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| 1 | A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV) infected pneumonia(standard version)显示文摘In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province;and then named '2019 novel coronavirus(2019-nCoV)' by the World Health Organization(WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development;we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control(including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV. | Ying-Hui Jin Lin Cai Zhen-Shun Cheng Hong Cheng Tong Deng Yi-Pin Fan Cheng Fang Di Huang Lu-Qi Huang Qiao Huang Yong Han Bo Hu Fen Hu Bing-Hui Li Yi-Rong Li Ke Liang Li-Kai Lin Li-Sha Luo Jing Ma Lin-Lu Ma Zhi-Yong Peng Yun-Bao Pan Zhen-Yu Pan Xue-Qun Ren Hui-Min Sun Ying Wang Yun-Yun Wang Hong Weng Chao-Jie Wei Dong-Fang Wu Jian Xia Yong Xiong Hai-Bo Xu Xiao-Mei Yao Yu-Feng Yuan Tai-Sheng Ye Xiao-Chun Zhang Ying-Wen Zhang Yin-Gao Zhang Hua-Min Zhang Yan Zhao Ming-Juan Zhao Hao Zi Xian-Tao Zeng Yong-Yan Wang Xing-Huan Wang 无 | 2020 | Military Medical Research2020，7，1： | 161 |
| 2 | LAMOST Experiment for Galactic Understanding and Exploration (LEGUE)——The survey's science plan显示文摘We describe the current plans for a spectroscopic survey of millions of stars in the Milky Way galaxy using the Guo Shou Jing Telescope (GSJT, formerly called the Large sky Area Multi-Object fiber Spectroscopic Telescope - LAMOST). The survey will obtain spectra for 2.5 million stars brighter than r < 19 during dark/grey time, and 5 million stars brighter than r < 17 or J < 16 on nights that are moonlit or have low transparency. The survey will begin in the fall of 2012, and will run for at least four years. The telescope's design constrains the optimal declination range for observations to 10 < δ < 50 , and site conditions lead to an emphasis on stars in the direction of the Galactic anticenter. The survey is divided into three parts with different target selection strategies: disk, anticenter, and spheroid. The resulting dataset will be used to study the merger history of the Milky Way, the substructure and evolution of the disks, the nature of the first generation of stars through identification of the lowest metallicity stars, and star formation through study of open clusters and OB associations. Detailed design of the LAMOST Experiment for Galactic Understanding and Exploration (LEGUE) survey will be completed in summer 2012, after a review of the results of the pilot survey. | Li-Cai Deng Heidi Jo Newberg Chao Liu Jeffrey L. Carlin Timothy C. Beers Li Chen Hsu-Tai Lee Carl J. Grillmair Puragra Guhathakurta] Zhan-Wen Han Jin-Liang Hou Sebastien Lepine Jing Li Xiao-Wei Liu Kai-Ke Pan J. A. Sellwood Bo Wang Hong-Chi Wang Fan Yang Brian Yanny Hao-Tong Zhang Yue-Yang Zhang Zheng Zheng Zi Zhu | 2012 | Research in Astronomy and Astrophysics2012，12，7： | 10 |
| 3 | Clinical classification and gene mutation of Chinese probands with Charcot-Marie-Tooth disease Analysis of 57 cases显示文摘Charcot-Marie-Tooth(CMT) disease is the most common inherited peripheral neuropathic disorder.CMT is clinically and genetically heterogeneous.To date,27 genes associated with the disease have been cloned.The present study carried out clinical classification according to clinical,electrophysiological and pathological features,conducted inheritance classification according to inheritance patterns,and performed mutation analysis of 13 CMT disease genes(PMP22,CX32,HSPB1,MNF2,MPZ,HSPB8,GDAP1,NFL,EGR2,SIMPLE,RAB7,LMNA,MTMR2) in 57 Chinese probands with CMT.Five cases of AD-CMT1 and 13 cases of sporadic CMT1 were diagnosed as CMT1A;five cases of X-CMT1,one case of X-CMT2 and one case of sporadic CMT1 were diagnosed as CMTX1;four cases of AD-CMT2 were diagnosed as CMT2F;one case of AD-CMT2 and one case of sporadic CMT2 were diagnosed as CMT2A2;one case of AD-CMT2 was diagnosed as CMT2L;one case of AD-CMT2 was diagnosed as CMT2J;one case of AR-CMT1 was diagnosed as CMT4A.Among the 57 CMT probands,seven genotypes were determined among 34 patients,with a detection rate of 59.6%.The results indicated that the clinical classification and inheritance classification are indispensable for selecting potential disease genes for mutation detection,and for efficient molecular diagnosis. | Ruxu Zhang Xiaobo Li Xiaohong Zi Shunxiang Huang Fufeng Zhang Kun Xia Qian Pan Beisha Tang | 2011 | Neural Regeneration Research2011，6，9： | 4 |
