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| 1 | Cold-chain transportation in the frozen food industry may have caused a recurrence of COVID-19 cases in destination:Successful isolation of SARS-CoV-2 virus from the imported frozen cod package surface显示文摘Coronavirus disease 2019(COVID-19)pandemic has spread in 220 countries/regions towreak havoc to human beings around theworld.At present,the second wave of COVID-19 has begun in many European countries.The complete control of COVID-19 is very urgent.Although China quickly brought the virus under control,there have been eight sporadic outbreaks in China since then.Both in Xinfadi of Beijing and Dalian outbreak of COVID-19,environmental swab samples related to imported cold chain food were tested nucleic acid positive for SARS-CoV-2.In this outbreak in Qingdao,we directly isolated SARS-CoV-2 from the cod outer package's surface swab samples.This is the first time worldwide,SARS-CoV-2 were isolated from the imported frozen cod outer package's surface,which showed that imported frozen food industry could import SARS-CoV-2 virus. | Peipei Liu Mengjie Yang Xiang Zhao Yuanyuan Guo Liang Wang Jing Zhang Wenwen Lei Weifang Han Fachun Jiang William J.Liu George F.Gao Guizhen Wu | 2020 | Biosafety and Health2020，2，4： | 41 |
| 2 | Age-related rhesus macaque models of COVID-19显示文摘Background:Since December 2019,an outbreak of the Corona Virus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus(SARS-CoV-2)in Wuhan,China,has become a public health emergency of international concern.The high fatality of aged cases caused by SARS-CoV-2 was a need to explore the possible age-related phenomena with non-human primate models.Methods:Three 3-5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS-CoV-2,and then analyzed by clinical signs,viral replication,chest X-ray,histopathological changes and immune response.Results:Viral replication of nasopharyngeal swabs,anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS-CoV-2 challenge.Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema,notably,old monkeys exhibited diffuse severe interstitial pneumonia.Viral antigens were detected mainly in alveolar epithelial cells and macrophages.Conclusion:SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys.Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection. | Pin Yu Feifei Qi Yanfeng Xu Fengdi Li Peipei Liu Jiayi Liu Linlin Bao Wei Deng Hong Gao Zhiguang Xiang Chong Xiao Qi Lv Shuran Gong Jiangning Liu Zhiqi Song Yajin Qu Jing Xue Qiang Wei Mingya Liu Guanpeng Wang Shunyi Wang Haisheng Yu Xing Liu Baoying Huang Wenling Wang Li Zhao Huijuan Wang Fei Ye Weimin Zhou Wei Zhen Jun Han Guizhen Wu Qi Jin Jianwei Wang Wenjie Tan Chuan Qin | 2020 | Animal Models and Experimental Medicine2020，3，1： | 22 |
| 3 | A "green pathway" different from simple diffusion in soft matter: Fast molecular transport within micro/nanoscale multiphase porous systems显示文摘 | Jiantao Feng Fang Wang Xinxiao Han Zhuo Ao Quanmei Sun Wenda Hua Peipei Chen Tianwei Jing Hongyi Li Dong Han | 2014 | Nano Research2014，7，3： | 18 |
| 4 | Long Distance Transmission of SARS-CoV-2 from Contaminated Cold Chain Products to Humans——Qingdao City,Shandong Province,China,September 2020显示文摘Summary What is already known about this topic?Though coronavirus disease 2019(COVID-19)has largely been controlled in China,several outbreaks of COVID-19 have occurred from importation of cases or of suspected virus-contaminated products.Though several outbreaks have been traced to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)isolated on the outer packaging of cold chain products,live virus has not been obtained. | Huilai Ma Zhaoguo Wang Xiang Zhao Jun Han Yong Zhang Hong Wang Cao Chen Ji Wang Fachun Jiang Jie Lei Jingdong Song Shaofeng Jiang Shuangli Zhu Huihui Liu Dongyan Wang Yao Meng Naiying Mao Yanhai Wang Zhen Zhu Zhixiao Chen Bingling Wang Qinqin Song Haijun Du Qun Yuan Dong Xia Zhiqiang Xia Peipei Liu Yuchao Wu Zijian Feng Ruqin Gao George F.Gao Wenbo Xu | 2021 | China CDC weekly2021，3，30： | 13 |
