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| 1 | Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus显示文摘AIM To investigate the role of glucagon-like peptide-1(GLP-1)/glucagon receptors coagonist on renal dysfunction associated with diabetes and obesity. METHODS Chronic high-fat diet fed C57 BL/6 J mice, streptozotocintreated high-fat diet fed C57 BL/6 J mice and diabeticC57 BLKS/J db/db mice were used as models of diabetes-induced renal dysfunction. The streptozotocintreated high-fat diet fed mice and db/db mice were treated with the GLP-1 and glucagon receptors coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) for twelve weeks, while in chronic high-fat diet fed mice, coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) treatment was continued for forty weeks. Kidney function, histology, fibrosis, inflammation, and plasma biochemistry were assessed at the end of the treatment. RESULTS Coagonist treatment decreased body weight, plasma lipids, insulin resistance, creatinine, blood urea nitrogen, urinary albumin excretion rate and renal lipids. In kidney, expression of lipogenic genes(SREBP-1 C, FAS, and SCD-1) was decreased, and expression of genes involved in β-oxidation(CPT-1 and PPAR-α) was increased due to coagonist treatment. In plasma, coagonist treatment increased adiponectin and FGF21 and decreased IL-6 and TNF-?. Coagonist treatment reduced expression of inflammatory(TNF-α, MCP-1, and MMP-9) and pro-fibrotic(TGF-β, COL1 A1, and α-SMA) genes and also improved histological derangement in renal tissue.CONCLUSION Coagonist of GLP-1 and glucagon receptors alleviated diabetes and obesity-induced renal dysfunction by reducing glucose intolerance, obesity, and hyperlipidemia. | Vishal J Patel Amit A Joharapurkar Samadhan G Kshirsagar Brijesh K Sutariya Maulik S Patel Hiren M Patel Dheerendra K Pandey Rajesh H Bahekar Mukul R Jain | 2018 | World Journal of Diabetes2018，9，6： | 5 |
| 2 | 在有经历非肝的外科的肝疾病的病人的 Perioperative 风险因素显示文摘 The patients with liver disease present for various surgical interventions. Surgery may lead to complications in a significant proportion of these patients. These complications may result in considerable morbidity and mortality. Preoperative assessment can predict survival to some extent in patients with liver disease undergoing surgical procedures. A review of literature suggests nature and the type of surgery in these patients determines the peri-operative morbidity and mortality. Optimization of premorbid factors may help to reduce perioperative mortality and morbidity. The purpose of this review is to discuss the effect of liver disease on perioperative outcome; to understand various risk scoring systems and their prognostic significance; to delineate different preoperative variables implicated in postoperative complications and morbidity; to establish the effect of nature and type of surgery on postoperative outcome in patients with liver disease and to discuss optimal anaesthesia strategy in patients with liver disease. | Chandra Kant Pandey Sunaina Tejpal Karna Vijay Kant Pandey Manish Tandon Amit Singhal Vivek Mangla | 2012 | World Journal of Gastrointestinal Surgery2012，4，12： | 4 |
| 3 | Enzymic changes in response to zinc nutrition显示文摘 | Nalini Pandey Girish Chandra Pathak Amit Kumar Singh | 2002 | Plant Physiol2002，159，： | 1 |
| 4 | Novel, efficient and recyclable silica based organic- inorganic hybrid Nickel catalyst for degradation of dye pollutants in a newly designed chemical reactor 显示文摘 | K Sharma Shikha Gulati Amit Pandey | 2012 | Applied Catalysis B: Environmental2012，125，： | 1 |
| 5 | OpticalCDMA Networks Using Different Detection Tech-niques and Coding Schemes 显示文摘 | Negi C M Pandey Amit Soni G G | 2011 | International Journalof Future Generation Communication and Networking2011，4，3： | 1 |
| 6 | A framework for predictive web prefetching at the proxy level using data mining显示文摘 | Jyoti Pandey Amit Goel | 2008 | Intemational Journal of Computer Science and Network Security2008，8，6： | 1 |
| 7 | Enzymic changes in response to zinc nutrition显示文摘 | NALINI PANDEY GIRISH CHANDRA PATGAK AMIT KUMAR SINGH | 2002 | J Plant Physiol2002，，159： | 1 |
| 8 | Re- view on production and medical applications of s-polylysine 显示文摘 | Swet Chand Shukla Amit Singh Anand Kumar Pandey | 2012 | Biochemical Engineering Journal2012，65，15： | 1 |
| 9 | Experi- mental and numerical investigations of yield surface, texture, and deformation mechanisms in AA5754 over low to high temperatures and strain rates 显示文摘 | Amit Pandey Khan Akhtar S Eun - Young Kim | 2013 | International Journal of Plasticity2013，41，： | 1 |
