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| 1 | Does antecolic reconstruction decrease delayed gastric emptying after pancreatoduodenectomy?显示文摘Delayed gastric emptying(DGE) is a frequent complication after pylorus-preserving pancreatoduodenectomy(PpPD).Kawai and colleagues proposed pylorus-resecting pancreatoduodenectomy(PrPD) with antecolic gastrojejunal anastomosis to obviate DGE occurring after PpPD.Here we debate the reported differences in the prevalence of DGE in antecolic and retrocolic gastro/duodeno-jejunostomies after PrPD and PpPD,respectively.We concluded that the route of the gastro/duodeno-jejunal anastomosis with respect to the transverse colon;i.e.,antecolic route or retrocolic route,is not responsible for the differences in prevalence of DGE after pancreatoduodenectomy(PD) and that the impact of the reconstructive method on DGE is related mostly to the angulation or torsion of the gastro/duodeno-jejunostomy.We report a prevalence of 8.9% grade A DGE and 1.1% grade C DGE in a series of 89 subtotal stomach-preserving PDs with Roux-en Y retrocolic reconstruction with anastomosis of the isolated Roux limb to the stomach and single Roux limb to both the pancreatic stump and hepatic duct.Retrocolic anastomosis of the isolated first jejunal loop to the gastric remnant allows outflow of the gastric contents by gravity through a 'straight route'. | Nadia Peparini Piero Chirletti | 2012 | World Journal of Gastroenterology2012，18，45： | 8 |
| 2 | The 'meso' of the rectum and the 'meso' of the pancreas: similar terms but distinct concepts in surgical oncology显示文摘A correspondence between the 'meso' of the rectum and of the pancreas has recently been reported. Here we highlight the differences between mesorectum and mesopancreas. Based on anatomical findings from a series of 89 consecutive pancreaticoduodenectomies and 71 consecutive total mesorectal excisions, we observed that in contrast to the mesorectum, the mesopancreas did not have well-defined anatomic boundaries and was continuous and connected through its components with the para-aortic area. In rectal cancer,tumor deposits and nodal involvement could be confined to the mesorectum(i.e., within the mesorectal fascia), whereas in pancreatic carcinoma, tumor deposits and nodal metastases occurred in the boundless mesopancreatic area. Total mesorectal excision was made en bloc with the rectum by dissecting along the mesorectal fascia; this was not the case for mesopancreatic excision since anatomical demarcation of the mesopancreas did not exist. Moreover, the growth pattern of pancreatic cancer showed greater dispersion, which was more prominent at the invasive front of the tumor and could potentially affect the status of the resection margin. These findings indicate that the mesorectum and mesopancreas are completely distinct from the pathological, surgical, and oncological standpoints. | Nadia Peparini Roberto Caronna Piero Chirletti | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，5： | 5 |
| 3 | Mesopancreas:A boundless structure,namely the rationale for dissection of the paraaortic area in pancreaticoduodenectomy for pancreatic head carcinoma显示文摘This review highlights the rationale for dissection of the 16a2 and 16b1 paraaortic area during pancreaticoduodenectomy(PD)for carcinoma of the head of the pancreas.Recent advances in surgical anatomy of the mesopancreas indicate that the retropancreatic area is not a single entity with well defined boundaries but an anatomical site of embryological fusion of peritoneal layers,and that continuity exists between the neuro lymphovascular adipose tissues of the retropancreaticand paraaortic areas.Recent advances in surgical pathology and oncology indicate that,in pancreatic head carcinoma,the mesopancreatic resection margin is the primary site for R1 resection,and that epithelialmesenchymal transition-related processes involved in tumor progression may impact on the prevalence of R1 resection or local recurrence rates after R0 surgery.These concepts imply that mesopancreas resection during PD for pancreatic head carcinoma should be extended to the paraaortic area in order to maximize retropancreatic clearance and minimize the likelihood of an R1 resection or the persistence of residual tumor cells after R0 resection.In PD for pancreatic head carcinoma,the rationale for dissection of the paraaortic area is to control the spread of the tumor cells along the mesopancreatic resection margin,rather than to control or stage the nodal spread.Although mesopancreatic resection cannot be considered'complete'or'en bloc',it should be'extended as far as possible'or be'maximal',including dissection of16a2 and 16b1 paraaortic areas. | Nadia Peparini | 2015 | World Journal of Gastroenterology2015，21，10： | 3 |