| 5 | Application of atomic force microscopy to living samples from cells to fresh tissues显示文摘Atomic force microscopy is a novel method for imaging and characterization in biomedicine. However, high-resolution imaging of living samples from cells to tissues still remains a challenge. In this paper, two types of AFM working mode (contact mode and tapping mode) which are utilized for the imaging of living cells and tissues are discussed. A new magnetic tapping mode (MAC mode), which is more suitable for living samples, and a novel data collecting system named TREC, are also introduced. | CHEN PeiPei DONG HongTao CHEN Long SUN QuanMei HAN Dong | 2009 | Chinese Science Bulletin2009，54，14： | 8 |
| 6 | Parathyroid hormone increases alveolar bone homoeostasis during orthodontic tooth movement in rats with periodontitis via crosstalk between STAT3 and β-catenin显示文摘Periodontitis patients are at risk of alveolar bone loss during orthodontic treatment.The aim of this study was to investigate whether intermittent parathyroid hormone(1–34)treatment(iPTH)could reduce alveolar bone loss during orthodontic tooth movement(OTM)in individuals with periodontitis and the underlying mechanism.A rat model of OTM in the context of periodontitis was established and alveolar bone loss was observed.The control,iPTH and iPTH+stattic groups received injections of vehicle,PTH and vehicle,or PTH and the signal transducer and activator of transcription 3(STAT3)inhibitor stattic,respectively.iPTH prevented alveolar bone loss by enhancing osteogenesis and suppressing bone resorption in the alveolar bone during OTM in rats with periodontitis.This effect of iPTH was along with STAT3 activation and reduced by a local injection of stattic.iPTH promoted osteoblastic differentiation and might further regulate the Wnt/β-catenin pathway in a STAT3-dependent manner.The findings of this study suggest that iPTH might reduce alveolar bone loss during OTM in rats with periodontitis through STAT3/β-catenin crosstalk. | Cheng Zhang Tiancheng Li Chenchen Zhou Li Huang Yuyu Li Han Wang Peipei Duan Shujuan Zou Li Mei | 2020 | International Journal of Oral Science2020，12，4： | 4 |
| 7 | Analysis on Collapse Strength of Casing Wear显示文摘Carrying capacity of the casing will reduce after the casing is worn, which seriously affects the subsequent well drilling, well completion, oil extraction and well repair. A lot of researches on calculation of casing wear collapse strength have been done, but few of them focus on collapsing failure mechanism, and influencing factors and law of collapse strength. So, significant difference between estimated value and actual value of collapse strength comes into being. By theoretical analysis, numerical simulation and actual test, the collapsing failure mechanism of casing wear as well as the influencing factors and laws of collapse strength are investigated, and the investigation results show that collapse of crescent casing wear belongs to 'three hinged' instability. The severely-worn position on the casing is yielded into the plastic zone first then deformed greatly, which causes the plastic instability of the whole structure. The casing wear collapse strength presents changes of exponent, power function and linear trend with the residual casing wall thickness, wear radius and axial load, respectively. When the flexibility is less than 10°/30 m, the borehole bending has less impact on casing collapse strength. Thus, the computation model for the casing wear collapsing strength is established by introducing wear radius coefficient and casing equivalent yield strength, at the same time, the model is tested. The test results show that the relative error for the computation model is less than 5%. The research results provide a basis for design of the casing string strength and evaluation of down-hole safety. | LIANG Erguo LI Zifeng HAN Yong LI Guoqin GUO Peipei | 2013 | Chinese Journal of Mechanical Engineering2013，26，3： | 3 |
