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| 1 | NOD2 and ATG16L1 polymorphisms affect monocyte responses in Crohn's disease显示文摘AIM:To assess whether polymorphisms in NOD2 and ATG16L1 affect cytokine responses and mycobacterium avium subspecies paratuberculosis (MAP) survival in monocytes from Crohn's disease (CD) patients.METHODS:Monocytes were isolated from peripheral blood of CD patients of known genotype for common single nucleotide polymorphisms of NOD2 and ATG16L1.Monocytes were challenged with MAP and bacterial persistence assessed at subsequent time-points.Cytokine responses were assayed using a Milliplex multi-analyte profiling assay for 13 cytokines.RESULTS:Monocytes heterozygous for a NOD2 polymorphism (R702W,P268S,or 1007fs) were more permissive for growth of MAP (P=0.045) than those without.There was no effect of NOD2 genotype on subsequent cytokine expression.The T300A polymorphism ofATG16L1 did not affect growth of MAP in our model (P=0.175),but did increase expression of cytokines interleukin (IL)-10 (P=0.047) and IL-6 (P=0.019).CONCLUSION:CD-associated polymorphisms affected the elimination of MAP fromex vivo monocytes (NOD2),or expression of certain cytokines (ATG16L1),implying independent but contributory roles in the pathogenesis of CD. | Dylan M Glubb Richard B Gearry Murray L Barclay Rebecca L Roberts John Pearson Jacqui I Keenan Judy McKenzie Robert W Bentley | 2011 | World Journal of Gastroenterology2011，17，23： | 2 |
| 2 | The chemical bond in semiconductors显示文摘 | Pearson W B | 1960 | Progress in Semiconductors1960，5，： | 1 |
| 3 | Partial discharge diagnostics for gas insulated substation显示文摘 | PEARSON J S FARISH O HAMPTON B F | 1995 | IEEE Transactions on Dielectrics and Electrical Insulation1995，2，5： | 1 |
| 4 | Influence of electrochemical potential on the wear of metals,particularly nickel显示文摘 | Pearson B R Brook P A Waterhouse R B | 1988 | Tribology International1988，21，4： | 1 |
| 5 | Progress in semiconductors显示文摘 | MOOSER E PEARSON W B GIBSON A F | 1960 | Johniley & Sons1960，，5： | 1 |
| 6 | Phrenic nerve neurotization utilizing the spinal accessory nerve:technical note with potential application in patients with high cervical quadriplegia显示文摘 | Tubbs RS Pearson B Loukas M | 2008 | Childs Nerv Syst2008，24，11： | 1 |
| 7 | Nonlinear model-based control using second-order Volterra models显示文摘 | Doyle F J Ogunnaike B A Pearson R K | 1995 | Automatica1995，31，5： | 1 |
| 8 | Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study 显示文摘 | Kumarasamy KK Toleman MA Walsh TR Bagaria J Butt F Balakrishnan R Chaudhary U Doumith M Giske CG Irfan S Krishnan P Kumar AV Maharjan S Mushtaq S Noorie T Paterson DL Pearson A Perry C Pike R Rao B Ray U Sarma JB Sharma M Sheridan E Thirunarayan MA Turton J Upadhyay S Warner M Welfare W Livermore DM Woodford N | 2010 | Lancet Infect Dis2010，10，9： | 1 |
| 9 | Detecting aflatoxin in single corn kernels by transmittance and reflectance spectroscopy显示文摘 | Pearson T C Wicklow D T Maghirang E B | 2001 | Transactions-american Society of Agricultural Engineers2001，44，5： | 1 |
| 10 | The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain显示文摘 | Pearson R B Dennis P B Han J W | 1995 | EMBO J1995，14，21： | 1 |
| 11 | Preva-lence and treatment of pressure ulcers in northern New SouthWales显示文摘 | PEARSON A FRANCIS K HODQ KINSON B | 2000 | Aust J Rural Health2000，8，2： | 1 |
| 12 | A lifting technique for linear periodic systems显示文摘 | BAMIEH B PEARSON J FRANCIS B | 1991 | Systems & Control Letters1991，17，2： | 1 |
| 13 | Frequency fidelity of a compact CO2Doppler lidar transmitter 显示文摘 | RYE B J | 1992 | Appl Opt1992，31，30： | 1 |
| 14 | Landscape change and habitat availability in the southern highlands and Olympic Peninsula显示文摘 | Pearson S M Turner M G Darke J B | 1999 | Ecological Applications1999，9，4： | 1 |
| 15 | A lifting technique for linear periodic systems with applications to sampled-data control显示文摘 | Bamieh B Pearson J Francis B | 1991 | Systems & Control Letters1991，17，2： | 1 |
| 16 | Occurrence of velogenic viscerotropic Newcastle disease in pet and exotic birds in 1991显示文摘 | Panigraphy B Senne D A Pearson J E | 1993 | Avian Dis1993，37，： | 1 |
| 17 | Partial discharge diagnostics for gas insulated substations显示文摘 | PEARSON J S FARISH O HAMPTON B F | 1995 | IEEE Transaction on Dielectrics and Electrical Insulation1995，2，2： | 1 |
| 18 | Regional frequency analysis of an- nual maximum stream flow drought显示文摘 | Clause B Pearson C P | 1995 | Journal of Hydrol- ogy1995，173，： | 1 |
| 19 | Behavioural responses of sablefish,Anoplopoma fimbria,to bait odour 显示文摘 | L?kkeborg S Olla B A Pearson W H | 1995 | Journal of Fish Biology1995，46，： | 1 |
| 20 | The molecular genet-ics of cyanobacterial tox-icity as a basis for monitoringwater quality and public health risk显示文摘 | PEARSON L A NEIL AN B A | 2008 | Current Opin-ion in Biotechnology2008，19，： | 1 |
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