plant factories.Nevertheless, it is still a powerful tool and irreplaceable at present. We believed that thistechnique would promote plant factory development greatly with more robust, efficient,and reliable algorithms are developed in the future. | Zhiwei Tian Wei Ma Qichang Yang Famin Duan | 2022 | Information Processing in Agriculture2022，9，2： | 2 |
| 11 | The Effects of Cholecystojejunostomy and Biliary Drainage on Biliary Motor显示文摘Summary: Simulating physiological neuronal and hormonal conditions during digestive and interdigestive periods, the study identified the changes of the motility of biliary system including bile duct and sphincter of Oddi (SO) before and after cholecystojejunostomy. Thirty-five rabbits were divided into five groups randomly. The experimental groups received the venous injection of CCK 10 ng/kg, erythromycin 10 mg/kg, atropine 3 μg/kg and L-NAME 10 mg/kg respectively. Each rabbit underwent manometry through introducing a three-lumen catheter via the papilla retrogradely, using the low-compliance papillary infusion system. Then the gallbladder and the upper segment of the jejunum was anastomosed and the manometric procedures repeated after one week. SO basal pressure was increased, contraction amplitude decreased, contraction time shortened after cholecystojejunostomy. L-NAME, CCK and erythromycin could all excite SO. L-NAME could increase basal pressure and contraction amplitude, CCK increase basal pressure contraction amplitude and frequency, and erythromycin increase contraction amplitude, respectively. But comparing with that before cholecystojejunostomy, the increasing extent was decreased. The tensional and spontaneous contractions of the SO were under the control of the neural and hormonal mechanism. The anastomosis of gallbladder and jejunum and the drainage of bile made the tensional contraction stronger, but the spontaneous contraction weakened after the operation due to the decreases of the sensitivity of SO to hormonal factors. The clinical symptoms may not be relieved when the patients with SO dysfunction accepted cholecystojejunostomy. | ZHENG Qichang(郑启昌) CHEN Yanglong(陈阳龙) | 2002 | Journal of Huazhong University of Science and Technology(Medical Sciences)2002，22，2： | 2 |
| 12 | Differences in the primary culture, purification and biological characteristics between endothelial cells and smooth muscle cells from rat aorta显示文摘Objective: To investigate the differences of primary culture, purification and biological characteristics between endothelial cells and smooth muscle cells from rat aorta. Methods: Endothelial cells were obtained using the vascular ring adherence, collagenase digestion method and an improved vascular ring adherence method, while smooth muscle cells were separated from tissue sections of rat aorta. Clones of endothelial cells were selected by limiting dilution assay. Both cell types were identified using specific cell immunofluorescent markers, and phase contrast microscopy was used to observe the morphological disparity between endothelial cells and smooth muscle cells at the single cell and colony level. Cell proliferation was determined by the cell counting kit-8. Differences between endothelial cells and smooth muscle cells were evaluated in trypsin digestion time, attachment time and recovery after cryopreservation. Results: Endothelial cells were obtained by all three methods. The improved vascular ring method provided the most reproducible results. Cells were in good condition, and of high purity. Smooth muscle cells were cultured successfully by the tissue fragment culture method. Clonal expansion of single endothelial cells was attained. The two cell types expressed their respective specific markers, and the rate of proliferation of smooth muscle cells exceeded that of endothelial cells. Endothelial cells were more sensitive to trypsin digestion than smooth muscle cells. In addition, they had a shorter adherence time and better recovery following cryopreservation than smooth muscle cells. Conclusion: The improved vascular ring method was optimal for yielding endothelial cells. Limiting dilution is a novel and valid method for purifying primary endothelial cells from rat aorta. Primary rat endothelial cell and vascular smooth muscle cell cultures exhibited different morphological characteristics, proliferation rate, adherence time, susceptibility to trypsin digestion and recovery after cryopreservation. Our research can be a good foundation for further application in the regeneration of blood vessel. | Shaobo Hu Zifang Song Qichang Zheng Jun Nie | 2009 | Journal of Nanjing Medical University2009，23，4： | 2 |
| 13 | Identification of two-dimensional electrophoresis-separated proteins in human hepatoma cell by electrospray ion trap mass spectrometry显示文摘As one of the most important analytical methods in proteome research, mass spectrometry was utilized to identify proteins separated by two-dimensional electrophoresis in the human hepatoma cell line BEL-7404. The protein spots were excised from the gel, followed by in-gel digestion, and the peptide mappings were analyzed by liquid chromatography electrospray ion trap mass spectrometer. Nine proteins were identified via database searching, according to the molecular weights and amino acid sequences of peptides, among which two proteins have not been identified in the other liver-cell database. The sequence coverage was 21% -72%. Furthermore, the relationship between the expressed proteins and the liver carcinoma was discussed. | Rong Zeng Lirong Yu Xiaoxia Shao Qichang Xia | 2000 | Chinese Science Bulletin2000，45，16： | 2 |
| 14 | Linking environmental signals to plant metabolism:The combination of field trials and environment simulators显示文摘Breeding crops with enhanced nutrients is one of the major goals of plant breeding.Notably,plants intensively produce various specialized plant metabolites(e.g.,phenolic compounds and ca-rotenoids)in response to diverse external stimuli and changing environmental conditions,which have been reported as health-promoting compounds with various health benefits(Dong and Lin,2021).On the other hand,the varied growth environment and global climate change necessitates crops to have the qualities of good environmental adaptability(Eshed and Lippman,2019). | Jing Zhang Xiao Yang Xin Zhang Li Zhang Zixin Zhang Yang Zhang Qichang Yang | 2022 | Molecular Plant2022，15，2： | 1 |
| 15 | Auto MOC—A 2D neutron transport code for arbitrary geometry based on the method of characteristics and customization of AutoCAD显示文摘 | Qichang Chen Hongchun Wu Liangzhi Cao | 2008 | Nuclear Engineering and Design2008，，10： | 1 |
| 16 | An active heat storage-release system using circulating water to supplement heat in a Chinese solar greenhouse显示文摘 | Yang Qichang Zhang Yi Fang Hui | 2013 | Acta Hort2013，1037，： | 1 |
| 17 | Performance of a solar heat collection and release system for improving night temperature in a Chinese solar greenhouse显示文摘 | Fang Hui Zhang Yi Yang Qichang | 2015 | Applied Engineering in Agriculture of the ASABE2015，32，2： | 1 |
| 18 | Hopf bifurcation for delay differential equation with application to machine tool chatter显示文摘 | Xie Qizhi Zhang Qichang Han Jianxin | 2012 | Applied Mathematical Modelling2012，36，： | 1 |
| 19 | Normal form analysis of Hopf bifurcation exemplified by Duffing' s equation显示文摘 | Leung A Y T Zhang Qichang Chen Yushu | 1994 | Shock and Vibration1994，1，3： | 1 |
| 20 | Retention mechanism of ampheteric starch/polyaluminum silicate sulfate on wheat straw pulps显示文摘 | Liu Wenxia Long Yanquan Wang Qichang | 2000 | 4th INWPPC2000，2，： | 1 |
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