| 8 | Lnc-RP5 Regulates the mi R-129-5p/Notch1/PFV Internal Promoter Axis to Promote the Expression of the Prototype Foamy Virus Transactivator Tas显示文摘Prototype foamy virus(PFV)is a unique retrovirus that infects animals and humans and does not cause clinical symptoms.Long noncoding RNAs(lncRNAs)are believed to exert multiple regulatory functions during viral infections.Previously,we utilized RNA sequencing(RNA-seq)to characterize and identify the lncRNA lnc-RP5-1086 D14.3.1-1:1(lnc-RP5),which is markedly decreased in PFV-infected cells.However,little is known about the function of lnc-RP5 during PFV infection.In this study,we identified lnc-RP5 as a regulator of the PFV transcriptional transactivator(Tas).Lnc-RP5 enhanced the activity of the PFV internal promoter(IP).The expression of PFV Tas was found to be promoted by lnc-RP5.Moreover,mi R-129-5 p was found to be involved in the lnc-RP5-mediated promotion of PFV IP activity,while the Notch1 protein suppressed the activity of PFV IP and the expression of Tas.Our results demonstrate that lnc-RP5 promotes the expression of PFV Tas through the miR-129-5 p/Notch1/PFV IP axis.This work provides evidence that host lnc RNAs can manipulate PFV replication by employing mi RNAs and proteins during an early viral infection. | Shanshan Xu Liujun Chen Yinglian Tang Peipei Yuan Jun Yan Yingcheng Zheng Li Huang Zhi Li Yan Sun Song Han Jun Yin Qin Pan Biwen Peng Xiaohua He Wanhong Liu | 2020 | Virologica Sinica2020，35，1： | 1 |
| 9 | Effects of carbon sources on growth and extracellular polysaccharide production of Nostoc flagelliforme under heterotrophic high-cell-density fed-batch cultures显示文摘 | Zhen Ding Shiru Jia Peipei Han Nannan Yuan Ning Tan | 2013 | Journal of Applied Phycology2013，，4： | 1 |
| 10 | Corrosion and irradiation behavior of Fe-based amorphous coating in lead-bismuth eutectic liquids显示文摘Lead-bismuth eutectics (LBE) have considerable potential as a candidate material for accelerator-driven sub-critical systems(ADS).However,LBE corrosion and irradiation damage are two urgent challenges remaining to be solved for impellers of primary pumps.In this study,we have explored the possibility of using Fe-based amorphous coatings to overcome LBE corrosion and concurrently to sustain irradiation damage.Specifically,the Fe_(54)Cr_(18)Mo_(2)Zr_(8)B_(18)amorphous coating was prepared by high-velocity oxygen-fuel (HVOF) spraying on 316L steel and exposed to saturated oxygen static LBE for 500 h at 400℃.The coating with high thermal stability (T_(g)=615℃ and T_(x)=660℃) effectively prevented the substrate steel from being corroded by LBE owing to its unique long-range disordered atomic packing.The coating also exhibited strong irradiation resistance when being subjected to 45 dpa (displacement per atom) Au ion irradiation at room temperature,with no sign of crystallization even at the maximum implantation depth of 300 nm.Consequently,the hardness of the coatings before and after irradiation increased slightly.The current findings shed new insights into understanding corrosion mechanism and irradiation behavior of amorphous solids in LBE and expand the application range of amorphous materials. | LU ZhiChao PENG Xiang Yang TANG YuHai HAN ShuYin WU Yuan FU EnGang DING XiangBin HOU Shuo LU GuangYao CAO PeiPei ZHANG YiBo LIU XiongJun MA Dong WANG Hui JIANG SuiHe LU ZhaoPing | 2022 | Science China(Technological Sciences)2022，65，2： | 1 |
| 11 | Comparisonof bacterial community structures of terrestrial cyanobacteriumNostoc flagelliforme in three different regions ofChina using PCR-DGGE analysis显示文摘 | Han Peipei Shen Shigang Jia Shiru | 2015 | World Journal ofMicrobiololy & Biotechnology2015，31，7： | 1 |
