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| 1 | Early Cenozoic Mega Thrusting in the Qiangtang Block of the Northern Tibetan Plateau显示文摘最近的印射和地震调查表明集中的压缩在在中央西藏的高原的 Qiangtang 块的早新生代期间形成了移动的戳表的广泛的建筑群沿着几个通常蘸北方的伟人相对向南方戳系统。那些在 450 km 的边阶宽块表演它制服拉萨块到南方并且被 Hohxil-Bayanhar 块制服到北方。系统主要是薄皮的与合拢联系使戳成鳞状。戳表主要是由显然在三叠纪的沙岩和页岩上滑动了的侏罗记石灰石的 floored,它局部地被包括,并且 ramped 向上并且过去古新始新世红床。在形成的古生代的变形岩石,二叠的碳酸盐和花岗石上面更深、带的铲起的一些中央戳一中央高举那把 Qiangtang 块划分成二部分。这些系统和他们的联系结构被很少 unconformably 覆盖使晚始新世渐新世的暴烈的岩石变形了或由中新世的湖床盖住。A 在邻近的拉萨块的北部分在块,以及块的北部分插入了系统,蘸到南方并且看起来由于在戳床单以内的第二等的调整。 | WU Zhenhan YE Peisheng Patrick J.BAROSH HU Daogong LU Lu ZHANG Yaoling | 2012 | Acta Geologica Sinica(English Edition)2012，86，4： | 23 |
| 2 | Scutellarin protects oxygen/glucose-deprived astrocytes and reduces focal cerebral ischemic injury显示文摘Scutellarin, a bioactive flavone isolated from Scutellaria baicalensis, has anti-inflammatory, anti-neurotoxic, anti-apoptotic and anti-oxidative effects and has been used to treat cardiovascular and cerebrovascular diseases in China. However, the mechanisms by which scutellarin mediates neuroprotection in cerebral ischemia remain unclear. The interaction between scutellarin and nicotinamide adenine dinucleotide phosphate oxidase 2(NOX2) was assessed by molecular docking study, which showed that scutellarin selectively binds to NOX2 with high affinity. Cultures of primary astrocytes isolated from the cerebral cortex of neonatal Sprague-Dawley rats were pretreated with 2, 10 or 50 μM scutellarin for 30 minutes. The astrocytes were then subjected to oxygen/glucose deprivation by incubation for 2 hours in glucose-free Dulbecco's modified Eagle's medium in a 95% N2/5% CO_2 incubator, followed by simulated reperfusion for 22 hours. Cell viability was assessed by cell counting kit-8 assay. Expression levels of NOX2, connexin 43 and caspase-3 were assessed by western blot assay. Reactive oxygen species were measured spectrophotometrically. Pretreatment with 10 or 50 μM scutellarin substantially increased viability, reduced the expression of NOX2 and caspase-3, increased the expression of connexin 43, and diminished the levels of reactive oxygen species in astrocytes subjected to ischemia-reperfusion. We also assessed the effects of scutellarin in vivo in the rat transient middle cerebral artery occlusion model of cerebral ischemia-reperfusion injury. Rats were given intraperitoneal injection of 100 mg/kg scutellarin 2 hours before surgery. The Bederson scale was used to assess neurological deficit, and 2,3,5-triphenyltetrazolium chloride staining was used to measure infarct size. Western blot assay was used to assess expression of NOX2 and connexin 43 in brain tissue. Enzyme-linked immunosorbent assay was used to detect 8-hydroxydeoxyguanosine(8-OHd G), 4-hydroxy-2-nonenal(4-HNE) and 3-nitrotyrosin(3-NT) in brain tissue. Immunofluorescence double staining was used to determine the co-expression of caspase-3 and Neu N. Pretreatment with scutellarin improved the neurological function of rats with focal cerebral ischemia, reduced infarct size, diminished the expression of NOX2, reduced levels of 8-OHd G, 4-HNE and 3-NT, and reduced the number of cells co-expressing caspase-3 and Neu N in the injured brain tissue. Furthermore, we examined the effect of the NOX2 inhibitor apocynin. Apocynin substantially increased connexin 43 expression in vivo and in vitro. Collectively, our findings suggest that scutellarin protects against ischemic injury in vitro and in vivo by downregulating NOX2, upregulating connexin 43, decreasing oxidative damage, and reducing apoptotic cell death. | Jing-Bo Sun Yan Li Ye-Feng Cai Yan Huang Shu Liu Patrick KK Yeung Min-Zhen Deng Guang-Shun Sun Prince LM Zilundu Qian-Sheng Hu Rui-Xin An Li-Hua Zhou Li-Xin Wang Xiao Cheng | 2018 | Neural Regeneration Research2018，13，8： | 16 |