| 4 | New lncRNA annotation reveals extensive functional divergence of the transcriptome in maize显示文摘Long non-coding RNAs(lncRNAs), whose sequences are approximately 200 bp or longer and unlikely to encode proteins, may play an important role in eukaryotic gene regulation. Although the latest maize(Zea mays L.) reference genome provides an essential genomic resource, genome-wide annotations of maize lncRNAs have not been updated. Here, we report on a large transcriptomic dataset collected from 749 RNA sequencing experiments across different tissues and stages of the maize reference inbred B73 line and 60 from its wild relative teosinte. We identified 18,165 high-confidence lncRNAs in maize, of which 6,873 are conserved between maize and teosinte. We uncovered distinct genomic characteristics of conserved lncRNAs,non-conserved lncRNAs, and protein-coding transcripts.Intriguingly, Shannon entropy analysis showed that conserved lncRNAs are likely to be expressed similarly to protein-coding transcripts. Co-expression network analysis revealed significant variation in the degree of co-expression. Furthermore, selection analysis indicated that conserved lncRNAs are more likely than non-conserved lncRNAs to be located in regions subject to recent selection, indicating evolutionary differentiation. Our results provide the latest genomewide annotation and analysis of maize lncRNAs and uncover potential functional divergence between proteincoding, conserved lncRNA, and non-conserved lncRNA genes, demonstrating the high complexity of the maize transcriptome. | Linqian Han Zhenna Mu Zi Luo Qingchun Pan Lin Li | 2019 | Journal of Integrative Plant Biology2019，61，4： | 2 |
| 5 | Aurora kinase small molecule inhibitor destructs mitotic spindle, suppresses cell growth, and induces apoptosis in oral squamous cancer cells显示文摘 | Chao Bin Pan Hong Zhang Huang Min Yan Jine Yao Jie Xu Zi Jie Long | 2008 | 中国口腔颌面外科杂志2008，6，B05： | 2 |
| 6 | Electrochemical oxida- tion of lignin at lead dioxide nanoparticles photoelectrodeposited on TiO2 nanotube arrays显示文摘 | Pan Ke Tian Min Jiang Zi -hua | 2012 | Electrochimica Acta2012，60，： | 1 |
| 7 | A redox based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso compounds显示文摘 | Lipton SA Choi YB Pan ZI | 1993 | Nature1993，364，： | 1 |
| 8 | The diagnostic criteria for primary osteoporosis and the incidence of osteoporosis in China显示文摘 | Zhonghou Liu Junhong Piao Lianping Pang Xiang Qing Su Nan Zi’ang Pan Yichao Guo Xiaohong Wang Fangfang Li Jingping Liu Xiaoguang Cheng | 2002 | Journal of Bone and Mineral Metabolism2002，，4： | 1 |
| 9 | The diagnostic criteria for primary osteoporosis and the incidence of osteoporosis in China显示文摘 | Zhonghou Liu Junhong Piao Lianping Pang Xiang Qing Su Nan Zi’ang Pan Yichao Guo Xiaohong Wang Fangfang Li Jingping Liu Xiaoguang Cheng | 2002 | Journal of Bone and Mineral Metabolism2002，，4： | 1 |
| 10 | THE ULTRASTRUCTURE AND ENZYME HISTOCHEMISTRY OF THE SUBSTANTIA GELATINOSA OF RAT SPINAL CORD UNDER THE INFLUENCE OF ELECTRO-ACUPUNCTURE ANALGESIA显示文摘Histochemistry and EM were used in this experiment to study the effect of EAon the spinal dorsal horn of rat. After 30 minutes EA, the pain threshold of EA rats were elevated400%, the acid phosphatase reaction in spinal dorsal horn of EA rats increased obviously, the roundagranular vesicles of the C-terminals of EA group was more than that of control’s. The results sug-gested that the histochemical components and numbers of synaptic vesicles in SG and their functionscould be regulated by acupuncture. | Pan Baohan Ge Zi, Institute of Acupuncture and Moxibustion, China Academy of TCM, Beijing 100700, China | 1993 | World Journal of Acupuncture-Moxibustion1993，3，1： | 1 |
