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| 1 | Genetically engineered K cells provide sufficient insulin to correct hyperglycemia in a nude murine model显示文摘基因类型 1 糖尿病 mellitus 的基于治疗的处理要求能综合并且响应生理的联盟者分泌机能上地活跃的胰岛素的一个代理人贝它房间的发展在周围的葡萄糖层次的相关变化。在这研究,鼠科的 enteroendocrine 房间线 STC-1 被稳定的转染遗传上修改。二个克隆房间被选择(STC-1-2 和 STC-1-14 ) 那在从 0 ~ 157.2 亩 IU/ml/10 (6 ) cells/d 表示胰岛素的 22 克隆之中分泌了胰岛素的高水平。在在文化媒介的葡萄糖集中从 1 公里被增加到 10 公里以后,分泌胰岛素从 40.3 +/- 升起了 0.8 ~ 56.3 +/- 3.2 亩 IU/ml (STC-1-2 ) ,并且从 10.8 +/- 0.8 ~ 23.6 +/- 2.3 亩 IU/ml (STC-1-14 ) 。在 STC-1-14 房间被植入进糖尿病的裸体老鼠以后,他们的血葡萄糖层次被归结为正常。身体重量损失也被改善。我们的数据建议遗传上设计的 K 房间以一种调整葡萄糖的方式分泌活跃胰岛素,并且在 vivo,学习证明多糖症能被房间的培植颠倒,建议到快速的人的胰岛素力量的遗传上设计的 K 房间的使用提供一条调整葡萄糖的途径对待糖尿病的多糖症。 | Yiqun Zhang Liqing Yao Kuntang Shen Meidong Xu Pinghong Zhou Weige Yang Xinyuan Liu Xinyu Qin | 2008 | Acta Biochimica et Biophysica Sinica2008，40，2： | 4 |
| 2 | Endoscopic management of colorectal polyps显示文摘Colorectal polyps are premalignant lesions in the lower gastrointestinal tract.Endoscopic polypectomy is an effective strategy to prevent colorectal cancer morbidity and more invasive procedures.Techniques for the endoscopic resection of polyps keep evolving,and endoscopists are required to perform the most appropriate technique for each polyp.In this review,we outline the evaluation and classification of polyps,update the recommendations for optimal treatment,describe the polypectomy procedures and their strengths/weaknesses,and discuss the promising innovative methods or concepts. | Pingting Gao Kaiqian Zhou Wei Su Jia Yu Pinghong Zhou | 2023 | Gastroenterology Report2023，11，1： | 2 |
| 3 | Phosphorus fractions and alkaline phosphatase activity in sediments of a large eutrophic Chinese lake (Lake Taihu)显示文摘 | Yiyong Zhou Chunlei Song Xiuyun Cao Jianqiu Li Guoyuan Chen Zhuoying Xia Pinghong Jiang | 2008 | Hydrobiologia2008，，1： | 1 |
| 4 | TN: TP ratio and planktivorous fish do not affect nutrient-chlorophyll relationships in shallow lakes显示文摘 | Wang Haijun Liang Xiaoming Jiang Pinghong | 2008 | Freshwater Biology2008，53，5： | 1 |
| 5 | TN : TP ratio and planktivorous fish do not affect nutrient-chlorophyll relation-ships in shallow lakes显示文摘 | WANG Haijun LIANG Xiaomin JIANG Pinghong | 2008 | Fresh Water Biology2008，53，： | 1 |
| 6 | Perioperative management and treatment for complications during and after peroral endoscopic myotomy (POEM) for esophageal achalasia (EA) (data from 119 cases)显示文摘 | Zhong Ren Yunshi Zhong Pinghong Zhou Meidong Xu Mingyan Cai Liang Li Qiang Shi Liqing Yao | 2012 | Surgical Endoscopy2012，，11： | 1 |
| 7 | Perioperative management and treatment for complications during and after peroral endoscopic myotomy (POEM) for esophageal achalasia (EA) (data from 119 cases)显示文摘 | Zhong Ren Yunshi Zhong Pinghong Zhou Meidong Xu Mingyan Cai Liang Li Qiang Shi Liqing Yao | 2012 | Surgical Endoscopy2012，，11： | 1 |
| 8 | Phosphorus fractions and alkaline phosphatase activity in sediments of a large eutrophic Chinese lake (Lake Taihu)显示文摘 | Yiyong Zhou Chunlei Song Xiuyun Cao Jianqiu Li Guoyuan Chen Zhuoying Xia Pinghong Jiang | 2008 | Hydrobiologia2008，，1： | 1 |
| 9 | Perioperative management and treatment for complications during and after peroral endoscopic myotomy (POEM) for esophageal achalasia (EA) (data from 119 cases)显示文摘 | Zhong Ren Yunshi Zhong Pinghong Zhou Meidong Xu Mingyan Cai Liang Li Qiang Shi Liqing Yao | 2012 | Surgical Endoscopy2012，，11： | 1 |
| 10 | Perioperative management and treatment for complications during and after peroral endoscopic myotomy (POEM) for esophageal achalasia (EA) (data from 119 cases)显示文摘 | Zhong Ren Yunshi Zhong Pinghong Zhou Meidong Xu Mingyan Cai Liang Li Qiang Shi Liqing Yao | 2012 | Surgical Endoscopy2012，，11： | 1 |
| 11 | Approximate reliability analysis using normal polynomial and simulation results显示文摘 | Han Pinghong Lind N C | 1996 | Structural Safety1996，18，4： | 1 |