| 3 | Holocene aeolian stratigraphic sequences in the eastern portion of the desert belt(sand seas and sandy lands) in northern China and their palaeoenvironmental implications显示文摘This paper presents the environmental history and its responses to palaeoclimatic changes since the start of the Holocene in the eastern portion of the desert belt(sand seas and sandy lands) in northern China by comparing the aeolian sandpalaeosol sequences and their palaeoclimatic proxies. The optically stimulated luminescence(OSL) ages of the aeolian sandpalaeosol sedimentary sequences and a series of palaeoenvironmental proxies show that:(1) The large-scale dune landscape currently in the Kubuqi Sand Sea was formed during the Holocene in general;and the palaeosol was generally developed during the period of 4–2 ka, indicating conditions favorable for vegetation growth, soil development, and organic carbon accumulation due to increased precipitation or effective moisture and weakened aeolian activities;the large-scale expansion of dunes in the recent 2 ka is closely linked to human activities. The variable discharge of the Yellow River with diversions for irrigation may have resulted in a more consistent supply of aeolian particles for dune field expansion.(2) The dune landscape of the Hunshandake Sandy Land was likely formed around 12 ka, and before this, the western part of the Hunshandake Sandy Land would have been covered by a single large lake;it was obviously wetter than today in the sandy land during the period of 9.6–3 ka and the palaeosols were developed at the same time. But the aeolian activities have not been completely dormant in this long-lasting wetter epoch;because the Holocene wetter period was likely time-transgressive across the region.(3) The palaeosol of the Hulunbuir Sandy Land began to develop as early as 14.5 ka, probably continuing until the last 2 ka. The palaeosol development of various dune fields in the eastern portion of the desert belt(sand seas and sandy lands) in northern China is spatially heterogeneous, and even the palaeosol development time in different locations within each sandy land is inconsistent. During the middle Holocene(especially the 7.5–3.5 ka), all the sandy lands were stabilized in general and the intensity of aeolian activities was significantly weakened. The number of palaeoenvironmental records in the eastern portion of the desert belt(sand seas and sandy lands) in northern China has increased rapidly in the past decade, but the amount of published data still does not match the vast extent of the dune fields. It does require much more in-depth palaeoenvironmental studies for a full understanding of the relationship between aeolian activities and climate change in northern China. | Xiaoping YANG Peng LIANG Deguo ZHANG Hongwei LI Patrick RIOUAL Xulong WANG Bing XU Zhibang MA Qianqian LIU Xiaozong REN Fangen HU Yuxin HE Gang RAO Ninghua CHEN | 2019 | Science China Earth Sciences2019，62，8： | 10 |
| 4 | Nature:揭示干细胞惊人异质性显示文摘论文作者George Daley教授说:"这是一项非常基础的研究,但它阐明了多能性状态广泛性。我们捕获了干细胞不同状态的详细分子谱。"研究人员通过采用多种变量如不同的化学物质、培养环境和遗传敲除来扰乱多能干细胞,研究人员探究了它们的发育景观。随后,他们分析了每个细胞的遗传组成,观察了每个细胞多能状态的微小波动。他们发现内部、化学和环境信号影响干细胞方式的许多细微差异,揭示出了复杂的发育调控因子"决策"回路。 | Roshan M.Kumar Patrick Cahan Alex K.Shalek Rahul Satija A.Jay Daley Keyser Hu Li Jin Zhang Keith Pardee David Gennert John J.Trombetta Thomas C.Ferrante Aviv Regev George Q.Daley James J. Collins | 2014 | 岭南现代临床外科2014，14，6： | 10 |
