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| 1 | Over expression of resistin in adipose tissue of the obese induces insulin resistance显示文摘AIM: To compare resistin mRNA expression in subcutaneous adipose tissue (SAT) and its correlation with insulin resistance (IR) in postmenopausal obese women. METHODS: A total of 68 postmenopausal women (non obese = 34 and obese = 34) were enrolled for the study. The women of the two groups were age matched (49-70 years). Fasting blood samples were collected at admission and abdominal SAT was obtained during surgery for gall bladder stones or hysterectomy. Physical parameters [age, height, weight, body mass index (BMI)] were measured. Biochemical (plasma insulin and plasma glucose) parameters were estimated by enzymatic methods. RNA was isolated by the Trizol method.SAT resistin mRNA expression was done by real time- reverse transcription polymerase chain reaction (RT-PCR) by using Quanti Tect SYBR Green RT-PCR master mix. Data was analyzed using independent Student's t test, correlation and simple linear regression analysis. RESULTS: The mean weight (52.81 ± 8.04 kg vs 79.56 ± 9.91 kg; P < 0.001), BMI (20.23 ± 3.05 kg/m 2 vs 32.19 ± 4.86 kg/m 2 ; P < 0.001), insulin (8.47 ± 3.24 U/mL vs 14.67 ± 2.18 U/mL; P < 0.001), glucose (97.44 ± 11.31 mg/dL vs 109.67 ± 8.02 mg/dL; P < 0.001) and homeostasis model assessment index (2.01 ± 0.73 vs 3.96 ± 0.61; P < 0.001) were significantly higher in postmenopausal obese women compared to postmenopausal non obese women. The mean serum resistin level was also significantly higher in postmeno-pausal obese women compared to postmenopausal non obese women (9.05 ± 5.15 vs 13.92 ± 6.32, P < 0.001). Furthermore, the mean SAT resistin mRNA expression was also significantly (0.023 ± 0.008 vs 0.036 ± 0.009; P < 0.001) higher and over expressed 1.62 fold (upregulated) in postmenopausal obese women compared to postmenopausal non obese women. In postmeno-pausal obese women, the relative SAT resistin mRNA expression showed positive (direct) and significant correlation with BMI (r = 0.78, P < 0.001) and serum resistin (r = 0.76, P < 0.001). Furthermore, the SAT resistin mRNA expression in postmenopausal obese women also showed significant and direct association (r = 0.45, P < 0.01) with IR, while in postmenopausal non obese women it did not show any association (r = -0.04, P > 0.05). CONCLUSION: Increased SAT resistin mRNA expres-sion probably leads to inducing insulin resistance and thus may be associated with obesity-related disorders in postmenopausal obese women. | Sadashiv Sunita Tiwari S Dhananjai Bhola N Paul Sandeep Kumar Abhijit Chandra Mahendra PS Negi | 2012 | World Journal of Diabetes2012，3，7： | 10 |
| 2 | Outbreak of Japanese encephalitis on the island of Saipan, 1990显示文摘 | Paul WS Moore PS Karabatsos N | 1993 | J Infect Dis1993，167，5： | 1 |
| 3 | Starvation-survival processes of a marine Vibrio显示文摘 | Amy PS Pauling C Morita RY | 1983 | Appl Environ Micrbiol1983，45，3： | 1 |
| 4 | Clinical,radiologic,and arthroscopic assessment of discoid lateral meniscus显示文摘 | Rao PS Rao SK Paul R | 2001 | Arthroscopy2001，17，3： | 1 |
| 5 | ovarian cancer side population defines cells with stem cell-like characteristics and mullerian substance responsiveness显示文摘 | Paul PS Rafael PV Peter TM | 2006 | Proc Natl Acad Sci USA2006，103，11： | 1 |
| 6 | Acyclovir Bioavailability in Human Skin显示文摘 | Greg EP Paul Dunn Vinod PS | 1992 | J Invest Dermatol1992，98，6： | 1 |
| 7 | Abnormal spatial selection and tracking in children with amblyopia显示文摘 | Ho Cs Paul PS Asirvatham A | 2006 | Vision Res2006，46，19： | 1 |
| 8 | Hemolytic anaemia as first manifestation of Wilson's disease: a report of two cases 显示文摘 | Santra G Paul R Choudhury PS | 2014 | J Assoc Physicians India2014，62，10： | 1 |
| 9 | Clinical, radiologic, and arthrescopic assess- ment of discoid lateral meniscus 显示文摘 | Rao PS Rao SK Paul R | 2001 | Arthrescopy2001，3，： | 1 |
| 10 | Effects of prenatal alcohol exposure on fine motor coordination and balance: A study of two adult samples显示文摘 | Paul DC Paul DS Ann PS | 2006 | Neuropsychologia2006，44，： | 1 |
| 11 | Wet and dry deep cavity preparations compared by a novel odontoblast culture technique 显示文摘 | Kimberly GH Paul DE James PS | 2001 | J Endod2001，27，2： | 1 |
| 12 | Phylogenetic analysis of the putative M (ORF6) and N (ORF7) genes of porcine reproductive and respiratory syndrome virus (PRRSV):implication for the existence of two genotypes of PRRSV in the USA and Europe显示文摘 | Meng XJ Paul PS Halbur PG | 1995 | Arch Virol1995，140，： | 1 |
| 13 | Sequences comparison of open reading frames 2 to 5 of low and high virulence United states isolates of porcine reproductive and respiratory syndrome virus 显示文摘 | Meng XJ Paul PS Halbur PG | 1995 | JGen Virol1995，76，： | 1 |
| 14 | Phylogenic analysis of the putative M(ORF6) and N(ORF7) genes of porcine reproductive and respiratory syndrome virus (PRRSV):implication for the existence of two genotypes of PRRSV in the USA and Europe显示文摘 | Meng XJ Paul PS Halbur PG | 1995 | Arch Virol1995，140，： | 1 |
| 15 | Viral contributors to the porcine respiratory disease complex显示文摘 | Halbur PG Paul PS Andrews JJ | 1993 | In Proc Am Assoc Swine Pract1993，50，： | 1 |
| 16 | Comparison of the pathogenicity of two US porcine reproductive and respiratory syndrome virus isolates with that of the Lelystad virus显示文摘 | Halbur PG Paul PS Frey ML | 1995 | Veterinary Pathology1995，32，： | 1 |
| 17 | Epitope mapping of the major capsid protein of type 2 porcine circovirus (PCV2) by using chimeric PCV1 and PCV2 显示文摘 | Lekcharoensuk P Morozov I Paul PS | 2004 | J Virol2004，78，15： | 1 |
| 18 | The influence of diet on the gut microbiota显示文摘 | Karen PS Silvia WG Paul OS | 2013 | Pharmacological Research2013，69，1： | 1 |
| 19 | Estrogen therapy fails to alter amyloid deposition in the PDAPP model of Alzheimer's disease 显示文摘 | Green PS Bales K Paul S | 2005 | Endocrinology2005，146，6： | 1 |
| 20 | Abnormal spatial selec- tion and tracking in children with amblyopia显示文摘 | Ho CS Paul PS Asirvatham A etal | 2006 | Vision Res2006，46，19： | 1 |
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