| 4 | Enucleation for gastrointestinal stromal tumors at the esophagogastric junction:Is this an adequate solution?显示文摘The authors discussed the proposal by Coccolini and colleagues to treat gastrointestinal stromal tumors (GISTs) at the esophagogastric junction with enucleation and,if indicated,adjuvant therapy,reducing the risks related to esophageal and gastroesophageal resection.They concluded that,because the prognostic impact of a T1 high-mitotic rate on esophageal GIST is worse than that of a T1 high-mitotic rate on gastric GIST,enucleation may not be an adequate surgery for esophagogastric GISTs with a high mitotic rate in which the guarantee of negative resection margins and adjuvant therapies can be the only chance of survival. | Nadia Peparini Giovanni Carbotta Piero Chirletti | 2011 | World Journal of Gastroenterology2011，17，16： | 3 |
| 5 | Tumor rupture during surgery for gastrointestinal stromal tumors: Pay attention!显示文摘In a recently published letter to the editor, we debated the proposal by Coccolini et al to treat gastrointestinal stromal tumors (GISTs) of the esophagogastric junction with enucleation and, if indicated, adjuvant therapy. We highlighted that, because the prognostic impact of a T1 high-mitotic rate esophageal GIST is worse than that of a T1 high-mitotic rate gastric GIST, enucleation may not be adequate surgery for esophagogastric GISTs with a high mitotic rate. In rebuttal, Coccolini et al pointed out the possible bias in assessment of the mitotic rates due to the lack of standardized methods and underlined that the site and features of the tumor need to be carefully considered in evaluation of the risk-benefit balance. Here we confirm that, apart from the problematic issue of mitotic counting, enucleation should not be indicated for GISTs at any site to reduce the risk of tumor rupture, which has been recently considered to be an unfavorable prognostic factor, and to avoid microscopic residual tumor. | Nadia Peparini Piero Chirletti | 2013 | World Journal of Gastroenterology2013，19，12： | 3 |
| 6 | Ovarian malignancies with cytologically negative pleural and peritoneal effusions:demons or meigs pseudo-syndromes显示文摘 | Peparini N Chirletti P | 2009 | Int J Surg Pathol2009，17，5： | 1 |
| 7 | Blue-dye sentinel node mapping in thyroid carcinoma:debatable results of feasibility显示文摘 | Peparini N Maturo A Di Matteo FM | | 0，，05： | 1 |
| 8 | Mesopancreas: A boundless structure, namely R1 risk in pancreaticoduodenectomy for pancreatic head carcinoma显示文摘 | N. Peparini P. Chirletti | 2013 | European Journal of Surgical Oncology2013，，12： | 1 |
| 9 | The impact of epithelial–mesenchymal transition on R1 status of the mesopancreatic resection margin after pancreaticoduodenectomy for pancreatic carcinoma: A research proposal topic显示文摘 | Nadia Peparini Piero Chirletti | 2013 | European Journal of Cancer2013，，10： | 1 |
| 10 | Choice of the surgical treatment in early gastric cancer显示文摘 | Custureri FD Orazi V Peparini N | 2004 | Hepatogastroenterology2004，51，58： | 1 |
| 11 | Clearance of the retropancreatic margin in pancreatic carcinomas: Total mesopancreas excision or extended lymphadenectomy?显示文摘 | N. Peparini P. Chirletti | 2012 | European Journal of Surgical Oncology2012，，11： | 1 |
| 12 | Clearance of the retropancreatic margin in pancreatic carcinomas: Total mesopancreas excision or ex- tended lymphadenectomy? 显示文摘 | Peparini N Chirletti P | 2012 | Eur J Surg Oncol2012，38，11： | 1 |
| 13 | Extended lymphadenectomy does not improve prognosis in pancreatic carcinoma: is that really so?显示文摘 | Nadia Peparini Piero Chirletti | 2012 | Journal of Hepato-Biliary-Pancreatic Sciences2012，，3： | 1 |
| 14 | Blue-dye sentinel nodemapping in thyroid carcinoma: debatable results of feasibility 显示文摘 | Peparini N Maturo A Di Matteo FM | 2006 | Acta Chit Belg2006，106，5： | 1 |
| 15 | Clearance of the retropancreatic marginin pancreatic carcinomas: total mesopancreas excision or extended lymphadenectomy ? 显示文摘 | Peparini N Chirletti P | 2012 | Eur J Surg Oncol2012，38，11： | 1 |
| 16 | Lymph node ratio,number of excised nodes and sentinel-node concepts in breast cancer显示文摘 | Peparini N Chirletti P | | 0，，03： | 1 |
| 17 | Choice of the surgical treatment in early gastric cancer显示文摘 | Custureri F D'orazi V Peparini N | 2004 | Hepatogastroenterology2004，51，58： | 1 |
| 18 | Blue-dye sentinel node mapping in thyroid carcinoma:debatable results of feasibility显示文摘 | PEPARINI N MATURO A DI MATTEO F M | 2006 | Acta Chir Belg2006，106，： | 1 |
| 19 | Extended lymphadenectomy does not improve prognosis in pancreatic carcinoma:is that really so显示文摘 | Peparini N Chirletti P | | 0，，03： | 1 |
| 20 | Ovarian malignancies with cytologically negative pleural and peritoneal effusions: demons' or meigs' pseudo syndromes显示文摘 | Peparini N Chirletti P | 2009 | Int J Surg Pathol2009，17，5： | 1 |
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