| 5 | PCR-based methodologies for detection and characterization of Listeria monocytogenes and Listeria ivanovii in foods and environmental sources显示文摘Listeria monocytogenes is an important foodborne pathogen responsible for listeriosis,a fatal disease.It is widely distributed in various foods and environmental sources.In this review,we focused on addressing PCR-based technologies,including conventional PCR,qPCR and droplet digital PCR(ddPCR).Specifically,we described(a)conventional PCR and mono-,duplex-and multiplex-qPCR methodologies;(b)development and applications of gene HlyA-,Iap-,PrfA–and SsrA-based conventional and qPCR assays as well as PCR assays targeting newly identified gene targets for specific detection of L.monocytogenes;differentiation of viable from dead L.monocytogenes by qPCR in conjugation with propidium monoazide pretreatment;PCR-based serotype identification of L.monocytogenes isolates;PCR-based detection of L.ivanovii,infecting ruminants,differentiation of L.monocytogenes from other Listeria species;and sigB-gene based PCR identification of Listeria spp;(c)applications of ddPCR in detection of L.monocytogenes;and(d)application of qPCR assays in detection and subtyping of L.monocytogenes in milk and dairy products;meats,meat products and meat-processing environment;and seafood,seafood products and processing environment.Our goal was to provide a relatively comprehensive overview of PCR-based methodologies available in detection,characterization and subtyping of various strains of L.monocytogenes in foods and environmental sources. | Jin-Qiang Chen Stephanie Healey Patrick Regan Pongpan Laksanalamai Zonglin Hu | 2017 | Food Science and Human Wellness2017，6，2： | 9 |
| 6 | Miocene Tectonic Evolution from Dextral-Slip Thrusting to Extension in the Nyainqentanglha Region of the Tibetan Plateau显示文摘在西藏的 Nyainqentanglha 区域的右滑倒导致了 obliqueunderthrusting 和花岗石产生在对中间早中新世,但是在时代底高举并且紧张的指责统治了的前。东方西方右滑倒 Gangdise 差错系统合并进东北趋势东方,转动东方更远的北方进右滑倒北方 Damxung 剪碎带和 Jiali 的蘸东南的 Nyainqentanglha 戳系统指责。这些差错是形成了由当西方的块不到东方的开车了,早, Miocene,和大 Nyainqentanglha 花岗石的底盘在 18.3-11.0 妈形成了戳系统。Thedextral 滑倒运动在~ 1 结束了 1 个妈和底盘玫瑰,由在 8.6-8.3 妈的重力的砍标记,一个新差错系统发展了。西北趋势右滑倒差错形成了到 raisen 底盘的西北,而有某左首滑倒的东北趋势南方 Damxung 上投断层形成了到东南。后者被 thewest-northwest-trending Lhiinzhub 上投断层被右滑倒远代替到东方。这相对本地高举让存款保存了的 Eocene 和 Miocene 邻近那被区域抬升和一个系统的开始跟随通常纵贯抓住 ens 在在~ 6 .5 晚中新世妈。Theregional 高举南部的西藏的高原因此看起来发生在 8.3 妈和 6.5Ma 之间。Gulu, Damxung-Yangbajain 和 Angan 在 NyainqentanglhaMountains 的通行证东方被更早的东北趋势差错局部地控制的系统抓住。这些抓住 ens 统治随后的构造运动并且山向西北作为西北趋势右滑倒差错仍然很活跃。Miocene 是迎来了现代构造政体的大构造变化的一时间。 | WU Zhenhan Patrick J. BAROSH ZHAO Xun WU Zhonghai HU Daogong LIU Qisheng | 2007 | Acta Geologica Sinica(English Edition)2007，81，3： | 8 |
| 7 | ^(125)I-labeled anti-b FGF monoclonal antibody inhibits growth of hepatocellular carcinoma显示文摘AIM: To investigate the inhibitory efficacy of ^(125)I-labeled anti-basic fibroblast growth factor(b FGF) monoclonal antibody(m Ab) in hepatocellular carcinoma(HCC).METHODS: b FGF m Ab was prepared by using the 1G9B9 hybridoma cell line with hybridization technology and extracted from ascites fluid through a Protein G Sepharose affinity column. After labeling with ^(125)I through the chloramine-T method, b FGF m Ab was further purified by a Sephadex G-25 column. Gamma radiation counter GC-1200 detected radioactivity of ^(125)I-b FGF m Ab. The murine H22 HCC xenograft model was established and randomized to interventions with control(phosphate-buffered saline), ^(125)I-b FGF m Ab,^(125)I plus b FGF m Ab, b FGF m Ab, or ^(125)I. The ratios of tumor inhibition were then calculated. Expression of b FGF, fibroblast growth factor receptor(FGFR), plateletderived growth factor, and vascular endothelial growth factor(VEGF) m RNA was determined by quantitative reverse transcriptase real-time polymerase chain reaction. RESULTS: The purified b FGF m Ab solution was 8.145 mg/m L with a titer of 1:2560000 and was stored at-20 ℃. After coupling, ^(125)I-b FGF m Ab was used at a 1: 1280000 dilution, stored at 4 ℃, and its specific radioactivity was 37 MBq/mg. The corresponding tumor weight in the control, ^(125)I, b FGF m Ab, ^(125)I plus b FGF m Ab, and ^(125)I-b FGF m Ab groups was 1.88 ± 0.25, 1.625 ± 0.21, 1.5 ± 0.18, 1.41 ± 0.16, and 0.98 ± 0.11 g, respectively. The tumor inhibition ratio in the ^(125)I, b FGF m Ab, ^(125)I plus b FGF m Ab, and ^(125)I-b FGF m Ab groups was 13.6%, 20.2%, 25.1%, and 47.9%, respectively. Growth of HCC xenografts was inhibited significantly more in the ^(125)I-b FGF m Ab group than in the other groups(P < 0.05). Expression of b FGF and FGFR m RNA in the ^(125)I-b FGF m Ab group was significantly decreased in comparison with other groups(P < 0.05). Groups under interventions revealed increased expression of VEGF m RNA(except for ^(125)I group) compared with the control group.CONCLUSION: ^(125)I-b FGF m Ab inhibits growth of HCC xenografts. The coupling effect of ^(125)I-b FGF m Ab is more effective than the concomitant use of ^(125)I and b FGF m Ab. | Peng-Hui Hu Lan-Hong Pan Patrick Ting-Yat Wong Wen-Hui Chen Yan-Qing Yang Hong Wang Jun-Jian Xiang Meng Xu | 2016 | World Journal of Gastroenterology2016，22，21： | 4 |
| 8 | Phylogenetic Analysis of Brine Shrimp (Artemia) in China Using DNA Barcoding显示文摘DNA barcoding is a powerful approach for characterizing species of organisms,especially those with almost identical morphological features,thereby helping to to establish phylogenetic relationships and reveal evolutionary histories. In this study,we chose a 648-bp segment of the mitochondrial gene,cytochrome c oxidase subunit 1 (COI),as a standard barcode region to establish phylogenetic relation-ships among brine shrimp (Artemia) species from major habitats around the world and further focused on the biodiversity of Artemia species in China,especially in the Tibetan Plateau. Samples from five major salt lakes of the Tibetan Plateau located at altitudes over 4,000 m showed clear differences from other Artemia pop-ulations in China. We also observed two consistent amino acid changes,153A/V and 183L/F,in the COI gene between the high and low altitude species in China. Moreover,indels in the COI sequence were identified in cyst and adult samples unique to the Co Qen population from the Tibetan Plateau,demonstrating the need for additional investigations of the mitochondrial genome among Tibetan Artemia populations. | Weiwei Wang Qibin Luo Haiyan Guo Peter Bossier Gilbert Van Stappen Patrick Sorgeloos Naihong Xin Qishi Sun Songnian Hu Jun Yu | 2008 | Genomics, Proteomics & Bioinformatics2008，6，3： | 3 |
| 9 | Die design and process optimization of die cast V6 engine blocks显示文摘The use of aluminum, particularly for engine blocks, has grown considerably in the past ten years, and continues to rise in the automotive industry. In order to enhance the quality and engineering functionality of die cast engine blocks, die design and processes have to be optimized. In this study, a computer simulation software, MAGMAsoft, as an advanced tool for optimizing die design and casting process, was employed to virtually visualize cavity filling and patterns of a V6 engine block. The original die design and process was simulated first to establish a baseline. A reality check was used to verify the predicted results. Then, the die modification with a different runner system was made by using a CAD software, Unigraphics (UG). The simulation on combinations of the modified die design and revised process was performed to examine the effect of die modification