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| 1 | Brain-derived neurotrophic factor and inflammation in depression:Pathogenic partners in crime?显示文摘Major depressive disorder is a debilitating disorder affecting millions of people each year.Brain-derived neurotrophic factor(BDNF)and inflammation are two prominent biologic risk factors in the pathogenesis of depression that have received considerable attention.Many clinical and animal studies have highlighted associations between low levels of BDNF or high levels of inflammatory markers and the development of behavioral symptoms of depression.However,less is known about potential interaction between BDNF and inflammation,particularly within the central nervous system.Emerging evidence suggests that there is bidirectional regulation between these factors with important implications for the development of depressive symptoms and antidepressant response.Elevated levels of inflammatory mediators have been shown to reduce expression of BDNF,and BDNF may play an important negative regulatory role on inflammation within the brain.Understanding this interaction more fully within the context of neuropsychiatric disease is important for both developing a fuller understanding of biological pathogenesis of depression and for identifying novel therapeutic opportunities.Here we review these two prominent risk factors for depression with a particular focus on pathogenic implications of their interaction. | Grace A Porter Jason C O’Connor | 2022 | World Journal of Psychiatry2022，12，1： | 4 |
| 2 | Tenascin C upregulates interleukin-6 expression in human cardiac myofibroblasts via toll-like receptor 4显示文摘AIM:To investigate the effect of Tenascin C(TNC)on the expression of pro-inflammatory cytokines and matrixmetalloproteinases in human cardiac myofibroblasts(CMF).METHODS:CMF were isolated and cultured from patients undergoing coronary artery bypass grafting.Cultured cells were treated with either TNC(0.1μmol/L,24 h)or a recombinant protein corresponding to different domains of the TNC protein;fibrinogen-like globe(FBG)and fibronectin typeⅢ-like repeats(TNⅢ5-7)(both 1μmol/L,24 h).The expression of the proinflammatory cytokines;interleukin(IL)-6,IL-1β,TNFαand the matrix metalloproteinases;MMPs(MMP1,2,3,9,10,MT1-MMP)was assessed using real time RT-PCR and western blot analysis.RESULTS:TNC increased both IL-6 and MMP3(P<0.01)mR NA levels in cultured human CMF but had no significant effect on the other markers studied.The increase in IL-6 mR NA expression was mirrored by an increase in protein secretion as assessed by enzymelinked immunosorbant assay(P<0.01).Treating CMF with the recombinant protein FBG increased IL-6mR NA and protein(P<0.01)whereas the recombinant protein TNⅢ5-7 had no effect.Neither FBG nor TNⅢ5-7 had any significant effect on MMP3 expression.The expression of toll-like receptor 4(TLR4)in human CMF was confirmed by real time RT-PCR,western blot and immunohistochemistry.Pre-incubation of cells with TLR4neutralising antisera attenuated the effect of both TNC and FBG on IL-6 mR NA and protein expression.CONCLUSION:TNC up-regulates IL-6 expression in human CMF,an effect mediated through the FBG domain of TNC and via the TLR4 receptor. | Azhar Maqbool Emma J Spary Iain W Manfield Michaela Ruhmann Lorena Zuliani-Alvarez Filomena O Gamboa-Esteves Karen E Porter Mark J Drinkhill Kim S Midwood Neil A Turner | 2016 | World Journal of Cardiology2016，8，5： | 4 |
| 3 | A p34(cdc2)survival checkpoint in cancer显示文摘 | O'Connor DS Wall NR Porter AC | 2002 | Cancer Cell2002，2，1： | 1 |
| 4 | The first use of a combined value auction for transportation services显示文摘 | Ledyard J O Olson M Porter D | 2002 | Interfaces2002，32，5： | 1 |
| 5 | Simvastatin reduces human atrial myofibroblast proliferation independently of cholesterol lowering via inhibition of RhoA显示文摘 | Porter KE Turner NA O'Regan DJ | 2004 | Cardiovasc Res2004，61，4： | 1 |
| 6 | Nurse to a different tune显示文摘 | Porter O Crady | 1999 | Nurse Manage1999，30，7： | 1 |
| 7 | Simvastatin reduces human atrial myofibroblast proliferation independently of cholesterol lowering via inhibition of RhoA显示文摘 | Porter K E Turner N A O'Regan D J | 2004 | Cardiovasc Res2004，61，4： | 1 |
| 8 | Use of an efflux pump inhibitor to determine the prevalence of ettlux pump- mediated fluoroquinolone resistance and multidrug resistance in Pseudomonas aeruginosa 显示文摘 | Kriengkauykiat J Porter E Lomovskaya O | 2005 | Antimicrob Agents Chemother2005，49，2： | 1 |
| 9 | The first use of a combined value auction for transportation services显示文摘 | Ledyard J O Olson M Porter D | 2002 | Interfaces2002，32，5： | 1 |
| 10 | Implementation structures: a new u- nit of administrative analysis显示文摘 | Hjern B Porter D O | 1981 | Organization Studies1981，2，3： | 1 |
| 11 | Simvastatin reduces human atrial myofibroblast proliferation independently of cholesterol lowering via inhibition of RhoA 显示文摘 | Porter K E Turner N A O'Regan D J | 2004 | Cardiovasc Res2004，61，4： | 1 |
| 12 | Partnership economics nursing's challenge in a quantum age显示文摘 | Malloch K Porter O Grady T | 1999 | Nurs Econ1999，17，6： | 1 |
| 13 | Ap34(cdc2) survival checkpoint in cancer显示文摘 | O'Connor DS Wall NR Porter AC | 2002 | Cancer Cell2002，2，1： | 1 |
| 14 | Barraquer-Simons lipodystrophy, Raynaud's phenomenon and cutaneous vasculitis 显示文摘 | Porter WM O'Gorman-Lalor O Lane RJ | 2000 | Clin Exp Dermatol2000，25，4： | 1 |
| 15 | A p34(cdc2) survival checkpoint in cancer显示文摘 | O'Connor DS Wall NR Porter AC | 2002 | Cancer Cell2002，2，1： | 1 |
| 16 | Expression and regulation of the human β-defensins hBD-1 and hBD-2 in intestinal epithelium显示文摘 | O'Neil D A Porter EM Elewaut D | 1999 | J Immunology1999，163，： | 1 |
| 17 | The First Use of a Combined Value Auction for Transportation Services显示文摘 | OLSON M PORTER D | 2002 | Interfaces2002，32，5： | 1 |
| 18 | A p34 (cdc2) survival check point in cancer显示文摘 | O' Connor DS Wall NR Porter AC | 2002 | Cancer Cell2002，2，1： | 1 |
| 19 | Tilt-table testing and oral metoprolol therapy in young patients with unexplained syncope显示文摘 | O'Marcaigh A Maclellan-Tobert SG Porter CJ | 1994 | Pediatrics1994，93，： | 1 |
| 20 | Simvastafin reduces human atrial myofibroblast proliferation independently of cholesterol lowering via inhibition of RhoA 显示文摘 | Porter KE Turner NA O'Regan D J | 2004 | Cardiovase Res2004，61，4： | 1 |
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