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| 1 | Different profiles of cytokine expression during mild and severe acute pancreatitis显示文摘AIM:To study secretion patterns of proand anti-in-flammatory cytokines, and activation of various cellular subsets of leukocytes in peripheral blood.METHODS: We have conducted a prospective obser-vational study. One hundred and eight patients with a diagnosis of acute pancreatitis and onset of the disease within last 72 h were included in this study. The mRNA expression of 25 different types of cytokines in white blood cells was determined by quantitative real time polymerase chain reaction. Levels of 8 different cytokines in blood serum were measured by enzymelinked immunosorbent assay. Clinical data and cytokine expression results were subjected to statistical analysis.RESULTS: Severe and necrotizing acute pancreatitis (AP) is characterized by the significant depletion of circulating lymphocytes. Severe acute pancreatitis is as-sociated with a typical systemic inflammatory response syndrome and over-expression of pro-inflammatory cy-tokines [interleukin (IL)-6, IL-8, macrophage migration inhibitory factor (MIF)]. Serum IL-6 and MIF concentra-tions are the best discriminators of severe and necrotiz-ing AP as well as possible fatal outcome during the early course of the disease. CONCLUSION: Deregulation of cellular immune sys-tem is a key event leading to severe and necrotizing AP. IL-6 and MIF could be used as early predictors of complications. | Zilvinas Dambrauskas Nathalia Giese Antanas Gulbinas Thomas Giese Pascal O Berberat Juozas Pundzius Giedrius Barauskas Helmut Friess | 2010 | World Journal of Gastroenterology2010，16，15： | 49 |
| 2 | Early recognition of abdominal compartment syndrome in patients with acute pancreatitis显示文摘AIM:To assess the value of widely used clinical scores in the early identification of acute pancreatitis(AP) patients who are likely to suffer from intra-abdominal hypertension(IAH)and abdominal compartment syndrome(ACS). METHODS:Patients(n=44)with AP recruited in this study were divided into two groups(ACS and non-ACS) according to intra-abdominal pressure(IAP)determined by indirect measurement using the transvesical route via Foley bladder catheter.On admission and at regular intervals,the severity of the AP and presence of organ dysfunction were assessed utilizing different multifactorial prognostic systems:Glasgow-Imrie score,Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE-Ⅱ)score,and Multiorgan Dysfunction Score(MODS).The diagnostic performance of scores predicting ACS development,cut-off values and specificity and sensitivity were established using receiver operating characteristic(ROC)curve analysis. RESULTS:The incidence of ACS in our study population was 19.35%.IAP at admission in the ACS group was 22.0(18.5-25.0)mmHg and 9.25(3.0-12.4)mmHg in the non-ACS group(P<0.01).Univariate statistical analysis revealed that patients in the ACS group had significantly higher multifactorial clinical scores(APACHE Ⅱ,Glasgow-Imrie and MODS)on admission and highermaximal scores during hospitalization(P<0.01).ROC curve analysis revealed that APACHEⅡ,Glasgow-Imrie, and MODS are valuable tools for early prediction of ACS with high sensitivity and specificity,and that cut- off values are similar to those used for stratification of patients with severe acute pancreatitis(SAP). CONCLUSION:IAH and ACS are rare findings in patients with mild AP.Based on the results of our study we recommend measuring the IAP in cases when patients present with SAP(APACHEⅡ>7;MODS>2 or Glasgow-Imrie score>3). | Zilvinas Dambrauskas Audrius Parseliunas Antanas Gulbinas Juozas Pundzius Giedrius Barauskas | 2009 | World Journal of Gastroenterology2009，15，6： | 32 |
| 3 | Fatty acids of erythrocyte membrane in acute pancreatitis patients显示文摘AIM:To evaluate changes in the fatty acid composition of erythrocyte membrane phospholipids during severe and mild acute pancreatitis(AP)of alcoholic and nonalcoholic etiology.METHODS:All consecutive patients with a diagnosis of AP and onset of the disease within the last 72 h admitted to the Hospital of Lithuanian University of Health Sciences between June and December 2007 were included.According to the Acute Physiology and ChronicHealth Evaluation(APACHEⅡ)scale,the patients were subdivided into the mild(APACHEⅡscore<7,n=22)and severe(APACHEⅡscore≥7,n=17)AP groups.Healthy individuals(n=26)were enrolled as controls.Blood samples were collected from patients on admission to the hospital.Fatty acids(FAs)were extracted from erythrocyte phospholipids and expressed as percentages of the total FAs present in the chromatogram.The concentrations of superoxide dismutase and glutathione peroxidase were measured in