and process change on flow filling of V6 engine blocks. The simulated prediction indicates that the enhancement of cavity filling due to the die and process modification minimizes the occurrence of defects during casting, and consequently improves the quality of blocks. The results of mechanical testing show a significant increase in fatigue strengths, and a moderately improvement on tensile properties for the blocks die cast with the new die design and process in comparison with those produced by the original ones. | Henry HU Yeouli CHU Patrick CHENG | 2005 | China Foundry2005，2，1： | 3 |
| 10 | Chromite-induced magnesium isotope fractionation during mafic magma differentiation显示文摘To better understand the mechanism of Mg isotopic variation in magma systems, here we report high precision Mg isotopic data of 17 bulk rock samples including dunite, clinopyroxenite, hornblendite and gabbro and 10 pairs of dunite-hosted olivine and chromite separates from the well-characterized Alaskan-type Xiadong intrusion in NW China, which formed by continuous and high degree of lithological differentiation from mafic magmas. Chromite separates have highly variable δ^(26)Mg values from -0.10‰ to 0.40‰, and are consistently heavier than coexisting olivine separates(-0.39‰ to -0.15 T‰). Both mineral δ^(26)Mg values and the degrees of inter-mineral fractionation are well correlated with geochemical indicators of magma differentiation, indicating that these inter-sample and inter-mineral Mg isotope fractionations are caused by magma evolution. The δ^(26)Mg values range from -0.20‰ to -0.02‰ in the dunite,-043‰ in the clinopyroxenite,-043‰ to -0.28‰ in the hornblendite, 0.18 T‰ in the chromite-bearing hornblendite, and -0.56 T‰ to -0.16‰ in the gabbro. The Mg isotopic variations in different types of rocks are closely related to fractional crystallization and accumulation of different proportions of oxides vs. silicates. Chromite crystallization and accumulation is the most important factor in controlling Mg isotope fractionation during the formation of the Xiadong intrusion. Compared to basaltic and granitic magmas, differentiation of the Alaskan-type intrusions occurs at a relatively high oxygen fugacity, which favors chromite crystallization and consequently significant Mg isotope fractionations at both mineral and whole-rock scales. Therefore, Mg isotope systematics can be used to trace the degree of magma differentiation and related-mineralization. | Ben-Xun Su Yan Hu Fang-Zhen Teng Ke-Zhang Qin Yang Bai Patrick Asamoah Sakyi Dong-Mei Tang | 2017 | Science Bulletin2017，62，22： | 2 |
| 11 | Highlights of the 2nd International Symposium on Tribbles and Diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer显示文摘The Tribbles(TRIB) family of pseudokinase proteins has been shown to play key roles in cell cycle, metabolic diseases, chronic inflammatory disease, and cancer development. A better understanding of the mechanisms of TRIB pseudokinases could provide new insights for disease development and help promote TRIB proteins as novel therapeutic targets for drug discovery. At the 2 nd International Symposium on Tribbles and Diseases held on May 7–9, 2018 in Beijing, China, a group of leading Tribbles scientists reported their findings and ongoing studies about the effects of the different TRIB proteins in the areas of immunity, metabolism, fundamental cell biology and cancer. Here, we summarize important and insightful overviews from 4 keynote lectures, 13 plenary lectures and 8 short talks that took place during this meeting. These findings may offer new insights for the understanding of the roles of TRIB pseudokinases in the development of various diseases. | Bing Cui Patrick A. Eyers Leonard L. Dobens Nguan Soon Tan Peter D. Mace Wolfgang A. Link Endre Kiss-Toth Karen Keeshan Takuro Nakamura Warren S. Pear Yodit Feseha Jessica Johnston Arkatiz Carracedo Marcel Scheideler Zabran llyas Robert C. Bauer Jorge D. Erusalimsky Dominika Grzesik Juan Salamanca-Viloria Xiaoxi Lv Yishi Jin Ke Li Guillermo Velasco Shuang Shang Jose M. Lizcano Xiaowei Zhang Jichao Zhou Jiaojiao Yu Fang Hua Feng Wang Shanshan Liu Jinmei Yu Zhuowei Hu | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 2 |