| 12 | Strong-field photoionization of intense laser fields by controlling optical singularities显示文摘The spatial features of a light field, such as in the form of the optical singularities, provide a new degree of freedom for the application of light fields in different areas of science and technology. However, although the exploration of structured light is growing rapidly, the investigation of strong-field photoionization using such light fields is noticeably lagging behind. Here, we present an experimental study that reveals the signatures of intense, structured light fields with controlled optical singularities in strong-field photoionization. The different types of optical singularities can be identified through photoionization observables,i.e., photoelectron momentum distributions(PMDs). By concurrently shifting the locations of the phase and polarization singularities, the focal electric field features can be designated, and subsequently, the photoionization appearances can be manipulated. In this process, the behaviors of the different intense optical singularities are clearly visualized by the PMDs. This work will advance both the strong-field science and singularity optics. | Yiqi Fang Zhenning Guo Peipei Ge Xueyan Ma Meng Han Xiaoyang Yu Yongkai Deng Qihuang Gong Yunquan Liu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，7： | 1 |
| 13 | Metabolomic approachto optimizing and evaluating antibiotic treatmentin the axenic culture of cyanobacterium Nostoc flagelliforme显示文摘 | Han Peipei Jia Shiru Sun Ying | 2014 | World Journal of Microbiology & Biotechnology2014，30，9： | 1 |
| 14 | Biomimetic selenium nanosystems for infectious wound healing显示文摘Bacteria-related wound infection and healing have been a major issue for patients and health-care systems for decades.The rise and evolution of effective treatment will result in significant benefits to human beings.In ad-dition to standard antibacterial drugs,a combination of nanoparticles(NPs)and biological membranes is widely applied as a novel antibacterial agent against infectious pathogens.In this paper,the red blood cell membrane-encapsulated selenium nanoparticles(R-SeNPs)were fabricated for infectious wound healing.The stability,the immune evading capability,and the internal circulation time of the R-SeNPs were notably enhanced compared with those of bare selenium nanoparticles(SeNPs).Moreover,in vivo studies demonstrated the outstanding per-formance of the R-SeNPs in infectious wound healing.The biomimetic selenium nanosystem demonstrated the benefits of the combination of nanotechnology and bionics design and will contribute to wound healing in the future. | Mengkun Fang Han Zhang Yuze Wang Hui Zhang Dagan Zhang Peipei Xu | 2023 | Engineered Regeneration2023，4，2： | 0 |
| 15 | High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors显示文摘The global COVID-19 coronavirus pandemic has infected over 109 million people,leading to over 2 million deaths up to date and still lacking of effective drugs for patient treatment.Here,we screened about 1.8 million small molecules against the main protease(M^(pro))and papain like protease(PL^(pro)),two major proteases in severe acute respiratory syndrome-coronavirus 2 genome,and identified 1851M^(pro)inhibitors and 205 PL^(pro)inhibitors with low nmol/l activity of the best hits.Among these inhibitors,eight small molecules showed dual inhibition effects on both M^(pro)and PL^(pro),exhibiting potential as better candidates for COVID-19 treatment.The best inhibitors of each protease were tested in antiviral assay,with over 40%of M^(pro)inhibitors and over 20%of PL^(pro)inhibitors showing high potency in viral inhibition with low cytotoxicity.The X-ray crystal structure of SARS-CoV-2 M^(pro)in complex with its potent inhibitor 4a was determined at 1.8Åresolution.Together with docking assays,our results provide a comprehensive resource for future research on anti-SARS-CoV-2 drug development. | Yi Zang Mingbo Su Qingxing Wang Xi Cheng Wenru Zhang Yao Zhao Tong Chen Yingyan Jiang Qiang Shen Juan Du Qiuxiang Tan Peipei Wang Lixin Gao Zhenming Jin Mengmeng Zhang Cong Li Ya Zhu Bo Feng Bixi Tang Han Xie Ming-Wei Wang Mingyue Zheng Xiaoyan Pan Haitao Yang Yechun Xu Beili Wu Leike Zhang Zihe Rao Xiuna Yang Hualiang Jiang Gengfu Xiao Qiang Zhao Jia Li | 2023 | Protein & Cell2023，14，1： | 0 |
