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| 1 | Hydrogen peroxide primes heart regeneration with a derepression mechanism显示文摘当成年的人的心很限制了再生潜力时,成年 zebrafish 心能充分在 20% 室的切除术以后再生。尽管以前的报告建议象 FGF 和 PDGF 那样的发展发信号小径在成年的心新生被再使用,内在的细胞内部的机制仍然保持大部分未知。这里,我们显示出那 H 2 O 2 充当新奇 epicardial 和心肌的信号在成年 zebrafish 为新生告知心。未经触动的心的实时成像揭示了高度局部性的 H 2 O 2(~ 30 μ M ) 在在切除术地点的心外膜和邻近的紧缩的心肌层的生产。减少的 H 2有 Duox 禁止者 diphenyleneiodonium (点每英寸)或 apocynin 的 O 2形成,或清除 H 2当时,由过氧化氢酶 overexpression 的 O 2显著地损害了心脏的新生外长的 H 2 O 2在心脏的新生上救了点每英寸的禁止的效果,显示那 H 2 O 2是在这个过程的一个必要、足够的信号。机械学地,提高了 H 2 O 2 使动摇氧化还原作用敏感的磷酸酶 Dusp6 并且因此增加了 Erk1/2 的 phosphorylation。当 dusp6 的转基因的 overexpression 损害了心脏的新生时, Dusp6 禁止者 BCI 完成了类似的支持 regenerative 效果。H 2 O 2 在招募起一个双作用通过二条相对独立的小径的有免疫力的房间和支持的心新生。我们结束那 H 2 潜在地从 Duox/Nox2 产生的 O 2 由解开通过包含 Dusp6 的 derepression 机制发信号的地图 kinase 在 zebrafish 支持心新生。 | Peidong Han Xiao-Hai Zhou Nannan Chang Cheng-Lu Xiao Shouyu Yah He Ren Xin-Zhuang Yang Mei-Ling Zhang Qing Wu Boyang Tang Ju-Peng Diao Xiaojun Zhu Chuanmao Zhang Chuan-Yun Li Heping Cheng Jing-Wei Xiong | 2014 | Cell Research2014，24，9： | 10 |
| 2 | Targeted ablation of the histidine-rich Ca 2+ -binding protein (HRC) gene is associated with abnormal SR Ca 2+ -cycling and severe pathology under pressure-overload stress显示文摘 | Chang Sik Park Shan Chen Hoyong Lee Hyeseon Cha Jae Gyun Oh Sunghee Hong Peidong Han Kenneth S. Ginsburg Sora Jin Inju Park Vivek P. Singh Hong-Sheng Wang Clara Franzini-Armstrong Woo Jin Park Donald M. Bers Evangelia G. Kranias Chunghee Cho Do Han Kim | 2013 | Basic Research in Cardiology2013，，3： | 1 |
| 3 | Issues in polycrystalline diamond compact cutter---rock interac- tion from a metal machining point of view-part I: tem- perature, stresses, and forces 显示文摘 | CHE Demeng HAN Peidong GUO Ping | 2012 | Journal of Manufac- turing Science and Engineering2012，134，6： | 1 |
| 4 | Flexible Large-Area Graphene Films of 50-600 nm Thickness with High Carrier Mobility显示文摘Bulk graphene nanofilms feature fast electronic and phonon transport in combination with strong light-matter interaction and thus have great potential for versatile applications,spanning from photonic,electronic,and optoelectronic devices to charge-stripping and electromagnetic shielding,etc.However,large-area flexible close-stacked graphene nanofilms with a wide thickness range have yet to be reported.Here,we report a polyacrylonitrile-assisted’substrate replacement’strategy to fabricate large-area free-standing graphene oxide/polyacrylonitrile nanofilms(lateral size~20 cm).Linear polyacrylonitrile chains-derived nanochannels promote the escape of gases and enable macro-assembled graphene nanofilms(nMAGs)of 50-600 nm thickness following heat treatment at 3,000℃.The uniform nMAGs exhibit 802-1,540 cm^(2)V-1s-1carrier mobility,4.3-4.7 ps carrier lifetime,and>1,581 W m^(-1)K^(-1)thermal conductivity(n MAG-assembled 10μm-thick films,mMAGs).nMAGs are highly flexible and show no structure damage even after 1.0×10^(5)cycles of folding-unfolding.Furthermore,n MAGs broaden the detection region of graphene/silicon heterojunction from near-infrared to mid-infrared and demonstrate higher absolute electromagnetic interference(EMI)shielding effectiveness than state-of-the-art EMI materials of the same thickness.These results are expected to lead to the broad applications of such bulk nanofilms,especially as micro/nanoelectronic and optoelectronic platforms. | Shiyu Luo Li Peng Yangsu Xie Xiaoxue Cao Xiao Wang Xiaoting Liu Tingting Chen Zhanpo Han Peidong Fan Haiyan Sun Ying Shen Fan Guo Yuxing Xia Kaiwen Li Xin Ming Chao Gao | 2023 | Nano-Micro Letters2023，15，5： | 1 |
