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| 1 | Ellagic acid induces apoptosis through inhibition of nuclear factor κB in pancreatic cancer cells显示文摘AIM:To determine the effect of ellagic acid on apop-tosis and proliferation in pancreatic cancer cells and to determine the mechanism of the pro-survival effects of ellagic acid. METHODS:The effect of ellagic acid on apoptosis was assessed by measuring Phosphatidylserine externalization,caspase activity,mitochondrial membrane potential and DNA fragmentation;and proliferation by measuring DNA thymidine incorporation. Mitochondrial membrane potential was measured in permeabilized cells,and in isolated mitochondria. Nuclear factor kB(NF-kB) activity was measured by electromobility shift assay(EMSA) . RESULTS:We show that ellagic acid,a polyphenolic compound in fruits and berries,at concentrations 10 to 50 mmol/L stimulates apoptosis in human pancreatic adenocarcinoma cells. Further,ellagic acid decreases proliferation by up to 20-fold at 50 mmol/L. Ellagic acid stimulates the mitochondrial pathway of apoptosis associated with mitochondrial depolarization,cytochrome C release,and the downstream caspaseactivation. Ellagic acid does not directly affect mitochondria. Ellagic acid dose-dependently decreased NF-kB binding activity. Furthermore,inhibition of NF-kB activity using IkB wild type plasmid prevented the effect of ellagic acid on apoptosis. CONCLUSION:Our data indicate that ellagic acid stimulates apoptosis through inhibition of the prosu-rvival transcription factor NF-kB. | Mouad Edderkaoui Irina Odinokova Izumi Ohno Ilya Gukovsky Vay Liang W Go Stephen J Pandol Anna S Gukovskaya | 2008 | World Journal of Gastroenterology2008，14，23： | 30 |
| 2 | Ethanol dietincreases the sensitivith of rats to pancreatitis induced by cholecystokinin oc- tapeptide显示文摘 | Pandol ST Periskic S Gukovsky I | 1999 | Gastrenterology1999，117，： | 1 |
| 3 | Ethanol diet increases the sensitivity of rats to pancreatitis induced by cholecystokinin octapeptide显示文摘 | Pandol ST Periskic S Gukovsky I | | 0，，： | 1 |
| 4 | Substance P mediates cerulein-induced panceatic microciculatory dysfunction in mice显示文摘 | Ito Y Lugea A Pandol S J | 2007 | Pancreas2007，34，1： | 1 |
| 5 | Mechanisms of cell death after pancreatic duct obstruction in the opossum and the rat显示文摘 | AS Gukovskaya P Perkins V Zaninovic D Sandoval R Rutherford T Fitzsimmons SJ Pandol S Poucell-Hatton | 1996 | Gastroenterology1996，，3： | 1 |
| 6 | Impaired auto- phagy and organellar dysfunction in pancreatitis 显示文摘 | Gukovsky I Pandol S J Mareninova OA | 2012 | J Gastro- enterol Hepatol2012，27，2： | 1 |
| 7 | GMP modulates depletion-activated Ca2+ entry in pancreatic acinar cells显示文摘 | Bahnson T D Pandol S J Dionne V E | 1993 | J Biol Chem1993，268，10： | 1 |
| 8 | Reactive oxygen species produced by NAD (P)H oxidase inhibit apoptosis in pancreatic cancer cells 显示文摘 | Vaquero EC Edderkaoui M Pandol S J | 2004 | J Biol Chem2004，279，34： | 1 |
| 9 | Organellar dysfunction in the pathogenesis of pancreatitis显示文摘 | Gukovsky I Pandol S J Gukovskaya AS | 2011 | Antioxid Redox Signal2011，15，： | 1 |
| 10 | Impaired autophagy and organellar dysfimction in pancreatitis 显示文摘 | Gukovsky I Pandol S J Mareninova OA | 2012 | Gastroenterol Hepatol2012，2，27： | 1 |
| 11 | Acute pancreatitis: bench to the bedside 显示文摘 | Pandol S J Saluja AK Imrie CW | 2007 | Gastroenterology2007，132，3： | 1 |
| 12 | Acute panereatitis 显示文摘 | PANDOL S J | 2005 | Curr Opin Gastroenterol2005，21，5： | 1 |
| 13 | Organellar dysfunction in the pathogenesis of pancreatitis显示文摘 | Gukovsky I Pandol S J Gukovskaya A S | | 0，，10： | 1 |
| 14 | The acinar - ductal tango in the pathogenesis of acute pancreatitis 显示文摘 | Hegyi P Pandol S Venglovecz V | 2011 | Gut2011，60，4： | 1 |
| 15 | Acute pancreatitis: bench to the bedside 显示文摘 | Pandol S J Saluja A K Imrie C W | 2007 | Gastroenterology2007，132，3： | 1 |
| 16 | Effects of caerulein on the apical cytoskeleton of the pancreatic acinar cell 显示文摘 | O' Konski M S Pandol S J | 1990 | J Clin Invest1990，86，5： | 1 |
| 17 | Ethanol diet increases the sensitivity of rats to pancreatitis induced by chotecystokin octapeptid显示文摘 | Pandol ST Periskic S Gukovsky I | 1999 | Gastroenterology1999，117，3： | 1 |
| 18 | Epidemiolo- gy, risk factors, and the promotion of pancreatic cancer= role of the stellate cell显示文摘 | Pandol S Gukovskaya A Edderkaoui M | 2012 | J Gastroenterol Hepatol2012，27，2： | 1 |
| 19 | Ethanol diet increases the sensitivity of rats to pancreatitis induced by chotecystokin octapeptid显示文摘 | Periskic S Gukovsky I | 1999 | Gastroenterology1999，117，3： | 1 |
| 20 | Acute pancreatitis显示文摘 | | 2006 | Curr Opin Gastroenterol2006，22，5： | 1 |
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