| 12 | Toll‐like receptors 2 and 4 and the cryopyrin inflammasome in normal pregnancy and pre‐eclampsia显示文摘 | F Xie Y Hu SE Turvey LA Magee RM Brunham K‐C Choi M Krajden PCK Leung DM Money DM Patrick E Thomas P von Dadelszen | 2009 | BJOG: An International Journal of Obstetrics & Gy2009，，： | 1 |
| 13 | Examining the TechnologyAcceptance Model Using Physician Acceptance of Telemedicine Technol-ogy 显示文摘 | Hu P J Patrick Y K Chau OR | 1999 | Journal of Management information Systems1999，16，2： | 1 |
| 14 | Evaluation of the robusticity of mutual fund performance in Ghana using Enhanced Resilient Backpropagation Neural Network(ERBPNN)and Fast Adaptive Neural Network Classifier(FANNC)显示文摘Mutual fund investment continues to play a very important role in the world financial markets especially in developing economies where the capital market is not very matured and tolerant of small scale investors.The total mutual fund asset globally as at the end of 2016 was in excess of$40.4 trillion.Despite its success there are uncertainties as to whether mutual funds in Ghana obtain optimal performance relative to their counterparts in United States,Luxembourg,Ireland,France,Australia,United Kingdom,Japan,China and Brazil.We contribute to the extant literature on mutual fund performance evaluation using a collection of more sophisticated econometric models.We selected six continuous historical years that is 2010-2011,2012-2013 and 2014-2015 to construct a mutual fund performance evaluation model utilizing the fast adaptive neural network classifier(FANNC),and to compare our results with those from an enhanced resilient back propagation neural networks(ERBPNN)model.Our FANNC model outperformed the existing models in terms of processing time and error rate.This makes it ideal for financial application that involves large volume of data and routine updates. | Yushen Kong Micheal Owusu-Akomeah Henry Asante Antwi Xuhua Hu Patrick Acheampong | 2019 | Financial Innovation2019，5，1： | 1 |
| 15 | A wireless power pickup based on directional tuning control of magnetic amplifier 显示文摘 | William Hsu Jr-Uei Patrick Hu Aiguo Swain Ak- shya | 2009 | IEEE Transactions on Industrial Electronics2009，56，7： | 1 |
| 16 | Sustainability education in massive open online courses: A content analysis approach显示文摘 | Zhan Z H Patrick SW F Hu M | 2015 | Sustainability2015，，7： | 1 |
| 17 | Hazards posed by active major faults along the Golmud- Lhasa railway route, Tibetan Plateau, China显示文摘 | Wu Zhenhan Patrick J Barosh Daogong Hu | 2004 | Engineering Geology2004，74，34： | 1 |
| 18 | Hazards posed by active major faults along the Golmud-Lhasa railway route,Tibetan Plateau, China显示文摘 | Zhenhan Wu Patrick J Barosh Daogong Hu | 2004 | Engineering Geology2004，74，34： | 1 |
| 19 | A wireless power pickup based on directional tuning control of magnetic amplifier显示文摘 | Hsu Jr-Uei Wil iam Hu Aiguo Patrick | | 0，，07： | 1 |
| 20 | A frequency control method for regulating wireless power to implantable devices 显示文摘 | SI Ping HU Aiguo Patrick MALPAS Simon | 2008 | IEEE Transactions on Biomedical Circuits and Systems2008，2，1： | 1 |
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