| 11 | Transformation of hydroxylated and methoxylated 2,2′,4,4′,5-brominated diphenyl ether(BDE-99) in plants显示文摘The occurrence and fate of hydroxylated polybrominated diphenyl ethers(OH-PBDEs) and methoxylated polybrominated diphenyl ethers(Me O-PBDEs) have received significant attention. However, there is limited information on the metabolism relationship between OH-pentaB DEs and MeO-pentaB DEs that were frequently detected with relatively high concentrations in the environment. In this study, the biotransformation between OH-BDE-99 and MeO-BDE-99 was investigated in rice, wheat, and soybean plants. All the three plants can metabolize OH-BDE-99 to corresponding homologous methoxylated metabolites, while the transformation from MeO-BDE-99 to OH-BDE-99 could only be found in soybean. The conversion of parent compounds was the highest in soybean, followed by wheat and rice. Transformation products were found mainly in the roots, with few metabolites being translocated to the shoots and solution after exposure. The results of this study provide valuable information for a better understanding of the accumulation and transformation of OH-PBDEs and MeO-PBDEs in different plants. | Lili Pan Jianteng Sun Xiaodan Wu Zi Wei Lizhong Zhu | 2016 | Journal of Environmental Sciences2016，28，11： | 1 |
| 12 | An algorithm for preferential selection of spectroscopic targets in LEGUE显示文摘We describe a general target selection algorithm that is applicable to any survey in which the number of available candidates is much larger than the number of objects to be observed. This routine aims to achieve a balance between a smoothly- varying, well-understood selection function and the desire to preferentially select certain types of targets. Some target-selection examples are shown that illustrate different possibilities of emphasis functions. Although it is generally applicable, the algorithm was developed specifically for the LAMOST Experiment for Galactic Understanding and Exploration (LEGUE) survey that will be carried out using the Chinese Guo Shou Jing Telescope. In particular, this algorithm was designed for the portion of LEGUE targeting the Galactic halo, in which we attempt to balance a variety of science goals that require stars at fainter magnitudes than can be completely sampled by LAMOST. This algorithm has been implemented for the halo portion of the LAMOST pilot sur- vey, which began in October 2011. | Jeffrey L. Carlin Sebastien Lepine Heidi Jo Newberg Li-Cai Deng Timothy C. Beers Yu-Qin Chen Norbert Christlie Xiao-Ting Fu Shuang Gao Carl J. Grillmair PuragraGuhathakurta Zhan-Wen Han Jin-Liang Hou Hsu-Tai Lee Jing Li Chao Liu Xiao-Wei Liu Kai-Ke Pan J. A. Sellwood Hong-Chi Wang Fan Yang Brian Yanny Yue-Yang Zhan Zheng Zheng Zi Zhu | 2012 | Research in Astronomy and Astrophysics2012，12，7： | 1 |
| 13 | Synthesis and cytotoxic activity of heterocycle-substituted phthalimide derivatives显示文摘一系列代替 heterocycle 的 phthalimide 衍生物被综合。有杂环的戒指的在结构上多样的衍生物包括呋喃, imidazo [ 1,2-a ] pyridine , 1,3,4-thiadiazine , imidazo [ 2,1-b ][ 1,3,4 ] thiadiazine , pyrazole , 1,2,4-triazolo [ 3,4-b ][ 1,3,4 ] thiadiazine , thiazole 和 thiazoline ,被与包含氧,氮和硫原子的各种各样的 nucleophiles 中间的伪- bromoketone 的反应获得。他们的细胞毒素的活动也在 vitro 与五根人的癌症房间线被作比较。 | Ya Jun Yang Ya Nan Yang Jian Shuang Jiang Zi Ming Feng Hong Yan Liu Xian Dao Pan Pei Cheng Zhang | 2010 | Chinese Chemical Letters2010，21，8： | 1 |