| 10 | Current therapeutic modalities and chemopreventive role of natural products in liver cancer:Progress and promise显示文摘Liver cancer is a severe concern for public health officials since the clinical cases are increasing each year,with an estimated 5-year survival rate of 30%–35%after diagnosis.Hepatocellular carcinoma(HCC)constitutes a significant subtype of liver cancer(approximate75%)and is considered primary liver cancer.Treatment for liver cancer mainly depends on the stage of its progression,where surgery including,hepatectomy and liver transplantation,and ablation and radiotherapy are the prime choice.For advanced liver cancer,various drugs and immunotherapy are used as first-line treatment,whereas second-line treatment includes chemotherapeutic drugs from natural and synthetic origins.Sorafenib and lenvatinib are first-line therapies,while regorafenib and ramucirumab are secondline therapy.Various metabolic and signaling pathways such as Notch,JAK/STAT,Hippo,TGF-β,and Wnt have played a critical role during HCC progression.Dysbiosis has also been implicated in liver cancer.Drug-induced toxicity is a key obstacle in the treatment of liver cancer,necessitating the development of effective and safe medications,with natural compounds such as resveratrol,curcumin,diallyl sulfide,and others emerging as promising anticancer agents.This review highlights the current status of liver cancer research,signaling pathways,therapeutic targets,current treatment strategies and the chemopreventive role of various natural products in managing liver cancer. | Amit Kumar Singh Shiv Vardan Singh Ramesh Kumar Shashank Kumar Sabyasachi Senapati Abhay K Pandey | 2023 | World Journal of Hepatology2023，15，1： | 1 |
| 11 | Negative to posi- tive strain rate sensitivity in 5XXX series aluminum alloys: Experi- ment and constitutive modeling 显示文摘 | Farhoud Kabirian Khan Akhtar S Amit Pandey | 2014 | International Journal of Plas- ticity2014，55，： | 1 |
| 12 | Acute kidney injury in late pregnancy in developing countries显示文摘 | Jai Prakash Shashidhar Shree Niwas Aashish Parekh Laxmi Kant Pandey Loukrakpam Sharatchandra Puneet Arora Amit Kumar Mahapatra | 2010 | Renal Failure2010，，3： | 1 |
| 13 | Transport of liposomal and albumin loaded cureumin to living cells: An absorption and fluorescence spectroscopic study显示文摘 | Amit Kunwar Atanu Barik Ruehi Pandey | 2006 | Bioehimica et Biophysica Acta2006，，1760： | 1 |
| 14 | Evolution of subsequent yield surfaces and elastic constants with finite plastic deformation. Part-I: A very low work hardening aluminum alloy (Al6061-T6511)显示文摘 | Akhtar S. Khan Rehan Kazmi Amit Pandey Thomas Stoughton | 2009 | International Journal of Plasticity2009，，9： | 1 |
| 15 | Stable and efficient composite anion-exchange membranes based on silica modified poly (ethyleneimine)-poly (vinylalcohol) for electrodialysis 显示文摘 | Ravi P Pandey Amit K Thakur Vinod Shahi | 2014 | Journal of Member Science2014，，： | 1 |
| 16 | Evolution of subsequent yield surfaces and elastic constants with finite plastic deformation. Part III: Yield surface in tension–tension stress space (Al 6061–T 6511 and annealed 1100 Al)显示文摘 | Akhtar S. Khan Amit Pandey Thomas Stoughton | 2009 | International Journal of Plasticity2009，，10： | 1 |
| 17 | Evolution of subsequent yield surfaces and elastic constants with finite plastic deformation. Part II: A very high work hardening aluminum alloy (annealed 1100 Al)显示文摘 | Akhtar S. Khan Amit Pandey Thomas Stoughton | 2009 | International Journal of Plasticity2009，，10： | 1 |
| 18 | Re- view on production and medical applications of ~-polylysine显示文摘 | Swet Chand Shukla Amit Singh Anand Kumar Pandey | 2012 | Biochemical Engineering Journal2012，65，15： | 1 |
| 19 | Neuron Specific Enolase and C-reactive Protein Levels in Stroke and Its Subtypes: Correlation with Degree of Disability显示文摘 | Aparna Pandey Amit Kumar Shrivastava Kiran Saxena | 2014 | Neurochemical Research2014，，8： | 1 |
| 20 | Mechanism and recent updates on insulin-related disorders显示文摘Insulin,a small protein with 51 amino acids synthesized by pancreatic β-cells,is crucial to sustain glucose homeostasis at biochemical and molecular levels.Numerous metabolic dysfunctions are related to insulin-mediated altered glucose homeostasis.One of the significant pathophysiological conditions linked to the insulin associated disorder is diabetes mellitus(DM)(type 1,type 2,and gestational).Insulin resistance(IR)is one of the major underlying causes of metabolic disorders despite its association with several physiological conditions.Metabolic syndrome(MS)is another pathophysiological condition that is associated with IR,hypertension,and obesity.Further,several other pathophysiological disorders/diseases are associated with the insulin malfunctioning,which include polycystic ovary syndrome,neuronal disorders,and cancer.Insulinomas are an uncommon type of pancreatic β-cell-derived neuroendocrine tumor that makes up 2% of all pancreatic neoplasms.Literature revealed that different biochemical events,molecular signaling pathways,microRNAs,and microbiota act as connecting links between insulin disorder and associated pathophysiology such as DM,insuloma,neurological disorder,MS,and cancer.In this review,we focus on the insulin-related disorders and the underlying mechanisms associated with the pathophysiology. | Shashank Kumar Sabyasachi Senapati Neetu Bhattacharya Amit Bhattacharya Shashank Kumar Maurya Hadiya Husain Jasvinder Singh Bhatti Abhay Kumar Pandey | 2023 | World Journal of Clinical Cases2023，11，25： | 1 |
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