| 12 | Technical feasibility of salvage endoscopic full-thickness resection for a giant gastrointestinal stromal tumor located in low rectum after imatinib:a case report显示文摘Introduction Gastrointestinal stromal tumors(GISTs)in adults are nearly 10%–30%with a potential malignant tendency[1].Colorectal GISTs account for 5%of all cases and have a higher progression risk with a poor prognosis[2,3].Rectal GISTs usually need radical operations such as laparoscopy to obtain tumor-free margins.Sometimes,it is difficult for surgery to preserve the anal function because of the tumor size and location.Here,we report a case of a 70-year-old female with a giant GIST located in the lower rectum,which was removed by function-preserving endoscopic minimally invasive resection after routine imatinib therapy. | Jingyi Liu Bing Li Pinghong Zhou Mingyan Cai Yunshi Zhong | 2023 | Gastroenterology Report2023，11，1： | 0 |
| 13 | Overexpression of CIP2A is associated with poor prognosis in multiple myeloma显示文摘Cancerous inhibitor of protein phosphatase 2A(CIP2A),an endogenous protein phosphatase 2A(PP2A)inhibitor,has been identified as an oncoprotein in promoting cancer initiation and progression of several types of cancer.However,the expression and the role played by CIP2A in the pathogenesis of multiple myeloma(MM)remain unclear.In this study,we showed that CIP2A was overexpressed in human MM cell lines and MM patients’bone marrow tissues.Clinicopathologic analysis showed that CIP2A expression was significantly correlated with clinical stage and percent of plasma cells in bone marrow.Kaplan–Meier analysis revealed that patients with high CIP2A expression presented with poorer overall survival rates than those with low CIP2A expression.Moreover,CIP2A knockdown in MM cells resulted in attenuated proliferative abilities.In addition,CIP2A depletion sensitizes dexamethasone(Dex)-resistant cells to Dex.The effect of CIP2A on proliferation and Dex therapy was mediated by the inhibition of PP2A,which in turn activated Akt.In vivo studies confirmed that CIP2A regulated MM tumorigenesis and the phosphorylation of Akt.Taken together,our results suggest that CIP2A oncoprotein plays an important role in MM progression and could serve as a prognosis marker and a novel therapeutic target for the treatment of patients with MM. | Xuewen Liu Wei Cao Shanshan Qin Te Zhang Junnian Zheng Ying Dong Pinghong Ming Qian Cheng Zheng Lu Yang Guo Baofu Zhang Ying Liu | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 0 |
| 14 | Re-evaluation of indications and outcomes of endoscopic excision procedures for colorectal tumors:a review显示文摘Endoscopic submucosal dissection(ESD)and endoscopic mucosal resection(EMR)are useful therapeutic techniques for colorectal tumors.Currently,new techniques based on these procedures are available,such as endoscopic submucosal dissection with snare(ESD-S)and endoscopic mucosal resection with pre-cutting(EMR-P).For the excision of colorectal tumors,each of these techniques has been characterized as having a high total resection rate,low recurrence rate or low complication rate.In this study,we analysed clinical trials that had recently been published,to search for the most appropriate endoscopic treatment for colorectal tumors.Our search results revealed the following:for a tumor with a diameter less than 20mm,the surgeon should choose ESD,ESD-S,EMR-P or EMR,depending on the condition of the tumor.On the other hand,to excise a tumor larger than 20mm in diameter,ESD and ESD-S should be the first choices.However,if the patient has a high risk of complications due to ESD or ESD-S,the use of EMR-P would be suitable.Because of the high possibility of canceration in a tumor larger than 20mm in diameter,EMR is not the optimal endoscopic treatment for the excision of a colorectal tumor,due to a low total resection rate and a high recurrence rate. | Shilun Cai Yunshi Zhong Pinghong Zhou Jianmin Xu Liqing Yao | 2014 | Gastroenterology Report2014，2，1： | 0 |
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