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| 1 | AME证据系列001--转化医学协会:脓毒症诊断和早期识别的临床实践指南显示文摘脓毒症是一种由感染引起的异质性疾病,感染触发了一系列复杂的局部或者全身的免疫炎症反应,引起多器官功能衰竭,发病率和病死率显著升高。由于至今仍然没有诊断脓毒症的金标准,所以脓毒症的临床诊断仍是一个难题。因此,脓毒症的临床诊断需要不断改变来满足临床和研究的要求。然而,尽管有许多新型的生物标记和筛选工具去预测脓毒症发生的风险,但是这些措施的诊断价值和有效性不足以让人满意,并且没有充分的证据去建议临床使用这些新技术。因此,脓毒症的临床诊断标准需要定期更新去适应不断产生的新证据。这篇综述旨在呈现当前脓毒症的诊断和早期识别方面的最新研究证据。临床运用不同的诊断方法的推荐意见依赖于推荐、评价、发展和评估分级体系(Grades of Recommendation Assessment,Development and Evaluation,GRADE),因为大部分的研究是观察性研究,并没有对这些方法进行可靠评估,采用的是两步推理方法。未来需要更多研究来确认或者反驳某一特殊的指标检测,同时应该直接采用相关病人的结果数据。 | Zhongheng Zhang Nathan J.Smischney Haibo Zhang Sven Van Poucke Panagiotis Tsirigotis Jordi Rello Patrick M.Honore Win Sen Kuan Juliet June Ray Jiancang Zhou You Shang Yuetian Yu Christian Jung Chiara Robba Fabio Silvio Taccone Pietro Caironi David Grimaldi Stefan Hofer George Dimopoulos Marc Leone Sang-Bum Hong Mabrouk Bahloul Laurent Argaud Won Young Kim Herbert D.Spapen Jose Rodolfo Rocco 张建成(译) 尚游(译) 钟鸣(校) | 2016 | 临床与病理杂志2016，36，10： | 5 |
| 2 | Rapid detection of fluorescent and chemi-luminescent total coliforms and Escherichia coli on membrane filters显示文摘 | Van Poucke S O Nelis H J | 2000 | Journal of Microbiological Methods2000，42，3： | 1 |
| 3 | Molecular dissection of plant cytokinesis and phragmoplast structure: A survey of GFP-tagged proteins 显示文摘 | Van Damme D Bouget F Y Van Poucke K etal | 2004 | Plant Journal2004，40，： | 1 |
| 4 | A HinfⅠ PCRRFLP at the procine leptin gene显示文摘 | STRAIL A PEELMAN L POUCKE M | 1997 | Anim Genet1997，28，： | 1 |
| 5 | Determination of anabolic steroids in dietary supplements by liquid chromatography–tandem mass spectrometry显示文摘 | C. Van Poucke C. Detavernier R. Van Cauwenberghe C. Van Peteghem | 2006 | Analytica Chimica Acta (-)2006，，1： | 1 |
| 6 | Investigation into the possible natural occurrence of semiearbaside in Macrobrachium rosenbergii prawns 显示文摘 | POUCKE C V DETAVEMIER C WILLE M | 2011 | Agricultural and food Chemistry2011，59，5： | 1 |
| 7 | Characterization of the ovine ribosomal protein SA gene and its pseudogenes显示文摘 | BROEKE A V D POUCKE M V MARCOS-CARCAVILLA A | 2010 | BMC Genomics2010，11，： | 1 |
| 8 | Development of a Sensitive Chemiluminometric Assay for the Detection of β -Galactosidase in Permeabilized Coliform Bacteria and Comparison with Fluorometry and Colorimetry显示文摘 | S O Van Poucke H J Nelis | 1995 | Applied and Environmental Microbiology1995，61，12： | 1 |
| 9 | Integration of porcine chromosome 13 maps显示文摘 | Van Poucke M Yerle M Tuggle C | 2001 | Cytogenet Cell Genet2001，93，34： | 1 |
| 10 | Rapid detection of fluorescent and chemiluminescent total coliforms and Escherichia coli on membrane filters显示文摘 | S O Van Poucke H J Nelis | 2000 | Journal of Microbiological Methods2000，42，： | 1 |
| 11 | Bioencapsulation of the antibacterial drug sarafloxacin in nauplii of the brine shrimp Artemia franciscana 显示文摘 | Dixon B A Van Poucke S O Chair M | 1995 | Journal of aquatic animal health1995，7，： | 1 |
| 12 | Porcine PPARGCIA (peroxisome proliferative activated receptor gamma coactivator 1A) : coding sequence, genomic organization, polymorphisms and mapping 显示文摘 | Jacobs K Rohrer G Van Poucke M | 2006 | Cytogenet Genome Res2006，112，12： | 1 |
| 13 | Poreine PPARGC1A (peroxisome proliferative activated receptor gamma coactivator 1A):coding sequence,genomic organization,polymorphisms and mapping显示文摘 | Jacobs K Rohrer G van Poucke M | 2006 | Cytogenet Genome Res2006，112，： | 1 |
| 14 | Development of a multi-mycotoxin liquid chromatography/tandem mass spectrome- try method for sweet pepper analysis 显示文摘 | Monbaliu S Poucke CV Peteghem CV | 2009 | Rapid Communications in Mass Spectrometry2009，23，1： | 1 |
| 15 | Selection of reference genes for quantitative real-time PCR in bovine preimplantation embryos显示文摘 | Goossens K van Poucke M van Soom A | 2005 | BMC Dev Biol2005，5，： | 1 |
| 16 | Analysis of meat samples for anabolic steroids residues by liquid chromatography/tandem mass spectrometry 显示文摘 | Blasco C Poucke CV Peteghem CV | 2007 | J Chromatogr A2007，1154，12： | 1 |
| 17 | Development of a new set of reference genes for normalization of real-time RT-PCR data of porcine backfat and longissimus dorsi muscle,and evaluation with PPARGC1A显示文摘 | Erkens T van Poucke M Vandesompele J | 2006 | BMC Biotechnol2006，6，41： | 1 |
| 18 | Effect of calcium and calcium minerals in coal on its thermal analysis显示文摘 | MAES I I GRYGLEWICZ G YPERMAN J FRANCO D V MULLENS J VAN POUCKE L C | 1997 | Fuel1997，76，2： | 1 |
| 19 | Sulphur group analysis in solid matrices by atmospheric pressure-temperature programmed reduction显示文摘 | YPERMAN J MAES I I VAN DEN RUL H MULLENS S VAN AELST J FRANCO D V MULLENS J VAN POUCKE L C | 1999 | Anal Chim Acta1999，395，12： | 1 |
| 20 | Analysis of meat samples for anabolic steroids residues by liquid chromatography/tandem mass spectroraetry显示文摘 | C Blasco CV Poucke CV Peteghem | 2007 | J Chromatogr A2007，1154，12： | 1 |
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