| 5 | Cardiac cell type-specific responses to injury and contributions to heart regeneration显示文摘Heart disease is the leading cause of mortality worldwide.Due to the limited proliferation rate of mature cardiomyocytes,adult mammalian hearts are unable to regenerate damaged cardiac muscle following injury.Instead,injured area is replaced by fibrotic scar tissue,which may lead to irreversible cardiac remodeling and organ failure.In contrast,adult zebrafish and neonatal mammalian possess the capacity for heart regeneration and have been widely used as experimental models.Recent studies have shown that multiple types of cells within the heart can respond to injury with the activation of distinct signaling pathways.Determining the specific contributions of each cell type is essential for our understanding of the regeneration network organization throughout the heart.In this review,we provide an overview of the distinct functions and coordinated cell behaviors of several major cell types including cardiomyocytes,endocardial cells,epicardial cells,fibroblasts,and immune cells.The topic focuses on their specific responses and cellular plasticity after injury,and potential therapeutic applications. | Weijia Zhang Jinxiu Liang Peidong Han | 2021 | Cell Regeneration2021，10，1： | 0 |
| 6 | Seismic safety assessment with non-Gaussian random processes for train-bridge coupled systems显示文摘Extensive high-speed railway(HSR)network resembled the intricate vascular system of the human body,crisscrossing mainlands.Seismic events,known for their unpredictability,pose a significant threat to both trains and bridges,given the HSR’s extended operational duration.Therefore,ensuring the running safety of train-bridge coupled(TBC)system,primarily composed of simply supported beam bridges,is paramount.Traditional methods like the Monte Carlo method fall short in analyzing this intricate system efficiently.Instead,efficient algorithm like the new point estimate method combined with moment expansion approximation(NPEM-MEA)is applied to study random responses of numerical simulation TBC systems.Validation of the NPEM-MEA’s feasibility is conducted using the Monte Carlo method.Comparative analysis confirms the accuracy and efficiency of the method,with a recommended truncation order of four to six for the NPEM-MEA.Additionally,the influences of seismic magnitude and epicentral distance are discussed based on the random dynamic responses in the TBC system.This methodology not only facilitates seismic safety assessments for TBC systems but also contributes to standard-setting for these systems under earthquake conditions. | Zhao Han Gao Lei Wei Biao Tan Jincheng Guo Peidong Jiang Lizhong Xiang Ping | 2024 | Earthquake Engineering and Engineering Vibration2024，23，1： | 0 |
| 7 | TSCS: A blockchain-based tokenized subtitling crowdsourcing system显示文摘The language barrier is the biggest obstacle for users watching foreign-language videos.Because of this,videos cannot be famous across borders,and their viewership is limited to a single language and culture.The easiest way to solve this problem is to add subtitles in the language of the viewer.However,the current subtitling system lacks incentives,the ability to build a secure transaction environment,and a trusting relationship between video creators and subtitling makers.In response to the above situation,a tokenized subtitling crowdsourcing system(TSCS)based on blockchain and smart contract technologies is proposed.The source files for the subtitles are stored on the inter-planetary file system(IPFS)in the proposed system.Based on the ERC-721 standard,the returned corresponding address and subtitling-related information are made into a non-fungible token(NFT).At the same time,depending on the expected revenue from video view counts,the video token(VT),based on the ERC-777 standard and endorsed by the video platform,will be used as the payment token.The TSCS has two payment strategies:one-time and dividend.Through such a settlement mechanism,the subtitling maker’s revenue is also guaranteed by the code invariance and rule certainty of smart contract deployment.On the other hand,introducing an incentive mechanism for viewers to audit subtitles enables community autonomy,thus increasing the applicability of subtitles and the activity of users. | Huijian Han Peidong Chen Feng Yang Brekhna Brekhna Rui Zhang | 2023 | Blockchain(Research and Applications)2023，4，2： | 0 |
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