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| 1 | Rates and impact of hepatitis on human immunodeficiency virus infection in a large African cohort显示文摘AIM:To determine the rates and impact of hepatitis B virus(HBV) and hepatitis C virus(HCV) infections on response to long-term highly active antiretroviral therapy(HAART) in a large human immunodeficiency virus(HIV) population in Nigeria.METHODS:HBV and HCV as well as HIV infections are endemic in sub Saharan Africa.This was a retrospective cohort study of 19 408 adults who were recruited between June 2004 and December 2010 in the AIDS Prevention Initiative in Nigeria in Nigeria programme at Jos University Teaching Hospital.Serological assays,including HBV surface antigen(HBsAg) and hepatitis C antibody were used to categorise hepatitis status of the patients.HBsAg was determined using enzyme immunoassay(EIA)(Monolisa HBsAg Ultra3;Bio-Rad).HCV antibody was tested using third generation EIA(DIA.PRO Diagnostic,Bioprobes srl,Milan,Italy).HIV RNA levels were measured using Roche COBAS Amplicor HIV-1 monitor test version 1.5(Roche Diagnostics,GmbH,Mannheim,Germany) with a detection limit of 400 copies/mL.Flow cytometry was used to determine CD4+ cell count(Partec,GmbH Munster,Germany).Comparison of categorical and continuous variables were achieved using Pearson's χ 2 and Kruskal Wallis tests respectively,on MedCalc for Windows,version 9.5.0.0(MedCalc Software,Mariakerke,Belgium).RESULTS:With an overall hepatitis screening rate of over 90% for each virus;HBV,HCV and HBV/HCV were detected in 3162(17.8%),1983(11.3%) and 453(2.5%) HIV infected adults respectively.The rate of liver disease was low,but highest among HIV monoinfected patients(29,0.11%),followed by HBV coinfected patients(15,0.08%).Patients with HBV coinfection and triple infection had higher log 10 HIV RNA loads(HBV:4.6 copies/mL vs HIV only:4.5 copies/mL,P<0.0001) and more severe immune suppression(HBV:645,55.4%;HBV/HCV:97,56.7%) prior to initiation of HAART compared to HIV mono-infected patients(1852,48.6%)(P<0.0001).Of 3025 patients who were 4.4 years on HAART and whose CD4 cell counts results at baseline and end of follow up were available for analyses,CD4 increase was significantly lower in those with HBV co-infection(HBV:144 cells/mm3 ;HBV/HCV:105 cells/mm3) than in those with HCV co-infection(165 cells/mm3) and HIV mono-infection(150 cells/mm3)(P=0.0008).CONCLUSION:High rates of HBV and HCV infections were found in this HIV cohort.CD4 recovery was significantly diminished in patients with HBV co-infection. | Nimzing Gwamzhi Ladep Patricia Aladi Agaba Oche Agbaji Auwal Muazu Placid Ugoagwu Godwin Imade Graham Cooke Sheena McCormack Simon David Taylor-Robinson John Idoko Phyllis Kanki | 2013 | World Journal of Gastroenterology2013，19，10： | 3 |
| 2 | A novel parallel-kinematics mechanism for integrated, multi-axis nanopositioning显示文摘 | Jingyan Dong Qing Yao Placid M. Ferreira | 2007 | Precision Engineering2007，，： | 2 |
| 3 | Computatioa of stiffness and stiffness hounds for parallel link manipulators 显示文摘 | Bashar S Khasawneh E L Placid M F | 1999 | International Journal of Tools & Manufacture1999，39，2： | 1 |
| 4 | Development of in-service inspection techniques for nuclear power plants in india 显示文摘 | Placid Rodriguez | 1997 | International Journal of Pressure Vessels and Piping1997，73，1： | 1 |
| 5 | An Analytical Quadratic Model for the Geometric Error of a Machine Tool显示文摘 | Placid M Ferreira C Liu Richard | 1986 | Journal of Manufacturing Systems1986，5，1： | 1 |
| 6 | Verification of fromtolerances Part 11 :Cylindricity and straightness of a median line 显示文摘 | Kirsten Carr Placid Ferreirat | 1995 | Precision Engineering1995，17，： | 1 |
| 7 | Verification of fro-mtolerances Part Ⅱ:Cylindricity and straightness of a median line显示文摘 | CARR Kirsten FERREIRAT Placid | 1995 | Precision Engineering1995，17，： | 1 |
| 8 | Computation of stiffness and stiffness bounds for parallel link manipulators 显示文摘 | BASHAR S E PLACID M F | 1999 | International Journal of Machine Tools & Manufacture1999，39，2： | 1 |
| 9 | Dynamics,control and performance analysis of a novel parallel-kinematics mechanism for integrated, multi-axis nano-positioning 显示文摘 | Dong J Y Yao Q Placid M F | 2008 | Precision Engineering2008，32，： | 1 |
| 10 | Enidcine acquisition mode for in vivo radiometry in dynamic arc radiation therapy, nuclear instruments methods in physics research 显示文摘 | Confidant A Caramelize A Placid E | 2008 | Beam Interactions with Materials and Atoms2008，266，4： | 1 |
| 11 | Environmental monitoringsystem compliant with the IEEE 1451 standard and featuring asimplified transducer interface显示文摘 | Bissi L Placide P Scorzoni A | 2007 | Sensors and Actuators A:Physical2007，137，1： | 1 |
| 12 | Computation of stiffness and stiffness bounds for parallel link manipulators显示文摘 | PLACID M F | 1999 | International Joumal of ma chine tools & manufacture1999，39，2： | 1 |
| 13 | An analytical quadratic model for the geometric error of a machine tool 显示文摘 | Placid M Ferreira Liu C Richard | 1998 | Journal of Manufacturing Systems1998，189，5： | 1 |
| 14 | Adoption and Risk of ERP Systems in Manufacturing SMEs:a Positivist Case Study显示文摘 | Placide Poba- Nzaou Louis Raymond Bruno Fabi | 2008 | Business Process Management Journal2008，，14： | 1 |
| 15 | Development of inservice inspection techniques for nuclear power plants in India显示文摘 | Placid Rodriguez Baldev Raj | 1997 | Int J PresVes & Piping1997，73，： | 1 |
| 16 | Verification of from tolerances Part Ⅱ: Cylindricity and straightness of a median line 显示文摘 | KIRSTEN C PLACID F | 1995 | Precision Engineering1995，，17： | 1 |
| 17 | Computation of stiffness and stiffness bounds for parallel link manipulators显示文摘 | BASHAR S E PLACID M F | 1999 | International Journal of Machine Tools & Manufacture1999，39，2： | 1 |
| 18 | Computation of stiffness and stiffness bounds for parallel link manipulators 显示文摘 | Bashar S E Placid M F | 1999 | International Journal of Machine Tools and Manufacture1999，39，： | 1 |
| 19 | Dynamics, control and performance analysis of a novel parallel-kine nmtics mechanism for integrated, multi-axis nano positio- ning显示文摘 | DONG J Y YAO Q PLACID M F | 2008 | Precision Engineering2008，32，： | 1 |
| 20 | An analytical quadratic model for the geometric error of a machine tool显示文摘 | PLACID M FARREIRA LIU C R | 1986 | Journal of Manufacturing Systems1986，5，1： | 1 |
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