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| 1 | Keratinocyte 生长 factor-2 和自体同源的浆液加强处于在老鼠的角膜损坏的间充质的干细胞的再生效果显示文摘AIM:To investigate the healing process after severe corneal epithelial damage in rats treated with mesenchymal stem cells(MSCs)cultured with or without keratinocyte growth factor(KGF-2)and autologous serum(AS)on amniotic membrane(AM).Many patients are blind and devastated by severe ocular surface diseases due to limbal stem cell deficiency.Bone marrow-derived MSCs are potential sources for cellbased tissue engineering to repair or replace the corneal tissue,having the potential to differentiate to epithelial cells.METHODS:The study included 5 groups each including 10 female'Sprague Dawley'rats in addition to20 male rats used as bone marrow donors.Group I rats received AM+MSCs,Group II rats AM+MSCs cultured with KGF-2,Group III rats AM+MSCs cultured with KGF-2+AS,Group IV rats only AM and Group V rats,none.AS was derived from blood drawn from male rats and bone marrow was obtained from the femur and tibia bones of the same animals.Therapeutic effect was evaluated with clinical,histopathological and immunohistochemical assessment.MSC engraftment was demonstrated via detection of donor genotype(Y+)in the recipient tissue(X)with polymerase chain reaction.RESULTS:Corneal healing was significantly better in Groups I-III rats treated with MSC transplantation compared to Group IV and Group V rats with supportive treatment only.The best results were obtained in Group III rats with 90%transparency,70%lack of neovascularization,and 100%epithelium damage limited to less than 1/4 of cornea.CONCLUSION:We suggest that culture of MSCs with KGF-2 and AS on AM is effective in corneal repair in case of irreversible damage to limbal stem cells. | Ferda Alpaslan Pinarli Gülsen Okten Umit Beden Tunc Fisgin Mehmet Kefeli Nurten Kara Feride Duru Leman Tomak | 2014 | International Journal of Ophthalmology(English edition)2014，7，2： | 4 |
| 2 | Protection from cyclophosphamide-induced ovarian damage with bone marrow-derived mesenchymal stem cells during puberty显示文摘 | Kilic S Pinarli F Ozogul C Tasdemir N Naz Sarac G Delibasi T | 2014 | Gynecol Endocrinol2014，30，2： | 1 |
| 3 | Electrocardiographic find- ings after 5-HT3 receptor antagonists and chemotherapy in children with cancer显示文摘 | Pinarli F G Elli M Dagdemir A | 2006 | Pediatr Blood Cancer2006，47，5： | 1 |
| 4 | Treatment efficacy with bone marrow derived mesenchymal stem cells and minocy- cline in rats after cerebral ischemic injury 显示文摘 | Bilen S Pinarli F Ak F | 2013 | Stem Cell Rev2013，9，2： | 1 |
| 5 | Solar drying in sludge management in Turkey 显示文摘 | Kamil S N Pinarli V Salihoglu G | 2007 | Renewable Energy2007，32，10： | 1 |
| 6 | Late cardiac evaluation of children with solid tumors after anthracycline chemotherapy显示文摘 | Pinarli FG Oguz A Tunaoglu lS | 2005 | Pediatr Blood Cancer2005，44，6： | 1 |
| 7 | Combined genetic mutations have remarkable effect on deep venous thrombosis and/or pulmonary embolism occurence显示文摘 | Erdal Simsek Ahmet Yesilyurt Ferda Pinarli Nilnur Eyerci A. Tulga Ulus | 2013 | Gene2013，，： | 1 |
| 8 | Thyroid abnormalities in survivors of childhood cancer显示文摘 | Caglar AA OguzA Pinarli FG | 2014 | J Clin Res Pediatr Endocrinol2014，6，： | 1 |
| 9 | Solar drying in sludge management in Turkey显示文摘 | Salihoglu N K Pinarli V Salihoglu G | 2007 | Renewable Energy2007，32，10： | 1 |
| 10 | Steel foundry electric arc furnace dust management: stabilization by using lime and Portland cement显示文摘 | SALIHOGLU G PINARLI V | 2008 | Journal of Hazardous Materials2008，153，3： | 1 |
| 11 | Effect of wheat germ addition on the microbiological quality, in vitro protein digestibility, and gelatinization behavior of macaroni 显示文摘 | Ilkay pinarli Mehmet Oner Senol Ibanoglu | 2004 | Eu- ropean Food Research & Technology2004，219，： | 1 |
| 12 | Protection from cycloh- posphamide-induced ovarian damage with hone marrowderived rues enchymal stem cells during puberty显示文摘 | Kilic S Pinarli F Ozogul C el al | 2014 | Gynecol Endocrinol2014，30，2： | 1 |
| 13 | Effect of stem cell application onAsherman syndrome,an experimental rat model 显示文摘 | Kilic S Yuksel B Pinarli F | 2014 | J Assist ReprodGenet2014，31，8： | 1 |
| 14 | Type Ⅱ pleuropulmonary blastoma responsive to multimodal therapy显示文摘 | PINARLI F G OGUZ A CEYDA K | 2005 | Pediatr Hematol Oncol2005，22，1： | 1 |
| 15 | Protection from cyclophosphamide-induced ovarian damage with bone marrow- derived mes enchymal stem cells during puberty 显示文摘 | Kilic S Pinarli F Ozogul C | 2014 | Gynecol Endocrinol2014，30，2： | 1 |
| 16 | Protection from cyclophosphamide-induced ovarian damage with bone marrow derived mesenchymal stem cells during puberty显示文摘 | Kilic S Pinarli F Ozogul C | 2014 | Gynecol Endocrinol2014，30，2： | 1 |
| 17 | Solar drying in sludge management in Turkey显示文摘 | NEZIH KAMIL SALIHOGLU VEDAT PINARLI GU- RAY SALIHOGLU | 2007 | Renewable Energy2007，32，： | 1 |
| 18 | The role of dobutamine stress echocardiography in early diagnosis of cardiac toxicity in long -term survivors of asymptomatic children treated with anthracycline显示文摘 | Yildirim A Tunaoglu F S Pinarli F G | 2010 | Anadolu Kardiyol Derg2010，10，15： | 1 |
| 19 | Primary renal lymphoma and xanthogranulomatous pyelonephritis in childhood显示文摘 | Karadeniz C Oguz A Ataoglu O Citak C Buyan N Pinarli G | 2002 | J Nephrol2002，15，5： | 1 |
| 20 | Solardrying in sludge management in Turkey显示文摘 | Nezih Kamil Salihoglu Vedat Pinarli Guray Salihoglu | 2007 | Renewable Energy2007，32，10： | 1 |
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