erythrocytes.RESULTS:We found an increase in the percentages of saturated and monounsaturated FAs,a decrease in the percentages of total polyunsaturated FAs(PUFAs)and n-3 PUFAs in erythrocyte membrane phospholipids of AP patients compared with healthy controls.Palmitic(C16:0),palmitoleic(C16:1n7cis),arachidonic(C20:4n6),docosahexaenoic(DHA,C22:6n3),and docosapentaenoic(DPA,C22:5n3)acids were the major contributing factors.A decrease in the peroxidation and unsaturation indexes in AP patients as well as the severe and mild AP groups as compared with controls was observed.The concentrations of antioxidant enzymes in the mild AP group were lower than in the control group.In severe AP of nonalcoholic etiology,the percentages of arachidic(C20:0)and arachidonic(C20:4n6)acids were decreased as compared with the control group.The patients with mild AP of nonalcoholic etiology had the increased percentages of total saturated FAs and gama linoleic acid(C18:3n6)and the decreased percentages of elaidic(C18:1n9t),eicosapentaenoic acid(EPA,C20:5n3),DPA(C22:5n3),DHA(C22:6n3)as well as total and n-3 PUFAs in erythrocyte membrane phospholipids.CONCLUSION:The composition of FAs in erythrocyte membranes is altered during AP.These changes are likely to be associated with alcohol consumption,inflammatory processes,and oxidative stress. | Irma Kuliaviene Antanas Gulbinas Johannes Cremers Juozas Pundzius Limas Kupcinskas Zilvinas Dambrauskas Eugene Jansen | 2013 | World Journal of Gastroenterology2013，19，34： | 3 |
| 4 | Meta-analysis of prophylactic parenteral antibiotic use in acute necrotizing panereatitis显示文摘 | Dambrauskas Z Gulbinas A Pundzius J | 2007 | Medicina (Kaunas)2007，43，4： | 1 |
| 5 | Radiofrequency abla- tion of liver tumors (I): biological background 显示文摘 | Vanagas T Gulbinas A Pundzius J | 2010 | Medicina (Kaunas)2010，46，1： | 1 |
| 6 | The impact of morphologic and physiologic peculiarities of the pancreas on pancreas-related complications following pancreatoduodenectomy显示文摘 | Gulbinas A Barauskas G Pundzius J | 2003 | Medicina (Kaunas)2003，39，2： | 1 |
| 7 | Meta-analysis of prophylactic parenteral antibiotic use in acute necrotizing pancreatitis显示文摘 | Dambrauskas Z Gulbinas A Pundzius J | 2007 | Medicina:Kaunas2007，43，4： | 1 |
| 8 | Value of routine clinical tests in predicting the development of infected pancreatic necrosis in severe acute pancreatitis 显示文摘 | Dambrauskas Z Gulbinas A Pundzius J | 2007 | Scand ''J Gastroenterol2007，42，1： | 1 |
| 9 | Radiofrequency ablation of liver tumors (11) : clinical application and outcomes 显示文摘 | Vanagas T Gulbinas A Pundzius J | 2010 | Medici- ha( Kaunas Lithuania)2010，46，2： | 1 |
| 10 | Predicting development of infected necrosis in acute necrotizing pancreatitis 显示文摘 | Dambrauskas Z Pundzius J Barauskas G | 2006 | Medicina( Kau- haS)2006，42，6： | 1 |
| 11 | Prognostic factors for short and long-term survival in patients selected for liver transplantation显示文摘 | Sumskiene J Kupcinskas L Pundzius J | 2005 | Medicina(Kaunas)2005，41，1： | 1 |
| 12 | Value of the different prognostic systems and biological markers for predicting severity and progression of acute pancreatitis显示文摘 | Dambrauskas Z Gulbinas A Pundzius J | | 0，，7： | 1 |
| 13 | Value of routine clinical tests in predicting the development of infected pancreatic necrosis in severe acute pancreatitis 显示文摘 | Dambrauskas Z Gulbinas A Pundzius J | 2007 | Scand J Gastroenterol2007，42，1： | 1 |
| 14 | Clinical and anatomical basis for the classification of the structural parts of the liver 显示文摘 | Rutkauskas S Gedrimas V Pundzius J | 2006 | Medicina (kaunas)2006，42，2： | 1 |
| 15 | The impact of morphologic and physiologic peculiarities of the pancreas on pancreasrelated complications following pancreatoduodenectomy 显示文摘 | Gulbinas A Barauskas G Pundzius J | 2003 | Medicina(Kaunas)2003，39，2： | 1 |
| 16 | Value of routine clinical testsin predicting the development of infected pancreatic necrosis in severe acute pancreatitis 显示文摘 | Dambrauskas Z Gulbinas A Pundzius J | 2007 | Scand J Gastroenterol2007，42，10： | 1 |
| 17 | Meta-analysis of prophylactic parenteral antibiotic use in acute necrotizing pancreatitis显示文摘 | Damhrauskas Z Gulbinas A Pundzius J | 2007 | Medicina (Kaunas)2007，43，4： | 1 |
| 18 | Predicting development of infected necrosis in actue necrotizing pancreatitis显示文摘 | Dambrauskas Z Pundzius J Barauskas G | 2006 | Mesicina2006，42，： | 1 |
| 19 | Meta-analysis of ProPhylactic Parenteral antibiotic use in acute necrotizing Panereatitis显示文摘 | Dambrauskas Z Gulbinas A Pundzius J | | 0，，04： | 1 |
| 20 | Radiofrequency ablation of liver of tumors (1):biological background显示文摘 | Vanagas T Gulbinas A Pundzius J | 2010 | Medicina (Kaunas, Lithuania)2010，，： | 1 |
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