| 14 | A novel transgenic mouse model of Chinese CharcotMarie-Tooth disease type 2L显示文摘We previously found that the K141N mutation in heat shock protein B8(HSPB8) was responsible for Charcot-Marie-Tooth disease type 2L in a large Chinese family.The objective of the present study was to generate a transgenic mouse model bearing the K141N mutation in the human HSPB8 gene,and to determine whether this K141NHSPB8 transgenic mouse model would manifest the clinical phenotype of Charcot-Marie-Tooth disease type 2L,and consequently be suitable for use in studies of disease pathogenesis.Transgenic mice overexpressing K141NHSPB8 were generated using K141N mutant HSPB8 cDNA cloned into a pCAGGS plasmid driven by a human cytomegalovirus expression system.PCR and western blot analysis confirmed integration of the K141NHSPB8 gene and widespread expression in tissues of the transgenic mice.The K141NHSPB8 transgenic mice exhibited decreased muscle strength in the hind limbs and impaired motor coordination,but no obvious sensory disturbance at 6 months of age by behavioral assessment.Electrophysiological analysis showed that the compound motor action potential amplitude in the sciatic nerve was significantly decreased,but motor nerve conduction velocity remained normal at 6 months of age.Pathological analysis of the sciatic nerve showed reduced myelinated fiber density,notable axonal edema and vacuolar degeneration in K141NHSPB8 transgenic mice,suggesting axonal involvement in the peripheral nerve damage in these animals.These findings indicate that the K141NHSPB8 transgenic mouse successfully models Charcot-Marie-Tooth disease type 2L and can be used to study the pathogenesis of the disease. | Ruxu Zhang Fufeng Zhang Xiaobo Li Shunxiang Huang Xiaohong Zi Ting Liu Sanmei Liu Xuning Li Kun Xia Qian Pan Beisha Tang | 2014 | Neural Regeneration Research2014，9，4： | 1 |
| 15 | Development of a ferritin-based nanoparticle vaccine against the SARS-CoV-2 Omicron variant显示文摘Dear Editor,The COVID-19 pandemic has had a devastating effect on global health,resulting in over 6.2 million deaths worldwide.Continuous emergence of adaptive mutations of SARS-CoV-2 alters its pathogenicity and transmissibility,and renders its resistance to current vaccines and antiviral drugs.1 A new variant named Omicron discovered initially in South Africa has recently been proposed as a variant of concern(VOC)by the World Health Organization,because of its high transmissibility and resistance to current vaccines and therapeutic antibodies.2 Therefore,development of vaccines against prevalent variants including Omicron is urgently needed for COVID-19 prevention. | Wanbo Tai Benjie Chai Shengyong Feng Xinyu Zhuang Jun Ma Mujia Pang Lin Pan Zi Yang Mingyao Tian Gong Cheng | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 1 |
| 16 | A study of on/off timing channel based on packet delay distribution显示文摘 | YAO LIHAO ZI XIAOCHAO PAN LI | 2009 | Computers & Security2009，28，8： | 1 |
| 17 | Investigation of the relationship between SLA-1 and SLA-3 gene expression and susceptibility to Escherichia coli F18 in post-weaning pigs显示文摘 | Ye L Zi C Pan Z Y | 2012 | Comp Immunol Microb2012，35，1： | 1 |
| 18 | Visualization framework for inter-domain access control policy integration显示文摘 | Pan L Liu N Zi X | 2013 | Communications China2013，10，3： | 1 |
| 19 | Implementing a Passive Network Covert Timing Channel显示文摘 | ZI X YAO L PAN L | 2010 | Computers & Security2010，29，6： | 1 |
| 20 | A Fuzzy Neural Network for Fault Pattern Recognition显示文摘This paper combines fuzzy set theory with ART neural network, and demonstrates some important properties of the fuzzy ART neural network algorithm. The results from application on a ball bearing diagnosis indicate that a fuzzy ART neural network has an effect of fast stable recognition for fuzzy patterns. | PAN Zi wei, WU Chao ying Department of Mechanical Engineering, Anhui University of Technology, Maanshan 243002, P.R.China | 2001 | International Journal of Plant Engineering and Management2001，6，3： | 1 |
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