| 13 | Single-chain variable fragment antibody constructs neutralize measles virus infection in vitro and in vivo显示文摘Despite the availability of an effective measles virus(MeV)vaccine and efforts to increase vaccine coverage by the WHO,UNICEF,and their partners,MeV has not been eradicated,and the estimated global measles death rose from 89,780 in 2016 to 207,500 in 2019.1 Because there is an effective measles vaccine,antiviral development for measles has not been prioritized,but recent outbreaks have highlighted the need for drugs to prevent transmission in unvaccinated populations and to protect and treat immunocompromised individuals.We identified several neutralizing mouse monoclonal antibodies(mAbs)that target the MeV fusion(F)protein in its prefusion state2 and inhibit fusion and viral infection.We engineered a single-chain variable fragment(scFv)from the most potent anti-MeV F mAb.The scFv retains the ability to inhibit fusion and prevents infection in vitro,and intranasal administration of the scFv antibody construct prevents infection in vivo. | Cyrille Mathieu Marion Ferren Olivia Harder Francesca TBovier Tara CMarcink Camilla Predella Fabrizio Angius Jennifer Drew-Bear NValerio Dorrello Alex LGreninger Anne Moscona Stefan Niewiesk Branka Horvat Matteo Porotto | 2021 | Cellular & Molecular Immunology2021，18，7： | 0 |
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