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| 1 | Insight into the interaction of inhaled corticosteroids with human serum albumin: A spectroscopic-based study显示文摘It is well known that the safety and efficacy profile of an inhaled cortocosteroid(ICS) is influenced by the pharmacokinetic properties and associated pharmacodynamic effects of the drug. Freely circulating,protein unbound, and active ICS can cause systemic adverse effects. Therefore, a detailed investigation of drug-protein interaction could be of great interest to understand the pharmacokinetic behaviour of corticosteroids and for the design of new analogues with effective pharmacological properties. In the present work, the interaction between some corticosteroids and human serum albumin(HSA) has been studied by spectroscopic approaches. UV–Vis spectroscopy confirmed that all the investigated corticosteroids can bind to HSA forming a protein-drug complex. The intrinsic fluorescence of HSA was quenched by all the investigated drugs, which was rationalized in terms of a static quenching mechanism. The thermodynamic parameters determined by the Van't Hoff analysis of the binding constants(negative ΔH and ΔS values) clearly indicate thathydrogen bonds and van der Waals forces play a major role in the binding process between albumin and betamethasone, flunisolide and prednisolone, while hydrophobic forces may play a major role in stabilizing albumin-triamcinolone complexes. | Carlotta Pontremoli Nadia Barbero Guido Viscardi Sonja Visentin | 2018 | Journal of Pharmaceutical Analysis2018，8，1： | 2 |
| 2 | Cardiovascular and renal effects of hypemrieaemia and gout 显示文摘 | Viazzi F Leoncini G Pontremoli R | 2011 | Reumatismo2011，63，4： | 1 |
| 3 | Development of grade API X80 pipeline steel plates produced by controlled rolling 显示文摘 | Pontremoli M Bufalini P Aprile A | 1984 | Metals Technology1984，11，11： | 1 |
| 4 | Microalbumin-uria,cardiovascular,and renal risk in primary hypertension显示文摘 | Pontremoli R Leoncini G Ravera M | 2002 | J Am Soc Nephrol2002，13，3： | 1 |
| 5 | Therapeutic Approaches to Chronic Hyperuricemia and Gout 显示文摘 | Grassi D Pontremoli R Bocale R | 2014 | High Blood Press Cardiovasc Prev2014，，： | 1 |
| 6 | RAAS inhibition and renal protection显示文摘 | Leoncini G Viazzi F Pontremoli R | 2012 | Curr Pharm Des2012，18，7： | 1 |
| 7 | Reversible inactivation ofcalpain isoforms by nitric oxide显示文摘 | Michetti M Salamino F Melloni E Pontremoli S | 1995 | Biochem Biophys Res Commun1995，207，3： | 1 |
| 8 | Increased Renal Resistive Index in Patients with Essential H ypertension:a Marker of Target Organ Damage显示文摘 | Pontremoli R Viazzi F Martinoli C | 1999 | Nephrol Dial Transplant1999，14，： | 1 |
| 9 | Independent association of ECG abnor- malities with miemalbumirturia and renal damage in hypertensive patients without overt cardiovascular disease: data from Italy-Developing Education and aware- ness on MicroAlbuminuria in patients with hypertensive Disease study 显示文摘 | 5ciarretta S Pontremoli R Rosei EA | 2009 | J Hypertens2009，27，2： | 1 |
| 10 | Microalbuminuria,cardiovascular,and renal risk in primary hypertension显示文摘 | Pontremoli R Leoncini G Ravera M | 2002 | Am Soc Nephrol2002，13，3： | 1 |
| 11 | Indepent association of ECG abnormalitieswith microalburninuria and renal damage in hyperten- sive patients with hypertensive out overt cardiovascular disese: data from Italy - Develping Education and awareness on Micoalbuminuria in pa- tients with hypertensive disease study 显示文摘 | Sciarretta S Pontremoli R Rosei EA | 2009 | J Hypertens2009，7，2： | 1 |
| 12 | Antihypertensive Treatment and Renal Protection: the role of drugs inhibiting the renin-angiotensin-aldosterone system显示文摘 | Francesca Viazzi Giovanna Leoncini Roberto Pontremoli | 2013 | High Blood Pressure & Cardiovascular Prevention2013，，4： | 1 |
| 13 | Kidney and cardiovascular risk in primary hypertension显示文摘In patients with primary hypertension,therapeutic strategies should be based on global cardiovascular risk profile rather than on the severity of blood pressure alone.Accurate assessment of concomitant risk factors and especially of the presence and extent of subclinical organ damage is of paramount importance in definingindividual risk.Given the high prevalence of hypertension in the population at large,however,extensive diagnostic evaluation is often impractical or unfeasible in clinical practice.Low cost,easy to use markers of risk are needed to improve the clinical management of patients with hypertension.Early renal abnormalities such as a slight reduction in glomerular filtration rate and/or the presence of microalbuminuria are well known and powerful predictors of cardio-renal morbidity and mortality and provide a useful,low cost tools to optimize cardiovascular risk assessment.A greater use of these tests should therefore be implemented in clinical practice in order to optimize the management of hypertensive patients. | Francesca Viazzi Francesca Cappadona Barbara Bonino Roberto Pontremoli | 2015 | World Journal of Hypertension2015，5，4： | 1 |
| 14 | Serum Uric Acid and Target Organ Damage in Primary Hypertension显示文摘 | Francesca Viazzi Denise Parodi Giovanna Leoncini Angelica Parodi Valeria Falqui Elena Ratto Simone Vettoretti Gian Paolo Bezante Massimo Del Sette Giacomo Deferrari Roberto Pontremoli | 2005 | Hypertension2005，，5： | 1 |
| 15 | Increased renal resistive index in patients with essential hypertension:A marker of target organ damage显示文摘 | Pontremoli R Viazzi F Martinoli C | 1999 | Nephrol Dial Transplant1999，14，2： | 1 |
| 16 | Ambulatory arterial stiffness in- dex and renal abnormalities in primary hypertension 显示文摘 | Ratto E Leoncini G Pontremoli R | 2006 | J Hypertens2006，24，： | 1 |
| 17 | Cardiovascular and renal effects of hyperurieaemia and gout显示文摘 | Viazzi F Leonein{ G Pontremoli R | 2012 | Reumatismo2012，63，4： | 1 |
| 18 | En hanced activation of the respiratory burst oxidase in neutrophils from hypertensive patients Biochem显示文摘 | Pontremoli S Salamino F Sparatore B | 1989 | Biophys Res Commun1989，158，3： | 1 |
| 19 | C-reactive protein and target organ damage in untreated patients with primary hypertension显示文摘 | Ratto E Leoncini G Pontremoli R | 2007 | J Am Soc Hyper- tens2007，1，6： | 1 |
| 20 | Cardiovascular and renal effects of hyperuricaemia and gout显示文摘 | Viazzi F Leoncini G Pontremoli R | 2012 | Reumatismo2012，63，4： | 1 |
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