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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Refractive errors in high myopic eyes after phacovitrectomy for macular hole显示文摘AIM: To examine the refractive prediction error in high myopic eyes after phacovitrectomy.METHODS: This retrospective comparative case series included 91 eyes(18 high myopic eyes and 73 non-high myopic eyes) of 91 patients who underwent successful phacovitrectomy(phacoemulsification, intraocular lens implantation, and pars plana vitrectomy). The high myopic eyes were defined as the eye with more than 26.0mm of axial length. The postoperative prediction error of mean error and mean absolute error were evaluated at4 mo postoperatively. Axial length and keratometry measurement were performed preoperatively and 4mo postoperatively using the IOL Master.RESULTS: The refractive outcome after phacovitrectomy showed significantly greater myopic shift in the high myopic eyes [-1.08 ±0.87 diopters(D)] than that in the non-high myopic eyes(-0.43 ±0.63 D, P =0.004). Axial length and keratometric value in the high myopic eyes were significantly increased(P =0.043, 0.037 respectively),whereas those in the non-high myopic group were not significantly increased(P =0.135, 0.347 respectively). The change of the axial length in the myopic eye(0.46±0.28 mm)was greater than that in the non- high myopic eye(0.11 ± 0.34 mm; P <0.001).CONCLUSION: High myopic eyes showed more myopic shift than non-high myopic eyes after phacovitrectomy.The cause of myopic shift in high myopic eyes seems tobe attributed to actual elongation of the axial length in high myopia. | Donghyun Jee Yi-Ryeung Park Kyoung In Jung Eunchul Kim Tae Yoon La | 2015 | International Journal of Ophthalmology(English edition)2015，8，2： | 9 |
| 3 | Concurrence of iridocorneal endothelial syndrome in a patient with glaucomatocyclitic crisis显示文摘Dear Sir,Iam Jin A Choi,from the Department of Ophthalmology of St.Vincent Hospital of Suwon,Kyungki-do,South Korea.I write to present a case report of a young female treated with the diagnosis of Posner-Schlossman syndrome for several years,in which she was ultimately proved to have iridocorneal endothelial(ICE)syndrome.Posner-Schlossman syndrome(PS syndrome)is characterized by recurrent attacks of mild anterior uveitis with marked elevation of intraocular pressure(IOP)[1].The exact etiology of this syndrome is not fully established yet.However,the possible role of herpes simplex virus(HSV)is suggested by a study that revealed DNA evidence of the virus in all aqueous specimens of patients during acute attacks in PS syndrome[1,2].ICE is a spectrum of disease | Jin A Choi Yi Ryeung Park Tae Yoon La | 2014 | International Journal of Ophthalmology(English edition)2014，7，2： | 4 |
| 4 | Delivery of a therapeutic protein for bone regeneration from a substrate coated with graphene oxide显示文摘 | La WG Park S Yoon HH | 2013 | Small2013，9，23： | 1 |
| 5 | Dual roles of hyaluronic acids in multilayer films capturing nanocarriers for drug-eluting coatings显示文摘 | Park S Bhang SH La WG | 2012 | Biomaterials2012，33，： | 1 |
| 6 | Chronic cerebrovascular insuriciency induces dementia-like deficits inaged rats显示文摘 | De la Torre JC Fortin T Park GA | 1992 | Brain Res1992，582，2： | 1 |
| 7 | Sequential enzymolysis of human aorta and resultant stress-strain behavior显示文摘 | Hoffman AS Grande LA Park JB | | 0，，02： | 1 |
| 8 | Chronic cerebrovascular insufficiency induces dementia-like deficit in age rats显示文摘 | de la Torre JC Fortin T Park GA | 1992 | Brain Res1992，582，2： | 1 |
| 9 | Calcifying pseudoneoplasm of the spine 显示文摘 | Park P Schmidt LA Shah GV | 2008 | Clin Neurol Neurosurg2008，110，4： | 1 |
| 10 | Obesity and weight gain in adulthood and telomere length显示文摘 | Kim SM Parks CG DeRoo LA Chert H Taylor JA Cawthoo RM | 2009 | Cancer Epidemiol Biomarkers Prey2009，18，3： | 1 |
| 11 | Chronic cerebrovascular insufficiency induces dementia-like deficits in aged rats显示文摘 | Fortin T Park G A | 1992 | Brain Res1992，582，2： | 1 |
| 12 | The history and future of the fluorescence activated cell sorter and flow cytom?etry , a view from Stanford显示文摘 | Herzenberg LA Parks D Sabaf B | 2002 | Clin Chern2002，48，10： | 1 |
| 13 | Amorfrutin A and B, bibenzyl antimicrobial agents from Amorpha fruticosa 显示文摘 | Mitscher LA Park YH A1 - Shamma A | 1981 | Phytochemistry1981，20，4： | 1 |
| 14 | Chronic cerebrovaseular insufficiency induces dementia-like deficits in aged rats显示文摘 | de la Torte JC Fortin T Park GA | 1992 | Brain Res1992，582，2： | 1 |
| 15 | Nitric oxide delays the death of trophic factor-deprived PC12 cells and sympathetic neurons by a cGMP-mediated mechanism显示文摘 | Park DS Greene LA | 1996 | J Neurosci1996，16，： | 1 |
| 16 | Culture of hormone-dependent functional epithelial cells from rat thyroids显示文摘 | Ambesi-Impiombato FS Parks LA Coon HG | 1980 | Proc Natl Acad Sci U S A1980，77，6： | 1 |
| 17 | Chronic cerebrovascular insufficiency induces dementia-like deficits in aged rats 显示文摘 | de la Torre J C Fortin T Park G A | 1992 | Brain Res1992，582，2： | 1 |
| 18 | The role of heat shock pro- teins in spinal cord injury显示文摘 | Reddy SJ La Marca F Park P | 2008 | Neurosurg Focus2008，25，5： | 1 |
| 19 | Dietary fiber intake and risk of breast cancer in postmenopausal women: the National Insti?tutes of Health - AARP Diet and Health Study显示文摘 | Park Y Brinton LA Subar AF et a1 | 2009 | The Ameri?canJournal of clinical nutrition2009，90，66： | 1 |
| 20 | Calcifying pseudoneoplasm of the spine 显示文摘 | Park P Schmidt LA Shah GV | 2008 | Clin Neural Neurosurg2008，110，4： | 1 |
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