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| 1 | Ability of bone graft substitutes to support the osteoprogenitor cells: An in-vitro study显示文摘AIM: To compare seven commercially available bone graft substitutes(BGS) in terms of these properties and without using any additional biological growth factors.METHODS: Porcine osteoprogenitor cells were loaded on seven commercially available BGS and allowed to proliferate for one week followed by osteogenic induction. Staining for live/dead cells as well as scanning electron microscopy(SEM) was carried out to determine viability and cellular binding. Further outcome measures included alkaline phosphatase(ALP) assays with normalisation for DNA content to quantify osteogenic potential. Negative and positive control experiments were carried out in parallel to validate the results.RESULTS: Live/dead and SEM imaging showed higher viability and attachment with β-tricalcium phosphate(β-TCP) than with other BGS(P < 0.05). The average ALP activity in nmol/mL(normalised value for DNA content in nmol/μg DNA) per sample was 657.58(132.03) for β-TCP, 36.22(unable to normalise) for calcium sulphate, 19.93(11.39) for the Hydroxyapatite/Tricalcium Phosphate composite, 14.79(18.53) for polygraft, 13.98(8.15) for the highly porous β-Tricalcium Phosphate, 5.56(10.0) for polymers, and 3.82(3.8) for Hydroxyapatite.CONCLUSION: Under the above experimental conditions, β-TCP was able to maintain better the viability of osteoprogenitor cells and allow proliferation and differentiation(P < 0.05). | Ziad Dahabreh Michalis Panteli Ippokratis Pountos Mark Howard Peter Campbell Peter V Giannoudis | 2014 | World Journal of Stem Cells2014，6，4： | 3 |
| 2 | Growth factor release following femoral nailing显示文摘 | Peter V. Giannoudis Ippokratis Pountos John Morley Sarah Perry Hans Ivan Tarkin Hans-Christoph Pape | 2007 | Bone2007，，4： | 2 |
| 3 | Safety and efficacy of vena cava filters in trauma patients 显示文摘 | Giannoudis PV Pountos I Pape HC | 2007 | Injury2007，38，1： | 1 |
| 4 | Mesenchymal stem cell tissue engineering:techniques for isolation ,expansion and application 显示文摘 | Pountos I Corscadden D Emery P | 2007 | Injury2007，38，14： | 1 |
| 5 | Mesenchymal stem cell tissue engineering:Techniques for isolation,expansion and application显示文摘 | POUNTOS I CORSCADDEN D EMERY P | | 0，，04： | 1 |
| 6 | Release of growth factors and the effect of age, sex, and severity of injury after long bone frac- ture : A preliminary report 显示文摘 | Pountos I Georgouli T Henshaw K | 2013 | Acta orthopaedica2013，84，1： | 1 |
| 7 | Growth factor release following femoral nailing显示文摘 | Giannoudis P V Pountos I Morley J | | 0，，04： | 1 |
| 8 | Safety and efficacy of vena cava filters in trauma patients 显示文摘 | Giannoudis P Pountos I Pape HC | 2007 | Injury2007，38，1： | 1 |
| 9 | Release of growth factors and the effect of age,sex,and severity of injury after long bone frac- ture : A preliminary report显示文摘 | Pountos I Georgouli T Henshaw K | 2013 | Acta orthopaedica2013，84，1： | 1 |
| 10 | Mesenchymal stem cell tissue engineering: techniques for isolation, expansion and appli- cation显示文摘 | Pountos I Corscadden D Emery P | 2007 | Injury2007，38，4： | 1 |
| 11 | Mesenehymal stem cell tissue engineering: techniques for isolation, expansion and application 显示文摘 | Pountos I Corseadden D Emery P | 2007 | Injury2007，38，4： | 1 |
| 12 | Mesenchymal stem cell tissue engineering : techniques for isolation, expansion and application 显示文摘 | Pountos I Corscadden D Emery P | 2007 | Injury2007，38，： | 1 |
| 13 | Fracture non-union:can biomarkers predict outcome? 显示文摘 | Pountos I Georgouli T Pneumaticos S et aI | 2013 | Injury2013，44，12： | 1 |
| 14 | The effect of bone mor- phogenetic protein-2, bone morphogenetic protein-7, parathyroid hormone, and platelet-derived growth factor on the proliferation and osteogenic differentiation of mesenchymal stem cells derived from osteoporotic bone 显示文摘 | Pountos I Georgouli T Henshaw K | 2010 | J Orthop Trauma2010，24，9： | 1 |
| 15 | NSAIDS inhibit in vitro MSC chondrogenesis but not osteogenesis: implications for mechanism of bone formation inhibition in man显示文摘 | POUNTOS I GIANNOUDIS P V JONES E | 2011 | J Cell Mol Med2011，15，3： | 1 |
| 16 | Mesenchymal stem cell tissue en- gineering: techniques for isolation, expansion and application显示文摘 | Pountos I Corscadden D Emery P | 2007 | In- jury2007，38，1： | 1 |
| 17 | Do nonsteroidal anti- inflammatory drugs affect bone healing? A critical analysis 显示文摘 | Pountos I Georgouli T Calori GM | 2012 | Scien World J2012，2012，60： | 1 |
| 18 | Fracture non- union: Can biomarkers predict outcome 显示文摘 | Pountos I Georgouli T Pneumaticos S | 2013 | Injury2013，44，12： | 1 |
| 19 | Growth factor release following femoral nailing显示文摘 | Giannoudis PV Pountos I Morley J | 2008 | Bone2008，42，4： | 1 |
| 20 | Growth factorrelease following femoral nailing显示文摘 | Giannoudis PV Pountos I morley J | 2008 | Bone2008，42，4： | 1 |
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