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| 1 | Pit-and trench-forming osteoclasts:a distinction that matters显示文摘Osteoclasts(OCs)seeded on bone slices either drill round pits or dig long trenches.Whereas pits correspond to intermittent resorption,trenches correspond to continuous and faster resorption and require a distinct assembly of the resorption apparatus.It is unknown whether the distinction between pits and trenches has any biological relevance.Using OCs prepared from different blood donors,we found that female OCs achieved increased resorption mainly through pit formation,whereas male OCs did so through trench formation.Trench formation went along with high collagenolytic activity and high cathepsin K(CatK)expression,thereby allowing deeper demineralization.A specific CatK inhibitor abrogated the generation of trenches,while still allowing the generation of pits.OCs obtained from bone marrow were more prone to generate trenches than those obtained from blood.Scanning electron microscopy of bone surfaces eroded in vivo showed trenches and pits of similar size as those made by OCs in culture.We conclude that the distinction between trench-and pit-forming OCs is relevant to the differences among OCs from different skeletal sites,different individuals,including gender,and results from differences in colIagenolytic power.This indicates a biological relevance and highlights the importance of discriminating between pits and trenches when assessing resorption. | Ditte MH Merrild Dinisha C Pirapaharan Christina M Andreasen Per Kjxrsgaard-Andersen Anas MJ Mùller Ming Ding Jean-Marie Delaissé Kent Sùe | 2015 | Bone Research2015，3，4： | 2 |
| 2 | 查看详情显示文摘 | Hayden S M Mook H A Dai P C Perring T G Dogan F | | 0，，： | 1 |
| 3 | Effect of 10% carbamide peroxidebleachinggelon enamelmicrohardness,microstructure,and mineral content显示文摘 | Poto(c)nik I Kosec L Ga(s)per(s)i(c) D | 2000 | J Endod2000，26，4： | 1 |
| 4 | Lithogeochemical explo- ration for komatiite-associated Ni-sulfide deposits: strategies and limitations显示文摘 | Barnes S J Hill R E T Perring C S | 2004 | Mineralogy and Petrology2004，82，： | 1 |
| 5 | Using automated digital image analysis to provide quantitative petrographic data on olivine-phyric basalts显示文摘 | Perring C S Barnes S J Verrall M | 2004 | Computers & Geosciences2004，30，： | 1 |
| 6 | Local and systemic changes in squash gene expression in response to silverleaf whitefly feeding显示文摘 | van de Ven W T G Levesque C S Perring T M | 2000 | Plant Cell2000，12，： | 1 |
| 7 | An ecological-economic model for catchment management:The case of Tonameca,Oaxaca,Mexico显示文摘 | Avila-Foucat V S Perrings C Raffaelli D | 2009 | Ecological Economics2009，68，： | 1 |
| 8 | PCR characterization and typ- ing of Klebsiella pneumoniae using capsular type-specific, variable number tandem repeat and vimlenee gene targets显示文摘 | Turton JF Per C Elgohari S | 2010 | J Med Miero- bio12010，59，5： | 1 |
| 9 | A novel high density borohydride-air cell 显示文摘 | Amendola S C Per Onnerud Kelly M T | 1999 | 1 Power Sources1999，84，1： | 1 |
| 10 | Stock returns'sensitivities to crisis shocks:Evidence from developed and emerging markets显示文摘 | Calomiris C W Love I Pería M S M | 2012 | Journal of International Money and Finance2012，31，4： | 1 |
| 11 | Criteria for the recog- nition of metamorphosed or altered lamprophyres: A casestudy from the Archean of Kambalda显示文摘 | Perring C S Rock N M S Golding S | 1989 | Precambrian Research1989，52，： | 1 |
| 12 | Petrogenesis of the Squirrel Hills granite and associated magnetite-rich sill and vein complex: Lightning creek prospect, Cloncurry district, Northwest Queensland 显示文摘 | Perring C S Pollard P J Nunn A J | 2001 | Precambrian Research2001，106，34： | 1 |
| 13 | A note on thereasonableness of PERT hypotheses显示文摘 | Pleguezuelo R H Peréz J G Rambaud S C | 2003 | Operations ResearchLetters2003，31，1： | 1 |
| 14 | Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF‐A and TGFβ2 in vascular abnormalization显示文摘 | Lothar C Dieterich Sofie Mellberg Elise Langenkamp Lei Zhang Agata Zieba Henriikka Salom?ki Martin Teichert Hua Huang Per‐Henrik Edqvist Theo Kraus Hellmut G Augustin Tommie Olofsson Erik Larsson Ola S?derberg Grietje Molema Fredrik Pontén Patrik Georgii‐ | 2012 | J. Pathol2012，，3： | 1 |
| 15 | The Role of Agricultural Cooperatives in Sustaining the Wheat Diversity and Produc- tivity : the Case of Southern Ltaly 显示文摘 | Falco S D Smale M Perrings C | 2008 | Environmental and Resource Economics2008，，39： | 1 |
| 16 | The effect of Ni2+,Co2+,Zn2+,Cd2+ and Hg2+ on the growth rate of marine diatom Phaeodactylum tricornutum Bohlin:Microplate growth inhibition test显示文摘 | Horvati(c) J Per(s)i(c) V | 2007 | Bulletin of Environmental Contamination and Toxicology2007，79，5： | 1 |
| 17 | Using automated digital image analysis to providequantitative petrographic data on olivine-phyric basalts显示文摘 | PERRING C S BARNES S J VERRALL M | 2004 | Computers & Geosciences2004，30，： | 1 |
| 18 | Biological diversity,ecosystems,and the human scale显示文摘 | FOLKE C HOLLING C S PERRINGS C | 1996 | Ecological Applications1996，6，4： | 1 |
| 19 | Identification of heme oxygenase-1-specific regulatory CD8^sup +^ T cells in cancer patients显示文摘 | Andersen Mads Hald S?rensen Rikke B?k Brimnes Marie K Svane Inge Marie Becker Jürgen C Straten Per thor | 2009 | Journal of Clinical Investigation2009，，8： | 1 |
| 20 | Auditor ymo nitor ing dur ing acoustic neur oma remov al显示文摘 | 1 Slav it D H H ar ner S G H ar per C M Jr | 1991 | Arch Oto-laryng ol Head Neack Surg1991，117，： | 1 |
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