| 16 | 5-15 Investigation of the Neutron Transport Behavior in Granular Tungsten Target显示文摘A new concept of the Gravity-driven dense granular flow spallation target for ADS was proposed. The target material is discrete Tungsten-based alloys solid particles. The neutron transport behavior in granular Tungsten is very important for the design of spallation target.The neutron transport behavior in granular Tungsten target was studied in detail. | Han Rui Chen Zhiqiang Gou Boxing Shi Fudong Lin Weiping Ren Peipei Tian Guoyu Luo Fei Sun Qi | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 17 | 5-16 Benchmarking of Evaluated Neutron Nuclear Data for Granular Tungsten Target显示文摘The design of ADS spallation target requires precise and reliable nuclear data. ADS research team of Chinese Academy of Sciences (CAS) proposed a new concept for a Gravity-driven dense granular flow spallation target[1].The target material is Tungsten-based alloys solid particles. The neutron nuclear data of granular Tungsten is very important for the design of spallation target. | Han Rui Chen Zhiqiang Gou Boxing Shi Fudong Lin Weiping Ren Peipei Tian Guoyu Luo Fei Sun Qi | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 18 | Piezoelectric Peptide and Metabolite Materials显示文摘Piezoelectric materials are important for many physical and electronic devices.Although many piezoelectric ceramics exhibit good piezoelectricity,they often show poor compatibility with biological systems that limits their biomedical applications.Piezoelectric peptide and metabolite materials benefit from their intrinsic biocompatibility,degradability,and convenient biofunctionalization and are promising candidates for biological and medical applications.Herein,we provide an account of the recent progress of research works on piezoelectric peptide and metabolite materials.This review focuses on the growth mechanism of peptide and metabolite micro-and nanomaterials.The influence of self-assembly processes on their piezoelectricity is discussed.Peptide and metabolite materials demonstrate not only outstanding piezoelectric properties but also unique electronic,optical,and physical properties,enabling their applications in nanogenerators,sensors,and optical waveguiding devices. | Hui Yuan Peipei Han Kai Tao Shuhai Liu Ehud Gazit Rusen Yang | 2019 | Research2019，，1： | 0 |
| 19 | 5-17 Measurement of Leakage Neutron Spectra from Silicon Carbide Cylinders显示文摘The Accelerator-Driven Systems (ADS) is mainly used for nuclear transmutation of long-lived fission products, fuel breeding and energy production. China has started to develop the ADS project and is now underway vigorously.The combination of nuclear data with a Monte Carlo transportation code like MCNP-4C is widely applied to design such kind of nuclear engineering facilities. The integral experiment is conducted to benchmark the nuclear data, involved in design calculations, both with regard to the activation and the particle transport behavior. | Luo Fei Chen Zhiqiang Han Rui Shi Fudong Gou Boxing Lin Weiping Ren Peipei Tian Guoyu Sun Qi | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 20 | 5-18 Measurement of Leakage Neutron Spectra from Graphite Cylinders显示文摘Graphite is applied to many applications in the field of atomic energy. In the design of nuclear reactors, such as ADS, HTGRs and fusion reactors, graphite is among the primary candidate materials for a reflector zone to soften the neutron spectrum. Moreover, the accurate prediction of tritium breeding ratio and nuclear heating rate sets the necessity of using adequate nuclear data for carbon since they have strong influence on the feasibility of the overall design of fusion reactors. | Luo Fei Chen Zhiqiang Han Rui Shi Fudong Gou Boxing Lin Weiping Ren Peipei Tian Guoyu Sun Qi | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
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